KR20190131817A - A ginsenoside complex comprising insoluble substance curcumin - Google Patents

Abstract

The present invention is a composition for increasing the water solubility of poorly soluble substances including white ginseng extract, red ginseng extract and ginseng fruit extract; A poorly water soluble substance having increased water solubility comprising the composition; Cosmetic composition, food composition, pharmaceutical composition, and quasi-drug composition comprising the poorly soluble substance; And it relates to a method for increasing the water solubility of poorly soluble substances using the white ginseng root extract, red ginseng root extract and ginseng fruit extract and a method for producing a poorly soluble substance having increased water solubility.
The white ginseng root extract, red ginseng root extract and ginseng fruit extract according to the present invention can improve the water solubility of poorly soluble substances, and thus are useful for preparing orally and injectable poorly soluble substances, increasing storage stability, and increasing drug delivery ability / absorption rate. Can be utilized. In addition, the extract is derived from natural, so can be used safely without side effects to the human body.

Description

Ginsenoside complex comprising insoluble substance curcumin

The present invention is a composition for increasing the water solubility of poorly soluble substances comprising one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract; A poorly water soluble substance having increased water solubility comprising the composition; Cosmetic composition, food composition, pharmaceutical composition, quasi-drug composition, and feed composition comprising the poorly soluble substance; And it relates to a method for increasing the water solubility of poorly soluble substances using one or more extracts selected from the white ginseng root extract, red ginseng root extract and ginseng fruit extract and a method for preparing a composition containing poorly soluble substances having increased water solubility.

Solubilization (solubilization) of poorly soluble drugs is an essential technique in that they improve the bioavailability, stability and dispersibility of the drug and can be formulated in oral and injectable forms for administration into the body. A method of solubilizing a poorly soluble drug includes (1) dissolving the drug in a mixed solvent of a water miscible organic solvent and water; (2) modifying the structure of the drug to improve it to a salt form of an acid or base soluble in water; (3) combining the drug with a third substance to form a complex that is soluble in water; (4) A method of micellizing a drug in an aqueous solution by adding a surfactant is used (Leon Lachman, Lea & Febiger, Philadelphia, 1986).

Among the methods for solubilizing poorly soluble substances, solubilizing without changing the chemical structure of drugs using surfactants is widely used as a method for solubilizing various drugs. As the surfactant, nonionic surfactants such as sorbitan fatty acid ester derivatives (Tween) and polyoxyethylene monoalkyl ether derivatives (BRIJ and MYRJ series) are widely used. However, these surfactants are very limited in use due to side effects such as hypersensitivity reactions, there is a disadvantage that the drug is precipitated when left for a relatively long time due to the very low stability of micelles.

In addition, the conventional method as described above has been reported to cause serious side effects such as hypersensitivity of the human body using synthetic compounds such as surfactants and various acids or bases, due to low stability when stored or left for a long time It has been found to have the disadvantage that the drug is precipitated.

In order to solve this problem, studies have been actively conducted to solubilize poorly soluble substances using natural substances, and as an example, a method of extracting curcuminoids having increased water solubility using steviol glycosides. 10-2017-0118624) etc. are mentioned. However, further research is still needed on how to solubilize poorly soluble materials in a safer and more efficient manner.

Under these backgrounds, the present inventors have made diligent efforts to develop a method of increasing the water solubility of poorly soluble substances using natural substances. It was confirmed that this can be increased, to complete the present invention.

One object of the present invention is to provide a composition for increasing the water solubility of poorly soluble substances, including one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract.

Another object of the present invention is to provide a poorly water-soluble material having increased water solubility comprising the composition.

Yet another object of the present invention is to provide a cosmetic composition comprising the poorly water-soluble substance having increased water solubility.

Yet another object of the present invention is to provide a food composition comprising the poorly soluble substance having increased water solubility.

Yet another object of the present invention is to provide a quasi-drug composition comprising the poorly water-soluble substance having increased water solubility.

Yet another object of the present invention is to provide a feed composition comprising a poorly water-soluble substance having increased water solubility.

Still another object of the present invention is to provide a method for increasing water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract.

