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KR840004761A - N-글리코실화 카복스아미드 유도체의 제조방법 - Google Patents

N-글리코실화 카복스아미드 유도체의 제조방법 Download PDF

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Publication number
KR840004761A
KR840004761A KR1019830001562A KR830001562A KR840004761A KR 840004761 A KR840004761 A KR 840004761A KR 1019830001562 A KR1019830001562 A KR 1019830001562A KR 830001562 A KR830001562 A KR 830001562A KR 840004761 A KR840004761 A KR 840004761A
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KR
South Korea
Prior art keywords
general formula
group
preparing
following general
glycosylated
Prior art date
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KR1019830001562A
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English (en)
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KR920000312B1 (ko
Inventor
스태드러(외3) 피터
Original Assignee
귄터 피터즈,하인츠-게르트 뮐러
바이엘 아크티엔 게젤샤프트
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Application filed by 귄터 피터즈,하인츠-게르트 뮐러, 바이엘 아크티엔 게젤샤프트 filed Critical 귄터 피터즈,하인츠-게르트 뮐러
Publication of KR840004761A publication Critical patent/KR840004761A/ko
Application granted granted Critical
Publication of KR920000312B1 publication Critical patent/KR920000312B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

내용 없음

Description

N-글리코실화 카복스아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 글리코시드를 하기 일반식(Ⅱ)의 아민과 반응시켜 하기 일반식(Ⅲ)의 아민을 제조한 다음, 하기 일반식(Ⅳ)의 아실화제와 그 자체 공지의 방법으로 아실화시킴을 특징으로 하여 하기 일반식(Ⅰ)의 N-글리코실화 카복스아미드 유도체를 제조하는 방법.
    상기식들에 있어서, Z는 아노머 탄소원자에 결합된 글리코실기를 나타내고; R1은 수소 또는 임의로 치환된 직쇄 또는 측쇄의 포화 또는 단일 또는 다중으로 불포화된 탄소수 1내지 30의 알킬기로서, O,N 또는 S로 차단될 수도 있으며; R2는 수소 또는 O로 차단되거나, 산소-함유기 또는 할로겐으로 치환될 수 있는 직쇄 또는 측쇄의 포화 또는 단일 또는 다중으로 불포화된 알킬 또는 아르알킬기를 나타내며; X는 아실화 반응에 있어서의 일반적인 이탈기를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001562A 1982-04-14 1983-04-14 N-글리코실화 카복스아미드 유도체의 제조방법 KR920000312B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3213650.1 1982-04-14
DE3213650.1 1982-04-14
DE19823213650 DE3213650A1 (de) 1982-04-14 1982-04-14 N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr

Publications (2)

Publication Number Publication Date
KR840004761A true KR840004761A (ko) 1984-10-24
KR920000312B1 KR920000312B1 (ko) 1992-01-11

Family

ID=6160842

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001562A KR920000312B1 (ko) 1982-04-14 1983-04-14 N-글리코실화 카복스아미드 유도체의 제조방법

Country Status (19)

