KR20220107992A - Oral composition for preventing and improving sensitive teeth - Google Patents

Abstract

The present invention relates to an oral composition comprising an alkali metal salt, a betaine-based surfactant, and a glycinate-based surfactant. The oral composition of the present invention includes a specific surfactant and has excellent foamability without reducing the permeation of alkali metal salts.

Description

Oral composition for preventing and improving sore teeth {Oral composition for preventing and improving sensitive teeth}

The present invention relates to a composition for oral use. More particularly, it relates to a composition for oral cavity which has a preventive and ameliorating effect of shirin.

The surfactant included in the composition for oral use acts to improve oral cleaning power by reacting with water during oral cleaning to generate bubbles. The alkali metal salt contained in the composition for oral cavity penetrates into the pores and serves to reduce the release of calcium ions from the pores. Due to these effects, sirin may have prophylactic and therapeutic effects.

In conventional oral compositions such as toothpaste, when the content of alkali metal salts is increased for a preventive and therapeutic effect, the amount of foam decreases when using the composition for oral use, thereby increasing the user's reluctance.

Due to this problem, the amount of foam is maintained by using a surfactant while containing an alkali metal salt, and for people with sensitive oral cavity, such as those with a sore throat, an oral composition having an effect of lowering the objection when using the composition for oral use this was needed

Korean Patent No. 2146681

An object of the present invention is to provide a composition for oral use having an effect of preventing and improving symptoms of shirin and excellent foaming properties.

1. An oral composition comprising an alkali metal salt, a betaine-based surfactant and a glycinate-based surfactant.

2. The composition for oral use according to the above 1, wherein the alkali metal salt is a potassium salt.

3. The composition for oral use according to the above 2, wherein the potassium salt is at least one selected from the group consisting of potassium citrate, potassium nitrate, potassium chloride, potassium dihydrogen phosphate, potassium sulfate, potassium carbonate, potassium hydrogen carbonate, and alum.

4. The composition for oral use according to the above 2, wherein the potassium salt is included in an amount of 5 wt% to 10 wt% with respect to the total composition.

5. The composition for oral use according to the above 1, wherein the betaine-based surfactant is at least one of lauryl betaine, coco betaine, cocamidopropyl betaine, lauromidopropyl betaine and propyl betaine.

6. The composition for oral use according to the above 5, wherein the betaine-based surfactant is lauryl betaine.

7. The composition for oral use according to the above 6, wherein the lauryl betaine is contained in an amount of 0.5 wt% to 2 wt% based on the total composition.

8. The composition for oral use according to the above 1, wherein the glycinate-based surfactant is potassium cocoyl glycinate or sodium cocoyl glycinate.

9. The composition for oral use according to 8 above, wherein the glycinate-based surfactant is potassium cocoyl glycinate.

10. The composition for oral use according to the above 8, wherein the potassium cocoyl glycinate is included in an amount of 1% to 3% by weight based on the total composition.

11. The composition for oral use according to the above 1, comprising lauryl betaine as a betaine-based surfactant and potassium cocoyl glycinate as a glycinate-based surfactant in a weight ratio of 1:3 to 3:1.

12. The composition for oral use according to the above 1, further comprising an abrasive or an antibacterial agent.

13. The composition for oral use according to the above 12, wherein the abrasive is erythritol or silica.

14. The composition for oral use according to the above 12, wherein the abrasive is included in an amount of 20 wt% to 35 wt% with respect to the total composition.

15. The composition for oral use according to the above 12, wherein the antibacterial agent is at least one selected from the group consisting of fluorine, chlorhexidine, xylitol and penicillin.

16. The composition for oral use according to the above 12, wherein the antibacterial agent is included in an amount of 0.01 wt% to 3 wt% with respect to the total composition.

The composition for oral use of the present invention may contain an alkali metal salt, thereby exhibiting an anti-inflammatory effect.

The composition for oral use of the present invention can show excellent foaming properties without reducing the penetration of alkali metal salts, including specific surfactants.

Hereinafter, the present invention will be described in detail. Unless otherwise defined, all terms in this specification have the same general meaning as understood by those of ordinary skill in the art to which the present invention belongs, and in case of conflict with the meaning of the terms used in this specification, the The meaning used in the specification is followed.

