KR960702464A - Dc-89 유도체[dc-89 derivative] - Google Patents
Dc-89 유도체[dc-89 derivative]Info
- Publication number
- KR960702464A KR960702464A KR1019950705313A KR19950705313A KR960702464A KR 960702464 A KR960702464 A KR 960702464A KR 1019950705313 A KR1019950705313 A KR 1019950705313A KR 19950705313 A KR19950705313 A KR 19950705313A KR 960702464 A KR960702464 A KR 960702464A
- Authority
- KR
- South Korea
- Prior art keywords
- derivative
- so2r
- cor
- chem
- useful
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Earth Drilling (AREA)
- Video Image Reproduction Devices For Color Tv Systems (AREA)
- Gyroscopes (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Jib Cranes (AREA)
- Plural Heterocyclic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Refinement Of Pig-Iron, Manufacture Of Cast Iron, And Steel Manufacture Other Than In Revolving Furnaces (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP94-84714 | 1994-04-22 | ||
| JP8471494 | 1994-04-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR960702464A true KR960702464A (ko) | 1996-04-27 |
| KR100350260B1 KR100350260B1 (ko) | 2003-01-06 |
Family
ID=13838345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950705313A KR100350260B1 (ko) | 1994-04-22 | 1995-04-20 | 피롤로인돌유도체 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5641780A (ko) |
| EP (1) | EP0705833B1 (ko) |
| KR (1) | KR100350260B1 (ko) |
| AT (1) | ATE271557T1 (ko) |
| AU (1) | AU685939B2 (ko) |
| CA (1) | CA2165819C (ko) |
| DE (1) | DE69533277T2 (ko) |
| ES (1) | ES2220927T3 (ko) |
| PT (1) | PT705833E (ko) |
| WO (1) | WO1995029179A1 (ko) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4134597A (en) * | 1996-09-03 | 1998-03-26 | Kyowa Hakko Kogyo Co. Ltd. | Dc-89 derivatives |
| IL136489A0 (en) | 1997-12-08 | 2001-06-14 | Scripps Research Inst | Synthesis of cc-1065/duocarmycin analogs |
| GB0019950D0 (en) * | 2000-08-12 | 2000-09-27 | Smithkline Beecham Plc | Compounds |
| NZ529788A (en) * | 2001-05-31 | 2003-12-19 | Medarex Inc | Cytotoxins, prodrugs, linkers and stabilizers useful therefor |
| MXPA06013413A (es) * | 2004-05-19 | 2007-01-23 | Medarex Inc | Enlazadores quimicos y conjugados de los mismos. |
| US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| KR20070115967A (ko) * | 2005-02-18 | 2007-12-06 | 메다렉스, 인코포레이티드 | 전립선 특이 막 항원(ｐｓｍａ)에 대한 인간 모노클로날항체 |
| WO2006104677A2 (en) | 2005-03-24 | 2006-10-05 | Millennium Pharmaceuticals, Inc. | Antibodies that bind ov064 and methods of use therefor |
| US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| JP5290756B2 (ja) | 2005-09-26 | 2013-09-18 | メダレックス インコーポレイテッド | 抗体−薬剤コンジュゲート及びその使用 |
| ATE534629T1 (de) | 2005-10-26 | 2011-12-15 | Medarex Inc | Verfahren und verbindungen zur herstellung von cc-1065-analoga |
| CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| MX2009005776A (es) | 2006-12-01 | 2009-06-10 | Medarex Inc | Anticuerpos humanos que se enlazan al cd 22 y sus usos. |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| CA2672468A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind cd70 and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| CA2678514A1 (en) | 2007-02-21 | 2008-08-28 | Medarex, Inc. | Chemical linkers with single amino acids and conjugates thereof |
| WO2009026274A1 (en) | 2007-08-22 | 2009-02-26 | Medarex, Inc. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| BRPI0816014A8 (pt) | 2007-10-01 | 2018-06-19 | Bristol Myers Squibb Co | anticorpo humano monoclonal isolado, composição, conjugado anticorpo-molécula parceiro, mólecula isolada de ácido nucléico, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-mesotelina, método de inibição do crescimento de uma célula tumoral expressando a mesotelina, método de tratamento do câncer em um indivíduo, anticorpo anti-mesotelina isolado, e método de inibir o crescimento de uma célula expressando a mesotelina |
| KR20100101122A (ko) * | 2007-11-30 | 2010-09-16 | 브리스톨-마이어스 스큅 컴퍼니 | 항-ｒｇ-１ 항체의 접합체 |
| MY160126A (en) | 2009-05-13 | 2017-02-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| US20120231004A1 (en) | 2009-10-13 | 2012-09-13 | Oxford Biotherapeutic Ltd. | Antibodies |
