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KR930013124A - 미생물에 의한 트랜스-4-히드록시-l-프롤린의 제조방법 - Google Patents

미생물에 의한 트랜스-4-히드록시-l-프롤린의 제조방법 Download PDF

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KR930013124A
KR930013124A KR1019920024696A KR920024696A KR930013124A KR 930013124 A KR930013124 A KR 930013124A KR 1019920024696 A KR1019920024696 A KR 1019920024696A KR 920024696 A KR920024696 A KR 920024696A KR 930013124 A KR930013124 A KR 930013124A
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microorganism
sank
proline
hydroxy
trans
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KR1019920024696A
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KR960016874B1 (ko
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다쓰지 마쓰오까
노부후사 세리자와
쓰요시 호소야
고오헤이 후루야
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가와무라 요시부미
상꾜 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

구체적으로 클로노스타키스, 글리오클라디움 또는 넥트리아 속의 미생물 배양으로, 미생물에 의해 트랜스-4-히드록시-L-프롤린이 생산된다.

Description

미생물에 의한 트랜스-4-히드록시-L-프롤린의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (21)

  1. 트랜스-4-히드록시-L-프롤린을 생산하는 미생물을 배양하고 배양 브로쓰로 부터 생선된 트랜스-4-히드록시-L-프롤린을 분리하는 트랜스-4-히드록시-L-프롤린의 제조방법.
  2. 제1항에 있어서, 상기 미생물인 클로노스타키스(Clonjostachys)속, 글리오클라디움(Gliocladium)속 또는 넥트리아(Nectria)속의 종인 방법.
  3. 제2항의 있어서, 상기 미생물이 클로노스타키스 속의 종인 방법.
  4. 제3항에 있어서, 상기 미생물인 클로노스타키스 실리드로스포라 (Clonostachys cylindrospora)종의 균주인 방법.
  5. 제4항에 있어서, 상기 미생물이 클로노스타키스 실린드로스포라 SANK 14591 (FERM BP-3661)인 방법.
  6. 제3항에 있어서, 상기 미생물이 클로노스타키스 sp. SANK 18192(FERM BP-4096)인 방법.
  7. 제2항에 있어서, 상기 미생물이 글리오클라디움 속의 종인 방법.
  8. 제7항에 있어서, 상기 미생물이 글리오클라디움 sp. SANK 18092(FERM BP-4097)인 방법.
  9. 제2항에 있어서, 상기 미생물이 넥트리아 속의 종인 방법.
  10. 제9항에 있어서, 상기 미생물이 넥트리아 글리오클라디오이데스(Nectria gliocladioides)종의 균주인 방법.
  11. 제10항에 있어서, 상기 미생물이 넥트리아 글로오클라디오이데스 스말레이 et 한센(Nectria gliocladioides Smalley et Hansen) SANK 17992 (FERM BP-4098)인 방법.
  12. 제1항에 있어서, 클로노스타키스, 글로이클라디움 또는 넥트리아 균주의 배양을 의한 배양 배치의 pH가 5.0~7.0인 방법.
  13. 제1항에 있어서, 배양시 5℃~30℃의 온도 범위에서 효과적으로 수행되는 방법.
  14. 제13항에 있어서, 상기 온도가 15℃~28℃의 범위인 방법.
  15. 제14항에 있어서, 상기 온도가 23℃~28℃의 범위인 방법.
  16. 트랜스-4-히드록-L-프롤린을 생산하는 클로노스타키스 속, 글리오클라디움 속, 또는 넥트리아 속의 미생물을 5.0~7.0범위의 pH 및 15~28℃범위의 온도에서 배양하고, 생선된 트랜스-4-히드록시-L-프롤린을 배양 브로쓰로부터 분리하는 트랜스-4-히드록-L-프롤린의 제조방법.
  17. 제16항에 있어서, 상기 미생물이 클로노스타키스 실린드로스포라(Clonostachys cylindrospora) SANK 14591, 클로노스타키스 sp. SANK 18192, 글리오클라디움 sp. SANK 18092 및 넥트리아 글리오클라디오이데스 스말레이 et 한센 SANK 17992로 구성된 군으로 부터 선택되는 방법.
  18. 트랜스-4-히드록-L-프롤린 생산을 위한 클로노스타키스 실린드로스포라 SANK 14591의 분리된 배양.
  19. 클로노스타키스 sp. SANK 18192의 분리된 배양.
  20. 클로노스타키스 sp. SANK 18092의 분리된 배양.
  21. 트랜스-4-히드록시-L-프롤린의 생산을 위한 넥트리아 글리오클라디오이데스 스말레이 et 한센 SANK 17992의 분리된 배양.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920024696A 1991-12-17 1992-12-17 미생물에 의한 트랜스-4-히드록시-l-프롤린의 제조방법 KR960016874B1 (ko)

