KR20170009896A - Active compound combinations - Google Patents

Abstract

The present invention relates to (A) 2- {3- [2- (1- {3,5-bis (difluoromethyl) -1H-pyrazol- 1 -yl] acetyl} piperidin- -1,3-thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3- chlorophenyl methanesulfonate, (B) ) 2,6-dimethyl-1H, 5H- [1,4] dithieno [2,3-c: 5,6-c '] dipyrrol- , Propinaf or a polette, in particular a fungicidal composition. The present invention also relates to a method of healing or prophylactically controlling unwanted phytopathogenic fungi of plants or crops, the use of the formulations according to the invention for seed treatment, seed protection methods and finally treated seeds.

Description

[0001] ACTIVE COMPOUND COMBINATIONS [0002]

The present invention relates to (A) 2- {3- [2- (1- {3,5-bis (difluoromethyl) -1H-pyrazol- 1 -yl] acetyl} piperidin- -1,3-thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3- chlorophenyl methanesulfonate, (B) (Ethylphosphonate), CAS No. 39148-24-8 (known from FR-A-2254276) and (C) 2,6-dimethyl-1H, 5H- [1,4] : 5,6-c '] dipyrrol-1,3,5,7 (2H, 6H) -tetrone (CAS No. 16114-35-5, US 3364229 and WO 2010/043319), propyne ( (CAS No. 12071-83-9 (known from BE 611960)) or a polyphenol (" N - (trichloromethylthio) phthalimide, CAS No. 133-07-3, US 2553770), in particular fungicidal compositions.

The present invention also relates to a method of healing or prophylactically controlling a phytopathogenic fungus of a plant or a crop, the use of a combination according to the present invention for seed treatment, a seed protection method, and finally treated seeds.

Yl) acetyl} piperidin-4-yl) -1,3-dihydro-1H-pyrazol- Thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenyl methanesulfonate possesses fleshy bacterium (WO 2012/025557) . However, the active spectrum of these substances is focused on osmotic diseases.

In addition, the title compound was obtained from 2- {3- [2- (1- {3,5-bis (difluoromethyl) -1H-pyrazol-1-yl] acetyl} piperidin- -Thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenyl methanesulfonate is combined with other fungicides to produce phytopathogenic fungi of plants or crops Lt; RTI ID = 0.0 > (WO 2013/127704). ≪ / RTI > However, the activity spectrum of these mixtures is focused on osmotic diseases.

It is already known that phosphonates and derivatives (phosphonates) such as phosphonate ethylhydrogenphosphonate having the generic name of fosetyl-aluminum and derivatives thereof can be used for controlling phytopathogenic fungi (Pesticide Manual, 14th Edition (2006); "Modern Agrochemicals", Vol 4, No. 3, June 2005; FR-A-2254276). However, the activity of this material at low application rates is not always sufficient.

Compound 2, 6-Dimethyl-1H, 5H- [1,4] dithieno [2,3-c: 5,6-c '] dipyrrole-1,3,5,7 (2H, 6H) It is also known to be suitable for controlling phytopathogenic fungi in plants and crops (WO 2010/043319). However, the activity of this material at low application rates is not always sufficient.

The compound propinab is also known to be suitable for controlling phytopathogenic fungi in plants and crops (BE 611960). However, the activity of this material at low application rates is not always sufficient.

Compound pollen is also known to be suitable for controlling phytopathogenic fungi in plants and crops (US 2553770). However, the activity of this material at low application rates is not always sufficient.

Today's fungicides are becoming increasingly important as environmental and economic needs continue to increase, for example, for action spectrum, toxicity, selectivity, application rate, residue formation and favorable manufacturability, Therefore, it is an ongoing challenge to develop new fungicides that have advantages over at least some of the known counterparts in some areas.

The present invention provides, in some respects, a combination of active compounds having at least the stated purpose.

Surprisingly, according to the present invention

(A) 2- {3- [2- (1- {3,5-bis (difluoromethyl) -1H-pyrazol- 1 -yl] acetyl} piperidin- 3-thiazol-4-yl] -4,5-dihydro-l, 2-oxazol-5- yl} -3-chlorophenyl methanesulfonate and

(B) fosetyl-aluminum and

(C) propyne, polpet or 2,6-dimethyl-1H, 5H- [1,4] dithieno [2,3-c: 5,6-c '] dipyrrol- 2H, 6H) -tetrone,

Is expected to additionally improve the action spectrum for phytopathogenic fungi and / or microorganisms and / or pests to be controlled, as well as to have a very good fungicidal activity, and the compounds (A), (B) and (C) can be achieved in the following two ways. First, the application ratio of the compounds (A), (B) and (C) is reduced, but the action remains excellent as it is. Secondly, the formulations highly control the phytopathogenic fungi even when the two individual compounds are not nearly as effective in the range of low application rates. On the one hand, it has been found that the spectrum of the phytopathogenic fungi that can be controlled can be broadened considerably, and on the other hand, the stability can be enhanced.

However, in addition to the substantial synergistic effect on fungicidal activity, the combination of active compounds according to the present invention also has other surprising advantageous properties which can also be referred to as synergistic activity in a broader sense. Examples of such advantageous properties include enlargement of fungal and / or insecticidal activity spectrum against other phytopathogenic fungi and / or microorganisms and / or insects, for example resistant strains; Reduction of application rate of active ingredient; Sufficient pest control according to the composition according to the present invention, even at application rates where the individual compounds exhibit no activity; Favorable behavior during or during formulation, e.g., during grinding, sieving, emulsifying, dissolving or dispensing; Increased storage stability; Improvement of light stability; More favorable degradability; Improving toxicological or ecotoxicological behavior; Improved characteristics of useful plants, such as appearance, crop yield, better roots development, increased tillering, increased plant height, larger leaves, less dead root, stronger sprouts, Decreased seed requirement, more effective tillering, early flowering, early grain growth, few plant sections (apparel), growth of young stem growth, improved plant vitality and early germination; Or any other benefit that is familiar to those skilled in the art.

The formulations according to the invention can also provide a systemic improvement to the active compound used. Indeed, even if some of the bactericidal compounds used do not have or do not have any systemic properties, these compounds may exhibit such properties in the compositions according to the invention.

In a similar manner, the formulations according to the invention may allow the sustained fungicidal efficacy of the active compound used to be increased.

Another advantage of the combination according to the invention is that the achievement of efficacy enhancement can be expected.

In a preferred embodiment, the combination of active compounds according to the invention leads to one or more of the following characteristics:

Increase in spectrum, synergy, increase in yield, better roots development, more green leaves, increased tillering, increased plant height, larger leaves, less dead root, stronger sprouts, less fertilizer needed, more effective tillering , Early flowering, Early kernel growth, Less plant growth, Growth of young stem growth, Improved plant vitality, Early germination, Systemic improvement, Increased persistence of fungicidal efficacy, Increased achievable efficacy.

 Also preferably, the combination of the active compounds according to the invention leads to the following characteristics: a gradual increase in the spectrum.

Also preferably, the combination of active compounds according to the invention leads to the following properties: synergistic effect.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: improved yield.

 Also preferably, the combination of active compounds according to the invention leads to the following characteristics: better root system development.

 Also preferably, the combination of active compounds according to the invention leads to the following characteristics: more green leaves.

 Also preferably, the combination of active compounds according to the invention leads to the following characteristics: increased blooming.

 Also preferably, the combination of active compounds according to the invention leads to the following characteristics: increased plant height.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: larger leaf pieces.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: Less dead root.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: a strong shoot.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: a reduction in the amount of fertilizer required.

Also preferably, the combination of the active compounds according to the invention leads to the following characteristics: more effective tillering.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: early flowering.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: early kernel maturity.

Also preferably, the combination of the active compounds according to the invention leads to the following characteristics:

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: increased young stem growth.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: early germination.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: improved plant vitality.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: systemic improvement.

Also preferably, the combination of active compounds according to the invention leads to the following characteristics: an increase in persistence of fungicidal efficacy.

Also preferably, the combination of active compounds according to the invention leads to the following properties: an increase in the achievable potency.

The weight ratio of active ingredient compounds to the tertiary mixture is selected, for example, to produce the desired synergistic effect:

(A) :( B) :( C) is 1: 500: 200 to 1:50:10; Preferably 1: 200: 180 to 1: 100: 25.

(2H, 6H) -dicyclohexylcarbodiimide compound (C) is 2,6-dimethyl-1H, 5H- [1,4] - tetron, the most preferred weight ratio is 1: 200: 40 to 1: 150: 30.

(C) is propyne, the most preferred weight ratio is 1: 200: 180 to 1: 150: 150.

(C) is a poppet, the most preferred weight ratio is 1: 200: 150 to 1: 150: 100.

Where compounds (A), (B) or (C) can be present as tautomers, these compounds, where not specifically mentioned in each case, refer to the corresponding tautomeric forms .

The compound (A), (B) or (C) having at least one basic center may for example be a mineral acid such as perchloric acid, strong inorganic acids such as nitric acid, nitric acid, phosphoric acid or hydrohalic acid, Substituted C ₁ -C ₄ alkanecarboxylic acids such as acetic acid, saturated or unsaturated dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid and phthalic acid, hydroxycarboxylic acids such as ascorbic acid, lactic acid, , Strong organic carboxylic acids such as tartaric acid and citric acid or benzoic acid, or organic sulfones such as unsubstituted or halo-substituted C ₁ -C ₄ alkane- or aryl-sulfonic acids such as methane- or p-toluenesulfonic acid Acid and acid addition salts can be formed. The compound (A) or (B) having at least one acid group can be converted into a salt with a base, for example an alkali metal or an alkaline earth metal salt such as a metal salt such as sodium, potassium or magnesium salt, Or mono-, di- or tri-lower alkylamines, such as ethyl-, diethyl-, triethyl- or dimethylpropylamine, or mono-, di- or tri- Roxy-lower alkylamines, such as mono-, di- or tri-ethanolamines. In addition, corresponding internal salts may optionally be formed. In the context of the present invention, agriculturally advantageous salts are preferred. The free compound (A), (B) or (C) or salts thereof in the form of the free form and the compound (A), (B) or (A), (B) or (C), respectively, if necessary, according to the method of the present invention. This equivalence also applies to the tautomers of compounds (A), (B) or (C) and their salts.

The mixture according to the present invention may be the composition itself but the final use composition is generally prepared by adding other formulation auxiliaries, such as surfactants and / or extenders, to the compounds of formula (A), the compounds (B) and (C ), And an inert carrier, and then mixing the mixture with an oil preparation, an emulsifiable concentrate, a flowable agent, a wettable powder, a water-dispersible granule, a powder, a granule and the like. Formulations used alone or in combination with other inactive ingredients may be used as insecticides.

Specific additional constituents of this final composition are described below.

A "composition" can be prepared by formulating a compound of formula (A) and a compound (B) and (C) as described above and formulating a formulation or dilution thereof.

For the sake of clarity, the mixture means the physical combination of the compound of formula (A) and the compounds (B) and (C), while the composition comprises the mixture and the surfactant, solvent, carrier, pigment, defoamer, thickener and extender Means a combination of forms suitable for pesticide application of further additives.

