KR20170142518A - Companion animal cancer management assistance nutrient and the manufacture Method - Google Patents

Abstract

The present invention relates to a nutritional supplement for cancer management in companion animals, and a method of preparing the same. Specifically, the nutritional supplement comprises: 8-12 parts by weight of resveratrol; 8-12 parts by weight of rutin; 8-12 parts by weight of quercetin; 2-4 parts by weight of luteolin; 8-12 parts by weight of turmeric; 2-4 parts by weight of lycopene; 1.5-2.5 parts by weight of astaxanthin; 4-6 parts by weight of DHA; 4-6 parts by weight of EPA; 2-4 parts by weight of inulin; 3-5 parts by weight of an antioxidant; 8-12 parts by weight of vitamin E; 8-12 parts by weight of vitamin C; and 10-20 parts by weight of an excipient. Accordingly, the present invention provides a nutritional supplement which can address the problem of the veterinary medicine industry having practically no prevention or treatment means for cancer management in companion animals, such as regular health supplements and the like, and thus can serve to contribute greatly to the treatment of cancer in companion animals.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a nutritional supplement,

The present invention relates to a supplementary nutrient for the management of companion animal cancer diseases and a method for preparing the same, and more particularly, to a companion animal cancer disease control supplementary nutrient which is encapsulated in a tablet form by mixing a mixture of a plurality of substances such as rutin, .

As the population ages and the number of single households increases, people are increasingly self-centered and desperate. As a result, the number of people who recognize pets as family members or companions is increasing, and the pet animal market is also steadily growing. It is expected to expand rapidly to 2 trillion won in 2014 and 6 trillion won in 2020.

As the interest of these companion diseases is getting bigger and bigger day by day, the production and development of medicines for solving these problems are increasing day by day.

However, the development of information and medicines for cancer diseases, which is a fatal disease that interferes with the maintenance of life for not only humans but also companion animals, is underdeveloped, and studies on these diseases are still poor, There was a problem that, in the case of being infected with a disease that is difficult to be healed,

Korean Patent Publication No. 2015-0111724 Korean Patent Publication No. 2015-0115980

Disclosure of the Invention The present invention has been made to solve the above-mentioned problems, and provides a cancer disease-related nutritional agent excellent in anticancer effect in a companion animal using raw materials such as resveratrol, rutin, luteolin, It is what you want to do.

In order to attain this object, the cancer disease management supplement nutraceutical of the present invention comprises 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin, 2 to 4 parts by weight of luteolin, 2 to 4 parts by weight of lycopene, 1.5 to 2.5 parts by weight of astaxanthin, 4 to 6 parts by weight of DHA, 4 to 6 parts by weight of EPA, 2 to 4 parts by weight of inulin, 1.5 to 2.5 parts by weight of zinc oxide, 2.5-8 parts by weight of vitamin E, 8-12 parts by weight of vitamin E, 8-12 parts by weight of vitamin C and 10-20 parts by weight of an excipient.

Also, it is preferable to add 26 to 40 parts by weight of flavonoid, 8 to 12 parts by weight of turmeric, 3.5 to 6.5 parts by weight of nutritional agent, 8 to 12 parts by weight of omega-3 fatty acid, 2 to 4 parts by weight of inulin, 3-5 parts by weight of oxidizing agent, 24 parts by weight of an excipient and 10 to 20 parts by weight of an excipient to prepare a mixture, a pulverizing step of pulverizing the mixture and a pulverization step, And a filling step of filling the mixture passed through the drying step with a capsule.

26 to 40 parts by weight of the flavonoid is composed of 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin and 2 to 4 parts by weight of luteolin.

Also, 3.5 to 6.5 parts by weight of the nutrient is comprised of 2 to 4 parts by weight of lycopene and 1.5 to 2.5 parts by weight of astaxanthin.

In addition, 8 to 12 parts by weight of the omega-3 fatty acid is 4 to 6 parts by weight of DHA and EPA, respectively.

And 16 to 24 parts by weight of the vitamin is composed of 8 to 12 parts by weight of vitamin E and vitamin C, respectively.

The method for preparing the excipient comprises the steps of: preparing a first mixture of 2.55 to 3 parts by weight of molasses, 44 to 53 parts by weight of corn powder and 44 to 53 parts by weight of wheat, and adding 70 to 74 parts by weight of water 1 to 3 parts by weight of a culture medium of a useful microorganism in which Bacillus subtilis, Lactic acid bacteria and Yeast cells are mixed in the same ratio to prepare a second mixture, and the second mixture is introduced into an incubator at a temperature of 15 to 25 ° C for 1 And culturing the useful microorganisms for fermentation for 3 to 3 days.

