KR20210061663A - Hypo-allergenic skin cosmetic composition comprising bromothymol blue - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising bromothymol blue. In detail, bromothymol blue is used as a colorant, and bromothymol blue is 0.1mM. To this end, the present invention uses a cosmetic composition containing bromothymol blue as one means, and from this, it is possible to enjoy a non-irritating or mild-irritating effect on skin irritation.

Description

Hypo-allergenic skin cosmetic composition comprising bromothymol blue}

The present invention relates to a cosmetic composition comprising bromothymol blue, and in detail, bromothymol blue is used as a colorant, and bromothymol blue is 0.1mM. will be.

In 2016, the Ministry of Food and Drug Safety partially revised <Types, Standards and Test Methods for Pigments in Cosmetics>, and strengthened regulations on artificial synthetic colors such as tar and azo dyes, and the safety of pigments became an issue.

For example, the tar pigment is a synthesis of benzene or naphthalene contained in coal tar, which is a by-product of dry coal. Food tar pigments are azo pigments (red #2, yellow #4, yellow #5, red #40, red #102), xanthic pigments (red #3), indigoide pigments (blue #2) , Triphenylmethane-based pigments (Green No. 3, Blue No. 1), etc. are classified.

Tar pigments added to cosmetics are synthetic coloring agents used to color cosmetics. Although they vary by type, they are also ingredients to be aware of because they can cause allergies, coloring, odors, and dermatitis.

Tar pigments contained in basic cosmetics such as essences and creams are not added directly to the skin like lipstick, but are added to the cosmetics itself for a visual effect.In the United States, contact with the eye mucosa can cause irritation. It is forbidden to use in eye cream.

Under this recognition, the inventors of the present invention believe that Bromothymol Blue (Bromothymol Blue and abbreviated as'BTB') is used as a colorant (pigment) in the International Cosmetic Ingredient Dictionary (ICID), and is selected as an EWG Green grade. I realized that it was done.

The EWG Green level referred to here represents a low risk (safety, level 1-2) by the Envrironmental Working Group, a non-profit environmental organization in the United States. have.

If so, looking at the bromothymol blue that the present inventors have paid attention to here, bromothymol blue is produced by reacting bromine on thymol blue in acetic acid, and is decomposed into colorless crystals (recrystallized from acetic acid) at 130 to 135°C. It becomes colorless when heated and dehydrated in carbon dioxide 　 air flow, 　 easily soluble in ether, methanol and ethanol, not soluble in benzene, 　 toluene, 　 xylene, and insoluble in petroleum ether.

These uses of bromothymol blue have been widely known as acid-base indicators and adsorption indicators. In relation to the acid-base knowledge drug, which is one use, the color change range is pH 6.0-7.6. The acid color is yellow, the basic color is blue, and the alkaline solution is light dichroic. If the layer is thin, it appears blue, and if it is thick, it appears red. On the other hand, with respect to the knowledge of adsorption for other uses, thiocyanate is used as an appropriate, and becomes blue when adsorbed by precipitation in a neutral solution.

Like this, if the color change according to the pH of bromothymol blue is used, if the product is (weak) acidic, yellow will emit, allowing consumers to visually recognize the pH of the product. It can be used as a trans pigment that changes color according to the pH change of the preparation.

However, based on the above recognition, prior literature, etc., were searched, and development, research, or patents of cosmetic formulations using bromothymol blue could not be found, so the present inventors believe that cosmetic formulations using bromothymol blue were not found. In particular, we intend to develop and study bromothymol blue stabilization and raw materialization, and to develop a formulation using the same.

Based on what has been described in the'Background Technology', the problems to be solved by the present invention are as follows.

The first task is to replace artificial pigments such as tar pigments and azo pigments, and is stable in light, odor, precipitates, etc., and is to provide a primitive for providing pigments used in cosmetic compositions that are mild or non-irritating to the skin. Is in.

The second task is to provide a cosmetic composition having a variety of colors by using pigments that vary in color according to pH from the beginning of the first task.

The third task is to provide cosmetics of specific formulations-ampoule, mask pack, cleansing water-from the cosmetic composition according to the second task.

