KR20180089394A - Packing structure of patches - Google Patents

Abstract

An object of the present invention is to provide a method for producing an absorbent article which has a wide sealability temperature range while suppressing adherence performance of a patch or preventing volatilization of percutaneous absorption components and opening the packaging structure, Provided is a package structure of a patch with excellent sealability that is difficult to cause defects.
[MEANS FOR SOLVING PROBLEMS] A package structure for packaging a patch with a packaging material, characterized in that the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, By virtue of the packaging structure of the adhesive patch in which the resin layer containing the polyolefin resin is provided and the resin layer containing the heat sealable resin layer and the cyclic polyolefin resin is directly laminated, the volatilization of the active ingredient can be suppressed , It is possible to realize a wide seal suitability temperature range and a satisfactory seal impurity.

Description

Packing structure of patches

The present invention relates to a packaging structure for packaging a patch with a packaging material.

BACKGROUND OF THE INVENTION [0002] Patch materials pasted on the skin surface are widely used for the purpose of administering the percutaneous absorption component to the body and protecting the scar. Such patches are usually packaged with a packaging material to prevent deterioration of the patching performance due to oxygen or moisture in the air and to prevent the evaporation of the percutaneous absorption component such as a medicine.

In the package structure of the adhesive patch, since the absorbability of the percutaneous absorption component is low, and the openability of the packaging structure is easy to be secured, a packaging structure using the polyacrylonitrile resin as the innermost layer of the packaging material for packaging the adhesive patch is widely used (See, for example, Patent Documents 1 and 2).

International Publication No. 2005/072675 Japan 2009-160389

However, in such a packaging structure using the polyacrylonitrile resin as described above, it is difficult to secure the seal strength depending on the bagging conditions, because the temperature range of the seal suitability when the package structure is formed by the heat seal is narrow There was a case. Further, since the packing structure is difficult to obtain adhesion when foreign matter adheres to the heat-sealed surface, such as liquid inflow at the time of heat-sealing and attachment of powder, it is difficult to reduce the yield due to poor adhesion in the production process .

A problem to be solved by the present invention is to provide a cushioning material which has a wide seal suitability temperature range while suppressing the application of the patch to the paste or suppressing the volatilization of the percutaneous absorption component and opening the packaging structure, And it is an object of the present invention to provide a packaging structure of a patch with excellent sealing property which is difficult to adhere tightly even when adhesion occurs.

In the present invention, in a packaging structure for packaging a patch with a packaging material, the innermost layer in the packaging structure of the packaging material is made of a heat-sealing resin layer containing an olefin resin, A resin layer containing a cyclic polyolefin resin is provided, and a resin layer containing a heat-sealable resin layer and a cyclic polyolefin resin is directly laminated.

That is, the present invention provides a packaging structure for packaging a patch with a packaging material, wherein the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, In which a heat-sealable resin layer and a resin layer containing a cyclic polyolefin-based resin are laminated directly on a resin layer containing a cyclic polyolefin-based resin.

The package structure of the patch of the present invention is characterized in that the heat seal layer in contact with the paste application agent when packaging the patch is made of a resin layer containing an olefin resin and a resin layer containing a cyclic polyolefin resin It is possible to prevent the adhesive performance of the adhesive patch or the volatilization of the percutaneous absorption component to be favorably suppressed and to provide a seal that is well-known in a wide temperature range, It is possible to achieve a satisfactory sealability of the impurity which is hard to cause adhesion failure even when foreign matter such as liquid inflow or powder adhesion at the time of heat sealing is adhered.

Further, according to the packaging structure of the present invention having the above-described constitution, it is possible to achieve a homogeneous impregnable sealing property which is excellent in the automatic packaging machine suitability and hardly causes adherence failure even when foreign matter such as liquid inflow or powder adhesion is adhered during heat sealing . In addition, the heat seal strength necessary for the integrated packaging in which the adhesive patch is picked up and packed can be developed. It is possible to suppress the occurrence of pinholes and darts (leak and sealability defects) in the corners of the packaging bag because steps caused by the thickness (height) of the purchasing overlapped adhesive agent occur. In addition, since the inner surface of the polyethylene-based resin can be thermally fused, the polyethylene-based chuck used when the opening and closing is required several times after opening can be thermally fused, thereby facilitating the handling.

The packaging structure of the present invention is a packaging structure in which a patch is packaged with a packaging material, and the innermost layer in the packaging structure of the packaging material is a heat-sealable resin layer containing an olefin resin, A packaging structure having a resin layer containing a cyclic polyolefin resin and directly stacking a resin layer containing a heat sealable resin layer and a cyclic polyolefin resin.

[Packing material]

The packaging material used in the packaging structure of the present invention is a heat sealable resin layer (hereinafter referred to as a heat seal layer A) containing an olefin resin as the innermost surface layer in the package structure, and the heat seal layer A (Hereinafter referred to as a cyclic polyolefin resin layer (B)) containing a cyclic polyolefin-based resin is directly laminated on the substrate.

(Heat seal layer (A))

As the olefin resin used in the heat seal layer (A), a polyethylene-based resin, a polypropylene-based resin, or a copolymer thereof can be used. Examples of the polyethylene-based resin include polyethylenes of very low density polyethylene (VLDPE), linear low density polyethylene (LLDPE), linear medium density polyethylene (LMDPE), low density polyethylene (LDPE), medium density polyethylene (MDPE), and high density polyethylene (EMA), ethylene-ethyl acrylate copolymer (EMA), ethylene-ethyl acrylate copolymer (EMA), ethylene-ethyl acrylate copolymer Ethylenic copolymers such as maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride, maleic anhydride and maleic anhydride; And an ionomer of an ethylene-acrylic acid copolymer and an ionomer of an ethylene-methacrylic acid copolymer. These may be used alone or in combination of two or more. In particular, the heat sealability such as suppression of the percolation of the percutaneous absorption component and the deterioration of the adhesive performance of the patch (hereinafter sometimes referred to as volatilization of the active ingredient) and a wide range of heat seal suitability for temperature, LLDPE can be used preferably.

