KR20190005490A - Composition for thermoplastic wound dressing - Google Patents

Abstract

The present invention relates to a thermoplastic wound dressing composition which is coated on a skin wound, and can include a dressing material comprising a hydrophobic adhesive and a hydrophilic polymer, and a wax for supporting the dressing material.

Description

[0001] Composition for thermoplastic wound dressing [0002]

The present invention relates to a thermoplastic wound dressing composition which is applied to wound areas of the skin.

Skin is one of the organs that performs important functions to protect the human body from external stimuli and prevents the loss of water. If the skin is damaged by burns, various traumas, surgical treatments, etc., the protective function is lost, . In addition, various side effects due to moisture loss and bacterial infection from the outside cause difficulty in treatment of the affected part, and the risk of additional side effects such as secondary dysfunction or damage increases. Therefore, wound healing using proper dressing must be performed in order to accelerate wound healing and minimize secondary side effects. Since 1962 Winter has reported that skin wound healing has an excellent effect in a wet environment, many results have been reported to verify this fact. Currently, the wound healing method is used to create a wet environment in dry dressing using conventional gauze and the like It is rapidly changing to a dressing method.

The ideal requirement for dressing material to effectively heal wounds is to maintain a moist environment (maintain environment in which epithelial cells can unfold easily), prevent infection (prevent bacterial invasion from outside and inhibit proliferation), prevent excessive adhesion of wound dressings and dressings (To prevent damage to the epithelial tissue due to strong physical adhesion to the wound surface), thermal effect (maintain high oxygen tension due to thermal insulation and increase treatment efficiency) , Moisture permeability (to maintain high moisture permeability to prevent smoking of normal skin around the window), visibility, non-irritation, ease of use, and economy.

Generally, the wound dressing is attached and fixed to the wound by a separate adhesive tape. However, since the use thereof is troublesome, recently wound dressing having self-adhesive property is attracting attention.

Japanese Patent Application Laid-Open No. 10-2014-0089412

There are various kinds of dressings that can be applied to skin wounds. However, in order to adhere to the upper surface of the window, a number of dressing materials are applied to the upper surface of the window, or a primary dressing material having no adhesive property is applied, And it is fixed to the periphery. The use of such adhesives, adhesive tapes, and the like inevitably causes pain when the dressing material is removed, and skin irritation and allergic reactions to the adhesive ingredients are frequently observed. In particular, when dressing is required in a hairy body part, the dressing material and adhesive tape containing the adhesive component do not adhere well to the wound surface due to hair and cause considerable pain upon removal. In addition, if the dressing material is not properly adhered to the upper surface of the window by hairs, it can not provide the wet environment necessary for wound healing, and the wound can not be protected from the external environment, thereby increasing the risk of contamination and bacterial infection of the wound. Therefore, the inventors of the present invention have found that it is not irritating to the skin and adheres to the wound area without deteriorating the adhesiveness even in the hairy wound area, thereby keeping the wound surrounding environment moist and shielding from the external environment, and even when removing the dressing material, Non-induced dressing compositions were studied.

Accordingly, an object of the present invention is to provide a wound dressing which is not irritating to the skin, adheres to the wound area without deteriorating adhesiveness even in a hairy wound area, keeps the wound surrounding environment moist and blocks the external environment, In the dressing composition.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

In order to achieve the above object, a thermoplastic wound dressing composition coated on a skin wound area according to an embodiment of the present invention includes a dressing material including a hydrophobic adhesive and a hydrophilic polymer, and a wax for supporting the dressing material .

And the content ratio of the dressing material and the wax is 2: 8 to 8: 2.

Wherein the dressing material comprises 8 to 52% by weight of the pressure-sensitive adhesive and 7 to 40% by weight of the hydrophilic polymer.