The fourth task is to include the active ingredient in the cosmetics according to the third task, and to provide cosmetics having the effects of whitening, antioxidant, and UV protection.

One means of the present invention for solving the'problem to be solved' is as follows.

A cosmetic composition containing bromothymol blue is used as one means.

Preferably, the bromothymol blue is a cosmetic composition, characterized in that 0.1mM as one means.

In addition, preferably, a cosmetic composition characterized in that the skin irritation degree is mild or non-irritating is used as one means.

The effects of the present invention that can be obtained from the'problem solving means' are as follows.

The first effect is to replace artificial pigments such as tar pigments and azo pigments, and is stable in light, odor, sediment, etc., and can provide a primitive for providing pigments used in cosmetic compositions that are mild or non-irritating to the skin. have.

The second effect can provide a cosmetic composition having a variety of colors by using a pigment that changes color according to pH from the beginning of the first task.

The third effect can provide cosmetics of a specific formulation-ampoule, mask pack, cleansing water-from the cosmetic composition according to the second task.

The fourth effect is that the cosmetic according to the third task contains the active ingredient, and it is possible to provide a cosmetic having the effects of whitening, antioxidant, and UV protection.

1 is an experimental photo according to Experimental Example 1 (confirmation of the solubility of bromothymol blue (BTB) powder), 1a is a photo of BTB powder, 1b is a photo of a sample for testing BTB solubility, and 1c is according to pH. A photograph of the color change of the BTB solution (1mM), and 1d is a photograph of the color change of the BTB solution (0.1mM) according to pH.
2 is an experimental picture according to Experimental Example 2 (BTB solution stability test and color change), 2a and 2b are samples taken at the first week of the stability test, and 2c and 2d are formulations, and yellow and green samples are taken. will be.
3 is an experimental photo according to Experimental Example 2, which was taken at the 2nd and 3rd weeks, and 3a is the 2nd week and 3b is the 3rd week.
4 is a photograph of a sample taken at week 4 as an experimental photograph according to Experimental Example 2.
5 is a photograph of Experimental Example 3 (skin irritation test using a simple patch), in which 5a was taken immediately after attachment, and 5b was taken 2 hours after removal.
6 is an experimental photograph according to Experimental Example 1 (BTB mask pack formulation development), showing a comparison of photographs before and after inserting the fabric.
7 is an experimental photograph according to Experimental Example 2 (developing an ampoule formulation), showing a comparison of photographs before and after mixing.
8 is an experimental photograph according to Experimental Example 3 (BTB mask pack formulation stability test).
9 is an experimental photograph according to Experimental Example 4 (BTB ampoule formulation stability test).
10 and 11 are experimental photos according to Experimental Example 5 (BTB cleansing water formulation development and formulation stability test), and FIG. 10 is a first week, and FIG. 11 is a second week, third week, and fourth week experiment in order from left to right. It's a picture.

Specific structural or functional descriptions of the embodiments of the present invention disclosed in this specification or application are exemplified only for the purpose of describing the embodiments according to the present invention, and the embodiments according to the present invention may be implemented in various forms. And should not be construed as being limited to the embodiments described in this specification or application.

Since the embodiments according to the present invention can be modified in various ways and have various forms, specific embodiments are illustrated in the drawings and will be described in detail in the present specification or application. However, this is not intended to limit the embodiments according to the concept of the present invention to a specific form of disclosure, and it should be understood that all changes, equivalents, and substitutes included in the spirit and scope of the present invention are included.

Terms such as first and/or second may be used to describe various components, but the components should not be limited by the terms. The terms are only for the purpose of distinguishing one component from other components, for example, without departing from the scope of the rights according to the concept of the present invention, the first component may be named as the second component, and similarly The second component may also be referred to as a first component.

When a component is referred to as being "connected" or "connected" to another component, it is understood that it may be directly connected or connected to the other component, but other components may exist in the middle. It should be. On the other hand, when a component is referred to as being "directly connected" or "directly connected" to another component, it should be understood that there is no other component in the middle. Other expressions describing the relationship between components, such as "between" and "directly between" or "adjacent to" and "directly adjacent to" should be interpreted as well.