The present invention also relates to a method for controlling harmful microorganisms, comprising contacting said harmful microorganisms or their habitats with said composition.

The invention also relates to a method of treating seed, comprising contacting the seed with the composition as described above.

Finally, the present invention relates to seed treated with the composition described above.

Thus, the present invention also relates to compositions for controlling harmful microorganisms, in particular noxious fungi and bacteria, comprising an effective, yet non-phytotoxic, amount of the active ingredient of the present invention. These are preferably fungicidal compositions comprising adjuvants, solvents, carriers, surfactants or extenders suitable for agriculture.

In connection with the present invention, "control of harmful microorganisms" means a reduction in the number of harmful microorganisms, preferably 25-50% reduction compared to untreated plants (100%), as compared to the non- , More preferably 40-79% reduction compared to untreated plants (100%), even more preferably to completely inhibit the spread of harmful microorganisms (up to 70-100%). Controls may be protective, for the treatment of healing, already infected plants, or for protection of plants that have not yet been infected.

"Effective but non-phytotoxic amount" refers to an amount of a composition according to the present invention that is sufficient to control a fungal disease of a plant in a satisfactory manner or to completely eliminate fungal disease, while at the same time not causing any significant plant toxic symptoms . In general, this application rate can vary over a relatively wide range. This will depend on a number of factors, such as the fungus, plant, climate conditions to be controlled, and the composition of the composition according to the invention.

Suitable organic solvents include all polar and nonpolar organic solvents commonly used for formulation purposes. Preferred solvents are ketones such as methyl-isobutyl-ketone and cyclohexanone, amides such as dimethylformamide and alkanecarboxylic acid amides such as N, N-dimethyldecanamide and N, N-dimethyloctanamide , Cyclic solvents such as N-methyl-pyrrolidone, N-octyl-pyrrolidone, N-dodecyl-pyrrolidone, N-octyl-caprolactam, N-dodecyl- Such as xylitol, Solvesso ^TM , mineral oil, such as white spirit, petroleum, alkylbenzene and spindle oil, esters, such as propylene glycol mono Methyl ether acetate, adipic acid dibutyl ester, hexyl acetate, heptyl acetate, tri- n -butyl esters of citric acid and di- n -butyl esters of phthalic acid, and alcohols such as benzyl alcohol and 1-methoxy- -P .

According to the present invention, the carrier is a natural or synthetic organic or inorganic substance which is mixed or combined with the active ingredient to improve applicability, especially for plant or plant parts or seed applications. In general, the carrier, which may be a solid or a liquid, is inert and suitable for agricultural use.

Useful solid or liquid carriers are, for example, ammonium salts and ground natural minerals such as kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and finely divided silicas, alumina and natural or synthetic silicates Waxes, solid fertilizers, water, alcohols, especially butanol, organic solvents, mineral oils and vegetable oils and also derivatives thereof. Mixtures of these carriers may also be used.

Suitable solid fillers and carriers include inorganic particles such as carbonates, silicates, sulphates and oxides having an average particle size of 0.005 to 20 m, preferably 0.02 to 10 m, such as ammonium sulfate, ammonium phosphate, urea, calcium carbonate, calcium sulfate , Magnesium sulfate, magnesium oxide, aluminum oxide, silicon dioxide, so-called particulate silica, silica gel, natural or synthetic silicates, and plant products such as aluminosilicates and flour, wood powder / sawdust and cellulosic powders.

Solid carriers for granules useful are granulated and classified natural rocks such as, for example, calcite, marble, pumice, happosite and dolomite, or synthetic granules of inorganic and organic powders, and synthetic granules such as sawdust, coconut shells, corncobs and tobacco stalks. And granules of organic material.

Useful liquefied gas extenders or carriers are liquids which are gaseous at standard temperature and standard pressure, for example hydrocarbons and also aerosol propellants such as butane, propane, nitrogen and carbon dioxide.

Tackifiers such as carboxymethylcellulose and natural phosphates such as gum arabic, polyvinyl alcohol and polyvinyl acetate, polymers in the form of granules or latex, or natural phospholipids such as cephalins and lecithins and synthetic phosphatides, Lt; / RTI > Other additives may include mineral oil and vegetable oil.

If the extender used is water, for example, an organic solvent may also be used as the co-solvent. Useful liquid solvents are mainly aromatic compounds such as xylene, toluene or alkylnaphthalene; Chlorinated aromatic and chlorinated aliphatic hydrocarbons such as chlorobenzene, chloroethylene or dichloromethane; Aliphatic hydrocarbons such as cyclohexane or paraffins, such as mineral oil fractions, mineral oils and vegetable oils; Alcohols such as butanol or glycol and their ethers and esters; Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone; Strong polar solvents such as dimethylformamide and dimethylsulfoxide, and water.

The composition of the present invention may further comprise additional components, for example, a surfactant. Useful surfactants can be ionic or nonionic emulsifiers and / or foam formers, dispersants or wetting agents or mixtures of these surfactants. Examples of these surfactants include polyacrylates, lignosulfonates, phenol sulfonates or naphthalene sulfonates, polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty amines, substituted phenols (preferably alkyl phenols or Arylphenol), sulfosuccinic acid ester salts, taurine derivatives (preferably alkyltaurates), phosphoric acid esters of polyethoxylated alcohols or phenols, fatty esters of polyols, and derivatives of compounds including sulfates, sulfonates and phosphates , Such as alkylaryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates, protein hydrolysates, lignosulfite waste solutions and methylcellulose. If one active ingredient and / or one inert carrier is water insoluble and the application occurs in water, the presence of a surfactant is necessary. Preferably, the amount of surfactant may be from 5 to 40% by weight of the composition according to the invention.

Suitable surfactants (adjuvants, emulsifiers, dispersants, protective colloids, wetting agents and tackifiers) include all conventional ionic and nonionic dispersant materials such as ethoxylated nonylphenol, polyalkylene glycol ethers of linear or branched alcohols, A reaction product of an alkylphenol with ethylene oxide and / or propylene oxide, a reaction product of fatty acid amine and ethylene oxide and / or propylene oxide, a fatty acid ester, an alkylsulfonate, an alkylsulfate, an alkyl ether sulfate, an alkyl ether phosphate, Ethoxylated and propoxylated arylalkylphenols, such as the sulfated or phosphated arylalkylphenol-ethoxylates and ethoxy-and-propylated phenols, such as, for example, ≪ / RTI > Additional examples include natural and synthetic, water soluble polymers such as lignosulfonates, gelatins, gum arabic, phospholipids, starches, hydrophobically modified starches and cellulose derivatives, especially cellulose esters and cellulose ethers, further polyvinyl alcohols, Addition of methacrylic acid and methacrylic acid esters neutralized with polyvinyl acetate, polyvinyl pyrrolidone, polyacrylic acid, polymethacrylic acid and copolymers of (meth) acrylic acid and (meth) acrylic acid esters, and alkali metal hydroxides. Copolymers and also condensation products of optionally substituted naphthalenesulfonic acids with formaldehyde.

Dyes such as iron oxide, titanium oxide and inorganic pigments such as prussian blue and organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes and salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc, The same micronutrients may be used.

Defoamers that may be present in the formulation include, for example, silicone emulsions, long chain alcohols, fatty acids and salts thereof, as well as fluoro organic materials and mixtures thereof.

Examples of thickeners are polysaccharides, such as xanthan gum or non-gum, silicates, such as ataplugite, bentonite and particulate silica.

In some cases, other additional components may also be present, such as, for example, protective colloids, binders, tackifiers, thickeners, thixotropic substances, penetrants, stabilizers, sequestrants, In general, the active ingredient may be combined with any solid or liquid additive commonly used for formulation.

The mixtures or compositions of the present invention may be used as such or in the form of preparations thereof, or in the form of their preparations, such as aerosols, capsule suspensions, cold concentrates, warm concentrates, encapsulated Dustable powders, emulsifiable concentrates, oil-in-water emulsions, water-in-oil emulsions, macrogranules, microgranules, oil-dispersible powders, granules, granules, granules, granules, fluid concentrates for seed treatment, Oil-miscible liquid concentrates, oil-miscible liquids, gas, gas-generating products, foams, pastes, killing coatings seeds, suspension concentrates, suspension-emulsion concentrates, soluble concentrates, suspensions, Powders, dusts and granules, water-soluble granules or tablets, water-soluble and water-dispersible powders for seed treatment, wettable powders, natural products and synthetic materials impregnated with active compounds, Microcapsules in materials and polymeric materials, ULV antifreeze agents and warming agents.

The compositions of the present invention include not only ready-to-use preparations, but also preparations that can be applied to plants or seeds using suitable equipment and commercial concentrates that must be diluted with water before use. Commercial applications include, for example, dilution with water and subsequent spraying of the spray solution, application after dilution in oil, direct application without dilution, seed treatment or seed application of granules.

In general, the mixtures, compositions and formulations of the present invention comprise from 0.05 to 99% by weight, from 0.01 to 98% by weight, preferably from 0.1 to 95% by weight, more preferably from 0.5 to 90% by weight, most preferably from 10 to 70% By weight of active ingredient. For example, the mixtures, compositions and formulations of the present invention generally comprise from 0.0001 to 95% by weight, preferably from 0.001 to 60% by weight, of the active ingredient for special applications for protecting wood and woodwork products made therefrom.

The content of the active ingredient in the application form prepared from the preparation may vary over a wide range. The concentration of the active ingredient in the application form is generally 0.000001 to 95% by weight, preferably 0.0001 to 2% by weight.

The formulations mentioned may be prepared by the known process itself, for example by mixing the active ingredient with at least one conventional diluent, solvent or diluent, adjuvant, emulsifier, dispersant and / or binder or immobilizing agent, wetting agent, And UV stabilizers and, if necessary, dyes and pigments, defoamers, preservatives, inorganic and organic thickeners, adhesives, gibberellins, and also other processing aids and water. Depending on the type of formulation to be produced, further processing steps may be required, for example wet grinding, dry grinding or granulation.

The mixture or composition of the present invention may be used in combination with a pesticide, an attractant, a disinfectant, a bactericide, an acaricide, a nematicide, a fungicide, a growth regulator, a herbicide, a fertilizer, Or as a mixture with other (known) active compounds such as information substances.

The plant and plant part treatment of the present invention by the mixture or composition can be carried out by conventional treatment methods such as immersion, spraying, spraying, irrigation, evaporation, dusting, fogging, spraying, forming, applying, By means of trickle irrigation and in the case of propagation material, in particular seeds, also directly by drying seed treatment, wet seed treatment, slurry treatment, envelope formation, one or more layer coatings, . It is also possible to apply the mixture or composition in a microfluidic manner, or to inject the mixture or the composition or the active ingredient itself into the soil.

Plant / Crop Protection

The mixtures or compositions of the present invention have potent microbicidal activity and can be used, for example, to control unwanted microorganisms, such as fungi and bacteria, for protecting crops or protecting materials.

The present invention also relates to a method of controlling undesirable microorganisms, characterized in that the mixture or composition of the invention is applied to plant pathogenic fungi, plant pathogenic bacteria and / or their habitats.