The LDPE may be a low-density polyethylene in the form of a powder obtained by a high-pressure radical polymerization method, preferably a low-density polyethylene in the form of a homopolymer of ethylene by a high-pressure radical polymerization method.

As LLDPE and LMDPE, a low-pressure radical polymerization method using a single-site catalyst is used in which an ethylene monomer is used as a main component and an? -Olefin such as butene-1, hexene-1, octene- . The comonomer content is preferably in the range of 0.5 to 20 mol%, more preferably in the range of 1 to 18 mol%.

Examples of the single site catalyst include various single site catalysts such as a metallocene catalyst system such as a combination of a metallocene compound of transition metal IV or V of the periodic table and an organoaluminum compound and / or an ionic compound. Since the active sites of the single site catalyst are homogeneous, the molecular weight distribution of the obtained resin becomes sharp compared with the multi-site catalyst having nonuniform active sites. Therefore, when a film is formed on the film, precipitation of low molecular weight components is small, It is preferable that a resin having excellent physical properties such as adhesion strength is obtained.

The MFR (190 캜, 21.18 N) of the polyethylene-based resin is preferably 2 to 20 g / 10 min, more preferably 3 to 10 g / 10 min. When the MFR is in this range, extrusion moldability of the film is improved. The density of LLDPE is preferably from 0.905 g / cm3 to 0.925 g / cm3 from the viewpoints of packing suitability, impregnating sealability and pinhole resistance, and particularly preferably from 0.915 g / cm3 to 0.925 g / cm3 Is particularly preferable.

Examples of the polypropylene resin include propylene homopolymer, propylene -olefin random copolymer, propylene-ethylene copolymer, propylene-butene-1 copolymer, propylene-ethylene-butene-1 copolymer, Based catalyst-based polypropylene and the like. These may be used alone or in combination. Preferred is a propylene /? - olefin random copolymer, particularly a propylene /? - olefin random copolymer that is polymerized using a metallocene catalyst. When these polypropylene resins are used as the intermediate layer (B), the heat resistance of the film is improved and the softening temperature can be increased. Therefore, vapor such as boiling at 100 DEG C or less, hot filling, retort sterilization at 100 DEG C or higher · It can be suitably used as a laminate film for packaging materials having excellent high-pressure heat sterilization properties.

The polypropylene resin preferably has a MFR (230 캜) of 0.5 to 30.0 g / 10 min and a melting point of 110 to 165 캜, more preferably a MFR (230 캜) of 2.0 to 15.0 g / 10 minutes and a melting point of 115 to 162 ° C. When the MFR and the melting point are in this range, the film formability of the film is improved.

The heat seal layer (A) is preferably composed mainly of an olefin resin, because it is easy to ensure a wide range of heat seal suitability temperature range and it is easy to realize a favorable adhesion property. The heat seal layer (A) Is preferably an olefin resin other than the cyclic olefin-based resin as described above, more preferably 90 mass% or more, and particularly preferably 100 mass% or more. Further, 80% by mass of the olefin resin contained in the heat seal layer (A) is preferably an olefin resin having a density of 0.9 g / cm3 or more, because adhesion is easily obtained, and more preferably 90% by mass or more. In particular, 80% by mass of the olefin resin contained in the heat seal layer (A) is preferably a linear low density polyethylene resin, more preferably 90% by mass or more.

It is also preferable to contain a cyclic polyolefin resin in the heat seal layer (A) for suppressing volatilization or the like of the active ingredient. However, since it is easy to secure heat sealability such as a wide range of heat seal suitability temperature range and favorable adhesion, ) Is preferably 10 mass% or less, more preferably 5 mass% or less, and particularly preferably substantially no content. The content of the cyclic polyolefin-

The thickness of the heat seal layer (A) may be appropriately adjusted according to the manner of use, but it is preferable that the thickness of the heat seal layer (A) is in the range of 2 to 8 mu m since it is easy to secure favorable heat sealability while suppressing volatilization of the active ingredient , And more preferably 3 to 6 mu m.

(Cyclic polyolefin resin layer (B))

Examples of the cyclic polyolefin resin used in the cyclic polyolefin resin layer (B) include a norbornene polymer, a vinyl alicyclic hydrocarbon polymer, and a cyclic conjugated diene polymer. Of these, norbornene polymers are preferred. Examples of the norbornene polymer include a ring-opening polymer of a norbornene monomer (hereinafter referred to as "COP"), a norbornene copolymer (hereinafter referred to as "COC") obtained by copolymerizing a norbornene monomer and an olefin such as ethylene ) And the like. Further, hydrogenated products of COP and COC are particularly preferable. The weight average molecular weight of the cyclic olefin based resin is preferably from 5,000 to 500,000, more preferably from 7,000 to 300,000.

The norbornene polymer and the norbornene monomer as a raw material are alicyclic monomers having a norbornene ring. Examples of such norbornene monomers include norbornene, norbornene, tetracyclododecene, ethylidene norbornene, vinyl norbornene, ethylidene tetracyclododecene, dicyclopentadiene, dimethanotetrahydrofuran Phenylenorbornene, methoxycarbonylnorbornene, methoxycarbonyltetracyclododecene, and the like can be given. These norbornene monomers may be used alone or in combination of two or more.