The terms used in the present specification are only used to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In the present specification, terms such as "comprise" or "have" are intended to designate the presence of a set feature, number, step, action, component, part, or combination thereof, and one or more other features or numbers. It is to be understood that the presence or additional possibilities of, steps, actions, components, parts, or combinations thereof are not preliminarily excluded.

Unless otherwise defined, all terms used herein including technical or scientific terms have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs. Terms such as those defined in a commonly used dictionary should be interpreted as having a meaning consistent with the meaning of the related technology, and should not be interpreted as an ideal or excessively formal meaning unless explicitly defined in the present specification. .

The present invention will be described in detail as follows.

Experimental Example 1. Confirmation of the solubility of bromothymol blue (BTB) powder

The present inventors confirm the solubility of bromothymol blue (BTB) powder (see Fig. 1a) according to the solvent. By selecting an appropriate solvent as a cosmetic raw material, basic data for the task was derived.

The inventors proceeded in the following order.

(1) Conduct a solubility test of BTB powder using 4 solvents of purified water, 1,2-hexanediol, butylene glycol, and dipropylene glycol, and (2) check each dissolved BTB solution. , Checking the solubility of BTB Powder according to the solvent, (3) selecting an appropriate solvent, and checking the color of the BTB solution according to the pH.

The experimental results are as follows.

As a result of the BTB solubility test, the solubility was high in the order of 1,2-hexanediol> butylene glycol> dipropylene glycol> purified water (see FIG. 1b), but the difference in solubility was not significant. In conclusion, in order to apply to various formulations, “purified water” was set as the main solvent in order to cope with various changes such as viscosity and unit price.

Using 1 mM BTB solution as a stock, the color of the solution according to the pH change was confirmed. As a result, in acidic, weakly acidic, and basic, orange (pH 3.7), green (pH 6.5), and blue (pH 9.1) were respectively shown (see Fig. 1c). However, since the concentration of the solution was dark and the color was not distinguished on the photograph, a 10% solution was additionally prepared to derive the result. In the 10% solution, yellow (pH 4.5), green (pH 6.6), and blue (pH 8.1) appeared (see Fig. 1d).

For reference, according to known literature, it is known that bromothymol blue solution exhibits yellow color at pH 4 to 6, green color at pH 6 to 7, and blue color at pH 7 or higher.

Through Experimental Example 1, the present inventors recognized that purification of the solution through filtration is necessary for use as a cosmetic raw material as the remaining amount of powder is detected in the sample of the dissolved BTB solution, and in the case of a 1 mM BTB solution, the concentration is A thick 0.1mM BTB solution was set as the main stock for later experiments.

Experimental Example 2. BTB solution stability test and color change

Following [Experimental Example 1], the present inventors continued to test the stability of the BTB solution, and observed a color change accordingly (see FIGS. 2A to 2B).

That is, the stability of the BTB solution was tested according to the temperature and light changes of the finished BTB solution, and the change was recorded every week on a monthly basis. In addition, in relation to the color change, a 0.1mM BTB solution was used as a colorant to perform remixing, and the color change according to the pH was observed.

The observation results of the first week were summarized in the following [Table 1].

Condition color Drunk Occurrence of sediment 1 Week 1 Week 1 Week Temperature 5℃ O O O 25℃ O O O 37℃ O O O 45℃ O O O Cycle O O O ore O O O

As a result of the 1st week experiment, there were no other specific matters such as color change of the BTB solution by light and temperature, and the occurrence of precipitates.

As a result of confirming the color concentration and change appearing in the formulation by applying the BTB solution to the existing ampoule formulation, it was confirmed that the color was not dark and appeared in accordance with the pH, and it was possible to obtain a yellow ampoule and a green ampoule sample (Fig. 2c). And 2d).

Referring to FIGS. 3A, 3B and 4, the results of the 2nd and 3rd week experiments show that no other specific matters such as color change and precipitation occurred for the BTB solution by light and temperature, and the stability of physical properties also did not have any special matters. Showed.

As a result of the 4th week experiment, there were no other specific matters such as color change of the BTB solution by light and temperature, and the occurrence of sediment, and the stability of physical properties did not appear to be specific.

In summary, the stability test results for weeks 1 to 4 are summarized in the following [Table 2], and based on this data, the BTB solution was developed and formulations (mask pack, toner, ampoule, etc.) It was expected that the stability test for the above) could be conducted.