The present invention relates to an oral composition comprising an alkali metal salt, a betaine-based surfactant and a glycinate-based surfactant.

The composition for oral use of the present invention maintains the amount of foam by using an alkali metal salt and a specific surfactant together, thereby preventing and treating irritation caused by alkali metal salts and reducing the feeling of rejection and hypersensitivity when using the composition for oral use. can have Therefore, people with sensitive oral cavity, such as those with a sore throat disease, may feel less reluctance when using the composition for oral use.

In the present invention, the alkali metal salt penetrates into the pores of the tooth to relieve hypersensitivity, and pain can relieve symptoms.

In the present invention, the alkali metal salt may be used without limitation as long as it can be used in the oral composition, for example, the alkali metal salt may be a potassium salt.

In the present invention, the potassium salt helps to maintain the calcium balance of teeth. In addition, calcium ions may penetrate into the pores of the tooth to provide an anti-irritation effect.

In the present invention, the potassium salt may be a potassium salt of at least one of an organic acid and an inorganic acid.

In the present invention, organic acids include citric acid, acetic acid, lactic acid, tartaric acid, maleic acid, fumaric acid, formic acid, propionic acid, oxalic acid, trifluoroacetic acid, benzoic acid, gluconic acid, metasulfonic acid, glycolic acid, succinic acid, 4-toluenesulfonic acid, glutamic acid and aspartic acid. can be

In one embodiment of the present invention, the organic acid may be citric acid. In addition, in the present invention, the inorganic acid may be hydrochloric acid, hydrobromic acid, sulfuric acid or phosphoric acid. However, the present invention is not limited thereto.

In one embodiment of the present invention, examples of the potassium salt may be potassium citrate, potassium nitrate, potassium chloride, potassium dihydrogen phosphate, potassium sulfate, potassium carbonate, potassium hydrogen carbonate, or alum, specifically potassium citrate There is (see Formula 1). However, the present invention is not limited thereto.

[Formula 1]

Potassium citrate

In the present invention, the potassium salt may be included in an amount of 1 wt% to 20 wt%, for example, 1 wt% to 15 wt%, 3 wt% to 13 wt%, or 5 wt% to 10 wt% with respect to the entire composition may be included.

In the present invention, a betaine-based surfactant and a glycinate-based surfactant are used as the surfactant.

In one embodiment of the present invention, as the betaine-based surfactant, lauryl betaine, cocobetaine, cocamidopropyl betaine, lauromidopropyl betaine or propyl betaine, etc. are each alone or a mixture of two or more and can be used

In one embodiment of the present invention, as the glycinate-based surfactant, potassium cocoyl glycinate or sodium cocoyl glycinate may be used alone or in combination of two or more.

As an exemplary embodiment, the composition for oral use of the present invention may include lauryl betaine and potassium cocoyl glycinate as surfactants.

In the present invention, the surfactant may be included in an amount of 0.1 wt% to 10 wt% with respect to the entire composition, for example, 0.5 wt% to 10 wt%, 0.5 wt% to 7 wt%, or 1 wt% to 5 wt% may be included.

In the present invention, the surfactant may be lauryl betaine, which is a betaine-based surfactant, and the lauryl betaine may be included in an amount of 0.1 wt% to 10 wt% based on the total composition, for example, 0.1 wt% to 5 wt% %, 0.1 wt% to 3 wt% or 0.5 wt% to 2 wt% may be included.

In the present invention, the surfactant may be potassium cocoyl glycinate, which is a glycinate-based surfactant, and the potassium cocoyl glycinate may be included in an amount of 0.1 wt% to 10 wt% with respect to the entire composition, for example For example, it may be included in 0.1 wt% to 5 wt%, 0.1 wt% to 3 wt%, or 1 wt% to 3 wt%.

In the present invention, the composition for oral use may include lauryl betaine, a betaine-based surfactant, and potassium cocoyl glycinate, a glycinate-based surfactant, in a weight ratio of 1:10 to 10:1, for example, 1 It may be included in a weight ratio of :5 to 5:1, a weight ratio of 1:3 to 3:1, or a weight ratio of 2:3 to 3:2.

