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LU90838I2 - Zometa-acide zol-dronique et ses sels pharmaceutiquement acceptables - Google Patents

Zometa-acide zol-dronique et ses sels pharmaceutiquement acceptables

Info

Publication number
LU90838I2
LU90838I2 LU90838C LU90838C LU90838I2 LU 90838 I2 LU90838 I2 LU 90838I2 LU 90838 C LU90838 C LU 90838C LU 90838 C LU90838 C LU 90838C LU 90838 I2 LU90838 I2 LU 90838I2
Authority
LU
Luxembourg
Prior art keywords
halogen
substituted
phosphono group
atoms
zometa
Prior art date
Application number
LU90838C
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4280350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90838(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of LU90838I2 publication Critical patent/LU90838I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Control Of El Displays (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LU90838C 1986-11-21 2001-09-19 Zometa-acide zol-dronique et ses sels pharmaceutiquement acceptables LU90838I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH466686 1986-11-21

Publications (1)

Publication Number Publication Date
LU90838I2 true LU90838I2 (fr) 2001-11-19

Family

ID=4280350

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90838C LU90838I2 (fr) 1986-11-21 2001-09-19 Zometa-acide zol-dronique et ses sels pharmaceutiquement acceptables

Country Status (27)

Country Link
US (1) US4939130A (fr)
EP (1) EP0275821B1 (fr)
JP (1) JP2744238B2 (fr)
KR (1) KR960010752B1 (fr)
AT (1) ATE72816T1 (fr)
AU (1) AU607722B2 (fr)
CA (1) CA1338937C (fr)
CY (1) CY1827A (fr)
DD (1) DD270533A5 (fr)
DE (2) DE3776880D1 (fr)
DK (1) DK174098B1 (fr)
ES (1) ES2038692T4 (fr)
FI (1) FI87570C (fr)
GR (1) GR3003895T3 (fr)
HK (1) HK114894A (fr)
HU (1) HU199150B (fr)
IE (1) IE59816B1 (fr)
IL (1) IL84497A (fr)
LU (1) LU90838I2 (fr)
MX (1) MX9427A (fr)
NL (1) NL300058I2 (fr)
NO (2) NO173446C (fr)
NZ (1) NZ222610A (fr)
PH (1) PH24345A (fr)
PT (1) PT86167B (fr)
SG (1) SG92194G (fr)
ZA (1) ZA878698B (fr)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
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DE3640938A1 (de) * 1986-11-29 1988-06-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel
US5139786A (en) * 1989-07-07 1992-08-18 Ciba-Geigy Corporation Topical formulations
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
WO1992019629A1 (fr) * 1991-04-27 1992-11-12 Japat Ltd. Nouveaux composes de triazole
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
EP0642519B1 (fr) * 1992-05-29 2000-08-09 Procter & Gamble Pharmaceuticals Composes de phosphonate contenant du soufre, et destines au traitement du metabolisme anormal du calcium et du phosphate
CA2136820C (fr) * 1992-05-29 1997-09-09 Susan M. Kaas Composes phosphate heterocycliques azotes, a substituant thio, pour le traitement du metabolisme anormal du calcium et du phosphate
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
EP0646119B1 (fr) * 1992-05-29 1998-07-15 PROCTER & GAMBLE PHARMACEUTICALS, INC. Composes quaternaires de phosphonate contenant de l'azote et servant a traiter le metabolisme anormal du calcium et du phosphate ainsi que le tartre et la plaque dentaire
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
DE69324684T2 (de) * 1992-06-30 1999-11-25 Procter & Gamble Pharmaceuticals, Inc. Arzneimitteln zur behandlung von arthritis die phosphonate und nsaids enthalten
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US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
IL115041A0 (en) * 1995-08-23 1995-12-08 Yissum Res Dev Co Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them
WO1997012619A1 (fr) * 1995-09-29 1997-04-10 Novartis Ag Methode de traitement de la maladie naviculaire chez les chevaux
AU6452098A (en) 1997-03-07 1998-09-22 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
EP0970095B1 (fr) * 1997-03-07 2003-10-29 Metabasis Therapeutics, Inc. Nouveaux inhibiteurs de benzimidazole de fructose-1,6-bisphosphatase
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
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EP0998932A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Forme d'administration pharmaceutique contenant des diphosphonates ou leurs sels et méthode pour la fabriquer
EP0998933A1 (fr) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Procédé pour la préparation de compositions pharmaucetiques contenant des diphosphonates pour administration orale
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US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
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US9999629B2 (en) 2012-05-14 2018-06-19 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US9827192B2 (en) 2012-05-14 2017-11-28 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10111837B2 (en) 2012-05-14 2018-10-30 Antecip Bioventures Ii Llc Dosage forms for oral administration of zoledronic acid or related compounds
US10092581B2 (en) 2014-05-15 2018-10-09 Antecip Bioventures Ii Llc Osteoclast inhibitors such as zoledronic acid for low back pain treatment
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NO173446C (no) 1993-12-15
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HU199150B (en) 1990-01-29
ZA878698B (en) 1988-05-23
US4939130A (en) 1990-07-03
GR3003895T3 (fr) 1993-03-16
AU607722B2 (en) 1991-03-14
DK174098B1 (da) 2002-06-17
DD270533A5 (de) 1989-08-02
IE873148L (en) 1988-05-21
HUT46330A (en) 1988-10-28
ES2038692T3 (es) 1993-08-01
NL300058I1 (nl) 2001-12-01
NL300058I2 (nl) 2002-02-01
NO874856L (no) 1988-05-24
FI875096A0 (fi) 1987-11-18
SG92194G (en) 1995-04-28
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IL84497A (en) 1994-10-21
FI87570B (fi) 1992-10-15
FI875096A (fi) 1988-05-22
KR960010752B1 (ko) 1996-08-08
EP0275821A1 (fr) 1988-07-27
CA1338937C (fr) 1997-02-25
NO173446B (no) 1993-09-06
MX9427A (es) 1993-12-01
PT86167A (en) 1987-12-01
PT86167B (pt) 1990-08-31
EP0275821B1 (fr) 1992-02-26
DK609587A (da) 1988-05-22
NO874856D0 (no) 1987-11-20
HK114894A (en) 1994-10-27
FI87570C (fi) 1993-01-25
JPS63150291A (ja) 1988-06-22
ES2038692T4 (es) 2012-02-10
CY1827A (en) 1995-12-01
JP2744238B2 (ja) 1998-04-28
ATE72816T1 (de) 1992-03-15
DK609587D0 (da) 1987-11-20
NZ222610A (en) 1990-09-26
IL84497A0 (en) 1988-04-29
IE59816B1 (en) 1994-04-06
DE3776880D1 (de) 1992-04-02
KR880006204A (ko) 1988-07-22
PH24345A (en) 1990-06-13

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