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PE20010532A1 - FORMAS FARMACEUTICAS DE ADMINISTRACION ORAL AL MENOS PARCIALMENTE RETARDADAS CUYA SUSTANCIA ACTIVA FARMACEUTICA TRAMADOL SE ENCUENTRA AL MENOS PARCIALMENTE EN FORMA DE COMPUESTO FORMADO IN SITU CON UNA HIDROSOLUBILIDAD Menor o igual 100MG/ML, Y PROCE - Google Patents

FORMAS FARMACEUTICAS DE ADMINISTRACION ORAL AL MENOS PARCIALMENTE RETARDADAS CUYA SUSTANCIA ACTIVA FARMACEUTICA TRAMADOL SE ENCUENTRA AL MENOS PARCIALMENTE EN FORMA DE COMPUESTO FORMADO IN SITU CON UNA HIDROSOLUBILIDAD Menor o igual 100MG/ML, Y PROCE

Info

Publication number
PE20010532A1
PE20010532A1 PE2000000871A PE0008712000A PE20010532A1 PE 20010532 A1 PE20010532 A1 PE 20010532A1 PE 2000000871 A PE2000000871 A PE 2000000871A PE 0008712000 A PE0008712000 A PE 0008712000A PE 20010532 A1 PE20010532 A1 PE 20010532A1
Authority
PE
Peru
Prior art keywords
partially
situ
delayed
active substance
compound formed
Prior art date
Application number
PE2000000871A
Other languages
English (en)
Inventor
Johannes Heinrich Antonius Bartholomaus
Iris Ziegler
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20010532A1 publication Critical patent/PE20010532A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K9/1605—Excipients; Inactive ingredients
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
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  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UNA FORMA FARMACEUTICA ORAL QUE COMPRENDE a)CLORHIDRATO DE TRAMADOL, PARCIALMENTE RETARDADA, CARACTERIZADA PORQUE LA PROPORCION RETARDADA DE TRAMADOL ESTA CONSTITUIDA POR UN COMPUESTO FORMADO IN SITU DE TRAMADOL CON UNA HIDROSOLUBILIDAD ¾100mg/ml Y POR ENCONTRARSE EN EXCESO; b)OTRO EXCIPIENTE ACIDO O SUSTANCIA ACTIVA ACIDA TAL COMO LA SAL SODICA DE DICLOFENACO, NAPROXENO, ACIDO ACETIL SALICILICO, ACIDO SALICILICO, ACIDO BENZOICO, CICLAMATO, ACESULFAM; PORQUE LA PROPORCION DE LOS COMPONENTES EQUIMOLAR, PORQUE LA LIBERACION ES A LA MISMA VECOCIDAD, PORQUE SE PRESENTA COMO MULTIPLES PARTICULAS, GRANULOS, MICROPARTICULAS, MICROTABLETAS O PELLAS; Y TIENE UN REVESTIMIENTO RESISTENTE A JUGO GASTRICO; DICHA FORMULACION PUEDE SER UTIL PARA COMBATIR DOLORES, INCONTINENCIA URINARIA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE SE CARACTERIZA POR HUMEDECER VARIAS VECES CON MEDIOS ACUOSOS CON AGUA O SOLUCIONES ACUOSAS AGLUTINANTES Y SE FORMULAN CON APORTE DE ENERGIA EN FORMA DE PRESION O CALOR
PE2000000871A 1999-08-31 2000-08-25 FORMAS FARMACEUTICAS DE ADMINISTRACION ORAL AL MENOS PARCIALMENTE RETARDADAS CUYA SUSTANCIA ACTIVA FARMACEUTICA TRAMADOL SE ENCUENTRA AL MENOS PARCIALMENTE EN FORMA DE COMPUESTO FORMADO IN SITU CON UNA HIDROSOLUBILIDAD Menor o igual 100MG/ML, Y PROCE PE20010532A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19940944A DE19940944B4 (de) 1999-08-31 1999-08-31 Retardierte, orale, pharmazeutische Darreichungsformen

Publications (1)

Publication Number Publication Date
PE20010532A1 true PE20010532A1 (es) 2001-06-16

Family

ID=7919964

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000871A PE20010532A1 (es) 1999-08-31 2000-08-25 FORMAS FARMACEUTICAS DE ADMINISTRACION ORAL AL MENOS PARCIALMENTE RETARDADAS CUYA SUSTANCIA ACTIVA FARMACEUTICA TRAMADOL SE ENCUENTRA AL MENOS PARCIALMENTE EN FORMA DE COMPUESTO FORMADO IN SITU CON UNA HIDROSOLUBILIDAD Menor o igual 100MG/ML, Y PROCE

Country Status (29)

Country Link
US (2) US7906141B2 (es)
EP (2) EP1627633A1 (es)
JP (1) JP2003508428A (es)
KR (1) KR100735509B1 (es)
CN (1) CN1201732C (es)
AR (2) AR025428A1 (es)
AT (1) ATE320799T1 (es)
AU (1) AU781707B2 (es)
BR (1) BR0013823A (es)
CA (1) CA2382098C (es)
CO (1) CO5190688A1 (es)
CZ (1) CZ298948B6 (es)
DE (2) DE19940944B4 (es)
DK (1) DK1207867T3 (es)
ES (1) ES2260042T3 (es)
HK (1) HK1047231B (es)
HU (1) HUP0302086A2 (es)
IL (2) IL148407A0 (es)
MX (1) MXPA02002197A (es)
MY (1) MY129234A (es)
NO (1) NO20020976L (es)
NZ (1) NZ517554A (es)
PE (1) PE20010532A1 (es)
PL (1) PL354239A1 (es)
PT (1) PT1207867E (es)
RU (1) RU2240786C2 (es)
SK (1) SK285943B6 (es)
WO (1) WO2001015681A1 (es)
ZA (3) ZA200202478B (es)

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DE19940740A1 (de) * 1999-08-31 2001-03-01 Gruenenthal Gmbh Pharmazeutische Salze
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
US20050182056A9 (en) * 2002-02-21 2005-08-18 Seth Pawan Modified release formulations of at least one form of tramadol
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FR2845289B1 (fr) * 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
US8487002B2 (en) 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
BR122018068298B8 (pt) * 2003-08-06 2021-07-27 Gruenenthal Gmbh processo para a produção de um comprimido seguro contra abuso termo-moldado por extrusão sem descoramento
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
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