LU500687B1 - NUTRITIONAL OR DIETICAL COMPOSITION - Google Patents

Abstract

The present invention relates to a nutritional or dietetic composition for the prevention of nutritional deficiencies. In order to increase physical well-being and performance and to reduce susceptibility to infections, a food or dietary composition is proposed which preferably contains vitamin C, oligomeric proanthocyanidins (OPC), L-tryptophan and zinc. Furthermore, the nutritional or dietetic composition can also contain grape seed extract, acerola fruit juice powder, hyaluronic acid and/or green tea extract, the green tea extract containing polyphenols, epigallocatechin gallate and caffeine.

Description

NUTRITIONAL OR DIETICAL COMPOSITION

TECHNICAL AREA

The present invention relates to a nutritional or dietetic composition for

Prevention of nutritional deficiencies, which

Wide grape seed extract, oligomeric proanthocyanidins (OPC), acerola fruit juice powder,

Contains vitamin C, L-tryptophan and zinc. Preferably contains the nutritional or dietary

Composition also hyaluron and green tea extract, with the green tea extract

Contains polyphenols, epigallocatechin gallate and caffeine.

STATE OF THE ART

The disadvantage of today's lifestyle is that eating habits have changed drastically. Often due to lack of time or convenience, people are unable or unwilling to follow a healthy diet. With the waiver

Fruit or vegetables or the frequent consumption of ready meals, many people therefore experience a lack of vitamins and other nutrients.

To compensate for this, the market has produced a wide variety of dietary supplements. There is now an almost unmanageable number of different ones

Dietary supplements available. These include preparations with different

vitamins and ingredients. The ingredients are either individually or in

combination before.

Preparations are known which contain grape seed extract. The special

Grape seed extract is the high content of oligomeric proanthocyanidins (OPC), which is a generic term for flavones, isoflavonoids and neoflavonoids. OPC are secondary

Plant substances that have an antioxidant effect on body cells. The antioxidant

The capacity of a food can be measured using the ORAC value (Oxygen Radical Absorption

Capacity) are described. Thanks to its high OPC content, grape seed flour is one of the foods with the highest ORAC value.

Furthermore, preparations are known that the main ingredient fruit juice or pulp

Contain acerola cherry. This has a high vitamin C content. Secondary plant substances are also contained here. Vitamin C is known for its antioxidant properties and is one of the most commonly consumed vitamins. At the same time finds

Vitamin C, also known as ascorbic acid, a common application in the food industry. Here it is considered as a food additive E300

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

Antioxidant used to protect food from oxygen-induced deterioration. Furthermore, it is known that vitamin C serves as a radical scavenger in the body and consequently provides antioxidant protection of body cells. In addition, vitamin C is an important coenzyme of prolyl-4-hydroxylase, which is essential for the synthesis of collagen. A lack of vitamin C leads to scurvy.

Interestingly, the combination of OPC and vitamin C leads to a ten-fold increase in the effect of vitamin C. This synergistic effect can be explained by the fact that OPC acts as a natural booster of vitamin C, in that OPC depleted (reduced) vitamin C molecules are replaced by a Reduction-oxidation reaction (redox

reaction) regenerated several times.

L-tryptophan is one of the essential amino acids that the body cannot produce itself. Furthermore, L-tryptophan is a precursor of the neurotransmitter serotonin, which is why an increased intake of L-tryptophan has an influence on mood,

performance and well-being. The body also needs tryptophan

to form melatonin, niacin and vitamin B3. It has been shown that there is a lack of

L-tryptophan, among other things, to mood swings, anxiety and

states of aggression or insomnia.

Zinc is a trace element that is essential for metabolism. Zinc is a

Part of a variety of enzymes, such as RNA polymerase and the

carbonic anhydrase. Zinc is essential for sugar, fat and protein metabolism as well as for

Structure of the genetic material and involved in cell growth. In addition, the immune system as well as many hormones need zinc for the correct function. Zinc also dampens overshooting

reactions of the immune system.

A disadvantage of the previously available food supplements is that the protective effects on the biological system can only be achieved with individual preparations. In particular, no preparations are known which have an antioxidative and at the same time mood-enhancing effect.

TASK

It is therefore an object of the present invention to provide a nutritional or dietetic

Provide composition, which optionally in combination with other

Vitamins and minerals, especially in conditions of general physical and / or mental weakness, such. B. drive or concentration disorders, and

Susceptibility to infection can ensure an improvement in well-being. Furthermore, there is

Object of the invention therein the immune system, wound healing, the cardiovascular system,

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application to positively influence the metabolism and the complexion and to act as a mood enhancer.