The pressure-sensitive adhesive may be at least one selected from the group consisting of polybutylene, polyisoprene, polyisobutylene, isobutylene rubber, polyethylene-propylene rubber, polyethylene-propylene diene-modified rubber, styrene-butadiene-styrene, styrene- A styrene-ethylene-butylene-styrene copolymer polymer, a polyester, a polyamide, an epoxy, a silicone resin, a fluororesin, a polystyrene-based resin, an acrylic resin, a methacrylic resin, an olefin- An alkylphenol-aldehyde resin, a terpene resin, an aliphatic hydrocarbon resin, an aliphatic hydrocarbon resin, an aliphatic hydrocarbon resin, an alicyclic hydrocarbon resin, an alicyclic hydrocarbon resin, , Other hydrocarbon resins such as asphalt and bitumen, polyalkylated novolak resins, xylene-formaldehyde resins, Based pressure-sensitive adhesives, urethane pressure-sensitive adhesives, silicone pressure-sensitive adhesives and acrylic pressure-sensitive adhesives.

Wherein the hydrophilic polymer is selected from the group consisting of chitosan, agarose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cellulose, dextran, xanthan gum, carrageenan, alginate, starch, alginic acid, pectin, gelatin, polyacrylate, Amide and polymethacrylic acid salts.

The dressing material may further include an antibiotic or an antibacterial agent.

The antibiotic may be selected from the group consisting of bacitracin, erythromycin, mupirocin, fusidic acid, neomycin, sulfacetamide sodium, polymyxin B, B), and silver sulfadiazine (silver sulfadiazine).

The antibacterial agent may be an inorganic, organic or natural extract.

Wherein the inorganic antibacterial agent is at least one selected from silver, copper, zinc, copper, gold, platinum, calcium phosphate, zirconium phosphate, zeolite and manganese.

The organic antimicrobial agent is characterized by being at least one selected from chlorine, iodine compounds, phenol, alcohol, formalin and quaternary ammonium salts.

 The natural antimicrobial agent is at least one of phytoncide, grapefruit, fig, garlic, and extracts extracted from propolis.

The wax is characterized by being an animal wax, a vegetable wax, a mineral wax or a petroleum wax.

The animal wax is characterized in that it is at least one selected from beeswax, Chinese wax, lanolin, shellac wax and spermaceti.

The vegetable wax may be selected from the group consisting of bayberry wax, candelilla wax, carnauba wax, castor wax, esparto wax, Japan wax, Rice bran wax, soy wax, tallow tree wax, and the like. The wax of the present invention is not particularly limited as long as it is a waxy wax, a rice wax, a rice wax, a soy wax, and a tallow tree wax.

The mineral wax is characterized in that the mineral wax is at least one selected from ceresin wax, montan wax, ozocerite and peat wax.

The petroleum wax is characterized by being paraffin wax or microcrystalline wax.

When heat is applied to the composition, the composition changes from a solid state to a molten state.

Characterized in that the composition is immobilized on the skin in a solid state.

The dressing composition using the wax according to the present invention exists as a solid at room temperature and body temperature and is liquefied upon heating to be easily applied to the wound area and adhered to the wound area to protect the wound and keep the wound environment moist. Addition of a polymer such as a hydrocolloid increases the degree of absorption and tensile strength to exhibit excellent tackiness and absorbency. It is non-toxic, has no irritation to the skin, can be treated quickly, and does not leave residues when removed from the skin have.

In particular, even when the hair is scarred such as a scalp, it is possible to easily coat the wound by applying liquefied dressing material, and to maintain the wet environment, which is an essential element in the wound healing process, and to protect the wound from external environment Is provided by the dressing material. In addition, when removing the dressing material of the body part, the pain caused by the strong adhesive applied to the conventional dressing material is reduced, thereby enabling more comfortable skin dressing.

Figure 1 shows a tubular thermoplastic wound dressing composition.
Figure 2 shows a film-like thermoplastic wound dressing composition.
3 is a view illustrating a process of using a thermoplastic wound dressing according to an embodiment of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Is provided to fully convey the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings. &Quot; and / or "include each and every combination of one or more of the mentioned items. ≪ RTI ID = 0.0 >

The terminology used herein is for the purpose of illustrating embodiments and is not intended to be limiting of the present invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. The terms " comprises "and / or" comprising "used in the specification do not exclude the presence or addition of one or more other elements in addition to the stated element.

