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LT2958937T - Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą - Google Patents

Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą

Info

Publication number
LT2958937T
LT2958937T LTEP14708429.7T LT14708429T LT2958937T LT 2958937 T LT2958937 T LT 2958937T LT 14708429 T LT14708429 T LT 14708429T LT 2958937 T LT2958937 T LT 2958937T
Authority
LT
Lithuania
Prior art keywords
major histocompatibility
histocompatibility complex
mice expressing
expressing humanized
humanized major
Prior art date
Application number
LTEP14708429.7T
Other languages
English (en)
Inventor
Lynn Macdonald
Andrew J. Murphy
Vera VORONINA
Cagan Gurer
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of LT2958937T publication Critical patent/LT2958937T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
LTEP14708429.7T 2013-02-22 2014-02-20 Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą LT2958937T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767811P 2013-02-22 2013-02-22
PCT/US2014/017387 WO2014130667A1 (en) 2013-02-22 2014-02-20 Mice expressing humanized major histocompatibility complex

Publications (1)

Publication Number Publication Date
LT2958937T true LT2958937T (lt) 2018-11-26

Family

ID=50236326

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14708429.7T LT2958937T (lt) 2013-02-22 2014-02-20 Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą

Country Status (19)

Country Link
US (3) US10154658B2 (lt)
EP (3) EP2958937B1 (lt)
JP (2) JP6444321B2 (lt)
KR (1) KR102211267B1 (lt)
CN (2) CN105164154B (lt)
AU (2) AU2014218893C1 (lt)
CA (1) CA2900824A1 (lt)
CY (1) CY1121223T1 (lt)
DK (1) DK2958937T3 (lt)
ES (3) ES2697248T3 (lt)
HK (1) HK1214613A1 (lt)
HR (1) HRP20181866T1 (lt)
HU (1) HUE041878T2 (lt)
LT (1) LT2958937T (lt)
PL (1) PL2958937T3 (lt)
PT (1) PT2958937T (lt)
RS (1) RS57963B1 (lt)
SI (1) SI2958937T1 (lt)
WO (1) WO2014130667A1 (lt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
MY178723A (en) 2011-10-28 2020-10-20 Regeneron Pharma Genetically modified major histocompatibility complex mice
RS63220B1 (sr) 2011-10-28 2022-06-30 Regeneron Pharma Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
PL2958938T3 (pl) 2013-02-20 2019-11-29 Regeneron Pharma Myszy eksprymujące humanizowane ko-receptory komórek t
LT2958937T (lt) 2013-02-22 2018-11-26 Regeneron Pharmaceuticals, Inc. Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
AU2014249148B2 (en) * 2013-03-11 2020-04-02 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
HUE042412T2 (hu) 2013-09-23 2019-06-28 Regeneron Pharma Humanizált jelszabályozó protein gént tartalmazó nem-humán állatok
HUE043969T2 (hu) 2013-10-15 2019-09-30 Regeneron Pharma Humanizált IL-15 génnel rendelkezõ állatok
EP3409110A1 (en) 2013-11-19 2018-12-05 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
EP3693383A1 (en) 2014-04-08 2020-08-12 Regeneron Pharmaceuticals, Inc. Mouse-human fc-gamma-ri proteins and encoding dna
JP6598798B2 (ja) 2014-05-05 2019-10-30 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｃ５およびｃ３動物
NO2785538T3 (lt) 2014-05-07 2018-08-04
SI3157956T1 (sl) 2014-06-19 2020-06-30 Regeneron Pharmaceuticals, Inc. Nehumane živali, ki imajo humaniziran gen programirane celične smrti 1
BR112017005245A2 (pt) 2014-09-19 2017-12-12 Regeneron Pharma animal não humano geneticamente modificado, métodos para produzir célula t, hibridoma de célula t, um ácido nucleico, um anticorpo específico, uma célula humana, um animal não humano geneticamente modificado e para induzir uma resposta imunológica, célula, hibridoma de célula t, ácido nucleico, anticorpo específico, receptor de antígeno quimérico, embrião não humano, locus de um receptor de antígeno quimérico, e, composição de ácidos nucleicos.
PL3689140T3 (pl) 2014-11-24 2022-09-05 Regeneron Pharmaceuticals, Inc. Zwierzęta inne niż ludzie eksprymujące humanizowany kompleks CD3
US20160345549A1 (en) 2014-12-05 2016-12-01 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
LT3230320T (lt) * 2014-12-09 2021-01-11 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys humanizuotą diferenciacijos klasterio 274 geną
SG11201707691WA (en) 2015-04-06 2017-10-30 Regeneron Pharma Humanized t cell mediated immune responses in non-human animals
ES2872799T3 (es) 2015-11-20 2021-11-02 Regeneron Pharma Animales no humanos que tienen un gen 3 de activación linfocitaria humanizado
WO2017151453A1 (en) 2016-02-29 2017-09-08 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
KR20230156162A (ko) 2016-06-03 2023-11-13 리제너론 파마슈티칼스 인코포레이티드 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물
NZ761329A (en) 2017-09-29 2023-04-28 Regeneron Pharma Non-human animals comprising a humanized ttr locus and methods of use
EP4299732A3 (en) 2017-11-30 2024-03-27 Regeneron Pharmaceuticals, Inc. Rats comprising a humanized trkb locus
CN116514959A (zh) 2018-03-24 2023-08-01 瑞泽恩制药公司 用于产生针对肽-mhc复合物的治疗性抗体的经过基因修饰的非人动物、其制造方法和用途
JP7328243B2 (ja) 2018-03-26 2023-08-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療薬を試験するためのヒト化げっ歯類
ES2983967T3 (es) 2018-07-16 2024-10-28 Regeneron Pharma Modelos de roedores de enfermedad DITRA y usos de estos
JP7506686B2 (ja) 2019-04-04 2024-06-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化凝固因子１２遺伝子座を含む非ヒト動物
CN113874510A (zh) 2019-06-04 2021-12-31 瑞泽恩制药公司 包括具有β滑移突变的人源化TTR基因座的非人动物和使用方法
JP2022534560A (ja) 2019-06-07 2022-08-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化アルブミン遺伝子座を含む非ヒト動物
WO2021139799A1 (en) * 2020-01-10 2021-07-15 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric mhc protein complex
US20220322648A1 (en) 2021-03-31 2022-10-13 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrb repertoire
AU2023285085A1 (en) 2022-06-07 2024-12-19 Regeneron Pharmaceuticals, Inc. Multispecific molecules for modulating t-cell activity, and uses thereof
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
WO2024064860A1 (en) 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing components of human cellular immune system
WO2024159071A1 (en) 2023-01-27 2024-08-02 Regeneron Pharmaceuticals, Inc. Modified rhabdovirus glycoproteins and uses thereof