The norbornene copolymer is obtained by copolymerizing an olefin copolymerizable with the above norbornene monomer. Examples of such olefins include olefins having 2 to 20 carbon atoms such as ethylene, propylene and 1-butene ; Cycloolefins such as cyclobutene, cyclopentene, and cyclohexene; And non-conjugated dienes such as 1,4-hexadiene. These olefins may be used alone or in combination of two or more.

As the cyclic polyolefin-based resin, a ring-opening polymer (COP) of a norbornene monomer may be used as a commercially available product, for example, "ZEONOR" manufactured by Nippon Zeon Co., Ltd., and a norbornene- (COC) include, for example, "Aperu" manufactured by Mitsui Chemicals, Inc., and "TOPAS" manufactured by Polyplastics Shuze.

In the present invention, by using a packaging material in which the cyclic polyolefin resin layer (B) containing such a cyclic polyolefin resin is directly laminated with the heat seal layer (A), it is possible to prevent volatilization of the active ingredient, Can be realized.

The cyclic polyolefin resin layer (B) is preferably composed mainly of a cyclic polyolefin-based resin, since it is easy to suppress volatilization of an effective component and easily obtain a good opening property by heat of a packaging material. More preferably, at least 60 mass% of the resin component constituting the polyolefin resin layer (B) is a cyclic polyolefin resin, more preferably 80 mass% or more, and particularly preferably 90 mass% or more.

Further, 40% or more by mass of the resin component contained in the cyclic polyolefin resin layer (B) is added to the resin composition of the cyclic polyolefin resin layer (B) so that the glass transition point (Tg) Or less, more preferably 50 mass% or more, and particularly preferably 50 to 80 mass%, based on the total weight of the polyolefin resin. In the present invention, the glass transition point, melting point and the like are values measured by differential scanning calorimetry (DSC). The glass transition temperature of the low-Tg cyclic polyolefin-based resin is more preferably 90 deg. C or lower, particularly preferably 60 to 80 deg.

It is also preferable to use a cyclic polyolefin-based resin having a glass transition point of 100 占 폚 or less and a high-Tg cyclic polyolefin-based resin having a glass transition point of more than 100 占 폚 in combination with a cyclic polyolefin-based resin having a low Tg. By using a combination of a low-Tg cyclic polyolefin-based resin and a high-Tg cyclic polyolefin-based resin, it is easy to improve the tensile strength and heat resistance (tear resistance) of the resulting packaging material. The content of the high-Tg cyclic polyolefin-based resin tends to increase the tensile strength and heat resistance of the resulting packaging material, and it is easy to obtain favorable rigidity and sealability, and pinholes are easily suppressed. Therefore, the content of the cyclic polyolefin- Is preferably 60 mass% or less, more preferably 50 mass% or less, and particularly preferably 20 to 50 mass%, of the resin component contained in the resin composition. The glass transition temperature of the high-Tg cyclic polyolefin-based resin is preferably 120 占 폚 or higher, more preferably 130 占 폚 or higher, and particularly preferably 135 to 150 占 폚.

Among the cyclic polyolefin resin layers (B), the polyolefin resins such as polypropylene resins and polyethylene resins that do not contain a cyclic structure may be used in combination to improve heat resistance and breakage resistance Valid. When a polyolefin-based resin containing no cyclic structure is used, it is preferably 20% by mass or less, more preferably 10% by mass or less in the resin component contained in the cyclic polyolefin-based resin layer (B) , And more preferably 5 mass% or less. The lower limit of the content of the polyolefin resin containing no cyclic structure is preferably 1% by mass or more, and more preferably 2% by mass or more.

The thickness of the cyclic polyolefin resin layer (B) can be appropriately adjusted according to the manner of use. However, it is easy to secure a homogeneous impregnable sealing property while suppressing the volatilization of the active ingredient and the like, More preferably from 3 to 12 占 퐉, further preferably from 4 to 10 占 퐉, and particularly preferably from 5 to 8 占 퐉.

(Layer composition)

The packaging material used in the present invention is a packaging material comprising a laminated film in which at least the heat seal layer (A) and the cyclic polyolefin resin layer (B) are laminated. The layer structure of the laminated film used as the packaging material may be a layer structure of (A) / (B) composed of the heat seal layer (A) and the cyclic polyolefin resin layer (B) (Hereinafter referred to as a resin layer (C)) containing an olefin resin and a cyclic polyolefin resin layer (hereinafter referred to as a resin layer (D)) containing a cyclic polyolefin resin may be laminated .

Layer structure of (A) / (B) / (C), (A) / (B) / (D) B) / (C) / (D), and the like. Among them, the constitution of (A) / (B) / (C) / (D) is preferable because performance such as suppression of volatilization of the active ingredient, openability, heat sealability and the like can be easily adjusted easily. The layer (A) and the layer (C), the layer (B) and the layer (D) may be the same or different.

In the packaging material used in the present invention, by providing the resin layer (C), the flexibility, cold resistance, impact resistance, pinhole resistance, impregnating sealing property, lining resistance and the like of the packaging material can be suitably adjusted. For this reason, the olefin resin used for the resin layer (C) is desirably selected appropriately according to the use and the manner of use.

As the olefin resin used in the resin layer (C), an olefin resin similar to that of the heat seal layer (A) can be preferably used, but it is easy to obtain interlayer adhesion with other layers, It is preferable to use a polyethylene resin or a polypropylene resin, and a polyethylene resin is particularly preferable.