The known dosage forms of the active ingredients and the known

Combinations of active ingredients of individual active ingredients have the particular disadvantage that they do not allow the individual ingredients to be absorbed quickly and/or

Bioavailability in vivo is limited.

There is therefore a need to improve the absorbability of the individual active ingredients with a new one

To maximize the dosage or administration form and to improve the bioavailability of the active ingredients if possible during a single in vivo exposure.

SOLUTION

According to the invention, this object is achieved with one of the features of claim 1 having nutritional or dietary composition or a pharmaceutical

composition dissolved. Advantageous embodiments and developments of

Invention can be achieved with the features indicated in the subclaims.

GENERAL ADVANTAGES

The food or dietary composition according to the invention causes a general

Improved well-being and reduced susceptibility to infections. With the

The combination of the ingredients contained results in an antioxidant effect and a mood-enhancing effect, which has a positive effect on the performance of the

subjects/patients/consumers. In particular, by the

Combination of active ingredients the rapid absorbability of the individual ingredients from one

Improved dosage or administration form and their bioavailability in vivo.

DESCRIPTION OF THE INVENTION

The nutritional or dietary composition or pharmaceutical composition according to the invention

Composition includes an effective level of at least vitamin C, oligomers

Proanthocyanidins (OPC), L-Tryptohane and Zinc.

It is in principle possible to administer the ingredients of the food or dietary composition or pharmaceutical composition according to the invention alone (separately from one another), but the inventors of the present invention have

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application found that in particular the simultaneous (combined) administration / intake of the ingredients within a food or dietary composition or pharmaceutical composition synergistic effects for the

Receptivity / absorbability of the individual ingredients and the bioavailability of the

Drugs increased during a single in vivo exposure. Therefore, the ingredients (the administered compounds) are as an active ingredient in a pharmaceutical

composition before. Thus, the pharmaceutical composition of the invention may contain a therapeutically or pharmaceutically effective amount of at least one ingredient or an effective dosage amount of at least one ingredient (preferably all

Ingredients) include.

Alternatively, a nutritional, dietary or pharmaceutical composition according to the invention in which two or more dosage units, e.g. Am

Form of tablets, capsules, dragees and the like, may be required to be effective

Amount of at least one ingredient to administer over one or more

Periods of administration at less than the effective amount (i.e., once per day and twice per day), for example to determine the effective dose for an individual patient or subject, to desensitize an individual patient/subject to potential side effects, to enable an effective dosage adjustment or the build-up of an endogenous "active substance depot".

Grape seed extract is obtained from the seeds of the fruiting bodies (grapes) and the skin of grapevines. The seeds of the grapevine Vitis vinifera can preferably be used. For the production of grape seed flour, the grape seeds are extracted from the pressing residue, the pomace, after the pressing process for wine production. The seeds are cold-pressed to extract the grapeseed oil, which contains the OPC. By means of a specialist selectable chemical

Extraction methods (e.g. water, ethanol, chloroform) or physical

Extraction process, the extraction is accomplished in such a way that the content of oligomers

proanthocyanidins (OPC) is as high as possible. Corresponding procedures are from the

known in the art.

The therapeutically or pharmaceutically effective amount of grape extract in the compositions disclosed herein ranges from about 100 mg to about 1000 mg, preferably from 200 mg to 750 mg, for example from about 250 mg to about 450 mg or from about 250 mg to about 400 mg . As used herein, "therapeutically or pharmaceutically effective amount of grape extract" is an amount that

IAMG-0001-P-LU 25.09.2021 Luxembourg patent application provides a defined amount of oligomeric proanthocyanidins (OPC) and/or contain sufficient oligomeric proanthocyanidins (OPC) that a patient usually -i.e. be resorbed from the grape extract when it passes through the gastrointestinal tract as intended. In some embodiments, the therapeutically or pharmaceutically effective amount of grape extract in the composition disclosed herein can be selected from about 100 mg, about 150 mg, about 200 mg, about 250 mg, about 300 mg, about 350 mg, about 400 mg, about 450 mg, about 500 mg, about 550 mg, about 600 mg, about 650 mg, about 700 mg or about 750 mg.