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
JPH04501510A (ja) 1989-07-25 1992-03-19 セル　ジェネシス，インコーポレイティド 普遍的なドナー細胞及びキメラ性哺乳類宿主のための相同性組換え
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5489742A (en) * 1990-10-23 1996-02-06 Board Of Regents, The University Of Texas System Transgenic rats and animal models of inflammatory disease
GB9100481D0 (en) 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
AU2661692A (en) 1991-09-19 1993-04-27 President And Fellows Of Harvard College Transgenic mhc class i and class ii antigen-deficient mammals
EP0663952A4 (en) 1992-09-11 1997-06-11 Univ California TRANSGENIC NON-HUMAN ANIMALS WITH TARGETED INTERRUPTED TRANSDUCTION GENES IN LYMPHOCYTES.
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9315303D0 (en) 1993-07-23 1993-09-08 Zeneca Ltd Polypeptide
US5965787A (en) 1995-08-31 1999-10-12 Mayo Foundation For Medical Education And Research HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis
US6002066A (en) 1996-01-16 1999-12-14 Ortho Pharmaceutical Corp. H2-M modified transgenic mice
JP2000512127A (ja) 1996-03-05 2000-09-19 ザ スクリップス リサーチ インスティトゥート ヒトｈｌａ拘束性腫瘍抗原に特異的なｔ細胞受容体をコードする組み換え体
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
ES2323098T3 (es) 1997-09-16 2009-07-06 Oregon Health And Science University Moleculas de mhc recombinantes utiles para la manipulacion de celulas t especificas de antigeno.
US6372955B1 (en) 1998-02-17 2002-04-16 Ortho Mcneil Pharmaceutical, Inc. Methods for Producing B cells and antibodies from H2-O modified transgenic mice
CZ20013709A3 (cs) * 1999-04-23 2002-11-13 Pharmexa A/S Analog interleukinu 5, fragment nukleové kyseliny, vektor, buňka, přípravky a pouľití
AU1023401A (en) 1999-10-12 2001-04-23 Institut Pasteur Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice
US20030124524A1 (en) 2000-06-23 2003-07-03 Kenneth Kornman Screening assays for identifying modulators of the inflammatory or immune response
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2002222610A1 (en) 2000-12-13 2002-06-24 Sumitomo Pharmaceuticals Company, Limited Transgenic animal expressing hla-a24 and utilization thereof
CA2432133C (en) 2000-12-19 2012-11-13 Sunol Molecular Corporation Transgenic animals comprising a humanized immune system
FR2827302B1 (fr) 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US8895020B2 (en) 2002-04-19 2014-11-25 Washington University Single chain trimers and uses therefor
US20040072262A1 (en) 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
SE0301109D0 (sv) * 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DE10347710B4 (de) 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
JP4857450B2 (ja) 2004-03-09 2012-01-18 財団法人名古屋産業科学研究所 ヒト関節リウマチの病態を再現するトランスジェニック非ヒト哺乳動物
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
GB0425713D0 (en) * 2004-11-23 2004-12-22 Baker Matthew Immunogencity testing and antibody selection methods
EP1878798A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Method of producing a multichimeric mouse and applications to study the immunopathogenesis of human tissue-specific pathologies
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
HU0700534D0 (en) * 2006-11-24 2007-10-29 Mezoegazdasagi Biotechnologiai Transgenic animal with enhanced immune response and method for the preparation thereof
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
EP2262898B1 (en) 2008-03-07 2018-01-24 Regeneron Pharmaceuticals, Inc. Es cell-derived mice from diploid host embryo injection
CN102056946A (zh) * 2008-04-11 2011-05-11 中外制药株式会社 与多个分子的抗原反复结合的抗原结合分子
US20090328240A1 (en) 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
KR101987351B1 (ko) 2008-09-30 2019-06-10 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 인간 이외의 포유동물
ES2884309T3 (es) 2009-07-08 2021-12-10 Kymab Ltd Modelos de animales y moléculas terapéuticas
GB2472108B (en) 2009-08-27 2011-07-13 Budha Singh Dhinjan Wall bead
WO2011072204A1 (en) * 2009-12-10 2011-06-16 Regeneron Pharmaceuticals, Inc. Mice that make heavy chain antibodies
NZ601679A (en) 2010-02-08 2014-01-31 Regeneron Pharma Common light chain mouse
KR20150002894A (ko) 2010-03-11 2015-01-07 리나트 뉴로사이언스 코프. ｐＨ 의존성 항원 결합을 갖는 항체
EP2593551B1 (en) 2010-07-15 2016-09-14 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides
US9557323B2 (en) 2010-09-24 2017-01-31 The United States Of America As Represented By The Secretary Of The Navy Humanized transgenic mouse model
MY178723A (en) 2011-10-28 2020-10-20 Regeneron Pharma Genetically modified major histocompatibility complex mice
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
KR102234632B1 (ko) 2011-10-28 2021-04-02 리제너론 파아마슈티컬스, 인크. 사람화된 ｉｌ-6 및 ｉｌ-6 수용체
RS63220B1 (sr) 2011-10-28 2022-06-30 Regeneron Pharma Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
ES2884598T3 (es) 2012-11-05 2021-12-10 Regeneron Pharma Animales no humanos modificados genéticamente y métodos de uso de los mismos
PL2958938T3 (pl) 2013-02-20 2019-11-29 Regeneron Pharma Myszy eksprymujące humanizowane ko-receptory komórek t
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
LT2958937T (lt) 2013-02-22 2018-11-26 Regeneron Pharmaceuticals, Inc. Pelė, ekspresuojanti humanizuotą audinių dermės kompleksą
AU2014249148B2 (en) 2013-03-11 2020-04-02 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
EP2967014B1 (en) 2013-03-11 2019-10-16 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules
SG11201707691WA (en) 2015-04-06 2017-10-30 Regeneron Pharma Humanized t cell mediated immune responses in non-human animals