Accordingly, the present invention provides a nutrient that can solve the existing pet animal diseases related to the companion animal-related pharmaceutical industry, in which there is almost no preventive or therapeutic means such as a certain nutrient for the existing companion animal cancer diseases, It is possible to greatly contribute to the effect.

Brief Description of the Drawings Fig. 1 is a flow chart of a method for producing a cancer animal disease adjuvant of the present invention. Fig.

The present invention relates to an animal nutritional supplement for the treatment of cancer, comprising 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin, 2 to 4 parts by weight of luteolin, 8 to 12 parts by weight of turmeric, 4 to 6 parts by weight of EPA, 2 to 4 parts by weight of inulin, 1.5 to 2.5 parts by weight of zinc oxide, 1.5 to 2.5 parts by weight of magnesium oxide, 8 to 12 parts by weight of vitamin E, 8 to 12 parts by weight of vitamin C and 10 to 20 parts by weight of an excipient.

Hereinafter, the efficacy and effects of the respective ingredients constituting the adjuvant for cancer diseases for companion animals according to the present invention will be described.

First, the resveratrol, the routine, the quercetin and the luteolin constituting the flavonoid will be described.

Resveratrol is a phytoalexin-like, polyphenolic substance that plants produce when faced with a bad environment such as mold or pest. It is known to be helpful in many diseases of the human body. For example, anticancer, antiviral, neuroprotection, anti-aging, anti-inflammation, and prolongation of life have been reported.

Routine refers to a flavonoid-based pigment component contained in plants, which helps to eliminate reactive oxygen species and elasticity of capillaries, and is known to be effective for hypertension, diabetes, and hyperlipemia.

Luteolin is a family of flavonoids, a vegetable nutrient, and a yellow transparent substance. It has antioxidant activity, elimination of active oxygen, regulation of carbohydrate metabolism, and regulation of the immune system in the human body.

Quercetin is known for its excellent antioxidant ability to remove harmful free radicals, strengthens the capillaries to prevent arteriosclerosis, and softens the firm hard arteries. In addition, it has excellent anticancer effect, and is effective in preventing aging by blocking ultraviolet rays and removing active oxygen.

Turmeric is a spicy and bitter yellow medicine material. Curcumin ingredient in turmeric helps to prevent heart attack, can slow the onset of diabetes, can prevent cancer, is effective in brain activation and prevention of dementia, The pain can be relieved.

The efficacy and efficacy of lycopene and astaxanthin, which constitute nutrients, will be described.

Lycopene or lycopene is a pigment of red carotenoids, a phytochemical found in tomatoes and other red plants. It is in an isomeric relationship with carotene. Lycopene is the most common carotenoid in human body and one of the most effective carotenoid antioxidants.

Astaxanthin is a lipid-soluble natural carotenoid with strong antioxidant power, so called Super Vitamin E. If you have a high antioxidant ability that goes beyond β-carotene or vitamin E, it has excellent ability to remove excess oxygen generated in the body, and the ability to remove 'singlet oxygen', which is particularly toxic in active oxygen, More than twice that of β-carotene.

DHA and EPA are called omega-3s. When they are distributed in the nerve cell membrane and the retina, they deliver electrical stimulation at the cell membrane to the next cell at a high rate.

In addition, it helps to protect the cells and smooth metabolism, and is known to have a great effect on improving liver function, prevention of adult diseases, eye health, and prevention of osteoporosis.

Inulin is contained in many plants belonging to the Asteraceae family (also called Asteraceae, also called Compositae), especially in the roots and stems of plants such as Dalaria and obturator (Jerusalem artichoke or pig potato). Inulin produces a white and transparent powder that gives the sweetness of sucrose. Inulin molecules are small inactive fructose. It exits without being absorbed through the digestive system, and does not affect cellular activity. Because inulin is not absorbed in the body, it is used to sweeten the food that diabetics eat.

Hereinafter, vitamin E and vitamin C, which form a vitamin, will be described.

Vitamin E functions to protect cells from free radicals.

Vitamin C enhances the uptake of vitamin E and plays an antioxidant role in the extracellular environment.

The excipient is lactose or starch, which is added to make the medicine easy to eat or to have arbitrary color and shape when the quantity of liquor is low in preparation process such as tablets or pills. use.

Hereinafter, a method for producing the above excipient will be described, which is a material having the highest specific gravity by weight among components constituting the companion animal cancer disease auxiliary nutrient of the present invention.

Firstly, the first step is to prepare a first mixture of 2.55 to 3 parts by weight of molasses, 44 to 53 parts by weight of corn powder and 44 to 53 parts by weight of wheat flour.