The polyethylene-based resin preferably has a density of 0.915 to 0.950 g / cm 3, more preferably a density of 0.920 to 0.945 g / cm 3, because it is easy to obtain cold resistance, pinhole resistance, Can be used. In general, the melting point is preferably in the range of 70 to 130 占 폚, more preferably 80 to 125 占 폚. When the melting point is in this range, processing stability and co-extrusion processability with the cyclic polyolefin resin (a) are improved. The MFR (190 DEG C, 21.18 N) of the polyethylene-based resin is preferably 2 to 20 g / 10 min, more preferably 3 to 10 g / 10 min. When the MFR is in this range, extrusion moldability of the film is improved.

Of the polyethylene-based resins, LLDPE and LMDPE can be particularly preferably used since it is easy to obtain a good opening property by phosphorus and a pinhole property of a packaging material.

The polypropylene resin preferably has a MFR (230 占 폚) of 0.5 to 30.0 g / 10 min and a melting point of 110 to 165 占 폚, more preferably a MFR (230 占 폚) of 2.0 to 15.0 g / Min and a melting point of 115 to 162 ° C. When the MFR and the melting point are in this range, the film formability of the film is improved.

The content of the olefin resin in the resin layer (C) is preferably 80% by mass or more of the resin component constituting the resin layer (C), and more preferably 90% by mass or more.

In addition, resins other than the olefin-based resin may be mixed in a range that does not impair the effects of the present invention. As other resins that can be mixed at this time, it is preferable that a coextrusion lamination method such as the above-mentioned cyclic polyolefin resin can be applied.

The thickness of the resin layer (C) may be adjusted in accordance with the intended use, but it is preferably from 10 to 30 탆, more preferably from 13 to 20 탆, since it is easy to obtain good packing suitability and sealability.

With the above-described constitution, the packaging material used in the present invention can satisfactorily suppress the migration of the adhesive component in the case of laminating the base material described later or the printing ink in the case of providing the printing layer, By providing the resin layer (D), it can be particularly advantageously suppressed. In addition, it is preferable to adjust the curling resistance and the like.

As the cyclic polyolefin-based resin used for the resin layer (D), a cyclic polyolefin-based resin similar to that of the cyclic polyolefin-based resin layer (B) can be preferably used.

The resin layer (D) is preferably composed mainly of a cyclic polyolefin resin, and it is preferable that at least 80% by mass of the resin component constituting the resin layer (C) is a cyclic polyolefin resin, more preferably 90% by mass or more desirable.

The glass transition point of the cyclic polyolefin-based resin used for the resin layer (D) is preferably not higher than 200 占 폚 in terms of easiness of production by the coextrusion lamination method with other resin layers and easiness of obtaining the industrial raw material . As the cyclic polyolefin-based resin having such a Tg, the content of the norbornene-based monomer is preferably in the range of 40 to 90 mass%, more preferably 50 to 90 mass%, further preferably 60 to 85 mass% to be. When the content ratio is within this range, it is easy to improve the rigidity, easy tear property and laminate characteristics.

Further, since it is easy to inhibit the transition from the contents to the laminate layer of a low molecular weight compound and a volatile component, a high-Tg cyclic polyolefin-based resin having a glass transition point exceeding 100 캜 is mixed with a resin component By mass to 20% by mass to 60% by mass, and more preferably 20% by mass to 50% by mass. This range is preferable because it is easy to improve the heat resistance and stiffness of the resulting packaging material. The glass transition temperature of the high-Tg cyclic polyolefin-based resin is preferably 120 占 폚 or higher, more preferably 130 占 폚 or higher, and particularly preferably 135 to 150 占 폚.

On the other hand, the norbornene copolymer having a high Tg has a low tensile strength and is likely to be extremely broken and easily torn. Therefore, the balance between the rollability and the rollability at the time of film formation, slitting, It is also preferable to blend a cyclic polyolefin resin having a low Tg and a glass transition point having a glass transition point of 100 DEG C or lower together with the cyclic polyolefin resin having a high Tg. Particularly, it is preferable that COC having a Tg of less than 100 占 폚 is blended in order to exhibit a high seal strength and improve the resistance to rupture. The content of the low-Tg cyclic polyolefin-based resin is more preferably 50 mass% or more, and particularly preferably 50 to 80 mass% in the resin component contained in the resin layer (D). The glass transition temperature of the low-Tg cyclic polyolefin-based resin is more preferably 90 deg. C or lower, particularly preferably 60 to 80 deg.

It is also effective to blend a polyolefin resin such as a polypropylene resin or a polyethylene resin which has good compatibility with COC and does not contain a cyclic structure in the resin layer (D). When a polyolefin-based resin containing no cyclic structure is used, it is preferably 20% by mass or less, more preferably 10% by mass or less in the resin component contained in the cyclic polyolefin-based resin layer (B) , And more preferably 5 mass% or less. The lower limit of the content of the polyolefin resin containing no cyclic structure is preferably 1% by mass or more, and more preferably 2% by mass or more.

The thickness of the resin layer (D) may be appropriately adjusted in accordance with the intended use, but is preferably 1 to 10 탆, more preferably 2 to 8 탆, 5 mu m.

The laminated film used in the packaging material can be obtained by a conventional method in which the total thickness of the laminated film used for the packaging material is in the range of 10 to 100 Mu m, and more preferably in the range of 20 to 60 mu m.