Yet another object of the present invention is to provide a method for preparing a poorly soluble substance having increased water solubility, comprising the step of treating one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract to poorly soluble materials.

Another object of the present invention is a first step of mixing and heat-soluble dissolving one or more extracts selected from white ginseng extract, red ginseng root extract, ginseng fruit extract, and poorly soluble substances; And a second step of subjecting the mixture obtained in the first step to microwave (microwave), to provide a method for producing a poorly soluble substance-containing composition having increased water solubility.

This will be described in detail as follows. In addition, each description and embodiment disclosed in this invention is applicable to each other description and embodiment. That is, all combinations of the various elements disclosed in the present invention fall within the scope of the present invention. In addition, the scope of the present invention is not to be limited by the specific description described below.

One aspect of the present invention for achieving the above object provides a composition for increasing the water solubility of poorly soluble substances, including one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract.

The present invention provides white ginseng root, red ginseng root or ginseng fruit extract as a substance to increase the water solubility of poorly soluble substances.

The term "white ginseng" is also referred to as white ginseng, and means that the ginseng 4 years or more is processed to remove moisture from the epidermis and dry to 14% or less.

As used herein, the term "red ginseng root" is also referred to as red ginseng, and means that processed ginseng is steamed and dried to have a water content of 14% or less.

As used herein, the term "ginseng berry" means a fruit of 4 years old ginseng.

The white ginseng root, red ginseng root and ginseng fruit are known to be rich in saponin and have effects such as improving intestinal environment, preventing obesity, anticancer effect, improving immunity, improving fatigue, preventing depression, and preventing aging. However, the effect of increasing the water solubility for these poorly soluble substances is not known.

As used herein, the term "extract" refers to an extract obtained by extracting the white ginseng root, red ginseng root, ginseng fruit or a mixture thereof, a diluent or concentrate of the extract, a dried product obtained by drying the extract, and a crude agent or purified product of the extract. And extracts of all formulations that can be formed using the extract itself and the extract, such as mixtures thereof.

In addition, the extract may be extracted from natural, hybrid or variety plants of the respective plants, and may be extracted from plant tissue culture.

In addition, the method of extracting the white ginseng root, red ginseng root, ginseng fruit or a mixture thereof is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method, hot water extraction, alcohol extraction, juice extraction, ultrasonic extraction, reflux extraction, supercritical extraction, and the like, these may be performed alone or in combination of two or more methods. .

In addition, the kind of extraction solvent used in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent may include water, alcohols having 1 to 4 carbon atoms or mixed solvents thereof, and these may be used alone or in combination of one or more thereof.

Specifically, the extract of the present invention may be extracted from alcohol (ethanol) or juice extraction, it may be extracted and concentrated. More specifically, the white ginseng root extract and red ginseng root extract may be concentrated by extracting alcohol, and the ginseng fruit extract may be concentrated by extracting or extracting juice, but is not limited thereto. In the present invention, "juice" means squeezing juice from fruit or vegetables.

The white ginseng root extract, red ginseng root extract or ginseng fruit extract may be included in an amount of 1 to 25% (w / v) based on the total composition, but is not limited thereto.

For the purposes of the present invention, the white ginseng extract, red ginseng root extract or ginseng fruit extract may be to increase the water solubility of poorly soluble substances.

As used herein, the term " poorly soluble substance " means a substance having a property of being poorly soluble in a solvent such as water, and for the purposes of the present invention, may mean a substance having low water solubility. As the poor solubility of the substance decreases the bioavailability, stability and dispersibility, the utilization thereof is significantly reduced, and there is a continuous demand for a method of solubilizing the poorly soluble substance. The poorly soluble substance may mean a substance having a solubility in water of 0.001 mg / mL to 50 mg / mL, but is not limited thereto.

Specifically, the poorly soluble material may be a curcuminoid compound.

The term "curcuminoid" (curcuminoid) refers to a linear diaryheptanoid compound having a curcumin or curcumin derivative. It is a natural phenol, has a distinct yellow color, and is mainly found in turmeric. Curcuminoids have excellent antioxidant activity and are known to be used for the prevention or treatment of various diseases and conditions, including diabetes, lung cancer, breast cancer, leukemia, atopic dermatitis, rhinitis, liver disease, hangover, constipation, Alzheimer's, brain injury, and vascular dementia. However, it did not dissolve well in water, so there were many restrictions. Therefore, studies to increase its water solubility have been actively conducted.