Fungicides can be used to control plant pathogenic fungi to protect crops. They Especially knot fungus (Plasmodiophoromycetes), Tampere North captivity My three tests (Peronosporomycetes) (synonym: I fungus (Oomycetes), chytridiomycota (Chytridiomycetes), zygomycota (Zygomycetes), Ascomycetes (Ascomycetes), Basidiomycetes (Basidiomycetes), and Deuteromycetes (Synonyms: incomplete fungi) are distinguished by their excellent effect on broad spectrum phytopathogenic fungi, including soil-borne pathogens, which are members of the family. Some fungicides are systemically active, , Seed dressings or soil fungicides. In addition, they are particularly suitable for combating fungi that are prevalent in trees or plant roots.

Live in crop protection bacterial agent is used to control a pseudo mono Ada years old child (Pseudomonoadaceae), Li Jovi Asia (Rhizobiaceae), Enterobacter bacteria years old child (Enterobacteriaceae), Corey four bacteria years old child (Corynebacteriaceae) and Streptomyces setae years old child (Streptomycetaceae) .

Some plant pathogens of fungal diseases that may be treated in accordance with the present invention may be mentioned, for example, but not limited to:

Powdery mildew pathogens, for example, Blumeria species, for example Blumeria graminis ; Podosphaera species, for example, Podosphaera leucotricha ; Sphaerotheca species such as Sphaerotheca fuliginea ; Unsi Cronulla (Uncinula) species, for example, diseases caused by Uncinula necator;

Rust disease pathogens, for example, Gymnosporangium species such as Gymnosporangium sabinae ; Hemileia species, for example, Hemileia vastatrix ; Phakopsora species such as Phakopsora pachyrhizi and Phakopsora meibomiae ; Puccinia species such as Puccinia recondite , P. triticina , P. graminis or P. striiformis ; My right recess (Uromyces) species, for example, diseases caused by Uromyces appendiculatus;

Pathogens from the Oomycetes group, for example, Albugo species, for example Albugo candida ; Bremia species, for example, Bremia lactucae ; Peronospora species such as Peronospora pisi or P. brassicae ; Phytophthora species, for example, Phytophthora infestans ; Plasmopara species, for example, Plasmopara viticola ; Pseudoperonospora species, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis ; Pitti Titanium (Pythium) species, for example, diseases caused by Pythium ultimum;

For example, Alternaria species such as Alternaria solani ; Cercospora species, for example, Cercospora beticola ; Cladiosporium species, for example, Cladiosporium cucumerinum ; Cochliobolus species, for example, Cochliobolus sativus ( Drosophila ; Drechslera , synonym: Helminthosporium ) and Cochliobolus miyabeanus ; Colletotrichum species, for example, Colletotrichum lindemuthanium ; Cycloconium species, for example, Cycloconium oleaginum ; Diaporthe species, for example, Diaporthe citri ; Elsinoe species, for example, Elsinoe fawcettii ; Gloeosporium species, for example, Gloeosporium laeticolor ; Glomerella species, such as Glomerella cingulata ; Guignardia species, for example, Guignardia bidwelli ; Leptosphaeria species, such as Leptosphaeria maculans and Leptosphaeria nodorum ; Magnaporthe species, for example, Magnaporthe grisea ; Microdochium species, for example, Microdochium nivale ; Mycosphaerella species such as Mycosphaerella graminicola , Mycosphaerella arachidicola and Mycosphaerella fijiensis ; Phaeosphaeria species, for example, Phaeosphaeria nodorum ; Pyrenophora species such as Pyrenophora teres and Pyrenophora tritici repentis ; Ramularia species, for example, Ramularia collo-cygni and Ramularia areola ; Rhynchosporium species, such as Rhynchosporium secalis ; Septoria species such as Septoria apii and Septoria lycopersici ; Typhula species, such as Typhula incarnata ; Bento Liao (Venturia) species, for example, leaf blight caused by Venturia inaequalis (leaf blotch disease) and leaf wilt (leaf wilt diseases);

For example, Corticium species such as Corticium graminearum ; Fusarium (Fusarium) species, e.g., Fusarium oxysporum; Gaeumannomyces species, for example, Gaeumannomyces graminis ; Rhizoctonia species, for example, Rhizoctonia solani ; Sarocladium species such as Sarocladium oryzae ; Sclerotium species, for example, Sclerotium oryzae ; Tapesia species, for example Tapesia acuformis ; Tea Ella pray System (Thielaviopsis) species, for example, the roots caused by Thielaviopsis basicola and stem (stem) disease;

For example, Alternaria species such as Alternaria spp. ; Aspergillus species, such as Aspergillus flavus ; Cladosporium species, for example, Cladosporium cladosporioides ; Claviceps species, for example, Claviceps purpurea ; Fusarium (Fusarium) species, for example, Fusarium culmorum; Gibberella species, for example, Gibberella zeae ; Monographella species, for example, Monographella nivalis ; Counts thoria (Septoria) species, for example, the ear (ear) and leading (panicle) diseases caused by Septoria nodorum (including corncobs);

For example, Sphacelotheca species such as Sphacelotheca reiliana ; Tilletia species, for example, Tilletia caries ; Tilletia controversa ; Urocystis species, for example, Urocystis occulta ; Ustilago species, for example, Ustilago nuda ; A disease caused by Ustilago nuda tritici ;

For example, Aspergillus species such as Aspergillus flavus ; Botrytis species, for example, Botrytis cinerea ; Penicillium species such as Penicillium expansum and Penicillium purpurogenum ; Sclerotinia species, for example, Sclerotinia sclerotiorum ; Fruit rot caused by a species of Verticilium , for example, Verticilium alboatrum ;

For example, Alterna Liao (Alternaria) disease caused by Alternaria brassicicola; For example, the sick no Mai access (Aphanomyces) diseases caused by Aphanomyces euteiches; For example, the condition ascorbyl Kita (Ascochyta) caused by Ascochyta lentis; For example, asbestos peogil Ruth (Aspergillus) disease caused by Aspergillus flavus; For example, FIG sports Solarium (Cladosporium) Cloud disease caused by Cladosporium herbarum; Cochliobolus disease caused by, for example, Cochliobolus sativus ( Drosophila melanogaster, Bipolaris , synonym: Helminthosporium ); For example, the collation Sat tree glutamicum (Colletotrichum) disease caused by Colletotrichum coccodes; For example, Fusarium ' s disease caused by Fusarium culmorum ; Gibberella < / RTI > disease caused by, for example, Gibberella zeae ; For example, the condition mark and breech (Macrophomina) caused by Macrophomina phaseolina; For example, FIG micro caused by Microdochium nivale Kiwoom (Microdochium) disease; For example, it mono caused by Monographella nivalis that rapelra (Monographella) disease; For example, the condition penny room Solarium (Penicillium) caused by Penicillium expansum; For example, poma (Phoma) diseases caused by Phoma lingam; For example, Phomopsis disease caused by Phomopsis sojae ; For example, blood Saratov Tora (Phytophthora) disease caused by Phytophthora cactorum; For example, blood Reno Fora (Pyrenophora) disease caused by Pyrenophora graminea; For example, the pyrido caused by Pyricularia oryzae Kula Liao (Pyricularia) disease; For example, the error correcting capability of Titanium (Pythium) disease caused by Pythium ultimum; For example, the Li Estonian (Rhizoctonia) diseases caused by Rhizoctonia solani; Rhizopus disease caused by, for example, Rhizopus oryzae ; For example, the switch caused by Sclerotium rolfsii Klee Loti Titanium (Sclerotium) disease; For example, it forceps thoria (Septoria) diseases caused by Septoria nodorum; Typhula disease caused by, for example, Typhula incarnata ; For example, seed and soil decline, mold, wilt, decay and damping-off disease caused by Verticillium disease caused by Verticillium dahliae ;

For example, yttria-neck (Nectria) species, for example, the condition of the arm caused by Nectria galligena (cancerous disease), Hawke and broom (galls and witches'broom);

For example, parent nilri California (Monilinia) species, e.g., wilt caused by Monilinia laxa;

Exobasidium species, for example, exobasidium vexans ;

Taphrina species, for example, Crohn disease or leaf blight caused by Taphrina deformans ;

For example, Esca disease caused by Phaemoniella clamydospora and Phaeoacremonium aleophilum and Fomitiporia mediterranea ; For example, Eutypa moth roked by Eutypa lata ; For example, Kano Derma (Ganoderma) disease caused by Ganoderma boninense; For example, degenerative diseases of woody plants caused by Rigidoporus disease caused by Rigidoporus lignosus ;

For example, Botrytis (Botrytis) species, for example, flower and seed diseases caused by Botrytis cinerea;

For example, Rhizoctonia species such as Rhizoctonia solani ; HEL Minto sports Solarium (Helminthosporium) species, for example, the condition of the plant tuber caused by Helminthosporium solani;

For example, the video Playa Sumo Fora (Plasmodiophora) species, for example, nodule disease diseases caused by Plasmodiophora brassicae (club root disease);

Bacterial pathogens, such as Xanthomonas species, for example, Xanthomonas campestris pv. oryzae ; Pseudomonas (Pseudomonas) species, for example, Pseudomonas syringae pv. lachrymans ; El Winiah (Erwinia) species, for example, diseases caused by the Erwinia amylovora.

It is desirable to control the following diseases of soybean:

For example, alternaria leaf spot ( Alternaria spec. Atrans tenuissima ), anthracnose ( Colletotrichum gloeosporoides dematium var. Truncatum), brown spot ( Septoria glycines ), Serco- ( Cercospora leaf spot and blight; Cercospora kikuchii ), choanephora leaf blight ( Choanephora infundibulifera trispora (Syn.)), dactuliophora leaf spot ( Dactuliophora glycines ), Downy mildew ( Peronospora manshurica ) , Drechslera blight ( Drechslera glycini ), frogeye leaf spot ( Cercospora sojina ), leptosphaerulina leaf spot ( Leptosphaerulina trifolii ), phyllostica leaf spot ( Phyllosticta sojaecola ), pod and stem leaf blight (pod and stem blight; Phomopsis sojae ), powdery mildew (powdery mildew; Microsphaera diffusa), on the other Pierre noka Jeombyeong (Pyrenochaeta leaf spot; Pyrenochaeta glycines) , Li Estonian aerial, leaves, and spider web blight (Rhizoctonia aerial, foliage, and web blight; Rhizoctonia solani), leaf rust (rust; Phakopsora pachyrhizi Phakopsora meibomiae) , red mold disease (scab; Sphaceloma glycines , stemphylium leaf blight; Stemphylium botryosum , fungal diseases on leaves, stems, pods and seeds induced by a target spot ( Corynespora cassiicola ).

For example, black root rot ( Calonectria crotalariae ), charcoal rot ( Macrophomina phaseolina ), fusarium leaf blight or wilt, root rot, and pus rot and fusarium blight or wilt, root rot, mycoleptodiscus root rot; Mycoleptodiscus terrestris ; neocosmospora ( Neocosmopspora vasinfecta ); pod and stalk leaf blight ( Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti ) pod and stem blight, Diaporthe phaseolorum , stem canker, Diaporthe phaseolorum var caulivora , phytophthora rot, Phytophthora megasperma , brown stem rot ( Phialophora gregata ), pythium rot ; Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum ), rhizoctonia root rot Stem decay, and Rhizoctonia solani , sclerotinia stem decay ( Sclerotinia sclerotiorum ), sclerotinia southern blight ( Sclerotinia rolfsii ), tiellabiopsis root Thielaviopsis root rot; Fungal diseases on roots and stem bases induced by Thielaviopsis basicola ).

