KR20200115673A - 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 - Google Patents
1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 Download PDFInfo
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- osteoporosis
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- bone
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Abstract
상기 과제의 해결 수단은, 상기 방법에 있어서 1회당 100∼200 단위의 PTH가 격주 투여되는 것을 특징으로 하는 PTH를 유효 성분으로서 함유하는 약제이다.
Description
도 2는 신규 추체 골절 발생률의 경시 변화에 대한 피험약 투여의 영향을 나타낸다. 피험약 투여군을 「PTH 200군」, 대조약 투여군을 「P군」이라고 표기하였다.
도 3은 신규 추체 골절 발생률의 경시 변화에 대한 피험약 투여의 영향을 나타낸다. 피험약 투여군을 「PTH 200군」, 대조약 투여군을 「P군」이라고 표기하였다.
도 4는 피험약(「PTH 200군」) 또는 대조약(「P군」)을 주 1회의 빈도로 72주간 환자에게 투여하였을 때의 뇨 중 칼슘치의 변동에 대해서 시험한 결과를 나타낸다. 뇨 중 칼슘치/뇨 중 크레아틴치의 비를 투여 개시 전과 관찰주로 비교하였다. 뇨 중 칼슘의 측정은, 개시 시, 12주 후, 24주 후, 48주 후, 72주 후에 실시하였다. 표준 병용약(칼슘 610 ㎎, 비타민 D3 400 IU 및 마그네슘 30 ㎎)을 동의 취득 시부터 치험 종료까지 1일 1회 저녁 식사 후 복용하였다.
도 5는 피험약(「PTH 200군」) 또는 대조약(「P군」)을 주 1회의 빈도로 72주간 환자에게 투여하였을 때의 보정 혈청 칼슘치의 변동에 대해서 시험한 결과를 나타낸다. 혈청 칼슘의 측정은, 개시 시, 12주 후, 24주 후, 48주 후, 72주 후에 실시하였다. 혈청 칼슘 기준치: 8.4-10.4 ㎎/dL. 표준 병용약(칼슘 610 ㎎, 비타민 D3 400 IU 및 마그네슘 30 ㎎)을 동의 취득 시부터 치험 종료까지 1일 1회 저녁 식사 후 복용하였다.
Claims (2)
(1) 연령이 65세 이상이다.
(2) 기존의 골절이 있다.
(3) 골밀도가 청년 성인 평균치의 80% 미만이거나 또는 골위축도가 위축도 I도 이상이거나 또는 둘 다이다.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020217009475A KR102424644B1 (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
Applications Claiming Priority (4)
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JP2009208039 | 2009-09-09 | ||
JPJP-P-2009-208039 | 2009-09-09 | ||
PCT/JP2010/065379 WO2011030774A1 (ja) | 2009-09-09 | 2010-09-08 | 1回当たり100~200単位のpthが週1回投与されることを特徴とする、pth含有骨粗鬆症治療/予防剤 |
KR1020197023161A KR20190095552A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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KR1020197023161A Division KR20190095552A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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KR1020217009475A Division KR102424644B1 (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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KR20200115673A true KR20200115673A (ko) | 2020-10-07 |
KR102335703B1 KR102335703B1 (ko) | 2021-12-07 |
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KR20147029471A KR20140130754A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020177019824A KR20170089018A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR20157003153A KR20150021590A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020177019823A KR20170089017A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020207027785A KR102335703B1 (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020127005972A KR20120067336A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100~200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020217009475A KR102424644B1 (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020197023161A KR20190095552A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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KR20147029471A KR20140130754A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020177019824A KR20170089018A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR20157003153A KR20150021590A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020177019823A KR20170089017A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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KR1020127005972A KR20120067336A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100~200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020217009475A KR102424644B1 (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
KR1020197023161A KR20190095552A (ko) | 2009-09-09 | 2010-09-08 | 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제 |
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CA2770340C (en) * | 2009-11-18 | 2019-08-27 | Asahi Kasei Pharma Corporation | Preventive and/or therapeutic and/or aggravation suppressing agent for human arthritis deformans |
JP6235219B2 (ja) * | 2013-03-21 | 2017-11-22 | 旭化成ファーマ株式会社 | 脊椎椎体間固定術後の骨癒合促進剤 |
US10394953B2 (en) | 2015-07-17 | 2019-08-27 | Facebook, Inc. | Meme detection in digital chatter analysis |
CN110520148A (zh) * | 2017-02-01 | 2019-11-29 | 约翰霍普金斯大学 | 甲状旁腺激素与退行性椎间盘疾病的再生 |
CA3075984A1 (en) * | 2017-09-22 | 2019-03-28 | Asahi Kasei Pharma Corporation | Teriparatide-containing liquid pharmaceutical composition having excellent pharmacokinetics and/or safety |
CN116898955A (zh) * | 2017-09-22 | 2023-10-20 | 旭化成制药株式会社 | 稳定性优异的含有特立帕肽的液态药物组合物 |
JP2019060866A (ja) * | 2017-09-22 | 2019-04-18 | 旭化成ファーマ株式会社 | 液状医薬組成物の体内動態を予測する方法 |
JP7080487B2 (ja) | 2018-09-26 | 2022-06-06 | 東陽建設工機株式会社 | 鉄筋曲げ方法 |
CA3101326C (en) | 2018-10-29 | 2023-08-01 | Asahi Kasei Pharma Corporation | Method for preventing or treating osteoporosis, characterized by administering teriparatide or salt thereof at a frequency of twice a week |
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