Oligomeric proanthocyanidins (OPC) are phytochemicals and belong to the

group of polyphenols. For example, they come red in the seeds and the peel

grapes in front. OPC are also in nuts, blueberries, cranberries and others

contain berries. These OPCs are particularly suitable because they are present in their biologically native environment. The exact composition of the OPC can be determined, for example, via mass spectroscopic investigations, but is unimportant for the invention. The OPC selected for the composition according to the invention can therefore in their chemical composition, in particular the mass fraction of individual

total mass, vary. A variation is already dependent on which plant species is used to obtain the extract. Even if OPCs are obtained from the seeds of grapes for the composition according to the invention, OPCs from their chemical equivalents can also be used for the composition according to the invention. For example, the

Concentration of at least one specific OPC species in an OPC mixture can be increased if beneficial biological or pharmacological effects are associated with this OPC species

properties go hand in hand. Furthermore, OPC extracts can also be obtained from, for example, biologically modified organisms with increased concentrations of OPC or with a specific composition of OPC.

Acerola fruit juice powder or acerola powder is made from the fruiting body (cherry) of the

Acerola plant (Malpighia glabra) obtained. A common manufacturing process is that the cherry is pressed, water being removed from the fruit juice using known methods until a powder is obtained. Alternatively, the powder can be obtained using known methods by drying and grinding the pulp of the cherry. It has been shown that a freeze drying process or a

Spray drying process followed by a gentle grinding process

Manufacturing method of acerola powder is, since the content of vitamin C and

IAMG-0001-P-LU September 25, 2021 Luxembourg patent application for secondary plant substances. As an alternative to acerola powder, sea buckthorn powder can also be used.

The therapeutically or pharmaceutically effective amount of acerola fruit juice powder or

Acerola powder in the compositions disclosed herein ranges from about 100 mg to about 1000 mg, preferably from 200 mg to 750 mg, for example from about 250 mg to about 450 mg, or from about 250 mg to about 400 mg. As used herein, the "therapeutically or pharmaceutically effective amount of the acerola fruit juice powder or

acerola powder" means an amount that provides an amount of vitamin C as defined herein and/or contains sufficient vitamin C required by a patient -i.e. when properly passed through the gastrointestinal tract from the

acerola fruit juice powder or acerola powder is absorbed. In some embodiments, the therapeutically or pharmaceutically effective amount of acerola fruit juice powder or acerola powder in the composition disclosed herein can be selected from about 100 mg, about 150 mg, about 200 mg, about 250 mg, about 300 mg, about 350 mg, about 400 mg , about 450 mg, about 500 mg, about 550 mg, about 600 mg, about 650 mg, about 700 mg or about 750 mg.

Vitamin C (ascorbic acid) is found in high concentrations in acerola fruits but also in other fruits (e.g. sea buckthorn). The vitamin C contained in the food or diet composition according to the invention is preferably derived from the one used

Acerola powder, however, can also be synthesized chemically via known methods to increase the vitamin C content of the food or diet

further increase the composition. This is especially true when the desired

Vitamin C content cannot be provided by the acerola powder used.

The nutritional or dietary composition according to the invention preferably comprises a therapeutically or pharmaceutically effective amount of vitamin C, in particular a daily dose of 50 mg to 250 mg, particularly preferably 75 mg to 175 mg, such as about 80 mg, about 90 mg, for example 100 mg, about 110 mg, about 120 mg, about 130 mg, about 140 mg, about 150 mg, about 160 mg, about 170 mg. In this concentration range, the effects, the bioavailability and the absorbability of the active substances contained in the composition are advantageously increased, in particular with the oligomers

Proanthocyanidins (OPC) when exposed in vivo.

L-Tryptophan is an essential amino acid and a hormone and

Neurotransmitter precursor of serotonin. L-tryptophan is present with shares of up to about 2%

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

Foods such as soybeans, cashew nuts, peanuts, tuna and more. The L-tryptophan used for the food or dietary composition according to the invention can be obtained from fungi or by known methods

Microorganisms or chemical processes can be obtained.

The food or dietary composition according to the invention preferably comprises a therapeutically or pharmaceutically effective amount of L-tryptophan, in particular a daily dose of 50 mg to 500 mg, very particularly preferably 75 mg to 300 mg, such as about 80 mg, about 100 mg, about 120 mg, about 140 mg, about 160 mg, about 180 mg, about 200 mg, about 220 mg, about 240 mg, about 260 mg, about 280 mg. In this

Concentration range amplify the beneficial effects, bioavailability and

Resorbability of the active ingredients contained in the composition, in particular with the

Oligomeric proanthocyanidins (OPC) in an in vivo exposure.