Specifically, the curcuminoid compound may be curcumin (crcumin), dimethoxycurcumin (demethoxycurcumin), bisdemethoxycurcumin (bisdemethoxycurcumin) or a combination thereof, more specifically curcumin, but in the extract of the present invention As long as water solubility can be increased by this, it is not limited to this.

In a specific embodiment of the present invention, white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate, ginseng fruit extract extract concentrate was prepared, and a mixture thereof was treated with curcumin, a poorly soluble substance, which significantly increased the water solubility of curcumin. It was confirmed (Table 1, and FIGS. 1 to 4).

This suggests that the extract can increase the water solubility of poorly soluble substances and furthermore can be usefully used to broaden the utility of poorly soluble substances.

Another embodiment provides a poorly water soluble substance having increased water solubility comprising the composition.

The description of the "poorly soluble substance" is as described above.

Since the composition of the present invention includes one or more extracts selected from white ginseng extract, red ginseng root extract, and ginseng fruit extract that can increase the water solubility of poorly soluble substances, the poorly soluble substance including the same may increase the water solubility.

Another embodiment provides a pharmaceutical composition comprising the poorly soluble substance having increased water solubility.

The description of the "poorly soluble substance" is as described above.

In the present invention, since the pharmaceutical composition includes poorly soluble substances having increased water solubility, specifically curcuminoid compounds having increased water solubility, they may exhibit excellent antioxidant activity. Therefore, the pharmaceutical composition may prevent or treat various diseases through antioxidant activity.

Specifically, the disease may be diabetes, lung cancer, breast cancer, leukemia, atopy, rhinitis, liver disease, hangover, constipation, Alzheimer's, brain injury, vascular dementia, or a combination thereof, but is not limited thereto.

The term "prevention" means any action that inhibits or delays the symptoms of a disease by administration of a composition comprising a poorly soluble substance having increased water solubility.

The term "treatment" means any action in which the symptoms of the disease are improved or beneficially altered by administration of a composition comprising the poorly soluble substance having increased water solubility.

The pharmaceutical composition of the present invention may include 0.001 to 80, specifically 0.001 to 70, more specifically 0.001 to 60% by weight based on the total weight of the composition, but is not limited thereto.

In addition, the pharmaceutical composition may further comprise a pharmaceutically acceptable carrier, excipient or diluent commonly used in the manufacture of the pharmaceutical composition, the carrier comprises a non-naturally occuring carrier (carrier) can do. Specific examples of the carrier, excipient, and diluent include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, Microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate or mineral oil may be used, but is not limited thereto.

In addition, the pharmaceutical compositions are tablets, pills, powders, granules, capsules, suspensions, solvents, emulsions, syrups, sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilizers and suppositories, respectively, according to conventional methods. It may have any one formulation selected from the group consisting of, and may be various oral or parenteral formulations. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used. Tablets, pills, powders, granules, capsules and the like may be used for the solid preparation for oral administration, and the solid preparation may be at least one excipient such as starch, calcium carbonate, sucrose or lactose, Gelatin and the like can be used. In addition to the simple excipients, lubricants such as magnesium stearate, talc and the like can be used. As a liquid preparation for oral administration, suspending agents, liquid solutions, emulsions, syrups, etc. may be used.In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be used. Can be used. For parenteral administration, sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations or suppositories may be used. As the non-aqueous solvent and the suspension solvent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin and the like may be used, but are not limited thereto.

The pharmaceutical composition of the present invention may be administered in a pharmaceutically effective amount.

The term "administration" means introducing a composition comprising said sparingly soluble material into an individual in a suitable manner.

The term "individual" means all animals, including rats, mice, livestock, etc., including humans with or who may develop a disease. As a specific example, it may be a mammal including a human.

