KR890702039A - 1,25-디하이드록시 비타민 d의 분석 방법 - Google Patents
1,25-디하이드록시 비타민 d의 분석 방법Info
- Publication number
- KR890702039A KR890702039A KR1019890700617A KR890700617A KR890702039A KR 890702039 A KR890702039 A KR 890702039A KR 1019890700617 A KR1019890700617 A KR 1019890700617A KR 890700617 A KR890700617 A KR 890700617A KR 890702039 A KR890702039 A KR 890702039A
- Authority
- KR
- South Korea
- Prior art keywords
- antibody
- receptor protein
- dihydroxy vitamin
- vitamin
- binding
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 발명의 더 깊은 이해는 도면을 참조로 할 수 있다. 그러나, 하기의 바람직한 양태의 도면 및 설명은 단지 본 발명의 예라는 것을 알아야 한다. 본 발명의 전 범주를 나타내려는 것은 아니다. 오히려, 특허청구범위가 본 발명의 전 범주를 결정하기 위한 것으로 생각되어야 한다.
제1도는 도식형태로 본 발명의 개념을 도시한 것이다.
Claims (12)
- 샘플에 1,25-디하이드록시 비타민 D와 결합할 수 있는 수용체 단백질, 표지된 1,25-디하이드록시 비타민 D 및 수용체 단백질과 결합할 수 있는 항체를 가하고, 표지된 1,25-디하이드록시 비타민 D에 결합된 수용체 단백질과 항체와의 결합 정도를 상대적으로 측정하는 단계를 포함함을 특징으로 하여, 비타민 D운반 단백질이 함유된 샘플중의 1,25-디하이드록시 비타민 D의 존재를 측정하는 경쟁적 결합 분석방법.
- 제1항에 있어서, 표지된 1,25-디하이드록시 비타민 D가 방사능표지된 1,25-디하이드록시 비타민 D인 분석방법.
- 제2항에 있어서, 상기 측정 단계전에, 상기 항체에 결합된 수용체 단백질이 면역침전되는 분석방법.
- 제3항에 있어서, 샘플이 사람의 혈액, 사람의 혈장 또는 사람의혈청인 분석방법.
- 제3항에 있어서, 수용체 단백질이 피그(pig) 수용체인 분석방법.
- 제5항에 있어서, 항체가 피그 수용체 단백질에 대한 항체인 분석방법.
- 제6항에 있어서, 항체가 A.T.C.C. HB9496의 하이브리 도마에 의해 생성된 항체의 특징을 가지는 분석방법.
- 표지된 1,25-디하이드록시 비타민 D, 1,25-디하이드록시 비타민 D와 결합할 수 있는 수용체 단백질 및 수용체 단백질과 결합할 수 있는 항체를 함유함을 특징으로 하는 경쟁적 분석 키트(kit),
- 제8항에 있어서, 표지된 1,25-디하이드록시 비타민 D가 방사능 표지된 키트.
- 제9항에 있어서, 수용체 단백질이 피그 수용체 단백질인 키트.
- 제10항에 있어서, 키트가 추가로 비표지된 1,25-디하이드록시 비타민 D를 함유하고 항체가 바이오티닐화된 키트.
- 제8항에 있어서, 항체가 A.T.C.C. HB9496의 하이브리도마에 의해 생성된 항체의 특징을 가지는 키트.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US?86,413? | 1987-08-14 | ||
US07/086,413 US4816417A (en) | 1987-08-14 | 1987-08-14 | Assay for 1,25-dihydroxy vitamin D in sample containing vitamin D transport protein |
PCT/US1988/002693 WO1989001631A1 (en) | 1987-08-14 | 1988-08-08 | Assay for 1,25-dihydroxy vitamin d |
US86,413 | 1989-08-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890702039A true KR890702039A (ko) | 1989-12-22 |
KR940009957B1 KR940009957B1 (ko) | 1994-10-19 |
Family
ID=22198408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890700617A KR940009957B1 (ko) | 1987-08-14 | 1988-08-08 | 1,25-디하이드록시 비타민 d의 분석방법 |
Country Status (11)
Country | Link |
---|---|
US (1) | US4816417A (ko) |
EP (1) | EP0374172B1 (ko) |
JP (1) | JPH02503355A (ko) |
KR (1) | KR940009957B1 (ko) |
AU (1) | AU618025B2 (ko) |
CA (1) | CA1306189C (ko) |
DE (1) | DE3875619T2 (ko) |
DK (1) | DK164973C (ko) |
IE (1) | IE61127B1 (ko) |
IL (1) | IL87378A (ko) |
WO (1) | WO1989001631A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150110680A (ko) * | 2013-01-28 | 2015-10-02 | 디아소린 에스.피.에이. | 1,25-디히드록시비타민 d 및 관련 항체를 탐지하는 방법 및 키트 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202266A (en) * | 1987-10-14 | 1993-04-13 | Asahi Kasei Kogyo Kabushiki Kaisha | 25-hydroxy vitamin D3 derivatives, process for their production, and assay method using the same |
US5064770A (en) * | 1989-08-01 | 1991-11-12 | Wisconsin Alumni Research Foundation | Assay for 1,25-dihydroxy vitamin d receptor protein |
JPH06109727A (ja) * | 1992-08-14 | 1994-04-22 | Wisconsin Alumni Res Found | 1,25−ジヒドロキシビタミンdの検定法 |
AU1429397A (en) * | 1995-12-29 | 1997-07-28 | A And D Assay, Incorporated | Labeled vitamin d compounds and the use thereof |
US8133694B2 (en) * | 1998-06-25 | 2012-03-13 | Immundiagnostik Ag | Functional vitamin D derivatives and method of determining 25-hydroxy- and 1α, 25-dihydroxy vitamin D |