Condition color Drunk Occurrence of sediment 1week 2week 3week 4week 1week 2week 3week 4week 1week 2week 3week 4week Temperature 5℃ O O O O O O O O O O O O 25℃ O O O O O O O O O O O O 37℃ O O O O O O O O O O O O 45℃ O O O O O O O O O O O O Cycle O O O O O O O O O O O O ore O O O O O O O O O O O

Experimental Example 3. Skin irritation test using a simple patch

The present inventors conducted a simple test of the skin irritation of the BTB solution raw material itself before the clinical trial, and the experimental method is as follows.

(1) Prepare purified water, 0.1 mM BTB solution, 20%, 10%, and 5% solution, respectively, (2) attach patches 1 to 4 on the center of the subject's arm, and whether or not the sample is irritated for 4 hours Check the [No. 1: purified water, No. 2: BTB 5% solution, No. 3: BTB 10% solution, No. 4: BTB 20% solution]. (3) A total of 4 people participated, and the degree of irritation was evaluated by taking pictures after attaching and removing the patch.(4) The evaluation criteria were observed 2 hours after removal, and the skin reaction was evaluated by the Frosch & Kligman method. Was evaluated according to the following criteria. (5) The derivation of the result was confirmed through the individual's sensory evaluation.

The following [Table 3] summarizes the sensory evaluation criteria for skin irritation, and [Table 4] summarizes the experimental results for four personnel according to Experimental Example 3.

As a result of the experiment, a patch was attached according to each condition, and after attaching the patch for 2 hours, the patch was removed, and the skin condition of the subjects compared to the chart in [Table 3] was visually checked. As a result, no specific skin reaction was observed in both No. 1 to which purified water was attached and No. 2, 3, and 4 to which the BTB solution was attached as shown in FIGS. 5A and 5B (see Table 4). In view of this, BTB solution is expected to be in the category of mild or non-irritating to human skin.

Description After 30min (Standard) Slight erythema,
either spotty or diffuse

Moderate uniform erythema

Intense erythema with edema

Intense erythema with edema & vesicle

NO. Test material No of responder 2hr Reaction Grade 1+ 2+ 3+ 4+ 2hr Mean One Water 0 - - - - 0.0 0.0 2 BTB solution 5% 0 - - - - 0.0 0.0 3 BTB solution 10% 0 - - - - 0.0 0.0 4 BTB solution 20% 0 - - - - 0.0 0.0

The inventors of the above Experimental Example 3. Furthermore, by making an official request for a skin irritation test to the'Korea Dermatological Research Institute', 31 subjects who meet the predetermined selection criteria and do not meet the exclusion criteria are selected, applied on the back of the subject for 24 hours, and then removed. The condition was observed after 30 minutes, 24 hours and 48 hours. The results were evaluated based on our own standards applying the standards of the International Association of Contact Dermatitis (ICDRG) and the American Cosmetics Association (PCPC), and as a result, the sample was judged to be a'non-irritating substance' in terms of primary irritation (2019. 7. 31. Korean Institute of Dermatological Sciences, Isis Cosmetics, "ecis bt toner -01" and 2 other types, primary irritation evaluation test through 24 hours skin patch).

Experimental Example 4. BTB mask pack formulation development

As part of the development of a prototype containing the BTB solution, it was intended to develop a mask pack formulation, and the method proceeds in the following order (1) to (4).

(1) The mask pack sample is developed by dividing the first agent and the second agent.

(2) Agent 1 develops a transparent type and agent 2 is a blue type containing a BTB solution.

(3) Observe the color change without the mask fabric, and observe the color change when the mask fabric is inserted.

(4) Conduct sensory evaluation of the finished sample and conduct a stability test.

As a result according to Experimental Example 4, the present inventors confirmed the color change when preparing and blending the first agent and the second agent, respectively, and after mixing the transparent agent 1 and the blue agent 2, a yellow weakly acidic mask pack formulation was developed. In addition, the fabric and the first agent were put together in the mask pack pouch, and the second agent was separately put and packaged. After the second agent was added to the first agent, the mask pack was impregnated into the mask pack, and a mask pack including a yellow agent was developed (see FIG. 6).