The term "pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and an effective dose level refers to the type and severity of the subject, severity, age, sex, activity of the drug, Sensitivity to drug, time of administration, route of administration and rate of release, duration of treatment, factors including concurrent use of drugs, and other factors well known in the medical arts.

The pharmaceutical composition may be administered as a separate therapeutic agent or in combination with other therapeutic agents and may be administered sequentially or simultaneously with conventional therapeutic agents. In addition, single or multiple administrations can be made. Taking all of the above factors into consideration, it is important to administer an amount that can obtain the maximum effect in a minimum amount without side effects, which can be easily determined by those skilled in the art.

In addition, the pharmaceutical composition may be administered orally or parenterally (eg, applied intravenously, subcutaneously, intraperitoneally, or topically) according to a desired method, and the dosage may be determined by the condition and weight of the patient, and by disease. Depending on the extent, drug form, route of administration, and time, it may be appropriately selected by those skilled in the art. As a specific example, the pharmaceutical composition may generally be administered in an amount of 0.001 to 1000 mg / kg, more specifically 0.05 to 200 mg / kg, most specifically 0.1 to 100 mg / kg once a day or several times. However, the preferred dosage may be appropriately selected by those skilled in the art depending on the condition and weight of the individual, the severity of the disease, the form of the drug, the route of administration and the duration.

Another embodiment provides a food composition comprising the poorly soluble substance having increased water solubility.

The description of the "poorly soluble substance" is as described above.

Food composition of the present invention can be ingested on a daily basis, and unlike the general medicine because it has the advantage that there is no side effect that can occur when taking a long-term use of the drug as a natural product, poorly water-soluble substances that increased water solubility, specifically The antioxidant activity caused by curcuminoid compounds with increased water solubility can be exhibited at high levels.

The term "food" of the present invention, meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, drinks, tea, drinks, alcoholic beverages , Vitamin complexes, nutraceuticals and health foods, and includes all foods in the usual sense.

The health functional food (health functional food) is the same term as a food for special health use (FOSHU), food processed with high medical effect, medical treatment so that the bioregulatory function appears efficiently in addition to nutrition Means. Here, 'function (sex)' means to obtain a useful effect for health purposes such as nutrient control or physiological action on the structure and function of the human body. The health food (health food) means a food having an active health maintenance or promotion effect compared to the general food, the health supplement food (health supplement food) means a food for health supplement purposes. In some cases, the terms nutraceutical, health food, health supplement food may be used.

Specifically, the health functional food is a food prepared by adding the water-soluble poorly soluble substance of the present invention to food materials, such as beverages, teas, spices, gums, confections, or the like, encapsulated, powdered, suspensions, etc. Ingestion means to bring a specific effect on health, but unlike the general medicine has the advantage that there is no side effect that can occur when taking long-term use of food as a raw material.

The food of the present invention may be prepared by a method commonly used in the art, and may be prepared by adding raw materials and ingredients commonly added in the art. In addition, the food composition may be prepared in various forms of formulation as long as the formulation is recognized as a food.

In addition, the food composition may further include a physiologically acceptable carrier, the type of carrier is not particularly limited and may be used as long as the carrier is commonly used in the art.

In addition, the food composition may include additional ingredients that are commonly used in food compositions to improve the smell, taste, time and the like. For example, it may include vitamins A, C, D, E, B1, B2, B6, B12, niacin, biotin, folate, panthotenic acid, and the like. In addition, minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), copper (Cu) and chromium (Cr); And amino acids such as lysine, tryptophan, cysteine, valine and the like.

In addition, the food composition is a preservative (potassium sorbate, sodium benzoate, salicylic acid, sodium dehydroacetic acid, etc.), fungicides (bleaching powder and highly bleaching powder, sodium hypochlorite, etc.), antioxidants (butylhydroxyanisol (BHA), butylhydride) Oxytoluene (BHT), etc.), colorants (such as tar pigments), colorants (sodium nitrite, sodium nitrite, etc.), bleach (sodium sulfite), seasonings (such as MSG glutamate), sweeteners (ducin, cyclate, saccharin Foods such as sodium, etc.), fragrances (vanillin, lactones, etc.), swelling agents (alum, potassium D-tartrate, etc.), reinforcing agents, emulsifiers, thickeners (foils), coatings, gum herbicides, foam inhibitors, solvents, modifiers It may include food additives. The additive may be selected according to the type of food and used in an appropriate amount.