The composition for oral use of the present invention may further include an appropriate abrasive, antibacterial agent, and solvent commonly used in the preparation of oral compositions.

In the present invention, the abrasive may be used without limitation as long as it can be used in the oral composition. For example, the abrasive may be erythritol or silica.

In the present invention, the abrasive may be included in an amount of 20 wt% to 35 wt%, for example, 25 wt% to 35 wt% or 25 wt% to 30 wt% with respect to the entire composition.

In the present invention, the antibacterial agent may include a natural antibacterial agent, a chemical antibacterial agent, and the like. Specifically, it may include chemical antibacterial agents such as fluorine compounds, chlorhexidine, xylitol and penicillin. However, the present invention is not limited thereto.

In the present invention, the antibacterial agent may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt% or 0.05 wt% to 0.5 wt% with respect to the entire composition.

The composition for oral use of the present invention may further include arginine, MSM (Methylsulfonylmethane), and the like to prevent sore throat.

In addition, the composition for oral use of the present invention may further include a preservative, a wetting agent, or a fragrance as an additional additive.

The composition for oral use of the present invention may include a toothpaste, mouthwash, mouthwash, oral spray, or mouthwash formulation. However, the present invention is not limited thereto.

In an embodiment of the present invention, the composition for oral use includes potassium carbonate, citric acid, lauryl betaine, potassium cocoyl glycinate, MSM, arginine, menthol, sodium fluoride, erythritol, cyclodextrin, lemon essential oil, spearmint oil, It may contain peppermint essential oil, tea tree essential oil, sucralose, polyvinylpyrrolidone, xanthan gum and the balance of sorbitol.

The potassium carbonate may be included in an amount of 0.1 wt% to 20.0 wt% with respect to the total composition for oral use. In an embodiment of the present invention, the potassium salt may be included in an amount of 1.0 wt% to 10.0 wt%.

The citric acid may be included in an amount of 0.1 wt% to 20.0 wt% with respect to the entire composition for oral use. In an embodiment of the present invention, the potassium salt may be included in an amount of 1.0 wt% to 10.0 wt%.

The MSM may be included in an amount of 0.1 wt% to 10 wt%, for example, 0.1 wt% to 5 wt%, or 0.5 wt% to 5 wt%, based on the total weight of the composition.

The arginine may be included in an amount of 0.1 wt% to 10 wt%, for example, 0.1 wt% to 5 wt% or 0.5 wt% to 5 wt% with respect to the entire composition.

The menthol may be included in an amount of 0.1 wt% to 10 wt%, for example, 0.1 wt% to 5 wt% or 0.1 wt% to 3 wt% with respect to the total composition.

The sodium fluoride may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt% or 0.05 wt% to 0.5 wt% based on the total weight of the composition.

The sorbitol may be included in an amount of 30 wt% to 40 wt%, for example, in an amount of 33 wt% to 38 wt% or 34 wt% to 36 wt% with respect to the entire composition.

The erythritol may be included in an amount of 20 wt% to 40 wt%, for example, 20 wt% to 35 wt% or 23 wt% to 33 wt% with respect to the entire composition.

The cyclodextrin may be included in an amount of 1% to 20% by weight, for example, 5% to 15% by weight or 7% to 13% by weight based on the total weight of the composition.

The lemon essential oil may be included in an amount of 0.01% to 3% by weight, for example, 0.01% to 1% by weight or 0.05% to 0.5% by weight based on the total weight of the composition.

The spearmint oil may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt%, or 0.05 wt% to 1.0 wt%, based on the entire composition.

The peppermint essential oil may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt% or 0.05 wt% to 0.5 wt%, based on the total weight of the composition.

The tea tree essential oil may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt% or 0.05 wt% to 0.5 wt%, based on the total weight of the composition.

The sucralose may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt%, or 0.01 wt% to 0.5 wt%, based on the total weight of the composition.

The polyvinylpyrrolidone may be included in an amount of 0.1 wt% to 10 wt%, for example, 0.1 wt% to 5 wt% or 0.1 wt% to 3 wt% with respect to the entire composition.