When the four-layer structure of (A) / (B) / (C) / (D) is used as the layer constitution of the packaging material, it is easy to obtain favorable heat sealing property and easily suppress the volatilization of the active ingredient The thickness ratio of the layer (A) to the total thickness is preferably 10 to 25%, more preferably 10 to 20%. In addition, since it is easy to suppress the volatilization of the active ingredient and easy to obtain a good opening property, it is preferable that the thickness ratio to the total thickness of the layer (B) is 15 to 30%. Further, it is preferable that the ratio of the total thickness of the layer (D) and the layer (B) to the total thickness is 40% or more and 60% or less. The total thickness of the cyclic polyolefin resin layer (B) and the resin layer (C) can be appropriately adjusted in accordance with the intended use. However, since it is easy to ensure the desired opening property while suppressing volatilization of the active component, More preferably 6 to 15 mu m, and more preferably 8 to 13 mu m.

If necessary, components such as an antifogging agent, an antistatic agent, a heat stabilizer, a nucleating agent, an antioxidant, a lubricant, an anti-blocking agent, a release agent, an ultraviolet absorber and a colorant may be added to each resin layer, Lt; / RTI > Particularly, in order to impart processing suitability in film molding and packaging suitability of a charger, the coefficient of friction on the surface of the film of layers (A) and (D) is preferably 1.5 or less, ), It is preferable to add an actinic agent or an anti-blocking agent.

The method for producing the laminated film is not particularly limited, and for example, each resin or resin mixture used for each layer may be heated and melted by a separate extruder, and may be formed by a method such as coextrusion multilayer dice method or feed block method A coextrusion method in which each layer is laminated in a molten state and then molded into a film by inflation or a T-die / chill roll method can be preferably used. The co-extrusion method is preferable because a laminated film excellent in hygiene and excellent in cost performance can be obtained because the ratio of the thickness of each layer can be adjusted relatively freely. When a low-density polyethylene resin is used for the resin layer to be laminated with the layer containing the cyclic polyolefin resin used in the present invention, since the difference between the melting point and the Tg is large between them, the appearance of the film deteriorates during co- , It may be difficult to form a uniform layer structure. In order to suppress such deterioration, a T-die-chill roll method capable of melt extrusion at a relatively high temperature is preferable.

The packaging material to be used in the present invention may be a packaging material composed of the laminated film, but it is also possible to use the laminated film as a sealant film, and a packaging material made of a laminated film . As the base material, it is preferable to use a plastic substrate having high rigidity and high gloss, particularly a biaxially stretched resin film. In the case of applications that do not require transparency, aluminum foil may be used alone or in combination.

Examples of the stretched resin film include biaxially oriented polyester (PET), diatomaceous biaxially oriented polyester (PET), biaxially oriented polypropylene (OPP), biaxially oriented polyester Coextruded biaxially oriented polypropylene with polyamide (PA), ethylene vinyl alcohol copolymer (EVOH) as the core layer, coextruded biaxially oriented polypropylene coated with biaxially oriented ethylene vinyl alcohol copolymer (EVOH) and polyvinylidene chloride (PVDC) And stretched polypropylene. These may be used alone or in combination.

The laminate film is a film formed by laminating the above-described substrates on the laminated film obtained by the above-mentioned production method. Examples of the lamination method include dry lamination, wet lamination, non-solvent lamination, extrusion lamination and the like .

Examples of the adhesive used in the dry lamination include a polyether-polyurethane-based adhesive and a polyester-polyurethane-based adhesive. Various pressure sensitive adhesives can also be used, but it is preferable to use a pressure sensitive pressure sensitive adhesive. Examples of the pressure-sensitive adhesive include pressure-sensitive adhesives prepared by dissolving polyisobutylene rubber, butyl rubber, a mixture thereof in an organic solvent such as benzene, toluene, xylene and hexane, Ester, terpene-phenol copolymer, terpene-indene copolymer or the like, or a combination of 2-ethylhexyl acrylate-n-butyl acrylate copolymer, 2-ethylhexyl acrylate-ethyl acrylate-methacrylate Acrylate-based pressure sensitive adhesives obtained by dissolving an acrylic copolymer having a glass transition point of -20 占 폚 or lower in an organic solvent, and the like.

In the case of laminating the base material, the outermost surface of the base material of the laminated film may be laminated in order to improve the applicability of the above-mentioned adhesive or pressure-sensitive adhesive, or to laminate the base material after printing on the outermost surface It is preferable to carry out a surface treatment in order to improve the adhesion to the adhesive, the pressure-sensitive adhesive, and the printing ink. Such surface treatment may be, for example, surface oxidation treatment such as corona treatment, plasma treatment, chromic acid treatment, flame treatment, hot air treatment, ozone / ultraviolet ray treatment, or surface roughening treatment such as sandblasting, Is a corona treatment. If the surface on which the substrate is laminated is a layer containing a cyclic polyolefin resin, even after long-term storage after such treatment, there is no deterioration over time, and thus the final product can be stably provided.

[Patchwork]

The patch according to the present invention is used as a dressing agent, a paste agent, a plasters, a dressing agent, a transdermal absorption tape preparation or the like, which is used for attaching to human or animal skin for the purpose of administration of medicines, to be. As the form of the patch, a form in which a pressure-sensitive adhesive layer is provided on one side or both sides of the support is preferably exemplified. If necessary, the pressure-sensitive adhesive layer contains a percutaneous absorption component such as a medicament. Further, a release liner may be provided on the surface of the pressure-sensitive adhesive layer. According to the packaging structure of the present invention, when such a patch is used, volatilization of the active ingredient can be suppressed inevitably.

