PE20030718A1 - Lactamas como antagonistas de taquiquininas - Google Patents
Lactamas como antagonistas de taquiquininasInfo
- Publication number
- PE20030718A1 PE20030718A1 PE2002001201A PE2002001201A PE20030718A1 PE 20030718 A1 PE20030718 A1 PE 20030718A1 PE 2002001201 A PE2002001201 A PE 2002001201A PE 2002001201 A PE2002001201 A PE 2002001201A PE 20030718 A1 PE20030718 A1 PE 20030718A1
- Authority
- PE
- Peru
- Prior art keywords
- het
- antagonists
- aryl
- heterocycle
- piperidinone
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A LACTAMAS DE FORMULA I DONDE R ES HET-a; R1 ES FENILO; m ES 1-4; Z ES N(R3)(R4X); N(R3)Y, HETEROCICLO OPCIONALMENTE ESPIROCONDENSADO; Y ES ARILO, HET-b, HET-c, HETEROCICLO; X ES NR3R5, OR3, O-ARILO-1, O-HETb, O-HETc, ENTRE OTROS; R3 Y R6 SON H, ALQUILO; R4 Y R7 SON ALQUILENO; R5 ES COOR3, S(O)pR3, S(O)pARILO-1, ENTRE OTROS; HET b ES UN HETEROCICLO; HET-a Y HET-c SON HETEROCICLO AROMATICO; ARILO-1 ES FENILO, NAFTILO; p ES 0-2; n ES 0-4; SON COMPUESTOS PREFERIOS (5S)-5-(3,4-DICLOROFENIL)-1-(6-METIL-2-PIRIDINIL)-5-{2-[3-(4-MORFOLINIL)-1-AZETIDINIL]ETIL}-2-PIPERIDINONA; (5S)-5-(3,4-DICLOROFENIL)-1-(6-METIL-2-PIRIDINIL)-5-{2-[3-(4-HIDROXIPIPERIDINIL)-1-AZETIDINIL]ETIL}-2-PIPERIDINONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y A UNA COMPOSICION QUE COMPRENDE ADEMAS ANTAGONISTAS MUSCARINICOS, ANTAGONISTAS DE ALFA ADRENORECEPTORES, INHIBIDORES DE LA RECAPTACION DE SEROTONINA, ENTRE OTROS. LOS COMPUESTOS SON ANTAGONISTAS DE TAQUIQUININAS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ANTIINFLAMATORIAS, TRASTORNO DEL SISTEMA NERVIOSO CENTRAL, GASTROINTESTINAL, ENFERMEDAD CAUSADA POR HELICOBACTER PYLORI, AFECCIONES UROLOGICAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0130261.1A GB0130261D0 (en) | 2001-12-18 | 2001-12-18 | Lactams as tachykinin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030718A1 true PE20030718A1 (es) | 2003-08-18 |
Family
ID=9927858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002001201A PE20030718A1 (es) | 2001-12-18 | 2002-12-12 | Lactamas como antagonistas de taquiquininas |
Country Status (16)
Country | Link |
---|---|
US (1) | US7060836B2 (es) |
EP (1) | EP1456200A1 (es) |
JP (1) | JP2005514389A (es) |
AR (1) | AR037852A1 (es) |
AU (1) | AU2002366320A1 (es) |
BR (1) | BR0215017A (es) |
CA (1) | CA2470236A1 (es) |
GB (1) | GB0130261D0 (es) |
GT (1) | GT200200280A (es) |
HN (1) | HN2002000365A (es) |
MX (1) | MXPA04005221A (es) |
PA (1) | PA8561501A1 (es) |
PE (1) | PE20030718A1 (es) |
TW (1) | TW200302097A (es) |
UY (1) | UY27588A1 (es) |
WO (1) | WO2003051868A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7199250B2 (en) | 2002-12-20 | 2007-04-03 | Battelle Memorial Institute | Process for producing cyclic compounds |
FR2873373B1 (fr) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
JP2008521821A (ja) * | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
WO2006105035A2 (en) * | 2005-03-28 | 2006-10-05 | Vertex Pharmaceuticals Incorporated | Muscarinic modulators |
EP1943250A1 (en) | 2005-09-09 | 2008-07-16 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
JP5205971B2 (ja) * | 2006-01-27 | 2013-06-05 | 宇部興産株式会社 | テトラヒドロピラン化合物の製造方法 |
WO2007110449A1 (en) | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