Experimental Example 5. BTB ampoule formulation development

Following Experimental Example 4, an ampoule formulation was to be developed, and the method proceeds in the following order (1) to (4).

(1) The ampoule sample is divided into the first agent and the second agent to develop a formulation.

(2) Agent 1 develops a transparent type and agent 2 is a blue type containing a BTB solution.

(3) Fill the container with agent 1 and agent 2, and observe the color change when agent 1 and agent 2 are mixed.

(4) Conduct sensory evaluation of the finished sample and conduct a stability test.

As a result according to Experimental Example 5., the present inventors confirmed the color change during mixing and mixing after each preparation of the first agent and the second agent, and after mixing the transparent agent 1 and the blue agent 2, a yellow weakly acidic ampoule formulation was developed, In addition, the first agent and the second agent were separated and filled in the ampoule container, and the second agent was added to the first agent, and then the blue second agent was converted into a yellow agent, and an ampoule formulation was developed (see FIG. 7).

Experimental Example 6. BTB mask pack formulation stability test

It is intended to test the stability of the mask pack formulation using the BTB mask pack formulation prepared according to Experimental Example 4.

The order of the experiment is (1) The completed mask pack sample is checked for changes in color, odor, and sediment generation under temperature and light conditions, and (2) the stability test for the sample in which the first agent and the second agent are combined in the mask sheet. Proceed. At this time, the stability test is conducted on a monthly basis, and changes are recorded every week.

As a result of the 1st~2nd week experiment, no other specific matters such as color change, sediment generation, etc. for the mask pack sample by light and temperature occurred (see Fig. 8 and the following [Table 5]).

BTB Mask Pack Condition color Drunk Occurrence of sediment color Drunk Occurrence of sediment 1 Week 2 Week Temperature 5℃ O O O O O O 25℃ O O O O O O 37℃ O O O O O O 45℃ O O O O O O Cycle O O O O O O ore O O O O O O

Experimental Example 7. BTB ampoule formulation stability test

It is intended to test the stability of the ampoule formulation using the BTB ampoule formulation prepared according to Experimental Example 5.

The order of the experiment is (1) The complete ampoule sample is checked for changes in color, odor, and sediment generation under temperature and light conditions, and (2) for the ampoule, a stability test is performed on the sample in which the first agent and the second agent are combined. Proceed. At this time, the stability test is conducted on a monthly basis, and changes are recorded every week.

As a result of the 1st~2nd week experiment, no other specific matters such as color change and sediment generation of the ampoule sample by light and temperature occurred (see Fig. 9 and the following [Table 6]).

BTB ampoule Condition color Drunk Occurrence of sediment color Drunk Occurrence of sediment 1 Week 2 Week Temperature 5℃ O O O O O O 25℃ O O O O O O 37℃ O O O O O O 45℃ O O O O O O Cycle O O O O O O ore O O O O O O

Experimental Example 8. BTB cleansing water formulation development and formulation stability test

Following Experimental Examples 4 to 7. The present inventors conducted a cleansing water formulation and formulation stability test using a BTB solution.

In order to develop a cleansing water formulation, (1) the cleansing water prototype was aimed at developing a weakly acidic yellow formulation containing a BTB solution, and (2) the finished sample was subjected to a sensory evaluation and a stability test.

In addition, in order to test the stability of the BTB cleansing water formulation, (1) the finished cleansing water sample was checked for changes in color, odor, and sediment generation under temperature and light conditions, and (2) the stability test was based on one month. Progressed, and weekly changes were recorded.

As a result of the development of the BTB cleansing water formulation, a blue BTB solution (2nd agent) was mixed with the transparent cleansing water formulation (1st agent), and the color change was confirmed after mixing, and a yellow weakly acidic cleansing water formulation was developed. In addition, a cleansing water formulation was developed that turns yellow when the first agent and the second agent are separately filled, and the second agent is added to the first agent.

The stability test results of the BTB cleansing water formulation, the results of the 1st week experiment, the color change of the cleansing water sample by light and temperature, and the occurrence of sediment did not occur (see Fig. 10 and [Table 7]).