The fungicidal mixtures or compositions of the present invention may be used to cure or prevent / prevent phytopathogenic fungi. Accordingly, the present invention also relates to a method for the curative and protective control of phytopathogenic fungi using the active ingredients or compositions of the present invention applied to seeds, plants or plant parts, fruits, or soils where the plants grow .

Since the plant has excellent tolerance to the active ingredient at the concentration required to control the plant disease, it is possible to treat the plant top, nutritional propagation material and seed, and the soil.

All plant and plant parts can be treated according to the invention. A plant is any plant or plant population, such as wild or unwanted wild plants, cultivars, and plant varieties (which may or may not be protected by plant breed characteristics or the authority of the plant breeder). Cultivars and plant cultivars may be cultivated in a conventional breeding and breeding method that may be supplemented or supplemented by one or more biotechnological methods such as haploid, protoplast fusion, random and directed mutagenesis, using molecules or gene markers, It may be a plant obtained by a genetic engineering method. Plant parts should be understood to mean all ground and underground parts and organs of a plant, such as shoots, leaves, fruit flowers and roots, for example leaves, needles, stems, branches, flowers, fruit Sieve, fruit, seed, and also roots, caliber and rhizome. Crops, nutrition and breeding materials such as cuttings, caliber, rhizomes, weevils and seeds also belong to the plant parts.

The mixture or composition of the present invention is excellent in plant tolerance, toxic to a degree acceptable to warm-blooded animals, and excellent in environment-friendliness, so as to protect plants and plant organs, increase yields and improve the quality of harvested materials Do. They may preferably also be used as a crop protection composition. They are active for all stages or some stages of normal susceptible and resistant species and development.

Plants that can be treated according to the present invention include, but are not limited to, maize, soybean, alfalfa, cotton, sunflower, rapeseed, rapeseed, such as Brassica napus (e.g., canola, ), Brassica rapa , Brassica juncea (e.g. field mustard) and Brassica carinata , Arecaceae sp. ( E. G. Various fruits and vegetables of various plant classifications such as, for example, oil palm, coconut), rice, wheat, sugar beet, sorghum, oats, rye, barley, millet and sorghum, lime, flax, Roses, raspberries, rads, black currants and gooseberries such as Rosaceae sp . (For example, pome fruits such as apples and pears, as well as nuclei such as apricots, cherries, almonds and peaches, soft fruit) is a kind of Ribeirao Make (Ribesioidae sp.), Azusa Species (Juglandaceae sp.), Betulaceae species (Betulaceae sp.), Anacardiaceae species (Anacardiaceae sp.), Fagaceae species (Fagaceae sp.), Moraceae species (Moraceae sp.), Species (Oleaceae sp.) In oleic Asia ( for example, an olive tree), (for example the actinoids will Seah species (Actinidaceae sp.), lauraceae species (lauraceae sp.) (for example, avocados, cinnamon, camphor), musaceae species (musaceae sp.) Banana trees and farms), Rubiaceae sp. (For example coffee), Theaceae sp. (For example tea), Sterculiceae sp. Rutaceae sp. ) (For example lemon, orange, mandarin and grapefruit); Solanaceae sp. (For example tomatoes, potatoes, peppers, branches, tobacco), Liliaceae sp. , Compositiae sp . (For example, lettuce , Artichoke and chicory-root chicory, flower lettuce or common chicory), Umbelliferae sp . (For example, carrots, parsley, celery and rooted celery) (For example, leeks and onions), Cucurbitaceae sp . (Including cucumber-pickled cucumber, pumpkin, watermelon, calabash and melon), Alliaceae ap. Cruciferae sp. (For example, white cabbage, broccoli, cauliflower, brussel sprout, chrysanthemum, colbbi, radish, horseradish, cabbage, cabbage), legumina For example, Leguminosae sp . (E.g., peanuts, peas, lentils and beans, including, for example, vineyards and berries), Chenopodiaceae sp. , Beetroot), Linaceae sp. (For example hemp), Cannabeacea sp. (For example cannabis), Malvaceae (for example, okra, Cocoa), Papaveraceae (for example, poppy), Asparagaceae (for example asparagus); Useful plants and ornamental plants in gardens and bushes, including turf, grass, grass grass and Stevia rebaudiana ; As well as genetically modified forms of these plants, respectively. A particularly preferred plant is soybeans.

In particular, the compounds, mixtures and compositions according to the invention are suitable for controlling the following plant diseases:

Albugo spp. (White rust) - in ornamental plants, vegetable crops (eg A. candida ) and sunflower (eg A. tragopogonis ) ; Alternaria spp. (For example A. brassicola or A. brassicae ) , in sugar beets (eg A. tenuis ), in fruits, rice, soybeans and also potatoes (for example, A. solani or A. alternata ) and tomatoes (for example A. solani or A. alternata ) and Alternaria spp. (blackhead); Aphanomyces spp. In beets and vegetables . ; Ascochyta spp. In cereals and vegetables . , For example A. tritici in wheat (ascorbic acid blight) and A. hordei in barley ; Bipolaris and Drechslera spp. (Complete three large:. Cochliobolus spp), for example, leaves of the corn banjeombyeong (D. maydis and B. zeicola), for example leaf blight shell of the grain (B. sorokiniana), and for example in rice and grass B. oryzae ; Blumeria (formerly: Erysiphe ) graminis ( centipedes ) in cereals (eg wheat or barley); Botryosphaeria spp. In grape vines . ('Slack Dead Arm disease') (eg B. obtusa ) ; Botrytis cinerea (full three genera: Botryotinia fuckeliana: seedlings ) in small fruits and seedless fruits (especially strawberries), vegetables (especially lettuce, carrots, celery and cabbage), rapeseeds, flowers, grapevines, forest crops and wheat Gray mold, gray rot); Bremia lactucae in lettuce; Ceratocystis (synonymous with Ophiostoma ) spp. In deciduous and coniferous trees . (Blue fungus), for example C. ulmi (Elm elixia ) in elm; Cercospora spp. (Three reohseu Fora banjeombyeong) in corn (for example C. zeae-maydis), rice, and in sugar beet (for example C. beticola), sugar from cane, vegetables, coffee, soybeans (for example C. sojina or C. kikuchil ) and rice; Tomatoes (for example C. fulvum: tomato leaf mold) and Cladosporium spp. , For example C. herbarum in wheat; Claviceps purpurea in grains; Cochliobolus (silent generation: Helminthosporium or Bipolaris ) spp. (Eg spotting) in corn (eg C. carbonum ), in grain (eg C. sativus, silent generation: B. sorokiniana: leaf blight) and in rice (eg C. miyabeanus, silent generation: H. oryzae ) ; Colletotrichum (full three large: Glomerella ) spp. (Anthrax) - in cotton (eg C. gossypii ) , in corn (eg C. graminicola: stem decay and anthrax), in seedless fruits, in potatoes (eg C. coccodes ) (For example, C. lindemuthianum ) and soybean (for example, C. truncatum ); Corticium spp. , For example C. sasakii (peel blight) in rice; Corynespora cassiicola in soybeans and ornamental plants ( spotty ); Cycloconium spp. , For example C. oleaginum in olives; Cylindrocarpon spp. (For example, black foliage of fruit trees or grapevines, full three large: Nectria or Neonectria spp.) - fruit trees, grape vines (eg C. liriodendn; full three large: Neonectria liriodendri, In many tubular trees; Dematophora in soybeans (full three roses : Rosellinia ) necatrix (roots / stem rot); Diaporthe spp. For example D. phaseolorum in soybeans (stem disease); Drechslera (synonym Helminthosporium, full three large: Pyrenophora ) spp. - in corn, grain, eg barley (eg D. teres, mussel barley) and wheat (eg D. tritici-repentis: DTR spotting ), rice and turf; Formitiporia (synonym Phellinus ) punctata, F mediterranea. Esca disease in grape vines due to Phaeomoniella chlamydospora (formerly Phaeoacremonium chlamydosporum ), Phaeoacremonium aleophilum and / or Botryosphaeria obtusa (grape vine wilt blight , apoflexia ); Elsinoe spp. - from E. pyri and from small seedless fruits ( E. veneta: anthrax) and also from grapes ( E. ampelina: anthrax); Entyloma oryzae in rice (leaf blotting ); Epicoccum spp. In wheat . (blackhead); Erysiphe spp. (Mildew) in sugar beets (E. betae), the vegetable (e. G. E. pisi), such as cucumber species (e. G. E. cichoracearum) and cabbage species, for example, for (for example, from rapeseed, E. cruciferarum ); Eutypa fata (Eutypa) in fruit trees, grape vines and many tubular trees (Eutypa cancer or eggplant blight, silent generation: Cytosporina lata, synonym Libertella blepharis ); Exserohilum in corn (synonym Helminthosporium ) spp. ( E.g. , E. turcicum ); Fusarium ( Gibberella spp. ) In various plants . F. graminearum or F. culmorum (root rot and leaf spot) in cereals such as wheat or barley, F. oxysporum in tomatoes, F. F. verticillioides in solani and corn; Gaeumannomyces graminis (wheat blight) in cereals (e. G. , Wheat or barley) and maize; Gibberella spp. - in grains (eg G. zeae ) and in rice (eg G. fujikuroi ); Glomerella cingulata in grapevines, causal and other plants and G. gossypii in cotton; Grainstaining complex in rice; Guignardia bidwellii (grapevine) in grape vines; From Gymnosporangium spp. , For example, G. sabinae (pear rust) on the ship; Helminthosporium spp. In corn, grain and rice . (Synonym Drechslera, full three large: Cochliobolus ); Hemileia spp., for example H. vastatrix in coffee (Coffee leaf rust); Isariopsis in grape vines clavispora (Synonym Cladosporium vitis ); Macrophomina in soy and cotton phaseolina (Synonym phaseoli ) (Root / stem rot); Microdochium (synonym Fusarium ) nivale in cereals (eg wheat or barley); Microsphaera diffusa (soybean) in soybean; Monilinia spp. , For example M. laxa in nuclear and other rosacea . M. fructicola and M. fructigena (flowers and eggplant blight); Mycosphaerella spp. In small fruits and peanuts without grains, bananas, seeds . , For example M. graminicola in wheat (silent generation: Septoria tritici , ≪ / RTI > S. fijiensis in banana; Peronospora spp. (Eg, P. destructor ) , tobacco ( P. tabacina ), and soybeans (eg P. brassicae ), in oilseed rape (eg P. parasitica ) For example P. manshurica ); Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybeans; Phialophora spp. For example, in grape vines (e.g., P. tracheiphila and P. tetraspora ) and in soy (e.g., P. gregata: stalks); Phoma lingam (root and stem rot) in rapeseed and cabbage and P. betae in sugar beet; Phomopsis spp. - in sunflower, grapevine (eg P. viticola ) and soybean (eg P. phaseoli , Diaporthe phaseolorum ); Physoderma maydis (maize) in corn; Phytophthora spp. (Wilt, roots, leaves, stalks and fruit rot), such as bell peppers and cucumber species (for example P. capsici ) In soybeans (e. G. P. megasperma, synonym P. sojae), potatoes and tomatoes (e. G. P. infestans yeopgobyeong and brown rot.) And from deciduous trees (oak, for example P. ramorum blight); Plasmodiophora brassicae from cabbage, rapeseed, radish and other plants; Plasmopara spp., For example P. viticola (grape vine Pere nospora, nociceptive) in grape vines and P. halstedii in sunflower; Podosphaera spp. In rose plants, hops, citrus fruits and seedless fruits . ( Centipedes ), such as P. leucotricha in apples; Polymyxa spp. , Viral diseases for example propagated in cereals, such as barley and wheat ( P. graminis ) and in sugar beet ( P. betae ) and in it; Pseudocercosporella herpotrichoides in cereals, for example wheat or barley, ( Tapestia yallundae ); Pseudoperonospora in various plants, eg P. cubensis in cucumber or P. humili in hops; Pseudopezicula tracheiphila (grapevine, Phylophora ) in grape vines; Puccinia spp. In various plants . (Rust), for example in cereals such as P. triticina (wheat brown rust), P. striiformis (yellow rust) in wheat, barley or rye. P. hordei (dwarf leaf rust), P. graminis (black rust) or P. recondita (brown rust of rye), P. kuehnii of sorghum and, for example, (for example P. asparagi) Asparagus ; Pyrenophora (silent generation: Drechslera ) tritici-repentis in wheat or P. teres in barley; Pyricularia spp ., For example, P. oryzae (full-size: Magnaporthe grisea. Blast) in rice and P. grisea in grass and grains; Pythium spp. In grass, rice, corn, wheat, cotton, rapeseed, sunflower, sugar beet, vegetables and other plants . (For example, P. ultimum or P. aphanidermatum ); . Ramularia spp, for example R. beticola in R. collo-cygni (Ramularia leaves and grass banjeombyeong / physiological banjeombyeong) in barley and sugar beet; Rhizoctonia spp. In cotton, rice, potato, grass, corn, rapeseed, potato, sugar beet, vegetables and various other plants . , For example R. solani (roots and stem rot) in soybeans, R. solani (peel blight) in rice, or R. cerealis (sheath blight) in wheat or barley; Rhizopus stolonifer from berries, carrots, cabbage, grapes and tomatoes; Rhynchosporium secalis in barley, rye and lime ; Sarocladium oryzae and S. attenuatum in rice (leaf spot corruption); Sclerotinia spp. In vegetables and crops . (For example, Sclerotinia sclerotiorum ) and soybean (for example, S. rolfsii ) , Septoria spp. , For example S. glycines in soybean, S. tritici ( Septoria leaf blight) in wheat and S. (synonym Stagonospora ) nodorum in grain (leaf blight and leaf blight); Uncinula (synonyms Erysiphe ) necat in grape vines or ( Centipedes , silent generation: Oidium tuckeri ); Setospaeria spp. (Spotty) - in corn (eg S. turcicum, synonymous Helminthosporium turcicum ) and in grass; Sphacelotheca spp. (Mild illness) - in corn (eg S. reiliana ), in sorghum and in sorghum; Sphaerotheca fuliginea ( centipedes ) in cucumber; Spongospora subterranea in potatoes and viral diseases transmitted to it; Stagonospora spp. , For example S. nodorum (leaf blight and leaf blight, full three formations: Leptosphaeria [synonym Phaeosphaeria ] nodorum in wheat); Synchytrium endobioticum in potato (potato carcinoma); Taphrina spp, for example T. deformans (leaf curl disease) on peach and T. pruni in plums (plum-bottle pocket); Thielaviopsis spp. In tobacco, scissors , vegetable crops, soybean and cotton . (Black root rot), for example T. basicola (synonym Chalara elegans ); Tilletia spp. ( Bunt or stinking smut ), for example T. tritici (synonyms T. caries, wheat flour) and T. controversa (Dandelion); Typhula at Barley or Wheat incarnata (Gray snow corruption); Urocystis spp., for example, U. occulta in rye; Uromyces spp. (Rust), such as beans (e.g. U. appendiculatus, synonym U. phaseolI ) and sugar beets (e.g. U. betae ) ; Ustilago spp. (For example, U. nuda and U. avaenae ), in corn (eg U. maydis ) and in sorghum; Venturia spp. (Spotting) - in apples (eg V. inaequalis ) and in pears; And Verticillium spp. In various plants such as fruit and tubular trees, grapevines, seedless small fruits, vegetables and crops . (Leaf and bud wilt), for example V. dahliae in strawberries, oilseed rape, potatoes and tomatoes.