Unless defined otherwise, all terms (including technical and scientific terms) used herein may be used in a sense commonly understood by one of ordinary skill in the art to which this invention belongs. Also, commonly used predefined terms are not ideally or excessively interpreted unless explicitly defined otherwise.

A thermoplastic wound dressing composition according to an embodiment of the present invention will be described. The thermoplastic wound dressing composition according to an embodiment of the present invention may include a dressing material including a hydrophobic adhesive and a hydrophilic polymer, and a wax for supporting the dressing material. The wax can support the coating material at room temperature.

Since the wax maintains a solid state at room temperature, it can have mechanical rigidity to support a dressing composition such as a dressing material. The wax has a melting point of 48 to 72 ° C, depending on its chemical composition. The wax maintains a solid state at room temperature. When heated, the wax becomes molten. When the wax is in thermal equilibrium with room temperature, the solid state is restored.

On the other hand, when heat is applied to the wax, it becomes soft like ointment. In the present invention, the wax is melted at a temperature at which the skin is not burned, and becomes totally ductile so as to be dressed with the dressing material together with the dressing material. When the thermoplastic wound dressing is applied to the wound area and the wax contained in the thermoplastic wound dressing becomes solid state through heat exchange with the surroundings, the dressing material can be fixed to the wound area without a separate support. Particularly, since the wax can be easily fixed in a solid state even in a region where hair is present in the body, the thermoplastic wound dressing composition of the present invention including wax and dressing material can be easily The dressing material can be fixed.

As such wax, animal wax, vegetable wax, mineral wax or petroleum wax may be used.

Here, the animal wax may be at least one selected from beeswax, Chinese wax, lanolin, shellac wax and spermaceti.

The vegetable wax may be selected from the group consisting of bayberry wax, candelilla wax, carnauba wax, castor wax, esparto wax, Japan wax, Rice bran wax, soy wax, tallow tree wax, and the like may be selected from the group consisting of rice wax, rice wax, rice wax, and the like.

The mineral wax may be at least one selected from ceresin wax, montan wax, ozocerite and peat wax.

The petroleum wax may be paraffin wax or microcrystalline wax.

As the wax contained in the thermoplastic wound dressing composition according to an embodiment of the present invention, beeswax, paraffin wax, candelilla wax, soy wax may be used have.

On the other hand, the dressing material may include a hydrophilic polymer and a pressure-sensitive adhesive having hydrophobicity. The dressing material may be formed in the form of a hydrocolloid mixed with, for example, a pressure-sensitive adhesive and a hydrophilic polymer. However, the dressing material is not limited thereto and may be in any form of a mixture form capable of treating wounds.

The hydrophobic pressure-sensitive adhesive imparts adhesive properties to the dressing composition. That is, it is possible to impart an adhesive property to the skin to fix the wax to the wound site. In addition, the hydrophobic pressure-sensitive adhesive can serve as a support for the hydrophilic polymer. It is mixed with the wax to develop a proper adhesive force and does not cause pain due to excessive adhesive force when the dressing is removed.

Examples of the hydrophobic pressure-sensitive adhesive include polybutylene, polyisoprene, polyisobutylene, isobutylene rubber, polyethylene-propylene rubber, polyethylene-propylene diene-modified rubber, styrene-butadiene-styrene, styrene- A styrene-ethylene-butylene-styrene copolymer polymer, a polyester, a polyamide, an epoxy, a silicone resin, a fluororesin, a polystyrene resin, an acrylic resin, a methacrylic resin, an olefin resin or the like Such as, for example, resins derived from vegetable oils, resins derived from vegetable oils, avocado oil, lanolin oil, jojoba oil, mineral oil, silicone oil, tea tree oil, mink oil, isopropyl myristate, petroleum resin, rosin, alkylphenol- Resins, other hydrocarbon resins such as asphalt and bitumen, polyalkylated novolak resins, xylene-formaldehyde Paper, may be used to at least any one selected from urethane-based pressure-sensitive adhesive, silicone-based pressure-sensitive adhesive and acrylic pressure-sensitive adhesive.

