PE20070518A1 - Compuestos de tiofeno bencimidazol como agentes inhibidores de plk - Google Patents
Compuestos de tiofeno bencimidazol como agentes inhibidores de plkInfo
- Publication number
- PE20070518A1 PE20070518A1 PE2006001041A PE2006001041A PE20070518A1 PE 20070518 A1 PE20070518 A1 PE 20070518A1 PE 2006001041 A PE2006001041 A PE 2006001041A PE 2006001041 A PE2006001041 A PE 2006001041A PE 20070518 A1 PE20070518 A1 PE 20070518A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- benzimidazol
- ethyl
- thiophenocarboxamide
- methyl
- Prior art date
Links
- OHNAITIAQLQHJY-UHFFFAOYSA-N 1h-benzimidazole;thiophene Chemical class C=1C=CSC=1.C1=CC=C2NC=NC2=C1 OHNAITIAQLQHJY-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- -1 BENZIMIDAZOLE THIOPHENE COMPOUND Chemical class 0.000 abstract 12
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 5
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical compound [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO TIOFENO BENCIMIDAZOL SELECCIONADO DE: 5-{6-[(METILSULFONIL)METIL]-1H-BENZIMIDAZOL-1-IL}-3-({(1R)-1-[2-(TRIFLUOROMETIL)FENIL]ETIL}OXI)-2-TIOFENOCARBOXAMIDA (FORMULA A), 3-{[(1R)-1-(2-CLOROFENIL)ETIL]OXI}-5-{6-[(METILSULFONIL)METIL]-1H-BENZIMIDAZOL-1-IL}-2-TIOFENOCARBOXAMIDA (FORMULA B), 5-{6-[(4-METILPIPERAZIN-1-IL)METIL]-1H-BENZIMIDAZOL-1-IL}-3-{(1R)-1-[2-(TRIFLUOROMETIL)FENIL]ETOXI}TIOFENO-2-CARBOXAMIDA (FORMULA C), 3-{[(1R)-1-(2-CLOROFENIL)ETIL]OXI}-5-{6-[(4-METILPIPERAZIN-1-IL)METIL]-1H-BENZIMIDAZOL-1-IL}-TIOFENO-2-CARBOXAMIDA (FORMULA D), 5-[6-(4-PIPERIDINILOXI)-1H-BENZIMIDAZOL-1-IL]-3-({(1R)-1-[2-(TRIFLUOROMETIL)FENIL]ETIL}OXI)-2-TIOFENOCARBOXAMIDA (FORMULA E), 3-{[(1R)-1-(2-CLOROFENIL)ETIL]OXI}-5-[6-(4-PIPERIDINILOXI)-1H-BENZIMIDAZOL-1-IL]-2-TIOFENOCARBOXAMIDA (FORMULA F), 5-{6-[(1-METIL-4-PIPERIDINIL)OXI]-1H-BENZIMIDAZOL-1-IL}-3-({(1R)-1-[2-(TRIFLUOROMETIL)FENIL]ETIL}OXI)-2-TIOFENOCARBOXAMIDA (FORMULA G) Y 3-{[(1R)-1-(2-CLOROFENIL)ETIL]OXI}-5-{6-[1-METIL-4-PIPERIDINIL)OXI]-1H-BENZIMIDAZOL-1-IL}-2-TIOFENOCARBOXAMIDA (FORMULA H), DONDE EL ASTERISCO INDICA UN CARBONO QUIRAL. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LAS QUINASAS TIPO POLO (PLK), LAS CUALES SON QUINASAS DE SERINA/TREONINA, Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71433705P | 2005-09-06 | 2005-09-06 | |
| US78624406P | 2006-03-27 | 2006-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070518A1 true PE20070518A1 (es) | 2007-06-12 |
Family
ID=37631488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001041A PE20070518A1 (es) | 2005-09-06 | 2006-08-28 | Compuestos de tiofeno bencimidazol como agentes inhibidores de plk |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7786127B2 (es) |
| EP (1) | EP1937671B1 (es) |
| JP (1) | JP5002597B2 (es) |
| KR (1) | KR20080047585A (es) |
| AR (1) | AR055616A1 (es) |
| AT (1) | ATE452132T1 (es) |
| AU (1) | AU2006287766B2 (es) |
| BR (1) | BRPI0615668A2 (es) |