As the support used in the patch, those which are hardly permeable to the percutaneous absorption component or the like contained in the pressure-sensitive adhesive layer can be preferably used. Examples of such a support include resin films and metal foils such as polyester, nylon, polyethylene, polypropylene, polyvinyl chloride, ethylene-ethyl acrylate copolymer and polytetrafluoroethylene. In addition, a film obtained by laminating these films or the like may be used. The thickness of the support is preferably 10 to 500 mu m, more preferably 10 to 200 mu m.

The pressure-sensitive adhesive to be used for the pressure-sensitive adhesive layer can be used without particular limitation as long as it has adhesiveness to the skin. Examples of the pressure sensitive adhesive include acrylic pressure sensitive adhesives, rubber pressure sensitive adhesives such as SIS (styrene-isoprene-styrene), SBS (styrene-butadiene-styrene), polyisoprene and polybutadiene, silicone pressure sensitive adhesives, vinyl ester pressure sensitive adhesives, Based adhesives, and the like. Among them, an acrylic pressure-sensitive adhesive can be preferably used because it is easy to contain a large amount of percutaneous absorption component in the pressure-sensitive adhesive and easily attaches to a well-known skin. In addition, the rubber-based pressure-sensitive adhesive is preferable because stability of the percutaneous absorption component and the like is easily obtained.

As the percutaneous absorption component to be contained in the pressure-sensitive adhesive layer, various physiologically active ingredients can be used depending on the use thereof, and examples thereof include an anesthetic drug, sedative drug, antidepressant drug, antipyretic analgesic drug, , An autonomic nerve drug, an antihistamine drug, a cardiovascular drug, an arrhythmia drug, a diuretic drug, a blood pressure lowering drug, a blood vessel lowering drug, a vasodilator, a peripheral vasodilator, atherosclerotic drug, Hormone drugs, external medicine for purulent diseases, anti-inflammatory drugs, hemostatic drugs, antipyretic drugs, diabetic drugs, anti-malignant tumor drugs, antibiotics, and anti-smoking medicines.

[Packing Structure]

The packaging structure of the present invention is a packaging structure in which a patch is packaged with a packaging material, and the package is packaged with the heat seal layer (A) of the packaging material as the innermost face. As the packaging structure, there is a structure in which a patch is sandwiched between two packaging materials on a film, heat sealing is applied to the periphery of the patch material, and a structure in which the paste material is sandwiched in one packaging material on the film, A package structure in which a roll film is sealed in a cylinder (pillow) shape by an automatic packaging machine, and then the top and bottom are sealed.

In the package structure of the present invention, an arbitrary tear initiation portion such as V notch, I notch, seam, or micropores may be formed on the seal portion in order to weaken the initial tear strength and improve the openability. In addition, a polyethylene-based chuck which can be opened and closed after opening may be provided on a part of the packaging structure.

The packaging structure of the present invention is advantageous in that it has the effect of suppressing the adherence performance of the patch and the volatilization of the percutaneous absorption component in a favorable manner, Seal adherence can be ensured and even when foreign matter such as liquid inflow or powder adhesion at the time of heat sealing is adhered, it is possible to achieve a homogeneous impregnant sealability in which adhesion failure is less liable to occur, Can be applied. Further, the packaging material used in the packaging structure of the present invention is excellent in the suitability of the automatic packaging machine, and it is possible to achieve a satisfactory impregnated sealability. In addition, it is possible to exhibit the heat seal strength necessary for the integrated packaging in which the adhesive patch is picked up and packed, and the occurrence of pinholes and darts (leak and sealability defects) in the corner portion of the packaging structure can be suppressed. Further, since the innermost heat seal layer can also be thermally fused with the polyethylene-based resin, it is also possible to provide a polyethylene-based chuck for use when opening and closing are required several times after opening.

(Example)

Next, the present invention will be described in more detail with reference to examples and comparative examples.

(Example 1)

As the resin component for forming each layer of the heat seal layer (A), the cyclic olefin resin layer (B), the intermediate resin layer (C) and the outermost resin layer (D) The resin and the resin mixture to be formed were adjusted.

≪ Heat seal layer (A) >

100 parts by mass of a linear low density polyethylene (density: 0.920 g / cm3, melting point 110 占 폚, MFR: 5 g / 10 minutes (190 占 폚, 21.18 N; hereinafter referred to as "LLDPE

≪ Cyclic olefin-based resin layer (B) >

15 g / 10 min (260 占 폚, 21.18 N), glass transition point: 70 占 폚, hereinafter referred to as "COC (1) 10 g / 10 min (260 占 폚, 21.18 N), glass transition point: 145 占 폚 (manufactured by Mitsui Chemicals, Inc.), 50 parts by mass of a norbornene- ; Hereinafter, referred to as " COC (2) ") 50 parts by mass

≪ Intermediate layer (C) >

(Hereinafter referred to as " LMDPE ") 100 parts by mass of a straight-chain-density polyethylene having a density of 0.930 g / cm3, a melting point of 125 占 폚, and an MFR of 5 g /

≪ Outermost layer (D) >

50 parts by mass of COC (1), 50 parts by mass of COC (2)

These resins were extruded for an extruder (diameter 50 mm) for the heat seal layer (A), an extruder (diameter 50 mm) for the cyclic olefin resin layer (B), an extruder (diameter 50 mm) for the intermediate layer (C) (Diameter: 40 mm), melted at 200 to 250 캜, and the molten resin was fed to a co-extruded multilayer film production apparatus (feed block and T-die temperature: 250 캜 (A) / (B) / (C) / (D), and the thickness of each layer was 3 μm / 6 μm / 15 μm / 6 mu m (total 30 mu m) was obtained, and then the surface of the outermost layer (D) was corona-treated. The surface tension due to the wetting reagent on the corona treated surface was 42 dyne / cm.