The hydrophobic pressure sensitive adhesive included in the thermoplastic wound dressing composition according to an embodiment of the present invention is preferably polybutylene, polyisobutylene, styrene-isoprene-styrene, acrylic resin, olefin resin, mineral oil, Can be used.

On the other hand, the hydrophilic polymer can be dispersed in the hydrophobic adhesive and the wax in the form of fine particles. The hydrophilic polymer can play a role of absorbing the exudate at the wound site and creating a wet environment.

Examples of the hydrophilic polymer include chitosan, agarose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cellulose, dextran, xanthan gum, carrageenan, alginate, starch, alginic acid, pectin, gelatin, polyacrylate, Amide and polymethacrylate may be used.

The hydrophilic polymer included in the thermoplastic wound dressing composition according to an embodiment of the present invention may be preferably carboxymethyl cellulose, alginate, pectin, gelatin, and the like.

In the thermoplastic wound dressing composition, the content ratio of the dressing material to the wax may be from 2: 8 to 8: 2. The adhesive strength to the skin is excellent in the range of the dressing material and wax content ratio of 2: 8 and 8: 2, and it is possible to secure the necessity as a dressing material. Also, when the dressing material is removed from the skin in the above-described range, the residue of the hydrophilic polymer can be removed without a foreign object. And, the dressing material can be removed from the skin without pain. The most preferable content ratio of the dressing material to the wax is 4: 6. The adhesion of the thermoplastic wound dressing composition to the skin was the most appropriate in the range of 4: 6, and when removing the dressing material from the skin, the foreign body sensation and pain were the least.

In the thermoplastic wound dressing composition, 8 to 52% by weight of a tackifier, 7 to 40% by weight of a hydrophilic polymer and 20 to 80% by weight of a wax. In the above range, the adhesive force and absorbency of the thermoplastic wound dressing composition of the present invention can be ensured. Also, when the dressing material is removed from the skin, the foreign body sensation can be minimized.

Such thermoplastic wound dressing compositions can be made into ointments or creams in tubular containers, as shown in Fig. In this case, due to the wax component, the thermoplastic wound dressing composition is in a solid state at room temperature, but when heat is applied to the thermoplastic wound dressing composition, the wax is melted and the thermoplastic wound dressing composition can be applied to the skin. When the contained wax is cured after application, the wax supports the dressing material, and the solid wax is adhered to the skin. Further, the dressing material is also adhered to the skin by the adhesive contained in the dressing material.

On the other hand, the dressing material may further include an antibiotic or an antibacterial agent to help the wound healing. Even if the wound site is infected with an external bacterium or before it is infected, wound healing can be more easily performed by an antibiotic or an antibacterial agent.

The antibiotics included in the dressing may be selected from the group consisting of bacitracin, erythromycin, mupirocin, fusidic acid, neomycin, sulfacetamide sodium, poly Polymyxin B, and silver sulfadiazine. ≪ / RTI >

The antimicrobial agent is a natural antimicrobial agent which is an inorganic, organic or natural extract.

The inorganic antimicrobial agent is characterized by being at least one selected from silver, copper, zinc, copper, gold, platinum, calcium phosphate, zirconium phosphate, zeolite and manganese.

The organic antimicrobial agent is characterized by being at least one selected from chlorine, iodine compounds, phenol, alcohol, formalin and quaternary ammonium salts.

 The natural antimicrobial agent is at least one of phytoncide, grapefruit, fig, garlic, and extracts extracted from propolis.

On the other hand, as shown in FIG. 2, the thermoplastic wound dressing composition of the present invention can be coated on a coating material.