| CA (1) | CA2621879A1 (es) |
| CR (1) | CR9786A (es) |
| CY (1) | CY1109916T1 (es) |
| DE (1) | DE602006011192D1 (es) |
| DK (1) | DK1937671T3 (es) |
| EA (1) | EA014111B1 (es) |
| ES (1) | ES2337929T3 (es) |
| HR (1) | HRP20100122T1 (es) |
| IL (1) | IL189897A0 (es) |
| JO (1) | JO2578B1 (es) |
| MA (1) | MA29816B1 (es) |
| MX (1) | MX2008003173A (es) |
| NO (1) | NO20081160L (es) |
| NZ (1) | NZ566345A (es) |
| PE (1) | PE20070518A1 (es) |
| PL (1) | PL1937671T3 (es) |
| PT (1) | PT1937671E (es) |
| SI (1) | SI1937671T1 (es) |
| TW (1) | TW200800967A (es) |
| WO (1) | WO2007030361A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495474A (zh) * | 2006-05-23 | 2009-07-29 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的噻吩-甲酰胺类 |
| JP2009539771A (ja) * | 2006-06-02 | 2009-11-19 | スミスクライン ビーチャム コーポレーション | 置換ベンゾイミダゾールチオフェンベンジルエーテル化合物 |
| EP2032563B1 (en) * | 2006-06-02 | 2010-06-02 | GlaxoSmithKline LLC | Benzimidazol substituted thiophene derivatives with activity on plk |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| EP2123627B1 (en) * | 2007-01-19 | 2013-11-20 | Ube Industries, Ltd. | Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group |
| US8236954B2 (en) | 2007-06-26 | 2012-08-07 | Glaxosmithkline Llc | Processes for preparing benzimidazole thiophenes |
| US8273890B2 (en) * | 2007-06-29 | 2012-09-25 | 4Sc Ag | Thiophene-imidazopyridines |
| EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| WO2009151914A1 (en) * | 2008-05-27 | 2009-12-17 | Smithkline Beecham Corporation | Methods for treating neoplasms with a combination of a plk inhibitor and retinoid |
| WO2009154645A1 (en) * | 2008-06-20 | 2009-12-23 | Smithkline Beecham Corporation | Methods for the treatment of central nervous system tumors |
| CA2745596A1 (en) | 2008-12-18 | 2010-10-28 | F. Hoffmann-La Roche Ag | Thiazolyl-benzimidazoles |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| BR112012010640A2 (pt) | 2009-11-05 | 2016-11-22 | Rhizen Pharmaceuticals S A | novos moduladores de quinase |
| SG194718A1 (en) | 2011-05-04 | 2013-12-30 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of protein kinases |
| KR101988079B1 (ko) | 2012-07-04 | 2019-06-11 | 리젠 파마슈티컬스 소시에떼 아노님 | 선택적 pi3k 델타 억제제 |
| KR102574152B1 (ko) * | 2020-03-27 | 2023-09-05 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 벤즈이미다졸 티오펜 유도체 화합물 |
| US20230158158A1 (en) * | 2020-03-27 | 2023-05-25 | Uppthera | Pyrazolo quinazoline derivative compounds inducing selective degradation of plk1 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CA2341409A1 (en) | 1998-08-31 | 2000-03-09 | Merck And Co., Inc. | Novel angiogenesis inhibitors |
| MXPA05001544A (es) * | 2002-08-08 | 2005-04-19 | Smithkline Beecham Corp | Compuestos de tiofeno. |
| AU2003903440A0 (en) * | 2003-07-04 | 2003-07-17 | James Hardie International Finance B.V. | Rainscreen apparatus and method |
