PA8483901A1 - Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida - Google Patents
Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuidaInfo
- Publication number
- PA8483901A1 PA8483901A1 PA19998483901A PA8483901A PA8483901A1 PA 8483901 A1 PA8483901 A1 PA 8483901A1 PA 19998483901 A PA19998483901 A PA 19998483901A PA 8483901 A PA8483901 A PA 8483901A PA 8483901 A1 PA8483901 A1 PA 8483901A1
- Authority
- PA
- Panama
- Prior art keywords
- group
- isosorbide
- employment
- alkyl
- decreased tolerance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE MONONITRATO DE ISOSORBIDA Y SUS SALES FARMACÉUTICAMENTE ACEPTABLES, QUE POSEEN ACTIVIDAD VASODILATADORA CON UN EFECTO DE TOLERANCIA DISMINUIDO, DE FÓRMULA GENERAL (1) EN LA QUE A Y B REPRESENTAN INDISTINTAMENTE CUALQUIERA DE LOS GRUPOS -ONO2 Y -Z-CO-R, SIENDO Z UN ÁTOMO DE OXÍGENO O DE AZUFRE, Y R UN GRUPO ALQUILO C1-C4, ARILO O ARALQUILO, EVENTUALMENTE SUBSTITUIDO, O EL GRUPO EN EL QUE R1 ES HIDRÓGENO O UN ALQUILO C1-C4, ARILO O ARALQUILO, EVENTUALMENTE SUBSTITUIDO, DE MANERA QUE SIEMPRE UNO DE A O B ES -ONO2, PERO NUNCA LOS DOS A LA VEZ, CUANDO Z ES UN ÁTOMO DE AZUFRE R ES UN GRUPO ALQUILO C1-C4, ARILO O ARALQUILO, EVENTUALMENTE SUBSTITUIDO, Y CUANDO Z ES UN ÀTOMO DE OXÌGENO R ES EL GRUPO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009802076A ES2142773B1 (es) | 1998-10-07 | 1998-10-07 | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8483901A1 true PA8483901A1 (es) | 2000-09-29 |
Family
ID=8305360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19998483901A PA8483901A1 (es) | 1998-10-07 | 1999-10-07 | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US20010051735A1 (es) |
| EP (1) | EP1120419B1 (es) |
| JP (1) | JP4659214B2 (es) |
| KR (1) | KR100641801B1 (es) |
| CN (1) | CN1096465C (es) |
| AP (1) | AP1555A (es) |
| AR (1) | AR020538A1 (es) |
| AT (1) | ATE323707T1 (es) |
| AU (1) | AU762724B2 (es) |
| BG (1) | BG65135B1 (es) |
| BR (1) | BR9914355B1 (es) |
| CA (1) | CA2346010C (es) |
| CO (1) | CO5180544A1 (es) |
| CU (1) | CU23162A3 (es) |
| CZ (1) | CZ294551B6 (es) |
| DE (2) | DE69930949T2 (es) |
| DK (1) | DK1120419T3 (es) |
| EA (1) | EA003360B1 (es) |
| EE (1) | EE04374B1 (es) |
| ES (2) | ES2142773B1 (es) |
| GB (1) | GB2359810B (es) |
| GE (1) | GEP20043162B (es) |
| GT (1) | GT199900173A (es) |
| HR (1) | HRP20010256B1 (es) |
| HU (1) | HUP0103937A3 (es) |
| ID (1) | ID29946A (es) |
| IL (2) | IL142391A0 (es) |
| IS (1) | IS2312B (es) |
| NO (1) | NO328584B1 (es) |
| NZ (1) | NZ510855A (es) |
| OA (1) | OA11661A (es) |
| PA (1) | PA8483901A1 (es) |
| PE (1) | PE20001083A1 (es) |
| PL (1) | PL200028B1 (es) |
| PT (1) | PT1120419E (es) |
| RS (1) | RS50112B (es) |
| TR (1) | TR200100961T2 (es) |
| WO (1) | WO2000020420A1 (es) |
| YU (1) | YU25201A (es) |
| ZA (1) | ZA200102836B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| EP1941876A1 (en) * | 2006-12-28 | 2008-07-09 | Lacer, S.A. | Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension |
| ES2332565B1 (es) * | 2007-01-23 | 2010-10-21 | Lacer, S.A. | Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios. |
| IE20070934A1 (en) | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Efficient aspirin prodrugs |
| EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
| US8003811B2 (en) * | 2008-02-07 | 2011-08-23 | Nicox S.A. | Nitric oxide donor compounds |