BTB Cleansing Water Condition color Drunk Occurrence of sediment 1 Week Temperature 5℃ O O O 25℃ O O O 37℃ O O O 45℃ O O O Cycle O O O ore O O O

As a result of the 2nd to 4th week experiment, no other specific matters such as color change and precipitation of the cleansing water sample by light and temperature occurred (see FIGS. 11 and 8).

BTB Cleansing Water Condition color Drunk Occurrence of sediment color Drunk Occurrence of sediment color Drunk Occurrence of sediment 2 Week 3 Week 4 Week Temperature 5℃ O O O O O O O O O 25℃ O O O O O O O O O 37℃ O O O O O O O O O 45℃ O O O O O O O O O Cycle O O O O O O O O O ore O O O O O O O O O

As a result of the formulation stability test by light and temperature for the developed BTB cleansing water, no other matters such as color change and precipitation occurred in the formulation from week 1 to week 4 (see Table 9).

BTB Cleansing Water Condition color Drunk Occurrence of sediment 1week 2week 3week 4week 1week 2week 3week 4week 1week 2week 3week 4week Temperature 5℃ O O O O O O O O O O O O 25℃ O O O O O O O O O O O O 37℃ O O O O O O O O O O O O 45℃ O O O O O O O O O O O O Cycle O O O O O O O O O O O O ore O O O O O O O O O O O

Experimental Example 9. Additional 1st skin irritation test

Following Experimental Example 3 (simple skin irritation test), the present inventor further performed a primary skin irritation test.

In detail, from October 23, 2019 to the 25th of the same year, the KC Skin Clinical Research Center was supervised, and safety efficacy evaluation was conducted based on the three formulations (mask, ampoule, and cleansing water) according to the present invention. I did.

The test personnel were subjects who met the selection criteria and did not meet the exclusion criteria. The average age was about 46 years old, and each subject was subjected to a skin patch test using IQ UltimateTM. Apply 25 µl of each test substance (liquid, cream, etc.) to IQ UltimateTM, and attach the test substance to the skin by cutting it into 1 cm width x 1 cm length (pack, patch, etc.). The patch was attached for 24 hours, and 1 hour after patch removal and 24 hours after patch removal, two experts observed the degree of irritation according to the criteria of the International Contact Dermatitis Research Group (ICDRG). The observation result was evaluated according to the patch test in accordance with the guidelines for the evaluation of new cosmetic materials. 1) As a result of conducting the human application test for the skin patch of ecis bt Mask, it was determined as a non-irritating product with a skin irritation index of 0.00. 2) As a result of the skin patch primary irritation human application test of ecis bt ampoule, it was determined as a non-irritating product according to the criteria for skin irritation index of 0.00. It was judged as a non-irritating product according to the criteria with an index of 0.00.

On the other hand, based on such a cosmetic composition containing bromothymol blue, it can be implemented as an actual product in formulations such as mask packs, ampoules, and cleansing water. Looking specifically, cosmetics are composed of water-based ingredients, oil-based ingredients, and surfactants. It will be apparent to a person skilled in the art, but when subdividing it again, polymer compounds, pigments, flavors, and active ingredients are included in addition to aqueous raw materials, oily raw materials, and surfactants.

The aqueous raw material is usually a substance that accounts for more than 70% of the total, and may include purified water, ethanol, glycerin, propylene glycol, butylene glycol, etc., and in some cases, glacial water, green tea water, etc. as functional raw materials recently. can do. In addition, polyol may be included as a moisturizing agent, and this polyol refers to a highly hygroscopic water-soluble material that soothes dry and dead skin and makes the rough skin surface smooth and smooth from exposure to harmful environments.

The oily raw material is used for the purpose of suppressing evaporation of moisture from the skin and improving flexibility, and refers to giving a softening effect by forming a hydrophobic film on the skin surface. For example, vegetable oils such as olive oil, castor oil, and camellia oil, or animal oils such as turtle oil, mink oil, and egg yolk oil may be included, but are not limited thereto, but are not limited to waxes, higher fatty acids, higher alcohols, hydrocarbons, esters, Silicones and the like may be included.

The surfactant refers to a component intended to emulsify the aqueous and oily materials, and may include a dispersing agent, a wetting agent, a foaming agent, an antifoaming agent, a detergent, and the like.