| CN105585630B (zh) | 2010-07-29 | 2020-09-15 | Xencor公司 | 具有修改的等电点的抗体 |
| WO2012045085A1 (en) | 2010-10-01 | 2012-04-05 | Oxford Biotherapeutics Ltd. | Anti-rori antibodies |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| EA031181B1 (ru) | 2011-06-28 | 2018-11-30 | Оксфорд Байотерепьютикс Лтд. | Антитело, которое специфически связывается с bst1, или его антигенсвязывающий фрагмент, нуклеиновые кислоты, кодирующие его цепи, клетка-хозяин, способ получения этого антитела и применение для лечения рака и воспалительных заболеваний |
| WO2013022855A1 (en) | 2011-08-05 | 2013-02-14 | Xencor, Inc. | Antibodies with modified isoelectric points and immunofiltering |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| AU2012323287B2 (en) | 2011-10-10 | 2018-02-01 | Xencor, Inc. | A method for purifying antibodies |
| EP2922818B1 (en) | 2012-11-24 | 2018-09-05 | Hangzhou Dac Biotech Co., Ltd | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| KR102391731B1 (ko) | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | 신규한 이형이량체 단백질 |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US9738722B2 (en) | 2013-01-15 | 2017-08-22 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| LT2951203T (lt) | 2013-03-15 | 2019-09-10 | Xencor, Inc. | Heterodimeriniai baltymai |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| AU2014232416B2 (en) | 2013-03-15 | 2017-09-28 | Xencor, Inc. | Modulation of T Cells with Bispecific Antibodies and FC Fusions |
| WO2015052537A1 (en) | 2013-10-11 | 2015-04-16 | Oxford Biotherapeutics Ltd | Conjugated antibodies against ly75 for the treatment of cancer |
| FI3122757T3 (fi) | 2014-02-28 | 2023-10-10 | Hangzhou Dac Biotech Co Ltd | Varautuneita linkkereitä ja niiden konjugointikäyttötapoja |
| ES2775431T3 (es) | 2014-03-28 | 2020-07-27 | Xencor Inc | Anticuerpos biespecíficos que se unen a CD38 y CD3 |
| AU2015292326A1 (en) | 2014-07-24 | 2017-02-23 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| WO2016086196A2 (en) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| MA55043A (fr) | 2014-11-26 | 2021-12-29 | Xencor Inc | Anticorps hétérodimériques se liant à l'antigène cd3 et l'antigène cd20 |
| WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
| US10227411B2 (en) | 2015-03-05 | 2019-03-12 | Xencor, Inc. | Modulation of T cells with bispecific antibodies and FC fusions |
| JP6759326B2 (ja) | 2015-07-12 | 2020-09-23 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． | 細胞結合分子の共役のための架橋連結体 |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| CN108699136B (zh) | 2015-12-07 | 2022-03-18 | Xencor股份有限公司 | 结合cd3和psma的异二聚抗体 |
| IL263542B2 (en) | 2016-06-14 | 2024-10-01 | Xencor Inc | Bispecific antibodies inhibit immunological checkpoint |
| MX2018016265A (es) | 2016-06-28 | 2019-07-04 | Xencor Inc | Anticuerpos heterodimericos que se unen al receptor 2 de somatostatina. |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| US10501543B2 (en) | 2016-10-14 | 2019-12-10 | Xencor, Inc. | IL15/IL15Rα heterodimeric Fc-fusion proteins |
| AU2016429272A1 (en) | 2016-11-14 | 2019-05-02 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
| CN111132733A (zh) | 2017-06-30 | 2020-05-08 | Xencor股份有限公司 | 含有IL-15/IL-15Rα和抗原结合结构域的靶向异源二聚体Fc融合蛋白 |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| CA3082383A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
| SG11202005732XA (en) | 2017-12-19 | 2020-07-29 | Xencor Inc | Engineered il-2 fc fusion proteins |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| EP3781598A1 (en) | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| WO2019204665A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof |
| AU2019299357A1 (en) | 2018-07-02 | 2021-01-14 | Amgen Inc. | Anti-steap1 antigen-binding protein |
| KR20210069641A (ko) | 2018-10-03 | 2021-06-11 | 젠코어 인코포레이티드 | IL-12 이종이량체 Fc-융합 단백질 |
| SG11202109406TA (en) | 2019-03-01 | 2021-09-29 | Xencor Inc | Heterodimeric antibodies that bind enpp3 and cd3 |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