Zinc is an element that forms a layer of zinc oxide and zinc carbonate in air.

Since L-tryptophan is sensitive to oxidation, the co-presence of zinc, in addition to its biological effect according to the invention described above, is advantageous to prevent oxidation of L-tryptophan within the food or dietary

To prevent or delay composition. The presence of vitamin C also allows additional protection of L-tryptophan against oxidation.

The zinc is preferably freely available, i. H. in the form of zinc salts (non-chelated) or

zinc complexes (chelated form), and in an ionizable or ionized form to ensure it is bioavailable and easily absorbed. The oral and topical administration of zinc is mostly in ionic form as Zn?* ions, e.g. in the form of free divalent ions, zinc gluconate, zinc acetate, zinc propionate, zinc butyrate,

zinc betahydroxybutyrate, zinc benzoate, zinc formate, zinc ascorbate, zinc histidine complex or

mixtures of them.

The therapeutically or pharmaceutically effective amount of zinc or free ionic zinc in the composition according to the invention is preferably 1 mg to 20 mg, preferably 2 mg to 15 mg, for example about 3 mg, about 4 mg, about 5 mg, per dosage unit. about 6 mg, about 7 mg, about 8 mg, about 9 mg, about 10 mg, about 11 mg, about 12 mg, about 13 mg, about 14 mg.

Various proportions of the above-described ingredients of the food or dietary composition according to the invention were tested, the

Percentages by weight of the individual components, based on the proportion by weight of vitamin

C, as follows: grape seed extract: 1.3:1 to 5.0:1; Oligomeric proanthocyanidins

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

(OPC) 0.7:1 to 2.5:1; acerola fruit juice powder 1.5:1 to 5.0:1; L-tryptophan 0.8:1 to 3.0:1; Zinc 0.01: 1 to 0.12: 1. It has been shown that for the desired biological

Effect the following composition, based on the proportion by weight of vitamin C, is particularly advantageous: grape seed extract: 2.917: 1; oligomeric proanthocyanidins (OPC) 1.458:1; acerola fruit juice powder 2.667:1; L-tryptophan 1.667:1; Zinc 0.083:1.

In another embodiment, the composition of the invention is nutritional or dietetic

Composition additionally added hyaluronic acid and green tea extract to obtain further biological beneficial effects. Methods are known to those skilled in the art

Hyaluronic acid, in particular in the powder form preferred for the invention.

Furthermore, methods are known to the person skilled in the art for obtaining green tea extract(s), which is preferably obtained from the tea plant Camellia sinensis, but is not limited to this. The green tea extract according to the invention also includes extracts from others

Species of the tea plant family (Theaceae).

The green tea extract according to the invention comprises polyphenols, epigallocatechin gallate and

Caffeine. Other polyphenols can also be added to the food or dietetic composition according to the invention. In particular, the quantitative ratio

Polyphenols, epigallocatechin gallate and caffeine can be varied.

One embodiment of the nutritional or dietary composition preferably comprises the following ingredients, the proportions by weight of which are given as follows, based on the proportion by weight of vitamin C: hyaluronic acid 1.5:1 to 4.0:1; Green tea extract 1.5:1 to 4.0:1.

The green tea extract includes the following amounts, which are given as follows based on the proportion by weight of vitamin C: polyphenols 0.50:1 to 2.50:1;

epigallocatechin gallate 0.10:1 to 1.50:1; Caffeine 0.20:1 to 0.80:1.

The following quantities, based on the proportion by weight of vitamin C, have proven to be more preferred: hyaluronic acid 2.708:1; green tea extract 2.250:1; wherein the green tea extract comprises, by weight of vitamin C:

polyphenols 1.125:1; epigallocatechin gallate 0.338:1; Caffeine 0.158:1.

The composition of the ingredients according to the invention is preferably in the form of a tablet or a capsule, which is surrounded by a coating material. Various shell materials are known to those skilled in the art which shield the contents of the capsule from the environment. For example, the shell can be formed from hydroxypropylmethyl cellulose.