The mixtures and compositions according to the invention are particularly preferred for controlling the following plant diseases: Soybean disease: Cercospora kikuchii , Elsinoe glycines, Diaporthe phaseolorum var. sojae , Septaria glycines , Cercospora sojina , Phakopsora pachyrhizi , Phytophthora sojae , Rhizoctonia solani , Corynespora casiicola , and Sclerotinia sclerotiorum .

Plant Health

The mixtures and compositions according to the invention are suitable for promoting plant health.

Enhancement of plant health means that the mixture or composition of the present invention is useful as a plant growth regulator as described below, as a plant fortification / tolerance inducing compound as described below, for the performance of plant physiology as described below, This means that it can be used for increasing the yield in crops.

Plant growth regulation

In some cases, the mixtures or compositions of the present invention may also be formulated as herbicides, mildewers, growth regulators, or plant characteristics improvers, microbicides such as fungicides, antimicrobials, fungicides, antiviral agents (RLO), RLO (RIKKARA-type organism), MLO (mycoplasma-flow organism), and RLO If desired, they may also be used as intermediates or precursors for synthesizing other active ingredients.

The mixture or composition of the active ingredients of the present invention intervenes in plant metabolism and may therefore also be used as a growth regulator.

Plant growth regulators can exert various effects on plants. The effect of the substance depends essentially on the application period based on the stage of development of the plant and also on the amount and application form of the active ingredient applied to the plant or its environment. In each case, the growth regulator should have a specific, intended effect on the crop.

For example, plant growth regulating compounds may be used to inhibit plant nutrition growth. This inhibition of growth is economically beneficial, for example, in the case of grasses, because it can reduce the frequency of grassing in ornamental gardens, parks and athletic facilities, roadside, airport, or fruit growing. It is also important to inhibit the growth of herbaceous plants and herbaceous plants in the sidewalk and near pipelines or aerial cables, or in places that do not generally require strong plant growth.

The use of growth regulators to inhibit longitudinal growth of grains is also important. This makes it possible to reduce or completely eliminate the lodging risk of the plant before harvest. Moreover, growth control agents in grains can enhance the ability to act against clothing. The use of growth regulators to shorten and strengthen crops can increase fertilizer application rates, allowing crops to grow without risk of crop damage.

In many crops, it is possible to plant more densely due to the inhibition of nutritional growth, thus ensuring more yield per soil surface. Another advantage of the plant miniaturization thus obtained is that it is easy to cultivate and harvest crops.

Inhibition of nutrient plant growth may also lead to increased yield in that nutrients and anabolic products are more favorable to flowering and fruit formation than the nutrients of the plant.

Often, growth regulators may also be used to promote nutritional growth. This is a great benefit when harvesting nutrient plant parts. However, the promotion of nutritional growth also promotes reproductive growth with the formation of more assimilation products, which may result in larger and larger fruits.

In some cases, the increase in yield can be achieved without detecting changes in nutrient growth by manipulating the metabolism of the plant. In addition, growth regulators can be used to change the composition of the plant, thereby improving the quality of the harvest products. Thus, it is possible, for example, to increase sugar content in sugar beet, sugar cane, pineapple and also citrus fruit, or to increase protein content in soy or grain. For example, it is also possible to inhibit the saccharide from destroying the desired components, such as sugar beets or sugarcane, with a growth regulator before and after harvest. Moreover, it may also positively affect the production or removal of secondary plant components. One example is the emulsion of rubber tree.

Under the influence of growth regulators, unit-deficient fruit can be formed. In addition, it may be possible to affect the male and female flowers. It is also possible to produce neutral pollen, which is very important in breeding and hybrid seed production.

By using a growth regulator, the branch stretch of the plant can be controlled. On the one hand, destruction of apical dominance can promote the development of lateral branches, which is also highly desirable for growth control, especially for growing corn plants. However, on the other hand, it is also possible to inhibit the growth of the lateral branches. This action is particularly beneficial, for example, in the cultivation of cigarettes or tomatoes.

The amount of plant leaves can be controlled under the influence of growth regulators, and thus the leaves of the plant fall at the desired time. These deciduous events are very important for mechanically harvesting cotton and facilitate harvesting in other crops, for example, during viticulture. Plant deciduousness is also performed to reduce plant transplantation prior to their transplantation.

Growth regulators can also be used to regulate fruit planting. On the other hand, it is possible to prevent premature opening of the fruit trees. On the other hand, it is possible to achieve the desired mass by promoting the opening of the fruit number, or even the development of the flower ("swallow") and stop the alternation. The alternation should be understood as a characteristic of some fruit species whose quantity is changed every year due to endogenous factors. Finally, by using growth regulators at harvest time, they can reduce the power needed to remove fruit, allowing for mechanical harvesting or passive harvesting.

Growth regulators may also be used to promote or retard aging of the harvest material before, during and after harvest. This is particularly advantageous because it can be optimized to market requirements. In addition, in some cases, growth regulators may improve fruit color. In addition, growth regulators can be used to ensure that maturation is concentrated at a particular time. This makes it possible to harvest fully mechanical or manual crops, for example, in a single operation from cigarettes, tomatoes or coffee.

By using a growth regulator, it is possible to affect the dormancy of the seed or the plant eye, and thus, for example, in plants such as pineapple or ornamental plants at the time of breeding, , Or flowering occurs. In places where there is a risk of frost, it may be desirable to prevent damage from late-onset by delaying seed germination or germination using a growth regulator.

Finally, growth regulators can induce plant tolerance to frost, drought, or high salinity in the soil. As a result, plants can be grown in areas where cultivation is usually not feasible.

Induce resistance

The active compounds according to the invention can also exhibit a strengthening effect in plants. Thus, they can be used to assemble the defense system of the plant against attack by unwanted microorganisms.

In the present invention, a plant-fortified (resistant-inducing) substance means a substance that, when inoculated with an unwanted microorganism, can stimulate the plant's defense system in such a manner that the treated plant exhibits a high degree of resistance to these microorganisms.

The active compounds according to the invention are also suitable for increasing the crop yield. In addition, they show reduced toxicity, and plants show good tolerability.

In addition, plant physiological effects in connection with the present invention include:

Including resistance to temperature, tolerance to drought and recovery after drought stress, drug efficacy such as water efficiency (associated with reduced water consumption), flood resistance, ozone stress and UV tolerance, heavy metals, salts, pesticides Stress tolerance.