A urethane-based adhesive was applied to the corona-treated side so as to have an amount of 3.5 g / m 2, and then a biaxially stretched polyester film (thickness: 12 탆, melting point 260 캜, Toyobo Co.) was dry-laminated to obtain a laminated film.

(Example 2)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin components used in the cyclic olefin resin layer (B) and the outermost layer (D) were changed to the following ones, and the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 42 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

50 parts by mass of COC (1), 47 parts by mass of COC (2), linear low density polyethylene (density: 0.920 g / cm3, melting point 120 占 폚, MFR: 5 g / (2) ") 3 parts by mass

≪ Outermost layer (D) >

50 parts by mass of COC (1), 47 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 3)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

60 parts by mass of COC (1), 40 parts by mass of COC (2)

≪ Outermost layer (D) >

60 parts by mass of COC (1), 37 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 4)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

70 parts by mass of COC (1), 27 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

50 parts by mass of COC (1), 47 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 5)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. A biaxially stretched polyamide film (thickness 15 占 퐉, melting point 260 占 폚, manufactured by Unichica Corp.) was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

50 parts by mass of COC (1), 47 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

60 parts by mass of COC (1), 37 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 6)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

, 60 parts by mass of COC (1), a ring-opening polymer of a norbornene monomer ("APERU AP6013T" manufactured by Mitsui Chemicals, Inc., MFR: 15 g / 10 min (260 캜, 21.18 N) ; Hereinafter, referred to as " COC (3) "), 3 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

70 parts by mass of COC (1), 30 parts by mass of COC (2)

(Example 7)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin components used in the cyclic olefin resin layer (B), the intermediate layer (C), and the outermost layer (D) Corona treatment was carried out. The surface tension due to the wetting reagent on the corona treated surface was 45 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

50 parts by mass of COC (1), 47 parts by mass of COC (3), 3 parts by mass of LLDPE (2)

≪ Intermediate layer (C) >

LLDPE (2) 100 parts by mass

≪ Outermost layer (D) >

50 parts by mass of COC (1), 47 parts by mass of COC (2), 5 parts by mass of LLDPE (2)

(Example 8)

Extruded so that the thickness of each layer was (A) / (B) / (C) / (D) = 5 탆 / 6 탆 / 16 탆 / 3 탆 (total 30 탆) An extruded multilayer film was produced, and the surface of the surface layer (D) was subjected to corona treatment. The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

(Example 9)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 42 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

27 parts by mass of COC (1), 70 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

27 parts by mass of COC (1), 70 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 10)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

20 parts by mass of COC (1), 80 parts by mass of COC (2)

≪ Outermost layer (D) >

COC (2) 100 parts by mass

(Example 11)

(A) / (B) / (C) / (D) = 7 占 퐉 / 6 占 퐉 / 2 where the resin components used in the cyclic olefin resin layer (B) and the outermost layer (D) Extruded so as to have a thickness of 14 mu m / 3 mu m (total thickness 30 mu m), and the surface of the surface layer (D) was subjected to corona treatment. The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

97 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

17 parts by mass of COC (1), 80 parts by mass of COC (2), 3 parts by mass of LLDPE (2)

(Example 12)

A coextruded multilayer film was produced in the same manner as in Example 1 except that the resin component used in the cyclic olefin resin layer (B) and the outermost layer (D) was changed to the corona treatment on the surface layer (D) . The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Cyclic olefin-based resin layer (B) >

50 parts by mass of COC (2), 50 parts by mass of LLDPE (2)

≪ Outermost layer (D) >

50 parts by mass of COC (1), 50 parts by mass of LLDPE (2)

(Example 13)

A coextruded multilayer film was prepared in the same manner as in Example 2 except that the resin component used in the heat seal layer (A) was changed to the corona treatment on the surface of the surface layer (D). The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Heat seal layer (A) >

100 parts by mass of linear low density polyethylene (density: 0.905 g / cm3, melting point 95 占 폚, MFR: 4 g / 10 minutes (190 占 폚, 21.18 N; hereinafter referred to as "LLDPE (3)

(Example 14)

A coextruded multilayer film was prepared in the same manner as in Example 2 except that the resin component used in the heat seal layer (A) was changed to the corona treatment on the surface of the surface layer (D). The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Heat seal layer (A) >

90 parts by mass of LLDPE (1), 10 parts by mass of COC (2)

(Example 15)

A coextruded multilayer film was prepared in the same manner as in Example 2 except that the resin component used in the heat seal layer (A) was changed to the corona treatment on the surface of the surface layer (D). The surface tension due to the wetting reagent on the corona treated surface was 43 dyne / cm. The biaxially stretched polyester film was dry-laminated on the treated side in the same manner as in Example 1 to obtain a laminated film.

≪ Heat seal layer (A) >

70 parts by mass of LLDPE (1), 30 parts by mass of COC (2)

(Example 16)

A coextruded multilayer film was produced in the same manner as in Example 1, and the surface of the surface layer (D) was subjected to corona treatment. The surface tension due to the wetting reagent on the corona treated surface was 42 dyne / cm. A urethane adhesive was applied to the corona-treated side so as to have an amount of 3.5 g / m 2, and then an aluminum foil (12 탆) and a biaxially stretched polyester film (thickness: 12 탆, melting point 260 캜, Toyobo Co., Followed by dry lamination to obtain a laminated film.