In the next step, the second mixture is prepared by mixing 25 to 30 parts by weight of water, 1 to 3 parts by weight of a culture medium of useful microorganisms in which Bacillus subtilis, lactic acid bacteria and yeast bacteria are mixed in the same ratio, to 70 to 74 parts by weight of the first mixture, . (Here, it is desired to clarify that the limitation of the weight of the above steps is a result of many experiments and accumulated data.)

Next, the second mixture is added to an incubator, and the third step of fermenting the useful microorganism at a temperature of 15 to 25 ° C for 1 to 3 days is used to produce an excipient.

If the temperature is lower than 15 ° C, the ability to proliferate the microorganism decreases, and there is no effect. If the temperature exceeds 25 ° C, harmful microorganisms may develop and become rotten. When the incubation time is less than one day, it becomes difficult to reach an effective level of the useful microorganism culture level. If the incubation time is more than three days, the nutrient in the first mixture is insufficient to proliferate the useful microorganism and the microorganism is killed.

Hereinafter, a method for producing an anti-cancer animal disease adjuvant according to the present invention will be described with reference to FIG.

First, the compounding ratio is calculated and the materials are weighed. It is preferable to meter the raw material using an electronic balance or the like.

The supplementary nutrient is 26 to 40 parts by weight of flavonoid, 8 to 12 parts by weight of turmeric, 3.5 to 6.5 parts by weight of nutrients, 8 to 12 parts by weight of omega-3 fatty acid, 2 to 4 parts by weight of inulin, 3 to 5 parts by weight of oxidizing agent 16 to 24 parts by weight of vitamins and 10 to 20 parts by weight of an excipient to prepare a mixture. (Step of making mixture)

The composition of 26 to 40 parts by weight of the flavonoid is composed of 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin and 2 to 4 parts by weight of luteolin.

The composition of 3.5 to 6.5 parts by weight of the nutrient is composed of 2 to 4 parts by weight of lycopene and 1.5 to 2.5 parts by weight of astaxanthin.

 8 to 12 parts by weight of the omega-3 fatty acid comprises 4 to 6 parts by weight of DHA and EPA, respectively.

16 to 24 parts by weight of the vitamin is composed of 8 to 12 parts by weight of vitamin E and vitamin C, respectively.

Here, it is desired to clarify that the numerical values of the above weight parts are the result of many experiments and data.

It should be noted that 0.05 to 0.15 parts by weight of the mineral may be further added to the mixture prepared in the step of making the mixture. It is intended to reveal that the range of the weight portion is also the result of many experiments and data. Minerals are about 100 kinds of metal and nonmetal elements and exist in organic matter such as proteins, hemoglobin, enzymes, etc. There are about 20 kinds of inorganic salts in food.

These minerals are only 2 ~ 5% in the body, but they are essential nutrients for the maintenance of life. They are classified into large amounts and small amounts depending on the contents of the body. Among them, calcium and phosphorus account for more than 70% of minerals.

The minerals form a skeleton such as bone tissue and soft tissue within the body, maintain the acid base balance, activate the enzyme, and contribute to osmotic pressure maintenance as a constituent of body fluids.

The mixture preparation step blends each material to the above-described weight parts by using a blender (not shown). Stirring is carried out at normal temperature (15 ° C to 25 ° C) for about 30 minutes to make uniform components in all parts.

The mixture obtained through the preparation of the mixture is pulverized. (Powdering step)

In the pulverizing step, the mixture is preferably pulverized into particles of 0.2 to 2 mm. When the particle size is as described above, the effect of the mixture is most uniformly distributed.

The mixture having been subjected to the pulverization step is boiled at 90 ° C to 100 ° C for 4 minutes to 6 minutes. (Steaming stage)

If the juice is matured for less than 4 minutes, the effect is insignificant, and if it is more than 6 minutes, the nutrient is destroyed because it becomes too ripe.

And, it is preferable that the mixture is exposed to steam at 60 ° C to 80 ° C for 3 to 5 minutes immediately before proceeding to the steaming step so that the mixture is made ripe by steam.

It should be at least 60 ° C and at least 3 minutes. If the temperature exceeds 80 ° C or steam is irradiated for more than 5 minutes, it may adversely affect the composition of the mixture.

The mixture after the steaming step is dried at 80 to 90 degrees for 3 to 4 hours. (Drying step)

In the drying step, it is preferable that the mixture is dried at 80 to 90 ° C. for 3 to 4 hours, dried to a moisture content of 15 to 25%, and sterilized. Here, the drying temperature and the drying time are the results of many experiments and data.

