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PA7801701A1 - Compuestos ariltios - Google Patents

Compuestos ariltios

Info

Publication number
PA7801701A1
PA7801701A1 PA19957801701A PA7801701A PA7801701A1 PA 7801701 A1 PA7801701 A1 PA 7801701A1 PA 19957801701 A PA19957801701 A PA 19957801701A PA 7801701 A PA7801701 A PA 7801701A PA 7801701 A1 PA7801701 A1 PA 7801701A1
Authority
PA
Panama
Prior art keywords
compounds
aryltium
formula
provides
antibacterial
Prior art date
Application number
PA19957801701A
Other languages
English (en)
Inventor
Edward Faith Elslager
Rocco Dean Goglotti
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PA7801701A1 publication Critical patent/PA7801701A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
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    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
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    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION PROPORCIONA COMPUESTOS ARILTIOS QUE TIENE UNA ACTIVIDAD ANTIBACTERIANA Y ANTIBACTERIAL. LA INVENCION ADE-MAS PROPORCIONA UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO DE LA FORMULA I, JUNTO CON UN DILUYENTE, EXCIPIENTE O PORTADOR FARMACEUTICAMENTE ACEPTABLE. LAS FORMULACIONES ESPECIFICAMENTE PREFERIDAS UTILIZAN COMPUESTOS DONDE A ES FELILO, ESPECIFICAMENTE COMPUESTOS DE LA FORMULA I.
PA19957801701A 1994-08-05 1995-10-25 Compuestos ariltios PA7801701A1 (es)

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US08/286,816 US5463122A (en) 1994-08-05 1994-08-05 Arylthio compounds

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PA7801701A1 true PA7801701A1 (es) 1997-09-30

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BR (1) BR1100148A (es)
GT (4) GT199500039AA (es)
MD (1) MD1687G2 (es)
PA (1) PA7801701A1 (es)
PE (1) PE33796A1 (es)
TJ (1) TJ285B (es)
UY (1) UY24009A1 (es)
ZA (1) ZA956551B (es)

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EP0874835A1 (en) * 1995-12-15 1998-11-04 Warner-Lambert Company Method of making (s-(r*,r*))-3-methyl-2-(3-oxo-3h-benzo(d)isothiazol-2-yl)pentanoic acid and (s-(r*,r*)), l-2-(2-(2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl)benzoyl-amino)-3-methylpentanoic acid
US5932618A (en) * 1996-11-04 1999-08-03 Signal Pharmaceuticals, Inc. Anti-viral agents and methods relating to the use thereof
PL365459A1 (en) 2000-05-19 2005-01-10 Alcon, Inc. Aniline disulfide derivatives for treating allergic diseases
KR20020093981A (ko) 2000-05-19 2002-12-16 알콘, 인코퍼레이티드 알레르기성 질환 치료를 위한 벤즈아미드 디설파이드유도체를 포함하는 조성물
JP2003534318A (ja) 2000-05-19 2003-11-18 アルコン，インコーポレイテッド アレルギー性疾患を処置するために有用なジスルフィド誘導体
AU2003265382A1 (en) * 2002-08-23 2004-03-11 Pharmacia & Upjohn Company Llc Antibacterial benzoic acid derivatives
US20040110802A1 (en) * 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
CN1300106C (zh) * 2005-09-30 2007-02-14 浙江工业大学 2，2'－二硫代双苯甲酰氯的化学合成方法
GB0806634D0 (en) * 2008-04-11 2008-05-14 Univ Cardiff Chemical compounds

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US3574858A (en) * 1968-07-09 1971-04-13 Fmc Corp Microbiocide for controlling bacteria in water
US3663616A (en) * 1969-10-13 1972-05-16 Sherwin Williams Co Bis(2-carbamylphenyl)disulfides
US3736280A (en) * 1969-10-13 1973-05-29 Sherwin Williams Co Fungicidal compositions and methods of prohibiting the growth thereof
US3786150A (en) * 1971-12-27 1974-01-15 Fmc Corp Fungicidal use of certain benz(d)isothiazoles
GB1532984A (en) * 1975-04-10 1978-11-22 Ici Ltd Method for the control of micro-organisms
EP0062827B1 (en) * 1978-06-16 1986-07-23 Kyowa Hakko Kogyo Co., Ltd Novel benzamide derivatives
US4479950A (en) * 1982-11-05 1984-10-30 Usv Pharmaceutical Corporation Aroylaminoacid disulfides
DE3411385A1 (de) * 1984-03-28 1985-10-10 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von o,o'-dithiobenzamiden
US4975367A (en) * 1986-04-04 1990-12-04 Miles Inc. Catalytic test composition intended to produce a range of colors
AU8937491A (en) * 1990-10-22 1992-05-20 Research Corporation Technologies, Inc. Aryl and heteroaryl compounds having anti-retrovirus activity
MX9205549A (es) * 1991-09-30 1993-05-01 Jess G Thoene Metodo para el tratamiento de vih.

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Publication number Publication date
GT199500039AA (es) 1997-01-21
UY24009A1 (es) 2001-10-25
TJ285B (en) 2000-12-13
PE33796A1 (es) 1996-08-31
MD970135A (en) 1999-03-31
BR1100148A (pt) 2000-07-18
GT199500039CA (es) 1997-01-21
GT199500039BA (es) 1997-01-21
MD1687F2 (en) 2001-06-30
ZA956551B (en) 1996-03-25
MD1687G2 (ro) 2002-03-31
US5668178A (en) 1997-09-16
US5463122A (en) 1995-10-31
GT199500039A (es) 1995-08-04

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