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PE20030125A1 - PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS - Google Patents

PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS

Info

Publication number
PE20030125A1
PE20030125A1 PE2002000449A PE2002000449A PE20030125A1 PE 20030125 A1 PE20030125 A1 PE 20030125A1 PE 2002000449 A PE2002000449 A PE 2002000449A PE 2002000449 A PE2002000449 A PE 2002000449A PE 20030125 A1 PE20030125 A1 PE 20030125A1
Authority
PE
Peru
Prior art keywords
antibacterial agents
formula
pirido
pyrimidine
compounds
Prior art date
Application number
PE2002000449A
Other languages
English (en)
Inventor
Edmund Lee Ellsworth
Howard Daniel Hollins Showalter
Kim Marie Hutchings
Dai Quoc Nguyen
Rajeshwar Singh
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20030125A1 publication Critical patent/PE20030125A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

SE REFIERE A PIRIDO[1,2-c]PIRIMIDINA COMO AGENTE ANTIBACTERIANO DE FORMULA I DONDE R1 ES H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C2-C7, CICLOALQUILO C3-C7, ARILO, HETEROCICLO, HETEROARILO; R2 ES R1, HALO, NO2, NO, CN, OC(=O)Ra, COORb, COSRb; CONRcRd, NReRf; Ra, Rb, Rc, Rd, Re, Rf SON H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C1-C7, CICLOALQUILO C3-C7, ARILO, HETEROCICLO, ENTRE OTROS, R3, R4, R6 SON H, OH, (O)n-ALQUILO C1-C7, (O)n-ALQUENILO C2-C7, (O)n-ALQUINILO C2-C7, HALO, NO2, CN, NReRf; R1 Y R6 FORMAN UN ANILLO DE 4-8 MIEMBROS; n ES 0-1; R1 Y R6 JUNTOS FORMAN UN ANILLO DE 5-8 MIEMBROS; R5 ES H, ALQUILO C1-C7, ALQUENILO C2-C7, ALQUINILO C2-C7, OC(=0)ORb, COORb, COSRb, SO2Rb, ENTRE OTROS; J Y K SON C, N; O CUANDO J o K ES N, R4, R6 ESTAN AUSENTES. SON COMPUESTOS PREFERIDOS 2-AMINO-4-CICLOPROPIL-7-FLUORO-5-METIL-6-[3-(1-METILAMINOETIL)PIRROLIDIN-1-IL]-PIRIDO[1,2-c]PIRIMIDIN-1,3-DIONA, ESTER TERCBUTILICO DEL ACIDO {1-[1-(2-AMINO-4-CICLOPROPIL-7-FLUORO-5-METIL-1,3-DIOXO-2,3-DIHIDRO-1H-PIRIDO-[1,2-c]-PIRIMIDIN-6-IL)-4-METILPIRROLIDIN-3-IL]-ETIL}CARBAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE DNA-GIRASA O TOPOISOMERASA IV BACTERIANA RESISTENTE A QUINOLONAS
PE2002000449A 2001-05-30 2002-05-28 PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS PE20030125A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29433801P 2001-05-30 2001-05-30
US36507702P 2002-03-19 2002-03-19

Publications (1)

Publication Number Publication Date
PE20030125A1 true PE20030125A1 (es) 2003-02-12

Family

ID=31720253

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000449A PE20030125A1 (es) 2001-05-30 2002-05-28 PIRIDO[1,2-c]PIRIMIDINA COMO AGENTES ANTIBACTERIANOS

Country Status (11)

Country Link
US (1) US6864259B2 (es)
EP (1) EP1395585B1 (es)
JP (1) JP2004532876A (es)
AT (1) ATE315038T1 (es)
BR (1) BR0210099A (es)
DE (1) DE60208541D1 (es)
HN (1) HN2002000111A (es)
MX (1) MXPA03010799A (es)
PE (1) PE20030125A1 (es)
SV (1) SV2003001058A (es)
UY (1) UY27311A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10214257A1 (de) * 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
EP2500022B1 (en) * 2009-11-13 2015-12-16 Microbial Chemistry Research Foundation Antibacterial agent for drug-resistant bacteria and use of same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035619B1 (fr) 1980-03-10 1984-07-25 BERRI-BALZAC Société dite: Dérivés d'amino-3 (1H,3H) quinazolinedione-2,4
GB2097784A (en) 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
WO1994014809A1 (de) 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellierte uracilderivate
US5670506A (en) 1993-04-05 1997-09-23 Cell Therapeutics, Inc. Halogen, isothiocyanate or azide substituted xanthines
CN1053188C (zh) 1993-10-14 2000-06-07 艾博特公司 喹嗪酮类化合物
AU6908398A (en) 1996-10-28 1998-05-22 Versicor Inc Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones
DK1028950T3 (da) 1997-10-28 2003-09-01 Warner Lambert Co 7-substituerede quinazolin-2,4-dioner nyttige som antibakterielle midler
HUP0102514A3 (en) 1998-05-26 2002-03-28 Warner Lambert Co Pyrido-pyrimidin and pyrimido-pyrimidin derivatives as inhibitors of cellular proliferation and pharmaceutical compositions thereof
KR20020067701A (ko) 2000-01-24 2002-08-23 워너-램버트 캄파니 3-아미노퀴나졸린-2,4-디온 항균제

Also Published As

Publication number Publication date
MXPA03010799A (es) 2005-07-25
EP1395585B1 (en) 2006-01-04
US6864259B2 (en) 2005-03-08
ATE315038T1 (de) 2006-02-15
BR0210099A (pt) 2004-04-13
DE60208541D1 (de) 2006-03-30
HN2002000111A (es) 2002-07-08
US20030114458A1 (en) 2003-06-19
JP2004532876A (ja) 2004-10-28
SV2003001058A (es) 2003-03-18
EP1395585A1 (en) 2004-03-10
UY27311A1 (es) 2002-12-31

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Legal Events

Date Code Title Description
FD Application declared void or lapsed