Another embodiment provides a cosmetic composition comprising the poorly water-soluble substance having increased water solubility.

The description of the "poorly soluble substance" is as described above.

In the present invention, since the cosmetic composition includes a poorly soluble substance having increased water solubility, specifically a curcuminoid compound having increased water solubility, it may exhibit excellent antioxidant activity. Therefore, the cosmetic composition may exhibit various effects such as skin whitening, skin wrinkle improvement, skin trouble improvement, and skin aging prevention through antioxidant activity.

The cosmetic composition of the present invention may include 0.0001 to 80% by weight, specifically 0.0005 to 70% by weight, and more specifically 0.001 to 60% by weight of the poorly soluble substance having increased water solubility. If the content is less than 0.0001% by weight, it is not preferable because the original desired effect can not be sufficiently achieved, and if it exceeds 80% by weight, it is uneconomical because it is not expected to increase the effect as much as the increasing content. It can cause problems.

In addition, the cosmetic composition of the present invention is used for the skin, softening longevity (nutrition fluid), astringent longevity, nutrient longevity, nutrition cream, massage cream, essence, pack, skin adhesive patch, skin adhesive gel, powder, ointment It may be prepared in a conventional cosmetic form, such as suspension, emulsion, spray or cosmetic liquid, but is not limited thereto. In addition, the cosmetic composition may be made of a skin contact material in contact with the skin, such as cosmetics, soap, detergents and fibers.

In addition, the cosmetic composition is a cosmetic ingredient such as ordinary ingredients, such as oil, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, fragrances, etc. The carrier may further include, but is not limited to.

The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.

Specifically, when the formulation of the present invention is an ointment, paste, cream or gel, the carrier component is animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, Zinc oxide or the like may be used, but is not limited thereto. These may be used alone or in combination of two or more thereof.

In addition, when the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. may be used as the carrier component, and particularly in the case of a spray, additionally chlorofluoro Propellants, such as, but not limited to, loxadrocarbon, propane / butane or dimethyl ether. These may be used alone or in combination of two or more thereof.

In addition, when the formulation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier may be used as the carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, Benzyl benzoate, propylene glycol, 1,3-butylglycol oil and the like can be used, and in particular, cottonseed oil, peanut oil, corn seed oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or sorb Non-fatty acid esters may be used, but are not limited thereto. These may be used alone or in combination of two or more thereof.

In addition, when the formulation of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester as carrier components , Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant may be used, but is not limited thereto. These may be used alone or in combination of two or more thereof.

In addition, when the formulation of the present invention is a soap, as a carrier component, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolyzates, isethionates, lanolin derivatives, aliphatic alcohols, vegetable oils, glycerol, sugars and the like May be used, but is not limited thereto. These may be used alone or in combination of two or more thereof.

Another embodiment provides a quasi-drug composition comprising the poorly soluble substance.

The description of the "poorly soluble substance" is as described above.

Since the quasi-drug composition of the present invention includes a poorly water-soluble substance having increased water solubility, specifically, a curcuminoid compound having increased water solubility, the antioxidant activity thereof may be exhibited at a high level.

As used herein, the term "quasi drug" refers to articles used for the purpose of diagnosing, treating, ameliorating, alleviating, treating, or preventing a disease of a human or animal, which have a lesser effect than a pharmaceutical, for example, according to the pharmacological law. Quasi-drugs exclude products used for the purpose of medicines, and include products used for the treatment or prevention of diseases of humans / animals, and products with slight or no direct action on the human body.

The quasi-drug composition of the present invention may be prepared with one or more selected from the group consisting of body cleanser, foam, soap, mask, ointment, cream, lotion, essence and spray, but is not limited thereto.

When the poorly water-soluble substance having increased water solubility according to the present invention is used as an quasi-drug additive, it may be added as it is or used together with other quasi-drugs or quasi-drug components, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be appropriately determined depending on the intended use.

Another aspect provides a feed composition comprising the poorly soluble material.