Also Published As

Publication number Publication date
EP3421490B1 (en) 2020-04-01
ES2949029T3 (es) 2023-09-25
EP3699190C0 (en) 2023-06-07
US10154658B2 (en) 2018-12-18
RS57963B1 (sr) 2019-01-31
AU2014218893C1 (en) 2019-03-07
KR20150122710A (ko) 2015-11-02
PT2958937T (pt) 2018-11-27
EP2958937B1 (en) 2018-08-15
EP3699190B1 (en) 2023-06-07
JP6681939B2 (ja) 2020-04-15
EP2958937A1 (en) 2015-12-30
HK1214613A1 (zh) 2016-07-29
US20140245467A1 (en) 2014-08-28
AU2014218893B2 (en) 2018-08-30
JP2018126170A (ja) 2018-08-16
ES2697248T3 (es) 2019-01-22
EP3421490A1 (en) 2019-01-02
US20190133095A1 (en) 2019-05-09
DK2958937T3 (en) 2018-11-26
HUE041878T2 (hu) 2019-06-28
CN110192541B (zh) 2022-02-18
EP3699190B9 (en) 2023-10-04
AU2018271326C1 (en) 2022-01-13
CN110192541A (zh) 2019-09-03
KR102211267B1 (ko) 2021-02-04
US20220201994A1 (en) 2022-06-30
CY1121223T1 (el) 2020-05-29
CA2900824A1 (en) 2014-08-28
JP6444321B2 (ja) 2018-12-26
SI2958937T1 (sl) 2018-12-31
CN105164154A (zh) 2015-12-16
EP3699190A1 (en) 2020-08-26
AU2018271326B2 (en) 2021-07-01
WO2014130667A1 (en) 2014-08-28
AU2014218893A1 (en) 2015-09-10
HRP20181866T1 (hr) 2019-01-25
PL2958937T3 (pl) 2019-01-31
AU2018271326A1 (en) 2018-12-20
CN105164154B (zh) 2019-06-07
JP2016507247A (ja) 2016-03-10
ES2798751T3 (es) 2020-12-14
US11224208B2 (en) 2022-01-18

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