| WO2005037827A1 (en) * | 2003-10-16 | 2005-04-28 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
| WO2005037627A1 (ja) | 2003-10-20 | 2005-04-28 | Nsk Ltd. | ステアリング装置 |
| GB0402809D0 (en) | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
| JP2009507022A (ja) * | 2005-09-06 | 2009-02-19 | スミスクライン ビーチャム コーポレーション | ベンズイミダゾールチオフェン類の位置選択的調製方法 |
| ATE459620T1 (de) * | 2005-09-06 | 2010-03-15 | Glaxosmithkline Llc | Benzimidazolthiophenverbindungen als plk- modulatoren |
| WO2007087283A2 (en) | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2032563B1 (en) * | 2006-06-02 | 2010-06-02 | GlaxoSmithKline LLC | Benzimidazol substituted thiophene derivatives with activity on plk |
| JP2009539771A (ja) * | 2006-06-02 | 2009-11-19 | スミスクライン ビーチャム コーポレーション | 置換ベンゾイミダゾールチオフェンベンジルエーテル化合物 |
-
2006
- 2006-08-28 AU AU2006287766A patent/AU2006287766B2/en not_active Ceased
- 2006-08-28 DK DK06813896.5T patent/DK1937671T3/da active
- 2006-08-28 CA CA002621879A patent/CA2621879A1/en not_active Abandoned
- 2006-08-28 DE DE602006011192T patent/DE602006011192D1/de active Active
- 2006-08-28 SI SI200630582T patent/SI1937671T1/sl unknown
- 2006-08-28 PE PE2006001041A patent/PE20070518A1/es not_active Application Discontinuation
- 2006-08-28 ES ES06813896T patent/ES2337929T3/es active Active
- 2006-08-28 JP JP2008529190A patent/JP5002597B2/ja not_active Expired - Fee Related
- 2006-08-28 US US12/065,668 patent/US7786127B2/en not_active Expired - Fee Related
- 2006-08-28 AT AT06813896T patent/ATE452132T1/de active
- 2006-08-28 BR BRPI0615668-1A patent/BRPI0615668A2/pt not_active IP Right Cessation
- 2006-08-28 TW TW095131590A patent/TW200800967A/zh unknown
- 2006-08-28 PT PT06813896T patent/PT1937671E/pt unknown
- 2006-08-28 WO PCT/US2006/033683 patent/WO2007030361A2/en active Application Filing
- 2006-08-28 NZ NZ566345A patent/NZ566345A/en not_active IP Right Cessation
- 2006-08-28 HR HR20100122T patent/HRP20100122T1/hr unknown
- 2006-08-28 AR ARP060103742A patent/AR055616A1/es not_active Application Discontinuation
- 2006-08-28 EA EA200800546A patent/EA014111B1/ru not_active IP Right Cessation
- 2006-08-28 KR KR1020087007794A patent/KR20080047585A/ko not_active Ceased
- 2006-08-28 MX MX2008003173A patent/MX2008003173A/es active IP Right Grant
- 2006-08-28 PL PL06813896T patent/PL1937671T3/pl unknown
- 2006-08-28 EP EP06813896A patent/EP1937671B1/en active Active
- 2006-08-28 US US11/467,577 patent/US7595330B2/en not_active Expired - Fee Related
- 2006-08-28 JO JO2006286A patent/JO2578B1/en active
-
2008
- 2008-02-29 CR CR9786A patent/CR9786A/es not_active Application Discontinuation
- 2008-03-03 IL IL189897A patent/IL189897A0/en unknown
- 2008-03-05 NO NO20081160A patent/NO20081160L/no not_active Application Discontinuation
- 2008-03-31 MA MA30794A patent/MA29816B1/fr unknown
-
2010
- 2010-03-09 CY CY20101100224T patent/CY1109916T1/el unknown
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