Country Link
US (1) US4683222A (ko)
EP (1) EP0091645B1 (ko)
JP (1) JPS58188891A (ko)
KR (1) KR920000312B1 (ko)
AT (1) ATE25525T1 (ko)
AU (1) AU561016B2 (ko)
CA (1) CA1230594A (ko)
DE (2) DE3213650A1 (ko)
DK (1) DK162883A (ko)
ES (1) ES8402313A1 (ko)
FI (1) FI75172C (ko)
GR (1) GR78512B (ko)
HU (1) HU194262B (ko)
IE (1) IE55112B1 (ko)
IL (1) IL68350A (ko)
NO (1) NO157145C (ko)
PH (1) PH25527A (ko)
PT (1) PT76502B (ko)
ZA (1) ZA832580B (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213650A1 (de) * 1982-04-14 1983-10-27 Bayer Ag, 5090 Leverkusen N-glycosylierte carbonsaeureamid-derivate, verfahren zu ihrer herstellung sowie ihre verwendung zur beeinflussung der koerpereigenen abwehr
DE3339694A1 (de) * 1983-11-03 1985-05-15 Bayer Ag, 5090 Leverkusen Verwendung n-glycosilierter carbonsaeureamid-derivate als wachstumsfoerderer in der tierernaehrung
DE3403495A1 (de) * 1983-11-23 1985-05-30 Bayer Ag, 5090 Leverkusen Phosphorylierte glycosylamide, -harnstoffe, -carbamate und -thiocarbamate, verfahren zu ihrer herstellung sowie ihre verwendung
DE3344257A1 (de) * 1983-12-07 1985-06-13 Bayer Ag, 5090 Leverkusen Substituierte o-acyl-glycosylamide, verfahren zu iherer herstellung sowie ihre verwendung
DE3346623A1 (de) * 1983-12-14 1985-07-04 Bayer Ag, 5090 Leverkusen N-glycosylierte harnstoffe, carbamate und thiocarbamate, verfahren zu ihrer herstellung sowie ihre verwendung
DE3347522A1 (de) * 1983-12-30 1985-07-11 Troponwerke GmbH & Co KG, 5000 Köln N-glycosylierte carbonsaeureamid-derivate als mittel bei der bekaempfung von erkrankungen des rheumatischen formenkreises
DE3410238A1 (de) * 1984-03-21 1985-10-03 Bayer Ag, 5090 Leverkusen Glycolipid-aehnliche substanzen in liposomenform
DE3508025A1 (de) * 1985-03-07 1986-09-11 Bayer Ag, 5090 Leverkusen Substituierte o-sulfonyl-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3521994A1 (de) * 1985-06-20 1987-01-02 Bayer Ag N-(2-aminoacylamido-2-desoxy-hexosyl)-amide-, -carbamate und -harnstoffe, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3604681A1 (de) * 1986-02-14 1987-08-20 Bayer Ag Neue n-glycosylamidderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3812681A1 (de) * 1988-04-16 1989-11-02 Bayer Ag Substituierte n-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US5476924A (en) * 1989-01-27 1995-12-19 Duke University Protecting group for acetals and methods of using the same in the activation of saccharides
FR2676739B1 (fr) * 1991-05-22 1996-10-11 Stepan Europe N-alkyl, n-acetylosylamines, leur procede de preparation et leurs utilisations notamment en tant qu'agents tensioactifs ou agents de solubilisation pour l'isolement de proteines membranaires.
US5362480A (en) * 1991-12-31 1994-11-08 Lever Brothers Company, Division Of Conopco, Inc. Oral hygiene compositions containing amino sugars as antiplaque agents
US5455232A (en) * 1992-02-04 1995-10-03 Piljac; Goran Pharmaceutical preparation based on rhamnolipid
FR2709061B1 (fr) * 1993-08-17 1996-07-19 Ladislas Robert Utilisation d'oligosaccharides dans la prévention et le traitement du vieillissement des tissus.
ES2104416T3 (es) * 1993-08-30 1997-10-01 Bayer Ag Glicosilamidas de 2-aminoacilamino-2-desoxi-azucares.
DE4329094A1 (de) * 1993-08-30 1995-03-02 Bayer Ag (Glycosylamid)-uronsäure-derivate
AU7613694A (en) * 1993-08-30 1995-03-22 Bayer Aktiengesellschaft Glycosyl amides of 6-amino-6-deoxy sugars
AU4371996A (en) * 1994-12-16 1996-07-03 Alcon Laboratories, Inc. Ophthalmic formulations of substituted glycosides
US6290971B1 (en) * 1995-06-15 2001-09-18 Aventis Pasteur Limited Adjuvant compositions comprising a mineral salt and another immunostimulating compound
US5872111A (en) * 1997-05-19 1999-02-16 Lever Brothers Company, Division Of Conopco, Inc. Compositions comprising glycosylamide surfactants
US6670330B1 (en) 2000-05-01 2003-12-30 Theodore J. Lampidis Cancer chemotherapy with 2-deoxy-D-glucose
JP3664401B2 (ja) * 2003-01-22 2005-06-29 独立行政法人科学技術振興機構 Ｎ−グリコシド型糖脂質及びこれから成る中空繊維状有機ナノチューブ
US20050008699A1 (en) * 2003-07-11 2005-01-13 Fred Wehling Effervescent glucosamine composition
RU2392965C2 (ru) 2006-01-26 2010-06-27 Пфайзер Продактс Инк. Новые гликолипидные адъювантные композиции

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Also Published As

Publication number Publication date
DE3213650A1 (de) 1983-10-27
CA1230594A (en) 1987-12-22
IL68350A (en) 1988-09-30
PT76502A (en) 1983-05-01
ZA832580B (en) 1984-01-25
ES521422A0 (es) 1984-01-16
FI75172B (fi) 1988-01-29
EP0091645B1 (de) 1987-02-25
US4683222A (en) 1987-07-28
IE830840L (en) 1983-10-14
ES8402313A1 (es) 1984-01-16
AU561016B2 (en) 1987-04-30
IE55112B1 (en) 1990-06-06
DE3369851D1 (en) 1987-04-02
PT76502B (en) 1985-12-10
DK162883A (da) 1983-10-15
FI831230A0 (fi) 1983-04-12
NO831163L (no) 1983-10-17
NO157145C (no) 1988-01-27
AU1261583A (en) 1983-10-20
JPS58188891A (ja) 1983-11-04
FI831230L (fi) 1983-10-15
IL68350A0 (en) 1983-07-31
EP0091645A1 (de) 1983-10-19
FI75172C (fi) 1988-05-09
HU194262B (en) 1988-01-28
ATE25525T1 (de) 1987-03-15
GR78512B (ko) 1984-09-27
JPH0140036B2 (ko) 1989-08-24
KR920000312B1 (ko) 1992-01-11
NO157145B (no) 1987-10-19
PH25527A (en) 1991-07-24
DK162883D0 (da) 1983-04-13

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