[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PE20040805A1 - Indazolilpirrolotriazinas c-6 modificadas - Google Patents

Indazolilpirrolotriazinas c-6 modificadas

Info

Publication number
PE20040805A1
PE20040805A1 PE2003001275A PE2003001275A PE20040805A1 PE 20040805 A1 PE20040805 A1 PE 20040805A1 PE 2003001275 A PE2003001275 A PE 2003001275A PE 2003001275 A PE2003001275 A PE 2003001275A PE 20040805 A1 PE20040805 A1 PE 20040805A1
Authority
PE
Peru
Prior art keywords
substituted
indazol
carbamic
triazine
ethyl
Prior art date
Application number
PE2003001275A
Other languages
English (en)
Inventor
Gregory D Vite
John F Kadow
Ashvinikumar V Gavai
Harold Mastalerz
Brian E Fink
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20040805A1 publication Critical patent/PE20040805A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R ES ARILO O HETEROCICLO SUSTITUIDOS O NO; R1 ES ALQUILO SUSTITUIDO O NO; R2 ES H, ALQUILO, CICLOALQUILO, ARILO,SUSTITUIDOS O NO, ARALQUILO, O HETEROCICLO SUSTITUIDO O NO, O BIEN R2 PUEDE ESTAR AUSENTE; X ES O, S, C(R3)2, C(R3)3, NR3 o N(R3)2; R3 ES H, ALQUILO O ARILO SUSTITUIDOS O NO, ARALQUILO, O HETEROCICLO SUSTITUIDOS O NO. SON COMPUESTOS PREFERIDOS: ESTER (3S)-3-MORFOLINILMETILICO DEL ACIDO [5-ETIL-4-[[(1-FENILMETIL)-1H-INDAZOL-5-IL]AMINO]PIRROLO[2,1-f][1,2,4]TRIAZINA-6-IL]-CARBAMICO, ESTER (2R)-2-PIRROLIDINILMETILICO DEL ACIDO [5-ETIL-4-[[(1-FENILMETIL)-1H-INDAZOL-5-IL]AMINO]PIRROLO[2,1-f][1,2,4]TRIAZINA-6-IL]-CARBAMICO, ESTER 3-[(3S)-3-HIDROXI-1-PIPERIDINIL]PROPILICO DEL ACIDO [5-ETIL-4-[[(1-FNILMETIL)-1H-INDAZOL-5-IL]AMINO]PIRROLO[2,1-f][1,2,4]TRIAZINA-6-IL]-CARBAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y QUE PUEDE ESTAR COMBINADO CON AL MENOS OTRO AGENTE ANTI-CANCER O CITOTOXICO. ESTOS COMPUESTOS SON INHIBEN LA ACTIVIDAD DE LA TIROCINA CINASA DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO TALES COMO HER1, HER2, Y HER4, POR LO QUE SON UTILES PARA TRATAR ENFERMEDADES PROLIFERATIVAS, Y ENFERMEDADES ASOCIADAS CON LAS TRAYECTORIAS DE TRANSDUCCION DE SENAL QUE OPERAN A TRAVES DE LOS RECEPTORES DE CRECIMIENTO, COMO EL CANCER, PSORIASIS Y ATRITIS REUMATOIDE
PE2003001275A 2002-12-13 2003-12-12 Indazolilpirrolotriazinas c-6 modificadas PE20040805A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13

Publications (1)

Publication Number Publication Date
PE20040805A1 true PE20040805A1 (es) 2004-11-20

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001275A PE20040805A1 (es) 2002-12-13 2003-12-12 Indazolilpirrolotriazinas c-6 modificadas

Country Status (27)