US7087395B1 (en) | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
US7700365B2 (en) | 2004-10-29 | 2010-04-20 | Mayo Foundation For Medical Education And Research | Vitamin D deficiencies |
US20110212534A1 (en) * | 2008-08-11 | 2011-09-01 | Taylor Robert L | Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3 |
WO2014179737A2 (en) | 2013-05-03 | 2014-11-06 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
EP2661632B1 (en) | 2011-01-07 | 2018-03-07 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
US9052308B2 (en) | 2011-01-07 | 2015-06-09 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
EP2694980B1 (de) | 2011-04-04 | 2015-08-26 | Immundiagnostik AG | Bestimmung von vitamin-d-metaboliten in trockenblut |
US9244083B2 (en) | 2012-11-30 | 2016-01-26 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for detecting vitamin D |
US11261257B2 (en) | 2013-01-28 | 2022-03-01 | Diasorin S.P.A. | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies |
US10983136B2 (en) | 2013-01-28 | 2021-04-20 | Diasorin S.P.A. | Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker |
US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
CN110749664A (zh) * | 2019-08-29 | 2020-02-04 | 重庆同怡生物技术研究院有限公司 | 一种25-羟基维生素d结合蛋白的解离方法 |
CN116500281B (zh) * | 2023-06-26 | 2023-11-07 | 天津赛飞乐生物技术有限公司 | 1,25-二羟基维生素d的检测材料及制备方法、1,25-二羟基维生素d的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7713952A (nl) * | 1977-12-16 | 1979-06-19 | Philips Nv | Radio-immunologische methode voor het bepalen van de schildklierfunktie door een in vitro onderzoek in bloedserum. |
GB8317124D0 (en) * | 1983-06-23 | 1983-07-27 | Ekins R P | Free ligand assay |
US4585741A (en) * | 1983-08-25 | 1986-04-29 | Clevinger Brian L | Method of assay for vitamin D metabolites |
-
1987
- 1987-08-14 US US07/086,413 patent/US4816417A/en not_active Expired - Lifetime
-
1988
- 1988-08-05 CA CA000574017A patent/CA1306189C/en not_active Expired - Lifetime
- 1988-08-08 KR KR1019890700617A patent/KR940009957B1/ko not_active IP Right Cessation
- 1988-08-08 JP JP63506496A patent/JPH02503355A/ja active Granted
- 1988-08-08 IL IL87378A patent/IL87378A/xx not_active IP Right Cessation
- 1988-08-08 WO PCT/US1988/002693 patent/WO1989001631A1/en active IP Right Grant
- 1988-08-08 EP EP88907506A patent/EP0374172B1/en not_active Expired - Lifetime
- 1988-08-08 AU AU23256/88A patent/AU618025B2/en not_active Ceased
- 1988-08-08 DE DE8888907506T patent/DE3875619T2/de not_active Expired - Fee Related
- 1988-08-12 IE IE248588A patent/IE61127B1/en not_active IP Right Cessation
-
1990
- 1990-02-13 DK DK037590A patent/DK164973C/da not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150110680A (ko) * | 2013-01-28 | 2015-10-02 | 디아소린 에스.피.에이. | 1,25-디히드록시비타민 d 및 관련 항체를 탐지하는 방법 및 키트 |
Also Published As
Publication number | Publication date |
---|---|
JPH0551863B2 (ko) | 1993-08-03 |
WO1989001631A1 (en) | 1989-02-23 |
IE61127B1 (en) | 1994-10-05 |
AU618025B2 (en) | 1991-12-12 |
AU2325688A (en) | 1989-03-09 |
IE882485L (en) | 1989-02-14 |
DK37590D0 (da) | 1990-02-13 |
CA1306189C (en) | 1992-08-11 |
DE3875619T2 (de) | 1993-03-11 |
JPH02503355A (ja) | 1990-10-11 |
DK164973B (da) | 1992-09-21 |
US4816417A (en) | 1989-03-28 |
DE3875619D1 (de) | 1992-12-03 |
DK164973C (da) | 1993-02-08 |
IL87378A0 (en) | 1989-01-31 |
KR940009957B1 (ko) | 1994-10-19 |
EP0374172B1 (en) | 1992-10-28 |
IL87378A (en) | 1992-07-15 |
DK37590A (da) | 1990-04-06 |
EP0374172A1 (en) | 1990-06-27 |
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