(Comparative Example 1)

One side of a polyacrylonitrile-based resin film (Hytron BX, Tama Polysha, thickness 20 μm) was subjected to corona treatment, and a biaxially stretched polyester film was dry-laminated on the corona-treated side in the same manner as in Example 1 to obtain a laminate film ≪ / RTI >

(Comparative Example 2)

Ethylene vinyl alcohol copolymer resin film

(Evar film EF-E, Krresha Co., thickness 30 탆) was corona-treated on one side of the corona-treated side, and the biaxially stretched polyester was dry-laminated on the corona treated side in the same manner as in Example 1 to obtain a laminated film.

(Comparative Example 3)

One side of an LLDPE copolymer resin film (DIFARENL3500T, DIC SHARSE, thickness 30 mu m) was subjected to corona treatment, and the biaxially stretched polyester was dry laminated on the corona treated side in the same manner as in Example 1 to obtain a laminated film.

The following evaluations were performed on the films obtained in the above-mentioned Examples and Comparative Examples. The obtained results are shown in the following table.

[Loss Resistance Test]

The obtained laminated film was cut into test pieces each having a size of 63 mm x 76 mm in accordance with JIS K7128, and the tear strength was measured using an Elmendorf tearing tester (manufactured by TESTER SANGYO KK). From the obtained tear strength, the cutability was evaluated according to the following criteria.

○: Tear strength less than 110

X: Tear strength of 110 or more

[Adsorption test]

Each laminate film was made into a three-chamber seal pouch having a length of 100 mm and a width of 100 mm. After the mass was measured, 2 g of methyl salicylate (adsorption test 1) and chlorine dioxide (crepeling gel: Daikoyaku) And the opening was sealed with a heat seal. The container was allowed to stand at 25 DEG C under a constant temperature of 25 DEG C for 4 weeks, opened, and the contents were removed. The mass of the pouch was measured, and the adsorption rate was determined from the rate of change.

◎: Less than 2%

○: 2% or more and less than 5%

×: 5% or more

[Sealability of impurities (1)]

(Seal temperature: 150 占 폚, seal pressure: 0.2 MPa, seal time: 10 minutes) was applied to the seal layer surface of the laminate film prepared above with a cotton swab, 1 second). The strength before and after coating was measured to determine the rate of decrease in strength.

[Sealability of impurities (2)]

The sealant layer surface of the laminate film prepared above was dispersed with soluble cotton starch (research reagent: Aswan Co.) with a cotton swab and after 3 minutes, the seal surfaces were sealed with a seal (seal temperature: 150 ° C, seal pressure: 0.4 MPa, seal time: did. The strength before and after coating was measured to determine the rate of decrease in strength.

◎: Less than 10%

O: 10% to 20%

×: 20% or more

[Packing machine aptitude]

Each laminate film was formed into a four-chamber seal pouch having a length of 45 mm and a width of 85 mm while changing the seal temperature with a vertical type filler packing machine (Sanko Kikai Co., Ltd.). The seal strength was measured.

?: 20 N / 15 mm or more

○: 15 to 20

X: less than 15 N / 15 mm

[Pinhole property, Dart property]

Five sheets of three-piece seal pouches each having a length of 75 mm and a width of 55 mm were prepared for each of the laminated films and then five sheets of Saronpas (Hisamitsu Seika) were sealed, and then the openings (seal temperature: 0.5 MPa, seal time: 1 sec). The sealed package was allowed to stand at 25 ° C for 2 hours, then opened and the contents were removed, and pinholes and darts (seal leakage) were inspected with the seal checker solution.

◎: No pinhole, no dart

○: Pinhole, less than two darts

X: Pinhole, 3 or more darts

[Table 1]

[Table 2]

As apparent from the above table, the packaging structures of Examples 1 to 16 of the present invention can satisfactorily inhibit the volatilization of the active ingredient while having a favorable tearing property and a wide sealability temperature range, Even when adherence of foreign matter occurs, adherence of seal is poor, and the sealing property of the seal is excellent. In addition, pinholes and darts are less likely to occur, and packaging machine suitability is also excellent.

Claims (8)

A packaging structure for packaging a patch with a packaging material,
Wherein the innermost layer in the packaging structure of the packaging material is a heat sealable resin layer containing an olefin resin and a resin layer containing a cyclic polyolefin resin outside the heat sealable resin layer, And a resin layer containing a base layer and a cyclic polyolefin-based resin are directly laminated on each other. The method according to claim 1,
Wherein a resin layer containing an olefin resin and a resin layer containing a cyclic polyolefin resin are stacked in this order on the outer layer of the resin layer containing the cyclic polyolefin resin. 3. The method according to claim 1 or 2,
Wherein the content of the cyclic polyolefin resin in the resin component contained in the resin layer containing the cyclic polyolefin resin is 80 mass% or more. 4. The method according to any one of claims 1 to 3,
Wherein the content of the cyclic polyolefin resin having a glass transition temperature of 100 占 폚 or less in the cyclic polyolefin-based resin contained in the resin layer containing the cyclic polyolefin-based resin is 40 mass% or more. 5. The method according to any one of claims 1 to 4,
Wherein the heat sealable resin layer containing the olefin resin contains 80% by mass or more of linear low density polyethylene in the resin component contained in the resin layer containing the olefin resin. 6. The method according to any one of claims 1 to 5,
Wherein the linear low density polyethylene has a density of 0.905 g / cm 3 to 0.925 g / cm 3. 6. The method according to any one of claims 1 to 5,
Wherein a thickness of the heat sealable resin layer containing the olefin resin is 2 to 8 占 퐉. 7. The method according to any one of claims 1 to 6,
Wherein the content of the cyclic polyolefin resin in the heat sealable resin layer containing the olefin resin is 10% by mass or less.