As used herein, the term " feed " means any natural or artificial diet, one meal, or the like or a component of the one meal for the animal to eat, ingest and digest.

The feed may comprise feed additives or feed supplements.

The kind of the feed is not particularly limited, and may be used a feed commonly used in the art. Non-limiting examples of the feed include, but are not limited to, vegetable feeds such as cereals, fruits, food processing by-products, algae, fibres, pharmaceutical by-products, oils, starches, gourds or grain by-products; And animal feeds such as proteins, minerals, fats and oils, minerals, fats and oils, single cell proteins, zooplankton or foods. These may be used alone or in combination of two or more thereof.

Yet another aspect provides a method of increasing water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract with a poorly soluble substance.

Description of the "white ginseng extract", "red ginseng root extract", "ginseng fruit extract" and "poorly soluble substance" is as described above.

Specifically, the method may further comprise the step of treating the microwave (microwave) to one or more extracts selected from the white ginseng extract, red ginseng extract and ginseng fruit extract.

As used herein, the term "microwave" means a radio wave having a wavelength in a range of 1 mm to 1 m. Because of its short wavelength, it has almost the same properties as light and has strong sterilizing properties. Specifically, the microwave may be 1,500 to 13,000W, and may also be processed for 1 to 20 minutes, but is not limited thereto.

In addition, the mixing and the treatment step of the microwave may be performed at 80 to 100 ℃, but is not limited thereto.

Yet another aspect provides a method for preparing a water-soluble poorly soluble substance, comprising treating one or more extracts selected from white ginseng root extract, red ginseng root extract and ginseng fruit extract to poorly soluble substances.

Another embodiment is a first step of mixing and heat-soluble dissolving one or more extracts selected from white ginseng extract, red ginseng root extract, ginseng fruit extract, and poorly soluble substances; And a second step of treating the mixture obtained in the first step with microwaves, wherein the water-soluble increased water-soluble substance-containing composition is provided.

Description of the "white ginseng extract", "red ginseng root extract", "ginseng fruit extract" and "poorly soluble substance" is as described above.

One or more extracts selected from white ginseng root extract, red ginseng root extract and ginseng fruit extract of the present invention can increase the water solubility of poorly soluble substances, and thus can be usefully used in the preparation of poorly soluble substances having increased water solubility.

Specifically, the step of treating one or more extracts selected from the white ginseng extract, red ginseng root extract and ginseng fruit extract to a poorly soluble material may be a step of mixing the extract with a poorly soluble material.

The first step of the preparation method may be mixing in a solvent, or adding a poorly soluble substance to a solution containing one or more extracts selected from white ginseng root, red ginseng root or ginseng fruit. The second step may be to process the microwave for 1 to 20 minutes in the range of 1L (1500 W or more) to 25L (13000 W).

At least one extract selected from white ginseng root extract, red ginseng root extract and ginseng fruit extract according to the present invention may improve the water solubility of poorly soluble substances, thus making the poorly soluble substances into oral and injectable formulations, increasing storage stability and drug delivery ability. It can be usefully used to increase the absorption rate in the body. In addition, the extract is derived from natural, so can be used safely without side effects to the human body.

1 is an HPLC chromatogram showing the amount of curcumin dissolved in the concentrate as a result of dissolving curcumin using a white root muscle extract concentrate according to an embodiment of the present invention.
2 is an HPLC chromatogram showing the amount of curcumin dissolved in the concentrate as a result of dissolving curcumin using the red ginseng root extract concentrate according to an embodiment of the present invention.
3 is an HPLC chromatogram showing the amount of curcumin dissolved in the concentrate as a result of dissolving curcumin using a ginseng fruit extract concentrate according to one embodiment of the present invention.
4 is an HPLC chromatogram showing the amount of curcumin dissolved in the concentrate as a result of dissolving curcumin using a ginseng fruit juice concentrate according to one embodiment of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, these examples are for illustrative purposes only and the scope of the present invention is not limited to these examples.