Country Link
US (2) US6916815B2 (es)
EP (1) EP1569937B1 (es)
JP (1) JP4511367B2 (es)
KR (1) KR101073801B1 (es)
CN (2) CN1726216A (es)
AR (1) AR042450A1 (es)
AT (1) ATE534648T1 (es)
AU (1) AU2003300877B2 (es)
BR (1) BR0316755A (es)
CA (1) CA2509650C (es)
CO (1) CO5570660A2 (es)
DK (1) DK1569937T3 (es)
ES (1) ES2374393T3 (es)
HR (1) HRP20050535A2 (es)
IS (1) IS7890A (es)
MX (1) MXPA05006164A (es)
NO (1) NO20052733L (es)
NZ (1) NZ540338A (es)
PE (1) PE20040805A1 (es)
PL (1) PL377517A1 (es)
PT (1) PT1569937E (es)
RS (1) RS20050441A (es)
RU (1) RU2356903C2 (es)
TW (1) TW200420565A (es)
UA (1) UA80591C2 (es)
WO (1) WO2004054514A2 (es)
ZA (1) ZA200504507B (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0977563B1 (en) 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US20090197852A9 (en) * 2001-08-06 2009-08-06 Johnson Robert G Jr Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor
ES2318122T3 (es) 2002-04-23 2009-05-01 Bristol-Myers Squibb Company Compuestos de aril cetona pirrolo-triazina utiles como inhibidores de quinasa.
PL219736B1 (pl) * 2002-04-23 2015-07-31 Bristol Myers Squibb Co Pochodna pirolotriazynoaniliny, kompozycja farmaceutyczna i jej zastosowanie
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ATE450534T1 (de) 2002-08-23 2009-12-15 Sloan Kettering Inst Cancer Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
PL378121A1 (pl) 2003-02-05 2006-03-06 Bristol-Myers Squibb Company Sposób wytwarzania pirolotriazynowych inhibitorów kinazy
EP2633866A3 (en) * 2003-10-17 2013-12-18 Novo Nordisk A/S Combination therapy
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
US7064203B2 (en) * 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7102002B2 (en) * 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7253167B2 (en) * 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200600513A (en) * 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7102003B2 (en) * 2004-07-01 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine compounds
US7504521B2 (en) 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
PE20060421A1 (es) 2004-08-12 2006-06-01 Bristol Myers Squibb Co Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
EP1807106A2 (en) * 2004-10-05 2007-07-18 Oregon Health and Science University Compositions and methods for treating disease
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
CA2604222A1 (en) 2005-04-18 2006-10-26 Novo Nordisk A/S Il-21 variants
US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7405213B2 (en) * 2005-07-01 2008-07-29 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
EP2001886A2 (en) 2006-03-07 2008-12-17 Bristol-Myers Squibb Company Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
WO2008049920A2 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S Il-21 variants
US8211420B2 (en) * 2006-12-21 2012-07-03 Novo Nordisk A/S Interleukin-21 variants with altered binding to the IL-21 receptor
US20090083483A1 (en) * 2007-09-24 2009-03-26 International Business Machines Corporation Power Conservation In A RAID Array
US8166326B2 (en) * 2007-11-08 2012-04-24 International Business Machines Corporation Managing power consumption in a computer
US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
US8041521B2 (en) * 2007-11-28 2011-10-18 International Business Machines Corporation Estimating power consumption of computing components configured in a computing system
EP2274308A1 (en) * 2008-04-04 2011-01-19 Gilead Sciences, Inc. Pyrrolotriazinone derivatives for use as stearoyl coa desaturase inhibitors
CA2719288A1 (en) 2008-04-04 2009-11-12 Gilead Sciences, Inc. Triazolopyridinone derivatives for use as stearoyl coa desaturase inhibitors
WO2009126311A1 (en) * 2008-04-11 2009-10-15 The University Of Texas, M.D. Anderson Cancer Center Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
US8103884B2 (en) 2008-06-25 2012-01-24 International Business Machines Corporation Managing power consumption of a computer
US8041976B2 (en) * 2008-10-01 2011-10-18 International Business Machines Corporation Power management for clusters of computers
US8514215B2 (en) * 2008-11-12 2013-08-20 International Business Machines Corporation Dynamically managing power consumption of a computer with graphics adapter configurations
WO2010071885A1 (en) 2008-12-19 2010-06-24 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
CA2754909A1 (en) * 2009-03-11 2010-09-16 Ambit Biosciences Corp. Combination of an indazolylaminopyrrolotriazine and taxane for cancer treatment
WO2011112689A2 (en) * 2010-03-11 2011-09-15 Ambit Biosciences Corp. Saltz of an indazolylpyrrolotriazine
US9724352B2 (en) 2012-05-31 2017-08-08 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
CN105008366B (zh) * 2013-03-11 2017-11-14 百时美施贵宝公司 作为钾离子通道抑制剂的吡咯并哒嗪类化合物
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
EP2970294B1 (en) * 2013-03-11 2016-12-28 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
CN111533708B (zh) * 2020-06-12 2021-03-16 上海馨远医药科技有限公司 一种手性n-叔丁氧羰基吗啉-3-羧酸的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908056A (en) * 1986-04-25 1990-03-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
ES2200039T3 (es) 1995-12-08 2004-03-01 Pfizer Inc. Derivados heterociclicos sustituidos como antagonistas de crf.
DE69736711T2 (de) 1996-08-28 2007-09-20 Pfizer Inc. Substituierte 6,5-heterobicyclische-derivate
CN1351498B (zh) * 1999-05-21 2012-08-15 布里斯托尔-迈尔斯斯奎布公司 激酶的吡咯并三嗪抑制剂
AU6473600A (en) 1999-08-23 2001-03-19 Shionogi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
KR100847605B1 (ko) * 2000-11-17 2008-07-21 브리스톨-마이어스스퀴브컴파니 ｐ38 키나제 관련 질병의 치료 방법 및 키나제 억제제로서유용한 피롤로트리아진 화합물
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
ES2318122T3 (es) 2002-04-23 2009-05-01 Bristol-Myers Squibb Company Compuestos de aril cetona pirrolo-triazina utiles como inhibidores de quinasa.
PL219736B1 (pl) 2002-04-23 2015-07-31 Bristol Myers Squibb Co Pochodna pirolotriazynoaniliny, kompozycja farmaceutyczna i jej zastosowanie
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TWI329112B (en) 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine

Also Published As

Publication number Publication date
HRP20050535A2 (en) 2005-12-31
DK1569937T3 (da) 2012-01-02
AU2003300877B2 (en) 2010-02-18
CA2509650C (en) 2007-10-30
EP1569937A2 (en) 2005-09-07
CN101723948A (zh) 2010-06-09
RU2356903C2 (ru) 2009-05-27
WO2004054514A3 (en) 2004-10-07
WO2004054514A2 (en) 2004-07-01
KR20050084242A (ko) 2005-08-26
NO20052733D0 (no) 2005-06-07
US6916815B2 (en) 2005-07-12
EP1569937B1 (en) 2011-11-23
AR042450A1 (es) 2005-06-22
CA2509650A1 (en) 2004-07-01
EP1569937A4 (en) 2007-08-08
ES2374393T3 (es) 2012-02-16
RU2005120650A (ru) 2006-01-20
CN1726216A (zh) 2006-01-25
ZA200504507B (en) 2006-08-30
BR0316755A (pt) 2005-10-25
AU2003300877A1 (en) 2004-07-09
UA80591C2 (en) 2007-10-10
US20040142931A1 (en) 2004-07-22
JP4511367B2 (ja) 2010-07-28
US20050222153A1 (en) 2005-10-06
PT1569937E (pt) 2012-01-04
TW200420565A (en) 2004-10-16
KR101073801B1 (ko) 2011-10-13
NZ540338A (en) 2008-05-30
PL377517A1 (pl) 2006-02-06
US7148220B2 (en) 2006-12-12
MXPA05006164A (es) 2005-08-26
RS20050441A (en) 2007-04-10
CO5570660A2 (es) 2005-10-31
NO20052733L (no) 2005-07-07
ATE534648T1 (de) 2011-12-15
IS7890A (is) 2005-06-10
JP2006509826A (ja) 2006-03-23

Similar Documents

Publication Publication Date Title
PE20040805A1 (es) Indazolilpirrolotriazinas c-6 modificadas
PE20050679A1 (es) Compuestos de pirrolotriazina como inhibidores de la cinasa
RU2336275C2 (ru) Пиримидопроизводные, характеризующиеся антипролиферативной активностью, и фармацевтическая композиция
AR065937A2 (es) Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa
AR037368A1 (es) Imidazolilpirrolotriazinas c-5 modificadas y composiciones farmaceuticas que las comprenden
PE131699A1 (es) Inhibidores de aminotiazol de cinasas dependientes de ciclina
PE20040836A1 (es) Derivados de nucleosidos de pirimidina como inhibidores de la replicacion de rna del virus de la hepatitis c (vhc)
AR048642A1 (es) Compuestos de metil-aril o heteroaril-amida sustituida utiles como antagonistas del receptor de prostaglandinas e2; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento
PE20080931A1 (es) Imidazopirazinas como inhibidores de proteina quinasa
AR029222A1 (es) Compuesto derivado de amida, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para tratar enfermedades mediadas por la proteinquinasa
PE20070805A1 (es) Imidazopirazinas como inhibidores de proteinquinasa
EA200301306A1 (ru) Производные 1-фенилсульфонил-1,3-дигидро-2h-индол-2-она, их получение и их терапевтическое применение
PE20070621A1 (es) 2-amino-7,8-dihidro-6h-pirido(4,3-d)pirimidina-5-onas
NO2008011I2 (no) Emtricitabin (5-fluor-1-(2R,5S)-[2-(hydroksymetyl)-1,3-oksotiolan-5-y]ytosin
PE20060383A1 (es) Nuevos derivados amino de urea ciclicos como inhibidores de quinasa
PE20080677A1 (es) Inhibidores de pirrolotriazina cinaza
BR122012009489B8 (pt) processo para produzir 2-etóxi-1-{[2’-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso
PE20090727A1 (es) DERIVADOS DE AMIDA COMO INHIBIDORES DE NaV1.7
PE20010039A1 (es) Derivados de esteres del acido carbamico como agonistas y/o antagonistas del receptor metabotropico del glutamato
PE20040598A1 (es) Tetrahidropiranil-ciclopentil-tetrahidropiridopiridinicos como moduladores de la actividad de receptores de quimiocina
HUP0101511A2 (hu) 1-[(1-Szubsztituált-4-piperidinil)-metil]-4-piperidin-származékok, eljárás a vegyületek előállítására, a vegyületeket tartalmazó gyógyászati készítmények és intermedierjeik
KR880002834A (ko) α-알킬-4-아미노-3-퀴놀린메탄올 및 1-(4-아르알킬아미노-3-퀴놀리닐) 알칸온, 이의 제조방법 및 약제로서의 용도
KR960014102A (ko) 인돌로일구아니딘 유도체
BR0308145A (pt) Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto
PE20081850A1 (es) Derivados ciclizados como inhibidores de la eg-5

Legal Events

Date Code Title Description
FD Application declared void or lapsed