Here, drying to have a moisture content of 15 to 25% is intended to control the moisture content of the molded nutrients for different seasons. Furthermore, it is intended to suppress the occurrence of bacteria such as fungi when nutrients are distributed on the market.

In this case, sterilization treatment may be performed in the drying step to remove bacteria that may be contained in the nutrient molding.

The mixture thus dried is filled with a capsule. (Filling step)

The amount of the mixture to be contained in the filling step is most preferably 180 mg to 220 mg. The above amount (180 ~ 220mg) is the size and amount that the animal is most likely to swallow, and digestion is good when ingested.

Then, the filled capsule (containing the mixture) is accommodated in a certain container such as a plastic bottle or a glass bottle. (Step of putting into a container) The above step is a step just before commercialization on the market.

[Example]

Is an embodiment relating to the manufacture of cancer nutritional management auxiliary nutrients according to the present invention.

10 parts by weight of resveratrol, 10 parts by weight of lutein, 3 parts by weight of luteolin, 3 parts by weight of lycopene, 10 parts by weight of quercetin, 10 parts by weight of turmeric, 2 parts by weight of astaxanthin, 5 parts by weight of DHA, 5 parts by weight of EPA, 3 parts by weight of inulin, 2 parts by weight of zinc oxide, 2 parts by weight of magnesium oxide, 10 parts by weight of vitamin E, 10 parts by weight of vitamin C and 15 parts by weight of an excipient. The particles of the stirred mixture were pulverized to a size of 1 mm.

The powdered mixture was boiled for 5 minutes at 100 ° C, and the resulting mixture was dried at 85 ° C for 3 to 4 hours, sterilized, and filled into capsules to prepare a cancer nutritional supplement for companion animals .

While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments. In addition, it is obvious that various modifications can be made without departing from the scope of the technical idea of the present invention by anyone having ordinary skill in the art.

Claims (7)

For companion animal disease management supplementary nutrition,
The auxiliary nutrient may be selected from the group consisting of 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin, 2 to 4 parts by weight of luteolin, 8 to 12 parts by weight of turmeric, 2 to 4 parts by weight of lycopene, 1.5 to 2.5 weight parts of DHA, 4 to 6 weight parts of EPA, 2 to 4 weight parts of inulin, 1.5 to 2.5 weight parts of zinc oxide, 1.5 to 2.5 weight parts of magnesium oxide, 8 to 12 weight parts of vitamin E 8 to 12 parts by weight of vitamin C and 10 to 20 parts by weight of an excipient.
A method for preparing an animal nutritional supplement for animal care,
The supplementary nutrient may be selected from the group consisting of 26 to 40 parts by weight of flavonoids, 8 to 12 parts by weight of turmeric, 3.5 to 6.5 parts by weight of nutrients, 8 to 12 parts by weight of omega-3 fatty acids, 2 to 4 parts by weight of inulin, 16 to 24 parts by weight, and 10 to 20 parts by weight of an excipient to prepare a mixture to form a mixture;
A powdering step of powdering the mixture;
Mixing the mixture after the pulverization step at 90 DEG C to 100 DEG C for 4 to 6 minutes;
Drying the mixture after the steaming step at 80 ° C to 90 ° C for 3 to 4 hours;
A filling step of filling the mixture passed through the drying step with a capsule;
Wherein the method comprises the steps of:
3. The method of claim 2,
26 to 40 parts by weight of the flavonoid is composed of 8 to 12 parts by weight of resveratrol, 8 to 12 parts by weight of rutin, 8 to 12 parts by weight of quercetin and 2 to 4 parts by weight of luteolin. .
3. The method of claim 2,
Wherein 3.5 to 6.5 parts by weight of the nutrient is comprised of 2 to 4 parts by weight of lycopene and 1.5 to 2.5 parts by weight of astaxanthin. 3. The method of claim 2,
And 8-12 parts by weight of the omega-3 fatty acid is 4 ~ 6 parts by weight of DHA and EPA, respectively.
3. The method of claim 2,
Wherein the vitamin E and the vitamin C are contained in an amount of 8 to 12 parts by weight, respectively.
3. The method of claim 2,
The process for preparing the excipient
A first step of making a first mixture of 2.55-3 parts by weight of molasses, 44-53 parts by weight of corn powder and 44-53 parts by weight of wheat flour;
A second step of mixing 25 to 30 parts by weight of water with 1 to 3 parts by weight of a culture medium for useful microorganisms in which Bacillus subtilis, Lactic acid bacteria and Yeast cells are mixed in the same ratio to 70 to 74 parts by weight of the first mixture;
And a third step of fermenting the useful microorganism for 1 to 3 days at a temperature of 15 to 25 degrees by adding the second mixture to an incubator.

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