WO2007118854A1 (en) | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and the use thereof |
WO2007118853A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
EP2021005A4 (en) * | 2006-05-03 | 2009-11-25 | Cnsbio Pty Ltd | METHOD AND COMPOSITION FOR THE TREATMENT OF INFLAMMATORY PAIN |
US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
US7592345B2 (en) * | 2007-06-13 | 2009-09-22 | Hoffmann-La Roche Inc. | Piperazine and [1,4]diazepan derivatives as NK antagonists |
EP2175886A1 (en) * | 2007-06-28 | 2010-04-21 | CNSBio Pty Ltd | Combination methods and compositions for treatment of neuropathic pain |
KR101174980B1 (ko) * | 2007-09-14 | 2012-08-17 | 에프. 호프만-라 로슈 아게 | Nk3 수용체 길항제로서의 피페리딘 유도체 |
US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
EP2688403B1 (en) * | 2011-03-23 | 2017-05-31 | Trevena, Inc. | Opioid receptor ligands and methods of using and making same |
AU2016372028B2 (en) | 2015-12-14 | 2022-02-17 | Trevena, Inc. | Methods of treating hyperalgesia |
WO2017126635A1 (ja) * | 2016-01-22 | 2017-07-27 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN112321599B (zh) * | 2020-11-25 | 2023-05-30 | 合肥远志医药科技开发有限公司 | 一种药物中间体7-氧代-2-氮杂螺[3.5]壬烷的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
GB9600235D0 (en) * | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
-
2001
- 2001-12-18 GB GBGB0130261.1A patent/GB0130261D0/en not_active Ceased
-
2002
- 2002-12-06 WO PCT/IB2002/005234 patent/WO2003051868A1/en not_active Application Discontinuation
- 2002-12-06 CA CA002470236A patent/CA2470236A1/en not_active Abandoned
- 2002-12-06 MX MXPA04005221A patent/MXPA04005221A/es not_active Application Discontinuation
- 2002-12-06 BR BR0215017-4A patent/BR0215017A/pt not_active IP Right Cessation
- 2002-12-06 JP JP2003552752A patent/JP2005514389A/ja not_active Withdrawn
- 2002-12-06 AU AU2002366320A patent/AU2002366320A1/en not_active Abandoned
- 2002-12-06 EP EP02804985A patent/EP1456200A1/en not_active Withdrawn
- 2002-12-12 PE PE2002001201A patent/PE20030718A1/es not_active Application Discontinuation
- 2002-12-12 PA PA20028561501A patent/PA8561501A1/es unknown
- 2002-12-16 AR ARP020104878A patent/AR037852A1/es not_active Application Discontinuation
- 2002-12-16 HN HN2002000365A patent/HN2002000365A/es unknown
- 2002-12-17 GT GT200200280A patent/GT200200280A/es unknown
- 2002-12-17 TW TW091136374A patent/TW200302097A/zh unknown
- 2002-12-17 US US10/322,068 patent/US7060836B2/en not_active Expired - Fee Related
- 2002-12-17 UY UY27588A patent/UY27588A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20040132710A1 (en) | 2004-07-08 |
GB0130261D0 (en) | 2002-02-06 |
CA2470236A1 (en) | 2003-06-26 |
GT200200280A (es) | 2003-07-11 |
AU2002366320A1 (en) | 2003-06-30 |
BR0215017A (pt) | 2004-08-31 |
PA8561501A1 (es) | 2003-07-28 |
WO2003051868A1 (en) | 2003-06-26 |
MXPA04005221A (es) | 2004-08-19 |
JP2005514389A (ja) | 2005-05-19 |
TW200302097A (en) | 2003-08-01 |
HN2002000365A (es) | 2003-07-23 |
UY27588A1 (es) | 2003-07-31 |
AR037852A1 (es) | 2004-12-09 |
US7060836B2 (en) | 2006-06-13 |
EP1456200A1 (en) | 2004-09-15 |
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Legal Events
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