The xanthan gum may be included in an amount of 0.01 wt% to 3 wt%, for example, 0.01 wt% to 1 wt% or 0.05 wt% to 1.0 wt%, based on the total weight of the composition.

The composition for oral use of the present invention may have a preventive or therapeutic auxiliary effect of periodontal disease. Specifically, the periodontal disease may include toothache, dental caries, gingivitis, periodontitis, alveolar bone damage, alveolar osteoporosis, alveolar osteomalacia, alveolar osteopenia, alveolar bone remodeling disorder, and bad breath. However, the present invention is not limited thereto.

The oral composition according to the present invention may be used individually or in combination with other oral therapeutic agents, may be used sequentially or simultaneously with conventional therapeutic agents, and may be used singly or multiple times. In consideration of all of the above factors, it is important to use an amount that can obtain the maximum effect with a minimum amount without side effects, which can be easily determined by a person skilled in the art.

Specifically, the effective amount of the composition for oral use of the present invention may vary depending on the patient's age, sex, condition, weight, absorption of the active ingredient into the body, inactivation rate and excretion rate, disease type, and drugs used in combination. However, since it may vary depending on the conditions of the patient to be used, it is not limited to a specific effective amount.

Hereinafter, examples and experimental examples will be described in detail to explain the present invention in detail.

Example 1. Preparation of composition for oral use

Potassium carbonate 8.0% by weight, citric acid 8.0% by weight and surfactant 3.0% by weight, methylsulfonylmethane 3.1% by weight, arginine 1.9% by weight, menthol 0.7% by weight, sodium fluoride 0.3% by weight, erythritol 27.0% by weight, cyclodextrin 10.3% by weight %, lemon essential oil 0.2 wt%, spearmint oil 0.4 wt%, peppermint essential oil 0.2 wt%, tea tree essential oil 0.2 wt%, sucralose 0.2 wt%, polyvinylpyrrolidone 0.9 wt%, xanthan gum 0.4 wt% And the remaining amount of sorbitol was mixed to prepare a composition for oral use in Table 1 below.

Composition ratio of composition for oral use Raw material Content (wt%) potassium carbonate 8.0 citric acid 8.0 Surfactants 3.0 methylsulfonylmethane 3.1 arginine 1.9 menthol 0.7 sodium fluoride 0.3 erythritol 27.0 cyclodextrin 10.3 lemon essential oil 0.2 spearmint oil 0.4 peppermint essential oil 0.2 tea tree essential oil 0.2 sucralose 0.2 polyvinylpyrrolidone 0.9 xanthan gum 0.4 sorbitol 35.2 Total (wt%) 100

By varying the composition of lauryl betaine and potassium cocoyl glycinate as the surfactant, the oral compositions of Examples 1 to 3 of Table 2 below were prepared, and for comparison, the oral cavity without alkali metal salts of Table 3 Comparative Example 1, which is a composition for use, and Comparative Example 2, which does not contain a surfactant, were prepared.

Alkali metal salt and surfactant composition ratio of Examples Ingredients (wt %) Example 1 Example 2 Example 3 alkali metal salt Potassium Citrate
8.0% by weight Potassium Citrate
8.0% by weight Potassium Citrate
8.0% by weight Surfactants lauryl betaine
0.5% by weight lauryl betaine
1.2 wt% lauryl betaine
1.9 wt% Potassium Cocoyl Glycinate
2.5% by weight Potassium Cocoyl Glycinate
1.8 wt% Potassium Cocoyl Glycinate
1.1 wt% Purified water remaining amount remaining amount remaining amount other additives

Composition ratio of alkali metal salt and surfactant of Comparative Example Ingredients (wt %) Comparative Example 1 Comparative Example 2 alkali metal salt - Potassium Citrate
8.0% by weight Surfactants lauryl betaine
1.2 wt% - Potassium Cocoyl Glycinate
1.8 wt% Purified water remaining amount remaining amount other additives

In Comparative Example, when no alkali metal salt or surfactant was added, the same amount of purified water was added.

