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PE20021099A1 - Derivados de c-furano-2-il-metilamina sustituidos - Google Patents

Derivados de c-furano-2-il-metilamina sustituidos

Info

Publication number
PE20021099A1
PE20021099A1 PE2002000428A PE2002000428A PE20021099A1 PE 20021099 A1 PE20021099 A1 PE 20021099A1 PE 2002000428 A PE2002000428 A PE 2002000428A PE 2002000428 A PE2002000428 A PE 2002000428A PE 20021099 A1 PE20021099 A1 PE 20021099A1
Authority
PE
Peru
Prior art keywords
ethyl
phenylamine
aryl
alkyl
methyl
Prior art date
Application number
PE2002000428A
Other languages
English (en)
Inventor
Corinna Maul
Michael Przewosny
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20021099A1 publication Critical patent/PE20021099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A DERIVADOS DE C-FURANO-2-IL-METILAMINA Y C-TIOFENO-2-IL-METILAMINA SUSTITUIDOS DE FORMULA I DONDE A ES O, S; R1 ES ARILO, HETEROCICLILO, -(C1-6-ALQUIL)-ARILO, ENTRE OTROS; R2 ES -C(=O)R6, ALQUILO C3-C8; R3, R4, R5 SON H, F, Cl, Br, I, CN, OR7, ENTRE OTROS; R6 ES ARILO, HETEROCICLILO, ENTRE OTROS; R7 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8. SON COMPUESTOS PREFERIDOS 5-[1-(2-CLORO-FENILAMINO)-2-OXO-2-FENIL-ETIL]-2-METIL-FURAN-3-CARBOXILATO DE ETILO, 5-[1-(4-CLORO-2-METIL-FENILAMINO)-2-OXO-2-FENIL-ETIL]-2-METIL-FURAN-3-CARBOXILATO DE ETILO EXCEPTO N-(CICLOPROPIL-2-TIENILMETIL)-4,5-DIHIDRO-2-OXAZOLAMINA, N-(CICLOPROPIL-2-FURANILMETIL)-4,5-DIHIDRO-2-OXAZOLAMINA, 1,2-DI-2-FURANIL-2-(FENILAMINO)-ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON ANALGESICOS, ANESTESICOS, ANTIARRITMICOS
PE2002000428A 2001-05-22 2002-05-21 Derivados de c-furano-2-il-metilamina sustituidos PE20021099A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10125145A DE10125145A1 (de) 2001-05-22 2001-05-22 Substituierte C-Furan-2-yl-methylamin- und C-Thiophen-2-yl-methylamin-Derivate

Publications (1)

Publication Number Publication Date
PE20021099A1 true PE20021099A1 (es) 2003-01-25

Family

ID=7685874

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000428A PE20021099A1 (es) 2001-05-22 2002-05-21 Derivados de c-furano-2-il-metilamina sustituidos

Country Status (17)

Country Link
US (2) US6878740B2 (es)
EP (1) EP1392670B1 (es)
JP (1) JP2004532246A (es)
AR (1) AR035982A1 (es)
AT (1) ATE299873T1 (es)
AU (1) AU2002338989B2 (es)
CA (1) CA2448038C (es)
DE (2) DE10125145A1 (es)
DK (1) DK1392670T3 (es)
ES (1) ES2242869T3 (es)
HU (1) HUP0401162A3 (es)
MX (1) MXPA03010601A (es)
PE (1) PE20021099A1 (es)
PL (1) PL367535A1 (es)
PT (1) PT1392670E (es)
SI (1) SI1392670T1 (es)
WO (1) WO2002094802A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
KR100553398B1 (ko) 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
MX2012000435A (es) 2009-07-08 2012-06-01 Dermira Canada Inc Analogos de acido 5-(tetradeciloxi)-2-furancarboxilico (tofa) utiles en el tratamiento de trastornos o afecciones dermatologicas.
EP2897589B1 (en) * 2013-11-22 2018-01-03 Teva Branded Pharmaceutical Products R & D, Inc. An inhalable medicament
CN109153659A (zh) * 2016-05-31 2019-01-04 翰林大学产学研合作团队 五元杂环衍生物、其制备方法及包含其的药剂学组合物
CN112521357B (zh) * 2020-08-31 2021-10-08 深圳瑞健生物科技有限公司 一种长效低成瘾性hnk衍生物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3890445A (en) * 1973-01-05 1975-06-17 Richardson Merrell Inc Lactamimide derivatives useful as hypoglycemic agents
US3816457A (en) * 1973-01-05 1974-06-11 Richardson Merrell Inc Lactamimide derivatives
WO2001068816A1 (en) 2000-03-13 2001-09-20 Smithkline Beecham Corporation Human histamine h3 gene variant-3
DE10012820A1 (de) * 2000-03-16 2001-09-20 Bayer Ag Substituierte 1-Aryl-cyclopropylmethylamino-1,3,5-triazine
DE10059864A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Substituierte Amino-furan-2-yl-essigsäure- und Amino-thien-2-yl-essigsäure-Derivate

Also Published As

Publication number Publication date
CA2448038A1 (en) 2002-11-28
DE10125145A1 (de) 2002-11-28
PL367535A1 (en) 2005-02-21
US20040152734A1 (en) 2004-08-05
MXPA03010601A (es) 2004-03-09
US20050148550A1 (en) 2005-07-07
ES2242869T3 (es) 2005-11-16
ATE299873T1 (de) 2005-08-15
PT1392670E (pt) 2005-10-31
US6878740B2 (en) 2005-04-12
DK1392670T3 (da) 2005-08-08
AU2002338989B2 (en) 2007-06-07
SI1392670T1 (sl) 2005-12-31
US7317034B2 (en) 2008-01-08
JP2004532246A (ja) 2004-10-21
CA2448038C (en) 2010-09-28
WO2002094802A1 (de) 2002-11-28
DE50203686D1 (en) 2005-08-25
HUP0401162A3 (en) 2007-05-02
AR035982A1 (es) 2004-07-28
HUP0401162A2 (hu) 2004-10-28
EP1392670B1 (de) 2005-07-20
EP1392670A1 (de) 2004-03-03

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