Silica or another equivalent agent can be used as a release agent. Calcium L-ascorbate is used in the food industry as an antioxidant and stabilizer. The effect is the oxygen levels within one

To reduce food, or to increase its vitamin C content. For

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application the invention is, however, the precise design of the shell material or involved

Release agents and stabilizers not relevant. The expert can determine the exact

You can therefore choose the composition freely, taking care to protect the ingredients as well as possible from spoilage or oxygen.

In a further embodiment, the contents of the capsule or tablet containing the food or dietetic composition have a swellable material added to them. As swellable

Material can be, for example, konjac flour (also: glucomannan, food additive

E 425) or an equivalent equivalent. This has the advantage that the ingredients contained can be absorbed over a longer period of time, which means that a depot effect can be achieved.

The composition according to the invention can also comprise a disintegrant, which is preferably selected from crospovidone, sodium starch glycolate, croscarmellose

sodium and mixtures thereof. Preferably, the composition comprises from 1% to 10% of the disintegrant, the percentage being by weight based on the total weight of the

composition is related.

The composition according to the invention can also comprise a diluent, which is preferably selected from starch, microcrystalline cellulose, dicalcium phosphate,

lactose, sorbitol, mannitol, sucrose, methyl dextrins and mixtures thereof. Preferably, the composition comprises 10% to 85%, more preferably 30% to 70% of

disintegrant, the percentage by weight based on the total weight of the

composition is related.

The excipients such as the swellable material, disintegrant or diluent of the present invention may be intragranular, intergranular or mixtures thereof.

In an alternative embodiment, the ingredients according to the invention can also be in liquid or viscous form. For example, L-tryptophan is fat-soluble, so that a dosage form in a viscous or liquid fat phase is advantageous. A capsule may also contain essentially a liquid or viscous phase with at least one of the ingredients dispersed or emulsified therein.

In a further embodiment, a capsule with the invention

Compositions having a compartmentalized or stratified structure, with, for example, L-tryptophan being located at the center while the other ingredients are located in surrounding layers around it. This advantageously results in the fact that each layer represents a further diffusion barrier for oxygen. Furthermore, such an arrangement allows the ingredients to be ingested gradually. The

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

A person skilled in the art can also use an additional coating of the individual capsule layers

Passage, especially its duration, affect through the gastrointestinal tract.

In a further embodiment, the nutritional or dietary composition can additionally contain at least a pharmaceutically effective amount of one of the active ingredients and/or other ingredients such as vitamins and minerals.

In addition, the food or dietetic composition according to the invention can comprise a further pharmaceutically active component. The pharmaceutically active component can be, for example, an analgesic or another drug.

In another embodiment, the nutritional or dietary composition as

Additive for a pharmaceutical application or a cosmetic product, where the weight fraction of grape seed extract in the cosmetic (e.g. a

day cream) between 0.1 and 2.0%, preferably 0.2 and 1.0% and particularly preferably between 0.3 and 0.8%.

In summary, the inventive nutritional or dietary

Composition contribute to a reduction in oxidative stress, cell protection, increased vitality, stimulation of detoxification processes and support of the immune system.

The invention also relates to a composition as defined herein for use in

treatment of fatigue.

Furthermore, the present invention also encompasses one as defined herein

Composition for use as a radical scavenger, in particular in vivo in the

Treatment or prophylaxis of with free radicals or radical-associated

Diseases, especially from oxidative cell stress, such as premature

signs of aging.

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

EXEMPLARY EMBODIMENTS

The food or diet composition according to the invention can be in the form of two

Tablets to be taken orally once a day. The recommended

Daily dose of the ingredients in one embodiment of the composition:

Grape seed extract from Vitis vinifera: 350 mg; Oligomeric proanthocyanidins (OPC): 175 mg; Acerola fruit juice powder from Malphighia glabra: 320 mg; vitamin C: 120 mg; L

Tryptophan: 200 mg and Zinc: 10 mg. The tablet contains L-ascorbate as a stabilizer. The

The tablet's coating agent is formed from hydroxypropylmethylcellulose.

In an embodiment based on this, the ingredients of the nutritional or dietary composition are formed from grape seed extract from Vitis vinifera: 350 mg; Oligomeric proanthocyanidins (OPC): 175 mg; Acerola fruit juice powder

Malphighia glabra: 320 mg; vitamin C: 120 mg; L-tryptophan: 200 mg and zinc: 10 mg,

Hyaluronic Acid: 325 mg; Green tea extract: 270 mg (of which containing polyphenols 135 mg,

epigallocatechin gallate: 40.5 mg and caffeine: 18.9 mg). The tablet contains as a stabilizer

L-ascorbate. The tablet coating agent is formed from hydroxypropylmethylcellulose.