The coated material may be a woven fabric, a nonwoven fabric, a resin film, or the like, which is a surface on which the thermoplastic wound dressing composition of the present invention can be coated. Preferably, the material is liquid impermeable (waterproof) It is preferable to use a resin film. Examples of the resin film that can be used as the coating material include synthetic polymers such as polyurethane, polyethylene, silicone resin, natural rubber, synthetic rubber, polyglycolic acid, polylactic acid or copolymers thereof, polyvinyl alcohol, polyvinylpyrrolidone , Natural polymers such as collagen, gelatin, hyaluronic acid, sodium alginate, chitin, chitosan, fibrin and cellulose, or synthetic polymers derived therefrom, either alone or in combination.

In addition, the size and shape of the coated body are not limited, and they may be manufactured in a manner as described above for easy use by the user, and then cut into a predetermined size and then supplied to the rolls rolls.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Example  And Comparative Example

A thermoplastic wound dressing composition was prepared with the ingredients and contents shown in Table 1 below.

division Content (100% by weight) Dressing material Wax Comparative Example 1 13% by weight of a hydrophobic adhesive,
6% by weight hydrophilic polymer 81 wt% Example 1 8% by weight of a hydrophobic pressure-sensitive adhesive,
40% by weight of hydrophilic polymer 52 wt% Example 2 12% by weight of a hydrophobic pressure-sensitive adhesive,
32% by weight of hydrophilic polymer 56 wt% Example 3 16% by weight of a hydrophobic pressure-sensitive adhesive,
24% by weight of hydrophilic polymer 60 wt% Comparative Example 2 53% by weight of a hydrophobic adhesive,
28% by weight hydrophilic polymer 19 wt%

Based on the composition shown in Table 1, the hydrophilic polymer and the hydrophobic pressure-sensitive adhesive were mixed with the molten wax in a molten state at 60-100 ° C and stirred to disperse the hydrophilic polymer in the wax and the hydrophobic pressure-sensitive adhesive. Then, the thermoplastic wound dressing composition was prepared by allowing to stand at room temperature and then cooling.

Examples

The prepared thermoplastic wound dressing composition was used in a tube. The tube containing the composition was boiled in water at 48 DEG C to 100 DEG C (see FIG. 3A).

Subsequently, referring to Figs. 3B and 3C, the coagulated composition was applied to hairy skin areas. At this time, when the composition was in a molten state, it was easily applied to the skin part in the tube.

After the application was completed, the application was allowed to stand for a certain period of time, and the applied composition was fixed in a solid state at the skin area (see FIG. 3D). As described above, the composition of the present invention was easily applied to the skin area and fixed easily for use in the applied skin area. In particular, it can be easily applied and fixed to a hairy part of the body, and can function as a dressing material effective for wound healing.

Experimental Example

The thermoplastic wound dressing composition prepared was applied to the skin. The application process is as follows. The thermoplastic wound dressing composition was soaked in water at 48 [deg.] C to 100 [deg.] C to melt the solid wax at room temperature. The bath was maintained for 4 to 10 minutes. The thermoplastic wound dressing composition comprising molten wax was then applied to the skin. After the application, the skin stickiness was measured by standing for 1 hour. Thereafter, the applied thermoplastic wound dressing composition was removed from the skin, and a painful sensation such as a dressing residue remaining on the skin and removal was measured. The measurement results are shown in Table 2 below.

division Characteristic Adhesion to skin Foreign body feeling Pain at removal Comparative Example 1 X Low Low Example 1 △ Somewhat usually Example 2 ○ Somewhat less usually Example 3 ◎ Low Low Comparative Example 2 ◎ has exist Strong

As can be seen from Table 2 above, the thermoplastic wound dressing composition according to the present invention has excellent overall characteristics.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It will be understood that the invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (18)

