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KR970020109A - Covalent conjugate of streptokinase and polysaccharide and preparation method thereof - Google Patents

Covalent conjugate of streptokinase and polysaccharide and preparation method thereof Download PDF

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Publication number
KR970020109A
KR970020109A KR1019950036040A KR19950036040A KR970020109A KR 970020109 A KR970020109 A KR 970020109A KR 1019950036040 A KR1019950036040 A KR 1019950036040A KR 19950036040 A KR19950036040 A KR 19950036040A KR 970020109 A KR970020109 A KR 970020109A
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KR
South Korea
Prior art keywords
streptokinase
polysaccharide
covalent conjugate
polysaccharides
producing
Prior art date
Application number
KR1019950036040A
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Korean (ko)
Inventor
박진규
김명국
윤덕중
Original Assignee
강재헌
동국제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 강재헌, 동국제약 주식회사 filed Critical 강재헌
Priority to KR1019950036040A priority Critical patent/KR970020109A/en
Publication of KR970020109A publication Critical patent/KR970020109A/en

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  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

본 발명은 스트렙토키나제와 다당류를 결합시켜 얻은 공유결합체 및 그 제조 방법에 관한 것이다.The present invention relates to a covalent conjugate obtained by combining streptokinase and a polysaccharide and a method for producing the same.

본 발명의 스트렙토키나제와 다당류의 공유결합체는 다당류의 히드록시 메틸기를 산화시켜 알데히드가 반응기로서 부가된 다당류를 얻은 다음 스트렙토키나제와 쉬프염을 형성시킨 후 이를 환원시켜 제조한다.The covalent conjugate of the streptokinase and the polysaccharide of the present invention is prepared by oxidizing the hydroxy methyl group of the polysaccharide to obtain a polysaccharide to which aldehyde is added as a reactor, and then forming a Schiff salt with streptokinase and reducing it.

본 발명의 목적물은 체내 안정성 가와 항원성 감소는 물론 임상에 직접 사용할 수 있는 안전성도 높다.The object of the present invention has high stability in the body and antigenicity, as well as high safety that can be used directly in the clinic.

Description

스트렙토키나제와 다당류의 공유결합체 및 그 제조 방법Covalent conjugate of streptokinase and polysaccharide and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

스트렙토키나제와 다당류의 공유결합체를 주성분으로 포함하는 혈전 용해제.A thrombolytic agent comprising a covalent compound of streptokinase and polysaccharide as a main component. 제1항에 있어서, 다당류가 덱스트란, 덱스트린, 헤파린, 소듐 카복시메틸셀루로오스 및 히아누론산 중에서 선택된 것인 혈전 용해제.The thrombolytic agent according to claim 1, wherein the polysaccharide is selected from dextran, dextrin, heparin, sodium carboxymethylcellulose and hyaluronic acid. a) 다당류를 산화시켜 다당류의 알데히드 유도체를 제조하고 b) 다당류의 알데히드 유도체를 스트렙토키나제와 반응시켜 스트렙토키나제와 다당류의 쉬프염을 제조하고 c) 스트렙토키나제와 다당류의 쉬프염을 환원시키는 공정을 포함하는 스트렙토키나제와 다당류의 공유결합체의 제조방법.a) oxidizing polysaccharides to produce aldehyde derivatives of polysaccharides, b) reacting aldehyde derivatives of polysaccharides with streptokinase to prepare Schiff salts of streptokinase and polysaccharides, and c) reducing Schiff salts of streptokinase and polysaccharides. Method for producing a covalent conjugate of streptokinase and polysaccharide. 제3항에 있어서, a) 공정에서 제조된 다당류의 알데히드 유도체의 알데히드기 형성율이 15에서 25%인 것을 특징으로 하는 스트렙토키나제와 다당류의 공유결합체의 제조 방법.The method for producing a covalent conjugate of streptokinase and polysaccharide according to claim 3, wherein the aldehyde group formation rate of the aldehyde derivative of the polysaccharide prepared in step a) is 15 to 25%. 제3항에 있어서, a) 공정에서 산화제로 NaIO4를 사용하는 것을 특징으로 하는 스트렙토키나제와 다당류의 공유결합체의 제조 방법.The method for preparing a covalent conjugate of streptokinase and polysaccharide according to claim 3, wherein NaIO 4 is used as an oxidizing agent in the step a). 제3항에 있어서, a) 공정이 15∼30℃의 온도에서 30분에서 3시간 사이로 실시하는 것을 특징으로 하는 스트렙토키나제와 다당류의 공유결합체의 제조 방법.The method for producing a covalent conjugate of streptokinase and polysaccharide according to claim 3, wherein the step a) is carried out at a temperature of 15 to 30 ° C. for 30 minutes to 3 hours. 제3항에 있어서, b) 공정이 15∼30℃의 온도에서 30분에서 3시간사이로 실시되는 것을 특징으로 하는 스트렙토키나제와 다당류의 공유결합체의 제조 방법.The method for producing a covalent conjugate of streptokinase and polysaccharide according to claim 3, wherein the step b) is carried out at a temperature of 15 to 30 ° C. for 30 minutes to 3 hours. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950036040A 1995-10-18 1995-10-18 Covalent conjugate of streptokinase and polysaccharide and preparation method thereof KR970020109A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950036040A KR970020109A (en) 1995-10-18 1995-10-18 Covalent conjugate of streptokinase and polysaccharide and preparation method thereof

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Application Number Priority Date Filing Date Title
KR1019950036040A KR970020109A (en) 1995-10-18 1995-10-18 Covalent conjugate of streptokinase and polysaccharide and preparation method thereof

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KR970020109A true KR970020109A (en) 1997-05-28

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010000669A (en) * 2000-10-12 2001-01-05 김기환 Streptokinase-Human serum albumin conjugate as long-acting thrombolytic agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010000669A (en) * 2000-10-12 2001-01-05 김기환 Streptokinase-Human serum albumin conjugate as long-acting thrombolytic agent

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