The embodiments of the invention shown are each exemplary and not to be understood as limiting. The invention can also be carried out in other ways. For example, the ingredients can also be in a different

combination as disclosed herein. In addition, instead of the described

Ingredients also equivalent equivalents are used. Furthermore, the coating agents or stabilizers used are not to be classified as essential to the invention, since the person skilled in the art can select them depending on the desired application. So are they

Sizes of the tablets to be taken can be freely selected in a suitable manner by a person skilled in the art.

Therefore, while the invention has been described with reference to specific embodiments, it is not intended to be limited to the disclosed embodiments.

Those skilled in the art will recognize that variations and modifications can be made without departing from the true scope of the invention as defined by the claims and specification. It is therefore intended to include all within the scope of the invention

to include variations and modifications that come within the scope of the appended claims and their equivalents.

IAMG-0001-P-LU 09/25/2021 Luxembourg patent application

Claims (16)

PATENT CLAIMS A nutritional or dietary composition comprising an effective level of a combination of a) vitamin C; b) oligomeric proanthocyanidins; c) L-tryptophan; and d) zinc. 2. Nutritional or dietetic composition according to claim 1, wherein the composition comprises a) vitamin C; b) oligomeric proanthocyanidins in a weight ratio of 0.7:1 to 2.5:1, based on the proportion by weight of vitamin C; c) L-tryptophan in a weight ratio of 0.8:1 to 3.0:1 based on the weight of vitamin C; and d) zinc in a weight ratio of from 0.01:1 to 0.5:1 based on the weight fraction of the vitamin C. 3. Nutritional or dietetic composition according to claim 1 or 2, wherein the composition further comprises grape seed extract in a weight ratio of 1.3:1 to 5.0:1 based on the weight fraction of the oligomeric proanthocyanidins. 4. A nutritional or dietetic composition according to any one of claims 1 to 3, further comprising acerola fruit juice powder in a weight ratio of from 1.5:1 to 5.0:1 based on the weight fraction of the vitamin C. IAMG-0001-P-LU 09/25/2021 Luxembourg patent application 5. A nutritional or dietetic composition according to any one of the preceding claims, further comprising hyaluronic acid in a weight ratio of from 1.5:1 to 4.0:1 based on the weight fraction of the vitamin C. 6. A nutritional or dietetic composition according to any one of the preceding claims, further comprising green tea extract in a weight ratio of from 1.5:1 to 4.0:1 based on the weight fraction of vitamin C. 7. A nutritional or dietetic composition according to claim 4, further comprising a) polyphenols in a weight ratio of from 0.5:1 to 2.5:1 based on the weight fraction of the vitamin C; b) epigallocatechin gallate in a weight ratio of 0.1:1 to 1.5:1 based on the weight fraction of the vitamin C; and c) caffeine in a weight ratio of 0.2:1 to 0.8:1 based on the weight fraction of vitamin C. 8. A nutritional or diet composition according to any one of the preceding claims, wherein the nutritional or diet composition is in a capsule or surrounded by a shell material. 9. The nutritional or diet composition according to claim 8, wherein the nutritional or diet composition is in solid or liquid or viscous form within the capsule or shell material. 10. Nutritional or dietetic composition according to any one of claims 3 to 9, wherein the daily dose of grape seed extract is between 250 mg and 450 mg. 11. Nutritional or dietetic composition according to claim 10, wherein the daily dose of grape seed extract is 350 mg. IAMG-0001-P-LU 09/25/2021 Luxembourg patent application 12. Nutritional or dietetic composition according to any one of claims 1 to 11, wherein the daily dose of oligomeric proanthocyanidins is 175 mg. 13. A nutritional or diet composition according to any one of the preceding claims, wherein the nutritional or diet composition further comprises a swellable material. 14. A nutritional or diet composition according to any one of the preceding claims, wherein the nutritional or diet composition comprises at least a pharmaceutically effective amount of one of the active ingredients. 15. Nutritional or dietetic composition according to any one of the preceding claims, wherein the individual ingredients are dispersed or compartmentalized in the capsule or within the shell material. 16. Nutritional or dietetic composition according to any one of claims 1 to 7 or 17 to 19 as an additive for pharmaceutical applications or cosmetics. IAMG-0001-P-LU 09/25/2021 Luxembourg patent application