| EP2149577B1 (en) * | 2008-07-22 | 2011-04-27 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2149576A1 (en) | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbide Nitrates having vasodilating activity |
| EP2177216A1 (en) * | 2008-10-13 | 2010-04-21 | Lacer, S.A. | Use of dianhydrohexite mononitrate derivatives as healing agents |
| WO2010055138A1 (en) * | 2008-11-14 | 2010-05-20 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
| EP2199294A1 (en) * | 2008-12-19 | 2010-06-23 | Lacer, S.A. | New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds |
| EP2301941B1 (en) * | 2009-09-10 | 2013-06-19 | Cognis IP Management GmbH | Isosorbide glyceryl ether derivatives and their use in household applications |
| ES2587191T3 (es) | 2009-12-23 | 2016-10-21 | Arca Biopharma, Inc. | Métodos y composiciones para enfermedades y afecciones cardiovasculares |
| CN102241687A (zh) * | 2011-05-23 | 2011-11-16 | 中国人民解放军第四军医大学 | 抗缺血/再灌注损伤的药物 |
| JP6158194B2 (ja) | 2011-10-24 | 2017-07-05 | ニコックス サイエンス アイルランド | キノン系一酸化窒素供与化合物 |
| AU2014226533A1 (en) * | 2013-03-05 | 2015-08-13 | Archer Daniels Midland Company | Isohexide monotriflates and process for synthesis thereof |
| WO2014169976A1 (en) | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds |
| CN104650108B (zh) * | 2013-11-18 | 2017-05-24 | 富力 | 连翘脂素硫酸酯及其衍生物、制备方法及其应用 |
| CN105461731B (zh) * | 2014-08-07 | 2017-05-24 | 富力 | 连翘脂素布洛芬酯、其制备及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1356374A (fr) | 1963-02-12 | 1964-03-27 | Machine à fonctions multiples pour le travail du bois | |
| AU465217B2 (en) | 1971-04-29 | 1975-09-18 | American Home Products Corporation | Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol |
| US3886196A (en) | 1973-02-07 | 1975-05-27 | Phillips Petroleum Co | Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles |
| DE3028289C2 (de) | 1980-07-25 | 1986-11-27 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
| DE3248548A1 (de) * | 1982-12-29 | 1984-07-05 | Heinrich Mack Nachf., 7918 Illertissen | Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3421072A1 (de) | 1984-06-06 | 1985-12-12 | Heinrich Mack Nachf., 7918 Illertissen | 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3602067A1 (de) | 1986-01-24 | 1987-07-30 | Mack Chem Pharm | 2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel |
| DE3606634A1 (de) | 1986-02-28 | 1987-09-03 | Mack Chem Pharm | Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| IT1204571B (it) * | 1987-05-08 | 1989-03-10 | Chiesi Farma Spa | Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche |
| DE3741005A1 (de) | 1987-12-03 | 1989-06-15 | Mack Chem Pharm | Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5428061A (en) | 1988-09-15 | 1995-06-27 | Schwarz Pharma Ag | Organic nitrates and method for their preparation |
| JP2628756B2 (ja) * | 1988-09-15 | 1997-07-09 | シュバルツファルマ アクチェンゲゼルシャフト | 新規有機ニトレート及びそれらの製造方法 |
| US4891373A (en) * | 1988-11-23 | 1990-01-02 | Pfizer Inc. | Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments |
| CA2014520C (en) | 1989-04-17 | 1996-07-16 | Fumio Suzuki | Hexitol derivatives |
| NL9001955A (nl) * | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
| FR2680173A1 (fr) | 1991-08-07 | 1993-02-12 | Hoechst Lab | Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires . |
| US5665766A (en) * | 1992-07-30 | 1997-09-09 | Cal International Limited | Ester of an organic nitrate and a salicylate |