| CA3212665A1 (en) | 2021-03-09 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | 젠코어 인코포레이티드 | Cd3 및 gpc3에 결합하는 이종이량체 항체 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1238907A (en) * | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
| EP0340243B1 (en) * | 1986-12-19 | 1994-09-28 | The Upjohn Company | Cc-1065 analogs |
| JP2510335B2 (ja) * | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | Ｄｃ―８８ａ誘導体 |
| JPH05178858A (ja) * | 1991-06-28 | 1993-07-20 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−８９誘導体 |
| EP0520435A3 (en) * | 1991-06-28 | 1993-05-05 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivatives |
| JPH0597853A (ja) * | 1991-10-07 | 1993-04-20 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−８９誘導体の臭化水素酸塩 |
-
1995
- 1995-04-20 AU AU22671/95A patent/AU685939B2/en not_active Ceased
- 1995-04-20 US US08/564,178 patent/US5641780A/en not_active Expired - Fee Related
- 1995-04-20 DE DE69533277T patent/DE69533277T2/de not_active Expired - Fee Related
- 1995-04-20 CA CA002165819A patent/CA2165819C/en not_active Expired - Fee Related
- 1995-04-20 ES ES95916020T patent/ES2220927T3/es not_active Expired - Lifetime
- 1995-04-20 EP EP95916020A patent/EP0705833B1/en not_active Expired - Lifetime
- 1995-04-20 AT AT95916020T patent/ATE271557T1/de not_active IP Right Cessation
- 1995-04-20 KR KR1019950705313A patent/KR100350260B1/ko not_active IP Right Cessation
- 1995-04-20 WO PCT/JP1995/000779 patent/WO1995029179A1/ja active IP Right Grant
- 1995-04-20 PT PT95916020T patent/PT705833E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69533277D1 (de) | 2004-08-26 |
| AU685939B2 (en) | 1998-01-29 |
| EP0705833A1 (en) | 1996-04-10 |
| CA2165819C (en) | 2005-12-27 |
| EP0705833B1 (en) | 2004-07-21 |
| ES2220927T3 (es) | 2004-12-16 |
| US5641780A (en) | 1997-06-24 |
| PT705833E (pt) | 2004-11-30 |
| ATE271557T1 (de) | 2004-08-15 |
| CA2165819A1 (en) | 1995-11-02 |
| AU2267195A (en) | 1995-11-16 |
| DE69533277T2 (de) | 2005-07-21 |
| WO1995029179A1 (fr) | 1995-11-02 |
| EP0705833A4 (en) | 1997-04-02 |
| KR100350260B1 (ko) | 2003-01-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR960702464A (ko) | Dc-89 유도체[dc-89 derivative] | |
| EP0758653A4 (en) | IMIDAZOQUINAZOLINE DERIVATIVES | |
| EP0711768A4 (en) | BENZIMIDAZOLE DERIVATIVES | |
| NO302755B1 (no) | Morfinan-derivater | |
| ATE190983T1 (de) | Neue tetrapeptidderivate | |
| PL334915A1 (en) | Pyrrolidine derivatives exhibiting phospholipase a2 inhibiting activity | |
| MX9300222A (es) | Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion. | |
| AU9281198A (en) | Benzofuran derivatives | |
| DE69330639D1 (de) | Methotrexat-derivate | |
| ES2123873T3 (es) | Pirrolocarbazol. | |
| TW269687B (ko) | ||
| DK0882728T3 (da) | 1-methylcarbapenemderivater | |
| FI952420A0 (fi) | Glukopyranosidibentsotiofeenit | |
| ES2149180T3 (es) | Derivado de pirazolotiazolopirimidina. | |
| DE69422038D1 (de) | Benzopyranderivate | |
| ATE159253T1 (de) | 2-thiazolylpyrroleakrylate mit fungizider wirkung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19951127 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19991105 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20011127 Patent event code: PE09021S01D |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 20020619 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20020814 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20020814 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration | ||
| PR1001 | Payment of annual fee |
Payment date: 20050628 Start annual number: 4 End annual number: 4 |
|
| PR1001 | Payment of annual fee |
Payment date: 20060721 Start annual number: 5 End annual number: 5 |
|
| FPAY | Annual fee payment |
Payment date: 20070720 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
Payment date: 20070720 Start annual number: 6 End annual number: 6 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
Termination category: Default of registration fee Termination date: 20090710 |