LT3348547T - Benzimidazolo dariniai, kaip nav 1.7 (nuo įtampos priklausančio natrio kanalo ix tipo alfa subvieneto (scn9a)) inhibitoriai, skirti skausmui, dizurijai ir išsėtinei sklerozei gydyti - Google Patents
Benzimidazolo dariniai, kaip nav 1.7 (nuo įtampos priklausančio natrio kanalo ix tipo alfa subvieneto (scn9a)) inhibitoriai, skirti skausmui, dizurijai ir išsėtinei sklerozei gydytiInfo
- Publication number
- LT3348547T LT3348547T LTEP16844497.4T LT16844497T LT3348547T LT 3348547 T LT3348547 T LT 3348547T LT 16844497 T LT16844497 T LT 16844497T LT 3348547 T LT3348547 T LT 3348547T
- Authority
- LT
- Lithuania
- Prior art keywords
- scn9a
- dysuria
- nav
- gated
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015179663 | 2015-09-11 | ||
| PCT/JP2016/076645 WO2017043636A1 (ja) | 2015-09-11 | 2016-09-09 | 新規ベンズイミダゾール化合物およびその医薬用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3348547T true LT3348547T (lt) | 2020-11-10 |
Family
ID=58239905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP16844497.4T LT3348547T (lt) | 2015-09-11 | 2016-09-09 | Benzimidazolo dariniai, kaip nav 1.7 (nuo įtampos priklausančio natrio kanalo ix tipo alfa subvieneto (scn9a)) inhibitoriai, skirti skausmui, dizurijai ir išsėtinei sklerozei gydyti |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10407395B2 (lt) |
| EP (1) | EP3348547B1 (lt) |
| JP (1) | JP6768674B2 (lt) |
| KR (1) | KR102654710B1 (lt) |
| CN (1) | CN107922350B (lt) |
| AU (1) | AU2016319597B2 (lt) |
| CA (1) | CA2989992A1 (lt) |
| CY (1) | CY1123482T1 (lt) |
| DK (1) | DK3348547T3 (lt) |
| ES (1) | ES2818529T3 (lt) |
| HK (1) | HK1251225A1 (lt) |
| HU (1) | HUE052395T2 (lt) |
| LT (1) | LT3348547T (lt) |
| PL (1) | PL3348547T3 (lt) |
| PT (1) | PT3348547T (lt) |
| SI (1) | SI3348547T1 (lt) |
| TW (1) | TWI710554B (lt) |
| WO (1) | WO2017043636A1 (lt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017043636A1 (ja) * | 2015-09-11 | 2017-03-16 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール化合物およびその医薬用途 |
| AU2018236530B2 (en) * | 2017-03-15 | 2022-05-19 | Sumitomo Pharma Co., Ltd. | Deuterated benzimidazole compound and medicinal use thereof |
| US11242332B2 (en) | 2017-03-15 | 2022-02-08 | Sumitomo Dainippon Pharma Co., Ltd. | Method for producing benzimidazole derivative |
| JP7165501B2 (ja) * | 2017-03-15 | 2022-11-04 | 住友ファーマ株式会社 | 新規ベンズイミダゾール化合物からなる医薬 |
| KR102183676B1 (ko) | 2018-04-17 | 2020-11-27 | 주식회사 엘지화학 | 타원 편광판 및 유기발광장치 |
| CN115925699B (zh) * | 2022-02-25 | 2023-10-03 | 南京知和医药科技有限公司 | 具有镇痛活性的稠环化合物及其制备方法与用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04010545A (es) * | 2002-04-26 | 2005-01-25 | Pfizer Prod Inc | Inhibidores de metaloproteinasa de heteroariloxi-aril-espiero-pirimidina-2,4,6-triona n-sustituida. |
| NZ547109A (en) * | 2003-10-28 | 2010-03-26 | Vertex Pharma | Benzimidazoles useful as modulators of ion channels |
| EP1753730A1 (en) * | 2004-06-04 | 2007-02-21 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP2582666B1 (en) * | 2010-06-16 | 2014-08-13 | Purdue Pharma L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
| JPWO2012057262A1 (ja) | 2010-10-28 | 2014-05-12 | 日本新薬株式会社 | ピリジン誘導体及び医薬 |
| WO2012116440A1 (en) * | 2011-03-03 | 2012-09-07 | Zalicus Pharmaceuticals Ltd. | Benzimidazole inhibitors of the sodium channel |
| WO2012172043A1 (en) * | 2011-06-15 | 2012-12-20 | Laboratoire Biodim | Purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections |
| WO2013114250A1 (en) * | 2012-02-03 | 2013-08-08 | Pfizer Inc. | Benziimidazole and imidazopyridine derivatives as sodium channel modulators |
| CN104837820A (zh) | 2012-10-02 | 2015-08-12 | 大日本住友制药株式会社 | 咪唑衍生物 |
| CN105189481A (zh) * | 2013-03-13 | 2015-12-23 | 艾伯维公司 | 吡啶cdk9激酶抑制剂 |
| JP2016169161A (ja) * | 2013-07-19 | 2016-09-23 | 大日本住友製薬株式会社 | 新規イミダゾピリジン化合物 |
| US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| MA40957A (fr) * | 2014-10-09 | 2017-09-19 | Biomarin Pharm Inc | Inhibiteurs de biosynthèse d'héparane sulfate pour traiter des maladies |
| JP2018052817A (ja) | 2015-01-21 | 2018-04-05 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール誘導体およびその医薬用途 |
| MA41803A (fr) | 2015-03-24 | 2018-01-30 | Almirall Sa | Dérivés amino-indazoles utilisés comme inhibiteurs des canaux sodiques |
| KR20170140291A (ko) | 2015-04-21 | 2017-12-20 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 분해제(sard) 리간드 및 이의 사용 방법 |
| WO2017043636A1 (ja) * | 2015-09-11 | 2017-03-16 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール化合物およびその医薬用途 |
-
2016
- 2016-09-09 WO PCT/JP2016/076645 patent/WO2017043636A1/ja active Application Filing
- 2016-09-09 CA CA2989992A patent/CA2989992A1/en active Pending
- 2016-09-09 JP JP2017538545A patent/JP6768674B2/ja active Active
- 2016-09-09 PT PT168444974T patent/PT3348547T/pt unknown
- 2016-09-09 US US15/323,185 patent/US10407395B2/en active Active
- 2016-09-09 KR KR1020187007320A patent/KR102654710B1/ko active IP Right Grant
- 2016-09-09 EP EP16844497.4A patent/EP3348547B1/en active Active
- 2016-09-09 SI SI201630917T patent/SI3348547T1/sl unknown
- 2016-09-09 AU AU2016319597A patent/AU2016319597B2/en active Active
- 2016-09-09 ES ES16844497T patent/ES2818529T3/es active Active
- 2016-09-09 PL PL16844497T patent/PL3348547T3/pl unknown
- 2016-09-09 LT LTEP16844497.4T patent/LT3348547T/lt unknown
- 2016-09-09 CN CN201680052438.1A patent/CN107922350B/zh active Active
- 2016-09-09 TW TW105129360A patent/TWI710554B/zh active
- 2016-09-09 HU HUE16844497A patent/HUE052395T2/hu unknown
- 2016-09-09 DK DK16844497.4T patent/DK3348547T3/da active
- 2016-12-30 US US15/395,338 patent/US9688670B2/en active Active
-
2018
- 2018-08-17 HK HK18110573.4A patent/HK1251225A1/zh unknown
-
2020
- 2020-10-14 CY CY20201100973T patent/CY1123482T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2818529T3 (es) | 2021-04-13 |
| PL3348547T3 (pl) | 2020-12-14 |
| KR102654710B1 (ko) | 2024-04-03 |
| US9688670B2 (en) | 2017-06-27 |
| US20180170881A1 (en) | 2018-06-21 |
| AU2016319597B2 (en) | 2020-12-24 |
| KR20180044317A (ko) | 2018-05-02 |
| CN107922350B (zh) | 2022-04-19 |
| TW201713629A (zh) | 2017-04-16 |
| JPWO2017043636A1 (ja) | 2018-06-28 |
| US10407395B2 (en) | 2019-09-10 |
| JP6768674B2 (ja) | 2020-10-14 |
| DK3348547T3 (da) | 2020-09-14 |
| WO2017043636A1 (ja) | 2017-03-16 |
| US20170107211A1 (en) | 2017-04-20 |
| SI3348547T1 (sl) | 2020-10-30 |
| PT3348547T (pt) | 2020-10-12 |
| TWI710554B (zh) | 2020-11-21 |
| EP3348547A4 (en) | 2019-03-20 |
| HUE052395T2 (hu) | 2021-04-28 |
| HK1251225A1 (zh) | 2019-01-25 |
| EP3348547B1 (en) | 2020-07-22 |
| CN107922350A (zh) | 2018-04-17 |
| AU2016319597A1 (en) | 2018-02-01 |
| CA2989992A1 (en) | 2017-03-16 |
| EP3348547A1 (en) | 2018-07-18 |
| CY1123482T1 (el) | 2022-03-24 |
| RU2018105683A3 (lt) | 2019-12-26 |
| RU2018105683A (ru) | 2019-10-14 |
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