| IL120531A (en) | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
-
1998
- 1998-10-07 ES ES009802076A patent/ES2142773B1/es not_active Expired - Fee Related
-
1999
- 1999-09-30 AR ARP990104928A patent/AR020538A1/es active IP Right Grant
- 1999-10-04 EP EP99949015A patent/EP1120419B1/en not_active Expired - Lifetime
- 1999-10-04 AT AT99949015T patent/ATE323707T1/de not_active IP Right Cessation
- 1999-10-04 PL PL347030A patent/PL200028B1/pl not_active IP Right Cessation
- 1999-10-04 HU HU0103937A patent/HUP0103937A3/hu unknown
- 1999-10-04 IL IL14239199A patent/IL142391A0/xx active IP Right Grant
- 1999-10-04 JP JP2000574532A patent/JP4659214B2/ja not_active Expired - Fee Related
- 1999-10-04 ID IDW00200101008A patent/ID29946A/id unknown
- 1999-10-04 PE PE1999001005A patent/PE20001083A1/es not_active Application Discontinuation
- 1999-10-04 AP APAP/P/2001/002128A patent/AP1555A/en active
- 1999-10-04 EA EA200100422A patent/EA003360B1/ru not_active IP Right Cessation
- 1999-10-04 AU AU62041/99A patent/AU762724B2/en not_active Ceased
- 1999-10-04 DE DE69930949T patent/DE69930949T2/de not_active Expired - Lifetime
- 1999-10-04 KR KR1020017004374A patent/KR100641801B1/ko not_active IP Right Cessation
- 1999-10-04 OA OA1200100085A patent/OA11661A/en unknown
- 1999-10-04 BR BRPI9914355-0A patent/BR9914355B1/pt not_active IP Right Cessation
- 1999-10-04 RS YUP-252/01A patent/RS50112B/sr unknown
- 1999-10-04 CN CN99811802A patent/CN1096465C/zh not_active Expired - Fee Related
- 1999-10-04 PT PT99949015T patent/PT1120419E/pt unknown
- 1999-10-04 WO PCT/ES1999/000316 patent/WO2000020420A1/es not_active Application Discontinuation
- 1999-10-04 DK DK99949015T patent/DK1120419T3/da active
- 1999-10-04 CZ CZ20011257A patent/CZ294551B6/cs not_active IP Right Cessation
- 1999-10-04 GB GB0111172A patent/GB2359810B/en not_active Expired - Fee Related
- 1999-10-04 GE GEAP19995886A patent/GEP20043162B/en unknown
- 1999-10-04 CA CA002346010A patent/CA2346010C/en not_active Expired - Fee Related
- 1999-10-04 TR TR2001/00961T patent/TR200100961T2/xx unknown
- 1999-10-04 NZ NZ510855A patent/NZ510855A/xx not_active IP Right Cessation
- 1999-10-04 DE DE19983612T patent/DE19983612T1/de not_active Ceased
- 1999-10-04 EE EEP200100207A patent/EE04374B1/xx not_active IP Right Cessation
- 1999-10-04 YU YU25201A patent/YU25201A/sh unknown
- 1999-10-04 ES ES99949015T patent/ES2257871T3/es not_active Expired - Lifetime
- 1999-10-06 CO CO99063420A patent/CO5180544A1/es not_active Application Discontinuation
- 1999-10-07 GT GT199900173A patent/GT199900173A/es unknown
- 1999-10-07 PA PA19998483901A patent/PA8483901A1/es unknown
-
2001
- 2001-03-29 IS IS5910A patent/IS2312B/is unknown
- 2001-04-03 IL IL142391A patent/IL142391A/en not_active IP Right Cessation
- 2001-04-04 CU CU83A patent/CU23162A3/es not_active IP Right Cessation
- 2001-04-05 ZA ZA200102836A patent/ZA200102836B/xx unknown
- 2001-04-06 NO NO20011778A patent/NO328584B1/no not_active IP Right Cessation
- 2001-04-06 HR HR20010256A patent/HRP20010256B1/xx not_active IP Right Cessation
- 2001-04-06 US US09/827,868 patent/US20010051735A1/en not_active Abandoned
- 2001-04-06 BG BG105417A patent/BG65135B1/bg unknown
-
2003
- 2003-04-28 US US10/424,828 patent/US6858632B2/en not_active Expired - Fee Related
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