Biological stress tolerance, including increased fungal resistance and increased resistance to nematodes, viruses, and bacteria. In the present invention, biological stress tolerance preferably includes an increase in fungal resistance and an increase in resistance to nematodes.

Increase plant vitality including plant health and plant quality and seed vitality, reduce stall power, improve appearance, increase recovery, improve greening effect and improve photosynthesis efficiency.

Effect on plant hormones and / or functional enzymes.

The present invention relates to a method for improving the seedling growth and / or root growth and / or root growth, an improvement in early germination, an improvement in appearance, a better root system occurrence and / The number of spikes / m ² , the number of spikelets and / or flowering, the increase of the yield index, the bigger the leaves, the lesser leaves, the postcard improvement, the early maturity / early fruit completion, the more uniform maturation, Effects on Growth Regulators (Accelerators), including Larger Fruit / Vegetable Size, Youngest Resistance, and Reduced Lodging.

Increase in yield as well as increased yields, indicating total biomass per hectare, yield per hectare, grain / fruit weight, seed size and / or hectoliter weight, including:

Improved processability, uniform aging, improvement of graininess, improvement of wine yield, improvement of wine yield, improvement of brewing yield, improved liquid yield, harvestability, digestibility, settling value, falling number, pod stability in relation to size distribution (grain, fruit etc.) , Storage stability, fiber length / strength / uniformity improvement, increased milk and / or quality of silage feeding animals, application of cooking and frying;

Further improvements in fruit / grain quality, size distribution (grain, fruit etc.), increased storage / shelf life, hardness / softness, taste (incense, tissue etc.), grade (size, Includes improved marketability in terms of berry / fruit number, freshness, freshness, wax range, frequency of physiological disorders, color, etc.;

(Brix), polyphenol, starch content, nutrient quality, protein content, protein content, fatty acid, oil content, oil quality, amino acid composition, sugar content, acid content Gluten content / index, energy content, taste, etc.; And

Additional reduced undesirable ingredients include, for example, fungal hypoxia, aflatoxin degradation, geosmin level, phenol flavor, lacchase, polyphenol oxidase and peroxidase, and nitrate content.

Nutrient utilization efficiency, especially nitrogen (N) - utilization efficiency, phosphorus (P) - utilization efficiency, water efficiency, improved germination, respiration and / or CO ₂ assimilation rate, Sustainable agriculture.

For example, delayed senescence, including improvement in plant physiology, which is manifested by prolonged periods of high yielding long-term, full-bodied and subsequent color (greening), moisture content, and drying of plants. Thus, in the context of the present invention, it has been found that specific application of the active compound combination according to the present invention may prolong the leaf area period to retard plant maturation (senescence). The main advantage for the farmer is that it becomes longer and longer. Farmers also benefit from greater flexibility in harvesting.

The term " precipitator "in this context is a measure of protein quality and indicates the degree of settling of the powder suspended in the lactic acid solution over standard time intervals according to Zeleny (Zeleny value). This is taken as a measure of the baking quality. The gluten fraction swelling of the powder in the lactic acid solution affects the settling rate of the powder suspension. The higher the gluten content and the better the gluten quality, the lower the sedimentation rate and the higher the gellani test value. The sedimentation value of the flour depends on the wheat protein composition and is mainly related to the protein content, the firmness of the wheat, and the volume of the pan and fume loaf. The stronger correlation between loaf volume and zeleni sedimentation volume relative to SDS sedimentation volume can be attributed to protein content affecting both volume and gellani values ( Czech J. Food Sci. Vol. 21 , No. 3: 91-96, 2000).

In addition, the "polling water" referred to herein is a measure of the baking quality of cereals, particularly wheat. The polling number test shows that sprout damage can occur. This means that a change in the physical properties of the starch fraction of the wheat kernel has already occurred. In this regard, the poling water instrument analyzes the viscosity by measuring the resistance of the powder and water pastes to the poling plunger. The number of seconds this occurs is the polling number. The polling number result is recorded as an index of enzyme activity in wheat or flour samples, and the result is expressed in seconds of time. A high polling number (e.g., greater than 300 seconds) suggests minimal enzyme activity and a milky or powdery quality. Low polling numbers (e.g., under 250 s) suggest significant enzyme activity and sprout-damaged wheat or flour.

The term " better root system development "/ " root growth improvement" means longer roots, deeper roots growth, faster root growth, higher root dry weight / higher root mass, (Eg, WinRhizo), indicating a larger surface area, a larger root diameter, a higher root stability, a greater root branching, and a higher root and / Can be measured by analyzing the root composition.

The term "crop water efficiency" refers technically to the mass of agricultural produce per unit of consumed unit, and economically refers to the value of the product (s) produced per unit consumed unit, for example, Of biomass, cloth-kernel mass and number of spikes / m ² .

The term "nitrogen-utilization efficiency" refers technically to the mass of agricultural products per unit nitrogen consumed and, economically, refers to the value of the product (s) produced per unit nitrogen consumed and reflects absorption and utilization efficiency.

In addition to improved recording / color improvement and photosynthetic efficiency improvements, senescence delay can be measured by well known techniques such as the HandyPea system (Hansatech). Fv / Fm is a widely used parameter for suggesting the maximum quantum efficiency of the photo system II (PSII). This parameter is widely accepted as an optional indicator of plant photosynthesis performance, and healthy samples typically have a maximum Fv / Fm value of about 0.85. If the sample is exposed to a specific type of biological or abiotic stressor, a lower value will be observed, indicating a decrease in photochemical energy abolition capacity in PSII. Fv / Fm is presented as the ratio of mutation fluorescence (Fv) to the maximum fluorescence value (Fm). The figure of merit is essentially an indicator of sample vitality (see, for example, Advanced Techniques in Soil Microbiology , 2007 , 11 , 319-341; Applied Soil Ecology , 2000 , 15 , 169-182).

As well as improving the coloration and improving the color and improving the photosynthetic efficiency, senescence retardation can also be measured by measuring the net photosynthetic rate (Pn), for example, by measuring the chlorophyll content by Ziegler and Ehle pigment extraction methods, Fv / Fm ratio), shoot growth and final root and / or canopy biomass crystals, tillering density as well as root mortality.

 In the present invention, improvement of nutrient utilization efficiency including increase of root growth / better root system, improvement of greening, improvement of water efficiency (related to reduction of water consumption), especially nitrogen (N) It is desirable to improve the plant physiological effect selected from the group comprising.

In the increase of yield, improvement of protein and sugar content as well as settling value and polling number improvement for plants selected from the group of grain (preferably wheat) is preferred.

Preferably, the novel uses of the fungicide compositions of the present invention are: a) a method of preventing and / or curative preventing pathogenic fungi and / or nematodes, with or without resistance management, and b) methods for increasing root growth, Improvement in water efficiency, delay in senescence and increase in water quantity. An improvement in root system, water efficiency and N-utilization efficiency from group b) is particularly preferred.

Seed treatment

The present invention further includes a seed treatment method.

The present invention also relates to seed treated according to one of the methods described in the paragraph above. The seeds according to the present invention are used in a method for protecting seeds from unwanted microorganisms. In this method, seed treated with at least one active ingredient of the present invention is used.

The mixtures or compositions of the present invention are also suitable for treating seeds. Most crop damage caused by harmful organisms is triggered not only during seed storage and after seeding but also during plant germination and seed infection after germination. This is particularly important because the roots and buds of the growing plants are particularly sensitive and even the entire plant can tolerate some damage. Thus, it is of great interest to protect seeds and germplasm using suitable compositions.

It has long been known to treat plant pathogenic fungi by treating seeds of plants and is a constant improvement task. However, seed treatment has a number of problems that are difficult to solve in a satisfactory manner. For example, it is desirable to develop a method of protecting seeds and germination plants that does not require additional application of crop protection compositions after transplantation or after plant emergence, or where the additional application is at least substantially reduced. It is also desirable to optimize the amount of active ingredient used, in such a manner as to maximally protect seeds and germplasm from the invasion of phytopathogenic fungi without damaging the plant itself. In particular, the seed treatment method should also take into account the inherent fungi of transgenic plants in order to optimally protect seeds and germplasm by minimizing the use of crop protection compositions.

Accordingly, the present invention also relates to a method of treating seeds with the composition of the present invention to protect seeds and germplasm from invasion of phytopathogenic fungi. The present invention also relates to the use of the composition of the present invention for treating seeds to protect seeds and germplasm from plant pathogenic fungi. The present invention also relates to seed treated with the composition of the present invention so as to be protected from phytopathogenic fungi.

Control of phytopathogenic fungi that damage plants after emergence is accomplished primarily by treating the soil and plant parts with a crop protection composition. Efforts have been made to reduce the application amount of the active ingredient due to concerns that the crop protection composition may hurt the environment and human and animal health.

One advantage of the present invention is that due to the particular system of the mixtures and compositions of the present invention, treating the seeds with these mixtures and compositions protects not only the seed itself but also the plants after emergence from the plant pathogenic fungus. Thereby, it is not necessary to immediately treat the crop at the time of sowing or immediately thereafter.

In addition, it should be considered advantageous that the mixture or composition of the present invention is used in particular for transformed seeds so that plants grown from this seed can express proteins that act against pests. By treating the seed with the mixture or composition of the present invention, certain pests can be controlled, for example, by the expression of the insect protein alone. Surprisingly, we were able to observe additional synergistic effects that also increased the protective effect against pest infestation.

The compositions of the present invention are suitable for protecting seeds of any plant varieties used in agriculture, greenhouses, forests, or horticulture and viticulture. In particular, it may be used in the production of cereals (eg wheat, barley, rye, lime, maize, millet and oats), corn, cotton, soybeans, rice, potatoes, sunflower, (See below), rape, poppy, olive, coconut, cocoa, sugarcane, tobacco, vegetables (eg tomatoes, cucumbers, onions and lettuce), grass and corn plants. The treatment of cereals (eg wheat, barley, rye, lime and oats), corn and rice seeds is particularly important. Treatment of the soybean seeds is particularly preferred.

As described below, it is also particularly important to treat the transformed seeds with the mixture or composition of the present invention. This applies to seeds of plants that contain at least one heterologous gene capable of expressing a polypeptide or protein that is insoluble. Transgenic seeds within the heterologous gene of Bacillus (Bacillus), separation tank emptying (Rhizobium), Pseudomonas (Pseudomonas), theta Liao (Serratia), Trichoderma (Trichoderma), Clavinova bakteo (Clavibacter), glow mousse (Glomus) or glycidyl Eau radium ( Gliocladium ). ≪ / RTI > Preferably, the heterologous gene is derived from Bacillus sp. And its gene product is effective against European light moth moth and / or corn root worm. More preferably, the heterologous gene is derived from Bacillus thuringiensis .

In the context of the present invention, the compositions of the present invention are applied to the seed, alone or in a suitable formulation. Preferably, the seeds are treated in a state that is sufficiently stable to avoid any damage. Generally, seeds can be processed at any point between harvest and sowing. Usually, the seeds used are separated from the plant, and are separated from the genus, the bark, the stem, the skin, the hair or the flesh of the plant. Thus, it is possible, for example, to use seeds which have been harvested, washed, or dried to a moisture content of less than 15% by weight. On the other hand, it is also possible to use dried seeds after drying, for example, after treatment with water.