CLAIMS 1. A thermoplastic wound dressing composition coated on a wound site of the skin,
A dressing material comprising a hydrophilic polymer and a pressure-sensitive adhesive having hydrophobicity; And
And a wax for supporting the dressing material. The method according to claim 1,
Wherein the content ratio of the dressing material to the wax is from 2: 8 to 8: 2. 3. The method of claim 2,
Wherein the dressing material comprises from 8 to 52% by weight of the tackifier and from 7 to 40% by weight of the hydrophilic polymer. The method according to claim 1,
The pressure-sensitive adhesive may be at least one selected from the group consisting of polybutylene, polyisoprene, polyisobutylene, isobutylene rubber, polyethylene-propylene rubber, polyethylene-propylene diene-modified rubber, styrene-butadiene-styrene, styrene- A styrene-ethylene-butylene-styrene copolymer polymer, a polyester, a polyamide, an epoxy, a silicone resin, a fluororesin, a polystyrene-based resin, an acrylic resin, a methacrylic resin, an olefin- An alkylphenol-aldehyde resin, a terpene resin, an aliphatic hydrocarbon resin, an aliphatic hydrocarbon resin, an aliphatic hydrocarbon resin, an alicyclic hydrocarbon resin, an alicyclic hydrocarbon resin, , Other hydrocarbon resins such as asphalt and bitumen, polyalkylated novolak resins, xylene-formaldehyde resins, Based adhesive agent, a urethane-based adhesive agent, a silicone-based adhesive agent, and an acrylic-based adhesive agent. The method according to claim 1,
Wherein the hydrophilic polymer is selected from the group consisting of chitosan, agarose, hydroxypropylmethylcellulose, hydroxyethylcellulose, carboxymethylcellulose, cellulose, dextran, xanthan gum, carrageenan, alginate, starch, alginic acid, pectin, gelatin, polyacrylate, Amide and polymethacrylic acid salts. ≪ RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
Wherein the dressing material further comprises an antibiotic or an antimicrobial agent. The method according to claim 6,
The antibiotic may be selected from the group consisting of bacitracin, erythromycin, mupirocin, fusidic acid, neomycin, sulfacetamide sodium, polymyxin B, B) and silver sulfadiazine. The thermoplastic wound dressing composition according to claim 1, The method according to claim 6,

Wherein the antimicrobial agent is an inorganic antimicrobial agent, an organic antimicrobial agent, or a natural antimicrobial agent. 9. The method of claim 8,
Wherein the inorganic antimicrobial agent is at least one selected from the group consisting of silver, copper, zinc, copper, gold, platinum, calcium phosphate, zirconium phosphate, zeolite and manganese. 9. The method of claim 8,
Wherein the organic antimicrobial agent is at least one selected from the group consisting of chlorine, iodine compounds, phenol, alcohol, formalin and quaternary ammonium salts. 9. The method of claim 8,
Wherein the natural antimicrobial agent is at least one selected from the group consisting of phytoncide, grapefruit, fig, garlic, and propolis. The method according to claim 1,
Wherein the wax is an animal wax, a vegetable wax, a mineral wax or a petroleum wax. 13. The method of claim 12,
Wherein the animal wax is at least one selected from the group consisting of beeswax, Chinese wax, lanolin, shellac wax and spermaceti. 13. The method of claim 12,
The vegetable wax may be selected from the group consisting of bayberry wax, candelilla wax, carnauba wax, castor wax, esparto wax, Japan wax, Wherein the thermoplastic wicking dressing composition is at least one selected from the group consisting of wax, wax, rice bran wax, soy wax, and tallow tree wax. 13. The method of claim 12,
Wherein the mineral wax is at least one selected from the group consisting of ceresin wax, montan wax, ozocerite and peat wax. The thermoplastic wicking dressing composition of claim 1, wherein the mineral wax is selected from the group consisting of ceresin wax, montan wax, ozocerite and peat wax. 13. The method of claim 12,
Wherein the petroleum wax is paraffin wax or microcrystalline wax. ≪ RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
Wherein upon application of heat to the thermoplastic wound dressing composition, the composition changes from a solid state to a molten state. The method according to claim 1,
Wherein the thermoplastic wound dressing composition is fixed in a solid state on the skin.

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