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JP91-333353 1991-12-17
JP33335391 1991-12-17

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US (2) US5334517A (ko)
EP (1) EP0547898B1 (ko)
JP (1) JPH05236980A (ko)
KR (1) KR960016874B1 (ko)
AT (1) ATE176803T1 (ko)
CA (1) CA2085522A1 (ko)
DE (1) DE69228438T2 (ko)
DK (1) DK0547898T3 (ko)
ES (1) ES2129438T3 (ko)
GR (1) GR3030112T3 (ko)
HK (1) HK1010740A1 (ko)
IL (1) IL104111A (ko)
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US5854040A (en) 1993-09-07 1998-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing trans-4-hydroxy-L-proline
KR100356926B1 (ko) * 1993-09-07 2003-01-10 교와 핫꼬 고교 가부시끼가이샤 트랜스-4-히드록시-l-프롤린의제조법
JP3440100B2 (ja) * 1995-03-07 2003-08-25 協和醗酵工業株式会社 トランス−４−ヒドロキシ−ｌ−プロリン
KR100186758B1 (ko) 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
CA2345715C (en) 1998-09-30 2010-04-20 Allen Xue Gliocladium roseum strains useful for the control of fungal pathogens in plants
AUPR174800A0 (en) * 2000-11-29 2000-12-21 Australian National University, The Semiconductor processing
WO2009058943A1 (en) * 2007-10-31 2009-05-07 Montana State University Gliocladium isolate c-13 and methods of its use for producing volatile compounds and hydrocarbons
RU2571938C1 (ru) * 2014-11-12 2015-12-27 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Штамм микромицета clonostachys candelabrum f-1466, обладающий антибактериальной активностью в отношении возбудителя туляремии francisella tularensis 15/10
CN109196090A (zh) * 2016-05-12 2019-01-11 三得利控股株式会社 含有l-羟脯氨酸的酵母的菌体或菌体培养物或者它们的提取物及其用途以及l-羟脯氨酸的制造方法
WO2017195873A1 (ja) * 2016-05-12 2017-11-16 サントリーホールディングス株式会社 Ｌ－ヒドロキシプロリンを含有する酵母ヤロウィア・リポリティカの菌体もしくは菌体培養物又はこれらの抽出物及びその用途並びにｌ－ヒドロキシプロリンの製造方法
CN106977442A (zh) * 2017-04-28 2017-07-25 天津科技大学 一种羟脯氨酸的提取工艺

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GB1398591A (en) * 1972-02-10 1975-06-25 Ici Ltd Process for growing a fungus
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4642131A (en) * 1983-08-02 1987-02-10 The Ohio State University Production of disease suppressive compost and microorganism culture for use therein
US4900348A (en) * 1983-08-02 1990-02-13 The Ohio State University Research Foundation Production of disease suppresive compost and container media, and microorganism culture for use therein
DE3929570A1 (de) * 1989-09-06 1991-03-07 Degussa Mikrobiologisch hergestellte n-acyl-l-prolin-acylase, verfahren zu ihrer gewinnung und ihre verwendung
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JP3078296B2 (ja) * 1990-03-19 2000-08-21 協和醗酵工業株式会社 ４―ヒドロキシ―ｌ―プロリンの製造法
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
DE59106428D1 (de) * 1991-04-06 1995-10-12 Dresden Arzneimittel Verfahren zur fermentativen Herstellung und Isolierung von Cyclosporin A sowie neue Cyclosporin- bildende Stämme.
EP0555475B1 (en) * 1991-08-26 1997-05-14 Kyowa Hakko Kogyo Co., Ltd. Process for producing 4-hydroxy-l-proline

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EP0547898A3 (ko) 1994-08-03
US5334517A (en) 1994-08-02
ATE176803T1 (de) 1999-03-15
DE69228438T2 (de) 1999-09-02
TW223660B (ko) 1994-05-11
EP0547898A2 (en) 1993-06-23
ES2129438T3 (es) 1999-06-16
DK0547898T3 (da) 1999-09-20
HK1010740A1 (en) 1999-06-25
CA2085522A1 (en) 1993-06-18
IL104111A0 (en) 1993-05-13
US5407826A (en) 1995-04-18
EP0547898B1 (en) 1999-02-17
IL104111A (en) 1996-10-31
DE69228438D1 (de) 1999-03-25
KR960016874B1 (ko) 1996-12-23
JPH05236980A (ja) 1993-09-17
GR3030112T3 (en) 1999-07-30

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