In seed treatment, the amount of the composition of the present invention and / or the amount of the additional additive applied to the seed should be such that the seed germination is not adversely affected or the resulting plant is selected so as not to be harmed. This should be borne in mind, especially if it is an active ingredient that can have a phytotoxic action at a particular application rate.

The composition of the present invention can be applied directly, i.e. without diluting without additional ingredients. In general, it is preferred to apply the composition to the seeds in the form of a suitable preparation. Suitable formulations and seed treatment methods are known to those skilled in the art and are described, for example, in US 4,272,417, US 4,245,432, US 4,808,430, US 5,876,739, US 2003/0176428 A1, WO 2002/080675, WO 2002/028186 ≪ / RTI >

Mixtures or compositions that may be used in accordance with the present invention may be converted into conventional preparations such as solutions, emulsions, suspensions, powders, foams, slurries or other seed coating compositions and ULV preparations.

These preparations may be prepared by mixing the active ingredient or mixture with conventional additives such as conventional thickeners and also with solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, .

Useful dyes that may be present in seed dressing formulations that may be used in accordance with the present invention include all dyes conventional for this purpose. Both water-soluble pigments and water-soluble dyes can be used in the present invention. For example, Rhodamine B, C.I. Red dye 112 and C.I. Dyes known as Applicant 1 can be mentioned.

Useful wetting agents that may be present in the seed dressing formulations of the present invention are all materials conventionally used in the formulation of pesticidal active ingredients which promote wettability. It may be desirable to use alkylnaphthalene sulfonates such as diisopropyl- or diisobutylnaphthalene sulfonate.

Useful dispersing and / or emulsifying agents which may be present in the seed dressing formulations of the present invention include all nonionic, anionic and cationic dispersing agents conventionally used in the formulation of agricultural active ingredients. It may be desirable to use nonionic or anionic dispersants or mixtures of nonionic and anionic dispersants. Suitable nonionic dispersants are the ethylene oxide / propylene oxide block polymers, alkylphenol polyglycol ethers and tristyrylphenol polyglycol ethers and their sulfonated or sulfated derivatives. Suitable anionic dispersants are lignosulfonates, polyacrylates and arylsulfonates / formaldehyde condensates.

Defoamers that may be present in the seed dressing formulations of the present invention are all the foam inhibiting compounds commonly used in the formulation of active ingredients of the pesticide. It may be desirable to use a silicone defoamer and magnesium stearate.

Preservatives that may be present in the seed dressing formulations of the present invention are all compounds that can be used for this purpose in an agrochemical composition. For example, dichlorophen and benzyl alcohol hemiforme may be mentioned.

Secondary thickening agents that may be present in the seed dressing formulations of the present invention are all compounds that can be used for this purpose in an agrochemical composition. Cellulose derivatives, acrylic acid derivatives, xanthan, modified clay and highly dispersed silica are preferably used.

The tackifiers that may be present in the seed dressing formulations of the present invention are all conventional binders that can be used in seed dressing. Polyvinyl pyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylulose are preferable examples.

The gibberellins which may be present in the seed dressing formulations which can be used according to the invention are preferably gibberellins A1, A3 (= gibberellic acid), A4 and A7; Particularly preferably, gibberellic acid is used. Gibberellin is known (R. Wegler "Chemie der Pflanzenschutz und und Schaedlingsbekaempfungsmittel" [Chemisrty of Crop Protection Compositions and Pesticides], Vol 2, Springer Verlag, 1970, pp. 401-412).

Seed dressing formulations that may be used in accordance with the present invention may be used directly or prior to dilution with water to treat a wide variety of different types of seeds. At this time, an additional synergistic effect may occur due to the interaction with the substance formed by the expression.

Any mixing apparatus that can be used conventionally for seed dressing is useful for treating seeds with seed dressing formulations or water formulations that can be used in accordance with the present invention and formulations made therefrom. Specifically, the procedure employed in seed dressing involves introducing the seeds into a mixer, adding a certain predetermined amount of the seed dressing preparation after dilution itself or with water, and then mixing until the formulation is evenly distributed on the seed . In some cases, the drying process is followed.

Fungus poison

It is also possible to reduce the fungal toxic content in the harvested material and the food and feed prepared therefrom by the treatment according to the invention. Particularly, but not exclusively, fungicides can be identified: deoxynil valenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2- and HT2- Fumonisines, Zearalenone, Moniliformine, Fusarine, Diacothoxyscirpenole (DAS), Beauvericine, Enniatine, Fusaroproliferine, Fusarenole, Ochratoxines, Patuline, Ergot alkaloid and Aflatoxines, which can be used, for example, by the following fungal diseases: It can be induced: (. Fusarium spec) Fusarium species such as F. acuminatum, F. asiaticum, F. avenaceum , F. crookwellense, F. culmorum, F. graminearum (Gibberella zeae), F. equiseti, F. fujikoroi , F. musarum , F. oxysporum , F. proliferatum , F. poae , F. pseudograminearum , F. sambucinum , F. scirpi , F. semitectum , F. solani , F. sp A. oryrichoides , F. langsethiae , F. subglutinans , F. tricinctum , F. verticillioides and the like and also Aspergillus species such as A. flavus, A. parasiticus , A. nomius , A. ochraceus , A. clavatus , A. terreus, A. versicolor, Penny room Solarium species (Penicillium spec.), for example, P. verrucosum, P. viridicatum, P. citrinum , P. expansum, P. claviforme, P. roqueforti, Clavinova chef's species (Claviceps spec ), Such as C. purpurea , C. fusiformis , C. paspali , C. africana , Stachybotrys spec .

Material protection

In protecting the material, the mixture or composition of the present invention may be used to protect the industrial material from being infected and destroyed by harmful microorganisms, such as fungi and insects.

The mixture or composition of the present invention may also be used alone or as an antifouling composition together with other active ingredients.

Industrial materials are to be understood as meaning non-living materials manufactured for industrial use. Industrial materials intended to be protected by a mixture or composition of the invention from, for example, microbial changes or destruction include, but are not limited to, adhesives, glue, paper, wallpaper and board / cardboard, fabrics, carpets, leather, Paint, plastic products, cooling lubricants, and other materials that can be infected or destroyed by microorganisms. Included within the scope of the protected material may also be mentioned production plants and buildings, such as cooling water circuits, cooling and heating systems, exhaust and air conditioning systems, which may be adversely affected by the growth of microorganisms. Industrial materials that may be mentioned as preferred in the context of the present invention are adhesives, glue, paper, cardboard, leather, wood, paint, cold lubricants and heat transfer fluids, particularly preferably wood.

The mixture or composition of the present invention can prevent adverse effects such as decay, rot, discoloration, discoloration or mold formation.

In the case of wood treatment, the compounds or compositions according to the invention can also be used against fungal diseases which can grow on or within the timber. The term "timber" means all kinds of wood for all kinds of wood and architectural work, such as wood, high density wood, laminate and plywood. The method for treating timber according to the present invention consists primarily of contacting one or more compounds according to the invention or a composition according to the invention; This includes, for example, direct application, spraying, dipping, injection, or any other suitable means.

The compounds of the present invention may also be used to protect objects in contact with seawater or salt water, particularly ship hulls, screens, nets, structures, vents and signaling equipment from fouling.

The method of the present invention for controlling harmful microorganisms can also be used to protect stored products. A storage product is understood to be a natural substance of vegetable or animal origin, or a processed product thereof, which is of natural origin and requires long-term protection. Storage products of vegetable origin, such as plants or plant parts, such as stems, leaves, tubers, seeds, fruits, kernels, etc., are being harvested in freshly harvested or (pre) dried, moistened, granulated, crushed, compressed or baked And then protected. The storage product also includes wood in both unprocessed forms such as building timber, telephone poles and barriers, or finished products such as furniture or wood products. Storage products for animal origin include, for example, leather, leather, fur and fur. The mixture or composition of the present invention can prevent adverse effects such as decay, rot, discoloration or mold formation.

Microorganisms capable of decomposing or changing industrial materials may be mentioned, for example, bacteria, fungi, yeast, algae and fungi. Mixture or composition of the invention preferably fungi, in particular molds, wood discoloration and wood destroying fungi (ascomycetes (Ascomycetes), Basidiomycetes (Basidiomycetes), and imperfect fungi (Deuteromycetes), and bonding fungi (Zygomycetes)), Slime Molds biological and It acts on algae. These include Alterna Liao (Alternaria), for example Alterna Ria Te Nuys (Alternaria tenuis), Aspergillus peogil Ruth (Aspergillus), for example, asbestos peogil loose nigeo (Aspergillus niger), kaeto hate (Chaetomium), for example, For example, Chaetomium globosum , Coniophora , such as Coniophora puetana , Lentinus , for example Lentinus tigrinus , Penicillium , such as Penicillium glaucum , Polyporus , such as Polyporus versicolor , Aureobasidium , and the like, , for example, Aureobasidium pullulans (Aureobasidium pullulans), switch nucleoside poma (Sclerophoma), for example, scan nucleoside poma pita EO pillar (Sclerophoma pityophila), Trichoderma (trichoderma), such as Trichoderma cheated to (Tricho Derma viride , Ophiostoma spp., Ceratocystis spp., Humicola spp., Petriella spp. A bacterium belonging to the genus Petriella spp., Trichurus spp., Coriolus spp., Gloeophyllum spp., Pleurotus spp. Poria spp., Serpula spp. And Tyromyces spp., Cladosporium spp., Paecilomyces spp., Mucor spp. ( Mucor spp.), Escherichia (Escherichia), for example, Escherichia coli (Escherichia coli), Pseudomonas (Pseudomonas), for example Pseudomonas Ke rugi labor (Pseudomonas aeruginosa); Staphylococcus such as Staphylococcus aureus , Candida spp. And Saccharomyces spp., For example, Saccharomyces cerevisiae , such as Staphylococcus aureus , Candida spp. And Saccharomyces spp. Microorganisms in Saccharomyces cerevisae can be mentioned.

Antimicrobial activity

The mixtures or compositions of the present invention also exhibit very good antibacterial activity. These particular skin fungi (dermatophyte) and yeasts, molds and more fungi (e.g. Candida albicans (Candida albicans), Candida glabrata (Candida species (Candida species), such as Candida glabrata)) and epi Dermo python flow kosum ( Epidermophyton floccosum), Asda peogil Ruth nigeo (Aspergillus noger) and Asda peogil Ruth Fu fumigatus (Aspergillus fumigatus) and tricot python species, such as Aspergillus peogil Ruth species (Aspergillus species), tricot Python menta him fight (Trichophyton mentagrophyte) as (Trichophyton species), micro sports Ron has a very broad antibacterial spectrum for car varnish (Microsporon canis) and brother dough am (micro sports Rhone species (Microsporon species), such as audouinii)). These fungal lists do not limit the antimicrobial spectrum that can be controlled, and are for illustrative purposes only.

Thus, the mixtures or compositions of the present invention can be used in both medical and non-medical applications.

