KR970004035B1 - Dentifrice compositions - Google Patents

Abstract

The oral hygiene agent is prepared by mixing salt and ox gall including glycocholic acid and taurocholic acid at 1:3 or 3:1 ratio, putting this into proper vessel like paper and completely sealing it with mud. Then incinerate properly the sealed composition at 800~1700 deg.C until fat and water of ox gall are perfectly vaporized. And crush it to produce the powder state with soft brown color.

Description

Toothpaste composition

The present invention comprises an oral hygiene agent made by mixing sintered gallcolic acid and salt containing glycocholic acid and taurocholic acid and salt to prevent periodontal disease such as plaque removal effect and gingivitis. And toothpaste compositions useful for treatment.

Fragra is a bacterial film formed on the surface of the tooth formed as a sticky high molecular weight material formed by food intake and microorganisms present in the mouth. In order to suppress or remove such plaques, conventionally, physical methods such as using toothbrushes containing toothbrushes and appropriate abrasives, and fungicides have been used. Recently, dextran and glucan, which are intermediate stages of forming plaques using enzymes, have been used. The method of decomposing a high molecular material, etc., is used. However, when the enzyme is used, there are problems such as poor compatibility with components generally used in enzymes and toothpaste compositions.

In addition, as a preventive agent for periodontal disease, sodium chloride, antifrasminant, allantoin derivatives, vitamins, amino acids, etc. are conventionally used as a composition for enhancing oral hygiene.

The present inventors have focused on the fact that the uric acid solution contains glycocholine acid and taurcholine acid, of which the choline acid component inhibits plaque formation and inhibits periodontal disease, and the ingested salt component acts to alleviate periodontal disease. As a result of using oral hygiene made by mixing and mixing salt and biliary juice in the toothpaste composition, it has been surprisingly found that the plaque removal effect and the periodontal disease prevention and treatment effect are greatly improved, thus completing the present invention.

The present invention relates to a toothpaste composition characterized by containing an oral hygiene agent made by mixing and painting a scavenger (sorcere) and salt.

The toothpaste composition of the present invention preferably contains 0.1 to 10% by weight of the oral hygiene agent. If the oral hygiene is used at less than 0.1%, the effect is very bad, and if used at more than 10% by weight, it is difficult to manufacture toothpaste.

The oral hygiene agent used in the present invention is mixed with a scavenger (soe gallbladder) and salt in a ratio of 1: 3 to 3: 1 and put it in a container such as a suitable paper and completely sealed with mud, and then the temperature of 800 ℃ to 1700 ℃ It is a light brown powdery oral hygiene product made by ingesting properly and crushing the fat and water of Udam at high heat. If it is out of the mixing range there is a possibility of rupture during high temperature incineration heating and can not be sealed with mud and the like, it is impossible to manufacture milky salt and the effect on gingivitis is weak.

In general, the components used in the toothpaste composition of the present invention may include an abrasive, which may include calcium dihydrogen phosphate, precipitated silica, calcium carbonate, hydrous alumina, and the like, and preferably calcium dihydrogen phosphate and alumina. And the amount thereof is preferably 20 to 50% by weight.

In addition, a foaming agent is used to provide a sense of volume in use, and as the foaming agent, anionic surfactants and nonionic surfactants may be used, among which sodium lauryl sulfate and polyoxyethylene polyoxypropylene copolymer (trade name Pluronic) are used. It is preferable to use 5 to 5% by weight.

In addition, humectants which are important as toothpaste formers may be glycerin, polyethylene glycol, sorbitol liquid, amorphous sorbitol and maltitol, xylitol, and the like. It is preferable to use 60 weight%.

The binder used to keep the toothpaste in the proper paste state and to make the solid and liquid components such as powder abrasives into the proper disperse phase is mixed with carboxymethyl cellulose sodium, xanthan gum, carrageenan, capopol and the like by 0.1 To 10% by weight, preferably 0.5 to 5% by weight.

In the present invention, a suitable amount of fragrances, pigments for color harmony, preservatives, sweeteners and the like can be used.

Hereinafter, the components of the toothpaste compositions (Examples 1 to 5) and the conventional toothpaste compositions (Comparative Examples 1 to 3) of the present invention will be summarized as follows.

TABLE 1

Example 1

Plaque generation inhibition test

In order to measure the plaque production inhibition rate of the toothpaste composition according to the present invention, compared to the conventional toothpaste, a total of 40 adults were divided into 8 groups of test subjects for 2 weeks and then brushed by the brushing method, and then the plaque index was measured. As a result of the measurement, the plaque production inhibition rate of the toothpaste composition according to the present invention was 35 to 43%, which was superior to 9 to 12% of the conventional toothpaste.

Experimental Example 2

Comparative experiment of the periodontal disease prevention effect of Examples 1 to 5 and Comparative Examples 1 to 3

The toothpaste of the present invention and the comparative example toothpaste was brushed three times daily (for 3 minutes each) for 20 days, and after 20 days, the color change of the gum was measured to compare and maintain the health condition and improvement effect of the gums. Color change was performed using a Japanese color? 80 colorimeter.

TABLE 2

(* Figures are averages for each group)

L: Brightness Index a: Redness (+), Greenness (-)

b: yellow degree (+), blue degree (-)

** The more healthy gums, the brighter the index and the higher the redness, the lower the yellowness.

[Table 3] Average change value

As shown in the above table, in Examples 1 to 5 using the toothpaste composition according to the present invention, the brightness index (L) and the redness (a) were significantly improved as compared with the conventional comparative example, as well as the health of the gums.

Claims (3)

A toothpaste composition characterized by containing an oral hygiene agent made by mixing scavenger and salt. The dentifrice composition of claim 1 which contains 0.1 to 10% by weight of an oral hygiene agent. The dentifrice composition according to claim 1, wherein the ratio of daidam to salt is 1: 3 to 3: 1.