Experimental Example 1. Comparison of foaming performance of oral compositions

In order to confirm the amount of foam of the five oral compositions prepared in Example 1, the foaming performance was compared in the following way.

The test subject did not have dental caries, and 40 men and women in their 40s with even teeth were selected as test subjects, and after brushing with 5 types of oral compositions prepared in Example 1, the degree of foam generation during use of the oral compositions was evaluated. The sensory evaluation was conducted in a manner that gave 0 to 10 points for the It can be judged that the closer to 10 points, the better the foaming ability.

Experimental Example 2. Comparison of the improvement effect of the composition for oral use

In order to determine the improvement effect of the five oral compositions prepared in Example 1, the improvement effect of the five oral compositions was compared in the following way.

The test subjects were selected from the group of 40 patients with symptoms of shirin, and after brushing with 5 oral compositions prepared in Example 1 for 2 weeks, 3 times/day, the degree of numbness was 0 The sensory evaluation was carried out in a way that 10 points were given at the points. As the score is closer to 10, it can be judged that the symptoms of shirin are improved, and it can be judged that shirin has an excellent effect on improvement.

Effect of improving the foaming ability and syringing of the oral composition division (dot) bubble performance evaluation Sirin's improvement effect Example 1 10 9 Example 2 9 9 Example 3 10 8 Comparative Example 1 9 One Comparative Example 2 One 3

According to Table 4, Examples 1 to 3 containing potassium citrate as an alkali metal salt and lauryl betaine and potassium cocoyl glycinate mixed as surfactants all showed excellent foaming, and the improvement effect was improved. was found to be excellent.

On the contrary, in the case of Comparative Example 1 containing only the surfactant, the foaming ability is similar to the composition of the Example, but it can be seen that the improvement effect of the sirin is hardly shown, and in the case of Comparative Example 2 containing only the alkali metal salt, the foam It was confirmed that there was little production ability, and the improvement effect of Sirin did not show much.

Claims (16)

An oral composition comprising an alkali metal salt, a betaine-based surfactant and a glycinate-based surfactant.
The composition for oral use according to claim 1, wherein the alkali metal salt is a potassium salt.
The composition for oral use according to claim 2, wherein the potassium salt is at least one selected from the group consisting of potassium citrate, potassium nitrate, potassium chloride, potassium dihydrogen phosphate, potassium sulfate, potassium carbonate, potassium hydrogen carbonate, and alum.
The composition for oral use according to claim 2, wherein the potassium salt is included in an amount of 5 wt% to 10 wt% with respect to the total composition.
The composition for oral use according to claim 1, wherein the betaine-based surfactant is at least one of lauryl betaine, coco betaine, cocamidopropyl betaine, lauromidopropyl betaine, and propyl betaine.
The composition for oral use according to claim 5, wherein the betaine-based surfactant is lauryl betaine.
The composition for oral use according to claim 6, wherein the lauryl betaine is included in an amount of 0.5% to 2% by weight based on the total amount of the composition.
The composition for oral use according to claim 1, wherein the glycinate-based surfactant is potassium cocoyl glycinate or sodium cocoyl glycinate.
The composition for oral use according to claim 8, wherein the glycinate-based surfactant is potassium cocoyl glycinate.
The composition for oral use according to claim 8, wherein the potassium cocoyl glycinate is included in an amount of 1 wt% to 3 wt% with respect to the total composition.
The composition for oral use according to claim 1, comprising lauryl betaine as a betaine-based surfactant and potassium cocoyl glycinate as a glycinate-based surfactant in a weight ratio of 1:3 to 3:1.
The composition for oral use according to claim 1, further comprising an abrasive or an antibacterial agent.
The composition for oral use according to claim 12, wherein the abrasive is erythritol or silica.
The composition for oral use according to claim 12, wherein the abrasive is included in an amount of 20 wt% to 35 wt% with respect to the total composition.
The composition for oral use according to claim 12, wherein the antibacterial agent is at least one selected from the group consisting of fluorine, chlorhexidine, xylitol and penicillin.
The composition for oral use according to claim 12, wherein the antibacterial agent is included in an amount of 0.01 wt% to 3 wt% with respect to the total composition.