The polymer compound is a material used to maintain viscosity or product stability, and refers to a moisturizing agent, a surfactant, and the like, and may include guar gum, xanthan gum, alginate, and the like.

The pigment is to add a visual element of a cosmetic product, and may include artificial or natural pigments such as tar pigments and azo pigments, as disclosed at the beginning of the present specification. The present invention has significance in intending to use bromothymol blue in a cosmetic composition as a pigment to replace the tar and azo pigments, and as in Experimental Examples 1 to 8, a stability test, a simple skin irritation test, and stability as a formulation Etc.

Furthermore, the inventors of the present invention are based on the property of bromothymol blue, which changes color according to pH, the first component (the first agent) having one color, and bromothymol blue whose pH is adjusted to have the other color. It has been researched and developed so that it can be used as a trans colorant by using the included second component (agent 2), and the first agent and the second agent are mixed to obtain a mixed preparation having a new color, or the first agent and the second agent After adding or filling the agent separately, you can obtain a mixed preparation that allows buyers to mix the first agent and the second agent so that they have different colors.

The fragrance refers to a mixture of natural and artificial materials added to add fragrance to numerous consumer products. Fragrances are widely used in a variety of products to give a pleasant scent, remove the inherent odor of some ingredients, and improve the feeling of use of the product.

The active ingredient refers to various ingredients according to function and efficacy, and cosmetics suitable for skin type are developed according to each characteristic, and representative ingredients include hyaluronic acid, collagen, elastin, and peptide.

When the active ingredient is subdivided by function, it is largely divided into whitening, wrinkle improvement, and UV protection. In the case of whitening cosmetics, it is effective to brighten and brighten skin tone by preventing pigmentation and antioxidant activity. The whitening ampoule or black spot functions to improve the skin tone of pigmented areas on the face and body.

Next, anti-wrinkle cosmetics are effective in preventing aging by enhancing the skin's regenerative ability. In the case of ampoules or lifting serums, they play a role in enhancing skin elasticity through intensive use for a specific period.

In addition, sunscreen has been mainly used for sunscreen, but products with sunscreen are being developed for essences, creams, makeup bases, and foundations. In particular, unlike sunscreen products that are difficult to reapply, suncushion cosmetics are portable. It can be reapplied continuously, and sun protection, whitening, and wrinkle improvement are all possible in some cases.

By synthesizing the above, an embodiment of the present invention is summarized as follows.

A cosmetic composition containing bromothymol blue is used as one means.

Preferably, the bromothymol blue is a cosmetic composition, characterized in that 0.1mM as one means.

In addition, preferably, a cosmetic composition characterized in that the skin irritation degree is mild or non-irritating is used as one means.

On the other hand, the first agent having a transparent color; And a cosmetic composition composed of two agents having one color by adjusting pH as the cosmetic composition according to claim 1 above.

Preferably, the second agent may be a cosmetic composition characterized in that it is blue.

In addition, preferably, the first agent; And a cosmetic composition having a new color by mixing the two agents as one means.

Alternatively, preferably The first agent; And the two agents are separately filled or added,

A cosmetic composition that allows the purchaser to mix the first agent and the second agent to have a new color may be used as one means.

Meanwhile, a mask pack, ampoule, or cleansing water including the cosmetic composition of claim 1 may be used as one means.

On the other hand, a cosmetic composition, characterized in that it further comprises an aqueous raw material, an oily raw material, a surfactant, a polymer compound, a colorant, a fragrance, and an active ingredient may be used as one means.

On the other hand, the active ingredient is a cosmetic composition, characterized in that it contains a component that exhibits whitening, antioxidant, and UV protection functions.

Those of ordinary skill in the technical field related to the examples of the present invention will appreciate that it may be implemented in a modified form within a range not departing from the essential characteristics of the description.

Therefore, the disclosed methods should be considered from a descriptive point of view rather than a limiting point of view. The scope of the present invention appears in the claims rather than the detailed description of the invention, and all differences within the scope equivalent thereto should be construed as being included in the scope of the present invention.

Claims (1)

Including bromothymol blue,
The bromothymol blue is 0.1mM,
Cosmetic composition, characterized in that the skin irritation is mild or non-irritating.

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