Genetically modified organism

As mentioned above, it is possible to treat all plants and their parts according to the invention. In a preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional biological breeding methods such as mating or protoplast fusion, and also their areas are treated. In a further preferred embodiment, transplanted plants and plant cultivars obtained by genetic engineering (genetically modified organisms), and their parts, optionally in combination with conventional methods, are treated. The term " site "or" site of a plant "or" site of a plant " More preferably, the plant varieties commercially available or in use in each case are treated according to the invention. Plant cultivars represent new characteristics ("traits ") and are understood to mean plants obtained by conventional breeding, mutation or recombinant DNA techniques. These may be cultivars, cultivars, biotypes or genotypes.

The treatment method according to the present invention can be used for the treatment of genetically modified organisms (GMO), for example plants or seeds. Transgenic plants (or transgenic plants) are plants in which heterologous genes are stably integrated into the genome. The expression "heterologous gene" is inherently expressed or assembled outside the plant, and when introduced into the nucleus, the chloroplast or mitochondrial genome expresses the protein or polypeptide of interest, or downregulates or otherwise regulates the other gene (s) Refers to a gene that provides new or improved plant characteristics or other properties to the transformed plant by silencing (e.g., using antisense technology, co-suppression technology or RNAi technology [RNA interference]). The heterologous gene located in the genome is also called a transgene. The transgene gene defined by its specific location in the plant genome is referred to as a transgenic or transgenic event.

Plants and plant cultivars which are preferably treated according to the present invention include all plants which have genetic material (irrespective of whether they are obtained by breeding and / or biotechnological means) which imparts to the plants useful traits which are particularly advantageous.

Plant and plant cultivars which are also preferably treated according to the invention are resistant to one or more biological stresses, i.e. the plants are resistant to animal and microbial insects, such as nematodes, insects, mites, phytopathogenic fungi, It is more resistant to bacteria, viruses, and / or viroids.

Plants and plant cultivars that may also be treated according to the present invention are plants resistant to one or more abiotic stresses. Abiotic stress conditions include, for example, limited availability of nutrients, such as drought, cold exposure, heat exposure, osmotic stress, flood, increased soil salinity, increased mineral exposure, ozone exposure, , And shade avoidance.

Plants and plant cultivars that can also be treated according to the present invention are plants characterized by enhanced harvestability. Increased yields in such plants can result, for example, as a result of plant physiological, growth and developmental improvements such as water use efficiency, water retention efficiency, nitrogen utilization improvement, carbon assimilation enhancement, photosynthesis improvement, germination efficiency increase, have. Yields can also be adjusted by controlling the flowering rate, flowering regeneration for hybrid seed production, seedling growth, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or pod count, An improved plant architecture including, but not limited to, seed count per seed, seed mass, enhanced seed filling, reduced seed segregation, reduced dehiscence and lodging resistance. (Under stress and non-stress conditions). Additional yield traits include seed composition, such as carbohydrate content and composition for cotton or starch, protein content, oil content and composition, nutritional value, reduction of anti-nutritional compounds, improved processability and better shelf life.

Plants that can be treated in accordance with the present invention are hybrid plants that have already expressed the characteristics of hybrid stress or hybrid growth that generally result in higher yields and growth, health and resistance to biological and abiotic stress.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can be treated in accordance with the present invention are herbicide tolerant plants, i.e. plants that are made resistant to one or more of the given herbicides. Such plants can be obtained by selection of plants that contain genetic transformation, or mutations that confer such herbicide tolerance.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated in accordance with the present invention are plants that have been made resistant to attack by insect-resistant transgenic plants, i.e., certain target insects. Such plants can be obtained by gene selection or plant selection containing mutations that confer such insect resistance.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that may also be treated in accordance with the present invention are resistant to abiotic stress. Such plants can be obtained by gene selection or plant selection containing mutations that confer such stress resistance.

Plant or plant cultivars (obtained by plant biotechnology methods, such as genetic engineering) that can also be treated in accordance with the present invention are useful for modifying the quantity, quality and / or storage stability of crop yields and / .

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that may be treated in accordance with the present invention are plants with altered fiber properties, such as cotton plants. Such plants can be obtained by genetic transformation, or by selecting plants containing mutations that confer fiber property alterations.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which can also be treated according to the invention are plants with altered oil profile properties, such as rapeseed or related Brassica plants. Such plants can be obtained by genetic transformation, or by selecting plants that contain mutations that confer oil property alterations.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated in accordance with the present invention are plants with altered seed shattering properties, such as rapeseed or related Brassica plants. Such plants include plants which can be obtained by genetic transformation or by selection of plants containing mutations that confer such a change in seed defection characteristics and which exhibit delayed or reduced seed defection, such as rapeseed plants.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) that can also be treated in accordance with the present invention are plants that alter posttranslational protein modification patterns, such as tobacco plants.

Application rate and timing

When the mixture or composition of the present invention is used as a fungicide, the application rate may vary within a relatively wide range depending on the type of application. The application rate of the active ingredient of the present invention is

Ha, preferably 10 to 1,000 g / ha, more preferably 10 to 800 g / ha, even more preferably 50 to 300 g / ha, in the case of treating leaves, ha (where application is carried out routinely or sporadically, the rate of application may be reduced, particularly when using inert substrates such as rock wool or pearlite);

Preferably 2 to 200 grams per 100 kilograms of seed, preferably 3 to 150 grams per 100 kilograms of seed, more preferably 2.5 to 25 grams per 100 kilograms of seed, and even more preferably 2.5 to 12.5 grams per 100 kilograms of seed, g;

In the case of soil treatment, 0.1 to 10,000 g / ha, preferably 1 to 5,000 g / ha.

The application rates are given for illustrative purposes and are not intended to limit the invention.

Thus, the mixtures or compositions of the present invention may be used to protect plants against attack by pathogens mentioned within a period of time after treatment. The period of time in which the protection against the plant is provided is generally 1 to 28 days, preferably 1 to 14 days, more preferably 1 to 10 days, very preferably 1 to 7 days after the plant is treated with the mixture or composition , Or up to 200 days after seed treatment.

The process according to the invention also provides for the use or application of the compounds (I) and (II) and / or (III) simultaneously, separately or in a sequential manner. If the single active component is applied in a sequential manner, i. E. At different times, they are applied in one case followed by one component in a reasonably short period of time, e.g. several hours or days. Preferably, the application sequence of compounds (A) and (B) and / or (C) is not essential to practice the present invention.

The listed plants may particularly advantageously be treated according to the invention with a mixture or composition of the invention. The preferred ranges described above for the active ingredients or compositions also apply to these plant treatments. Treatment of plants with compounds or compositions specifically mentioned herein is particularly emphasized.

Example

The high fungicidal activity of the combination of active compounds according to the invention is evident from the following examples. Although the individual active compounds have been shown to have weak fungicidal activity, the formulations have activity that surpasses simply adding activity.

A synergistic effect of fungicides is always present if the fungicidal activity of the combination of active compounds exceeds the total activity of the individual active compounds being applied. The expected activity for the combination of the two given active compounds can be calculated using the Colby equation as follows (see Colby, SR, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations ", Weeds 1967 , 15 , 20 -22):

X is the effect when the active compound A is used in an application rate of m ppm (or g / ㏊)

Y is the effect when the active compound B is used in a concentration of n ppm (or g / ㏊)

Z is an effect when the active compound C is used in a concentration of r ppm (or g / ㏊)

E ₁ is an effect when the active compounds A and B are used in m and n ppm (or g / ㏊), respectively,

E ₂ is an effect when the active compounds A, B and C are used in m, n and r ppm (or g / ㏊), respectively,

, And for the ternary mixture

to be.

The degree of effectiveness is determined in%. 0% means the effect corresponding to that of the control, and 100% means that no disease was observed at all.

When the actual fungicidal activity exceeds the calculated value, the action of the combination is superadditive, i.e. there is a synergistic effect. In this case, the actual observed effect should be greater than the value of the expected effect (E) calculated using the above equation.

Another way to demonstrate synergism is the tamales method (cf. "Isoboles, a graphic representation of synergism in pesticides" in Neth. J. Plant Path., 1964 , 70, 73-80).

Hereinafter, the present invention will be described by the following examples. However, the present invention is not limited to these embodiments.

Example  A: Pitot Tora  About Invivo (in vivo ) Prevention test (tomato)

Solvent: acetone 24.5 parts by weight

 Dimethylacetamide 24.5 parts by weight

Emulsifier: alkylaryl polyglycol ether 1 part by weight

One part by weight of the active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration to prepare a suitable preparation of the active compound. To test the prophylactic activity, the young plant was sprayed with the active compound preparation at the specified application rate. After the spray coating has been dried, Phytophthora ( Phytophthora) infestans . The plants were then placed in an incubation cabinet at a relative atmospheric humidity of 100% and a temperature of about 20 < 0 > C.

The test was evaluated 3 days after inoculation. 0% means the effect corresponding to the untreated control, and 100% effect means no disease was observed. Obviously in the table below the activity observed in the combination of the active compounds according to the invention is above the calculated activity, i.e. synergistic effect exists.

Example  B: Bentouria  About Invivo (in vivo ) Prevention test (apple)

Solvent: acetone 24.5 parts by weight

 Dimethylacetamide 24.5 parts by weight

Emulsifier: alkylaryl polyglycol ether 1 part by weight

One part by weight of the active compound is mixed with the above-mentioned amount of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration to prepare a suitable preparation of the active compound. To test the prophylactic activity, the young plant was sprayed with the active compound preparation at the specified application rate. After the spray coating has dried, the apple black spot disease causative agent ( Venturia inaequalis . The plants were then placed in an incubation cabinet at 100% relative atmospheric humidity and at a temperature of about 20 < 0 > C for one day. The plants were then placed in a greenhouse at a relative atmospheric humidity of about 90% and a temperature of about 21 < 0 > C.

The test was evaluated 10 days after inoculation. 0% means the effect corresponding to the untreated control, and 100% effect means no disease was observed. Obviously in the table below the activity observed in the active formulations according to the invention is above the calculated activity, i.e. there is a synergistic effect.

Claims (8)

(A) 2- {3- [2- (1- {3,5-bis (difluoromethyl) -1H-pyrazol- 1 -yl] acetyl} piperidin- 3-thiazol-4-yl] -4,5-dihydro-1,2-oxazol-5-yl} -3-chlorophenyl methanesulfonate, and
(B) fosetyl-aluminum, and
(C) propyne, polpet or 2,6-dimethyl-1H, 5H- [1,4] dithieno [2,3-c: 5,6-c '] dipyrrol- 2H, 6H) -tetrone,
Lt; RTI ID = 0.0 > fusogenic < / RTI > active compound. Use of a combination of an active compound according to claim 1 for the control of unwanted phytopathogenic fungi. Use of a combination of an active compound according to claim 1 for treating seeds. Use of a combination of an active compound according to claim 1 for the treatment of transgenic plants. Use of a combination of an active compound according to claim 1 for the treatment of seeds of transgenic plants. A seed treated with a combination of an active compound according to claim 1. A method for the control of unwanted phytopathogenic fungi, characterized in that the combination of active compounds according to claim 1 is applied to unwanted phytopathogenic fungi and / or their habitats and / or seeds. Characterized in that the combination of the active compound according to claim 1 is mixed with an extender and / or a surfactant.