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KR970027075A - Separation method of optical isomer - Google Patents

Separation method of optical isomer Download PDF

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Publication number
KR970027075A
KR970027075A KR1019950042186A KR19950042186A KR970027075A KR 970027075 A KR970027075 A KR 970027075A KR 1019950042186 A KR1019950042186 A KR 1019950042186A KR 19950042186 A KR19950042186 A KR 19950042186A KR 970027075 A KR970027075 A KR 970027075A
Authority
KR
South Korea
Prior art keywords
acid
separation method
optical isomer
separating
optically active
Prior art date
Application number
KR1019950042186A
Other languages
Korean (ko)
Inventor
표성수
감종식
이기승
박정호
박정수
박병욱
Original Assignee
김준웅
주식회사 선경인더스트리
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김준웅, 주식회사 선경인더스트리 filed Critical 김준웅
Priority to KR1019950042186A priority Critical patent/KR970027075A/en
Publication of KR970027075A publication Critical patent/KR970027075A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

본 발명은 광학이성질체의 분리방법에 관한 것으로서, 더욱 상세하게는 (±)-3-(2-N, N-디메틸아미노에틸)-2-(3-피리딜)-티아졸리딘-4-온 라세미 화합물에 타르타르산 또는 캄포술폰산 등의 광학활성 산를 반응시켜 부분 입체이성질체 염(diastereomer salt)을 얻은 다음, 알칼리 수용액으로 추출하고 산용액으로 중화한 후 재결정하여 광학 이성질체를 분리하는 방법에 관한 것이다.The present invention relates to a method for separating the optical isomers, and more particularly, (±) -3- (2-N, N-dimethylaminoethyl) -2- (3-pyridyl) -thiazolidin-4-one The present invention relates to a method for separating optical isomers by reacting a racemic compound with an optically active acid such as tartaric acid or camphorsulfonic acid to obtain a diastereomer salt, followed by extraction with an aqueous alkali solution, neutralization with an acid solution, and recrystallization.

Description

광학이성질체의 분리방법Separation method of optical isomer

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

라세미 화합물에 광학활성 산을 반응시켜 염을 얻고 용해도 차이를 이용하여 광학활성 이성질체를 분리하는 방법에 있어서, 상기 광학활성 산으로는 타르타르산 또는 캄포술폰산을 라세미 화합물에 대하여 0.5~1.0 당량 사용하는 것을 특징으로 하는 (±)-3-(2-N, N-디메틸아미노에틸)-2-(3-피리딜)-티아졸리딘-4-온의 분리방법.In the method of reacting a racemic compound with an optically active acid to obtain a salt and separating the optically active isomer by using a difference in solubility, tartaric acid or camphorsulfonic acid is used in an amount of 0.5 to 1.0 equivalents with respect to the racemic compound. (±) -3- (2-N, N-dimethylaminoethyl) -2- (3-pyridyl) -thiazolidin-4-one. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950042186A 1995-11-20 1995-11-20 Separation method of optical isomer KR970027075A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019950042186A KR970027075A (en) 1995-11-20 1995-11-20 Separation method of optical isomer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950042186A KR970027075A (en) 1995-11-20 1995-11-20 Separation method of optical isomer

Publications (1)

Publication Number Publication Date
KR970027075A true KR970027075A (en) 1997-06-24

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ID=66588507

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950042186A KR970027075A (en) 1995-11-20 1995-11-20 Separation method of optical isomer

Country Status (1)

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KR (1) KR970027075A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58103386A (en) * 1981-12-11 1983-06-20 Sumitomo Chem Co Ltd Optically active aminoalcohol derivative and its preparation
JPH01279882A (en) * 1987-05-22 1989-11-10 Sumitomo Pharmaceut Co Ltd Novel thiazolidine-4-one derivative and acid addition salt thereof
JPH0429990A (en) * 1990-05-24 1992-01-31 Sumitomo Pharmaceut Co Ltd Production of optically active cis-thiazolidin-4-one derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58103386A (en) * 1981-12-11 1983-06-20 Sumitomo Chem Co Ltd Optically active aminoalcohol derivative and its preparation
JPH01279882A (en) * 1987-05-22 1989-11-10 Sumitomo Pharmaceut Co Ltd Novel thiazolidine-4-one derivative and acid addition salt thereof
JPH0429990A (en) * 1990-05-24 1992-01-31 Sumitomo Pharmaceut Co Ltd Production of optically active cis-thiazolidin-4-one derivative

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