Example 1 Enhancement of Water Solubility of Poorly Soluble Compounds

To increase the water solubility of poorly soluble substances, white ginseng extract, red ginseng extract, and ginseng fruit extract were used. As an example of a poorly water-soluble substance, a curcuminoid compound, specifically curcumin, was used. The extract was supplied and used in the form of a concentrate, and the concentrate was supplied from Korea Won ginseng or Shinwoo Corporation, respectively.

Thereafter, for 10-20% (v / v) curcumin, white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate or ginseng fruit extract extract concentrate was added in a ratio of 5-20% (v / v) and mixed.

The mixture was treated with microwave (1,500 ~ 13,000W) for 10 to 20 minutes, and the mixing and the treatment of the microwave were all performed at 80 to 100 ℃. By treating the mixture with microwaves, the extract can be prepared without using a solvent (alcohol) used in the conventional extraction method, can shorten the time required for the preparation of the extract, the extraction process is reduced As a result, the efficiency is increased. In addition, when microwave is used in the solubilization of curcumin, the solubility efficiency can be improved. Finally, the amount of curcumin adsorbed was quantified using HPLC, and the results are shown in Table 1 below and FIGS. 1 to 4.

Comparison of Water Solubility of Curcumin According to the Use of White Ginseng Root Extract, Red Ginseng Root Extract, Ginseng Fruit Extract Curcumin White Root Extract
concentrate Red Ginseng Root Extract
concentrate Ginseng Berry Extract Concentrate Ginseng Berry Extract
concentrate Content (g / L) 0.1 g or more 0.08 g or more 0.7 g or more 0.12 g or more

As a result, as shown in Table 1, and FIGS. 1 to 4, when curcumin is mixed with white ginseng root extract concentrate, red ginseng root extract concentrate, ginseng fruit extract concentrate, or ginseng fruit juice extract concentrate, the concentrate (extract) is used. It was confirmed that the amount of curcumin dissolved compared to the case did not. In addition, Figure 5 as a result of the case of extracting the curcumin with purified water only without using the extract in the above method, it was confirmed that the accommodated curcumin does not exist.

In other words, it can be seen that when using the extract according to the present invention, the water solubility of poorly soluble substances such as curcuminoid compounds can be increased.

From the above description, those skilled in the art will appreciate that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. In this regard, the embodiments described above are to be understood in all respects as illustrative and not restrictive. The scope of the present invention should be construed that all changes or modifications derived from the meaning and scope of the following claims and equivalent concepts rather than the detailed description are included in the scope of the present invention.

Claims (14)

A composition for increasing the water solubility of a poorly soluble substance, comprising one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract.
The composition of claim 1, wherein the white ginseng root extract or red ginseng root extract is extracted with an alcohol having 1 to 4 carbon atoms or a mixed solvent thereof.
The composition of claim 1, wherein the ginseng fruit extract is extracted with an alcohol having 1 to 4 carbon atoms or a mixed solvent thereof or extracted by juice.
The composition of claim 1, wherein the white ginseng root extract, red ginseng root extract or ginseng fruit extract comprises 1 to 25% (w / v) of the total composition.
The composition of claim 1, wherein the poorly soluble material is a curcuminoid compound.
The composition of claim 5, wherein the curcuminoid compound is curcumin.
A poorly water soluble substance having increased water solubility comprising the composition of claim 1.
Cosmetic composition containing the poorly soluble substance of claim 7.
A food composition comprising the poorly soluble material of claim 7.
The quasi-drug composition containing the poorly soluble substance of Claim 7.
A feed composition comprising the poorly soluble material of claim 7.
A method of increasing water solubility of a poorly soluble substance, comprising mixing one or more extracts selected from white ginseng extract, red ginseng extract and ginseng fruit extract with a poorly soluble substance.
A first step of mixing and thermally dissolving one or more extracts selected from white ginseng root extract, red ginseng root extract, ginseng fruit extract, and poorly soluble substances; And a second step of subjecting the mixture obtained in the first step to microwaves, wherein the water solubility is increased.
The solution of claim 13, wherein the first step comprises mixing white ginseng extract, red ginseng root extract, one or more extracts selected from ginseng fruit extract, and a poorly soluble substance in a solvent, or white ginseng root extract, red ginseng root extract, or ginseng fruit extract. To a poorly soluble substance.

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