KR20150032006A

KR20150032006A - Antimycotic cleanser composition containing heisclean

Info

Publication number: KR20150032006A
Application number: KR20130111962A
Authority: KR
Inventors: 조영진
Original assignee: 조영진
Priority date: 2013-09-17
Filing date: 2013-09-17
Publication date: 2015-03-25

Abstract

The present invention relates to an antifungal cleanser composition comprising heisclean or a composite of the heisclean and clotrimazole as an active ingredient. The composite of the present invention includes the heisclean and clotrimazole, thereby enhancing effect of removing pruritus and stench caused by dermatophytes. Therefore the composite can be useful for treating dermatomycosis.

Description

ANTIMYCOTIC CLEANSER COMPOSITION CONTAINING HEISCLEAN < RTI ID = 0.0 >

FIELD OF THE INVENTION The present invention relates to an antifungal cleanser composition, and more particularly to an antifungal cleanser composition comprising a combination of hygizin or hizzlin and clotrimazole as an active ingredient.

In recent years, the importance of skin has been emphasized due to increasing interest in appearance regardless of gender, and studies and cosmetic materials are being actively developed to improve the quality of skin. However, many consumers are unable to improve skin quality due to fungal skin infections.

On the other hand, dermatomycosis or fungal skin disease is a generic term for infectious skin diseases caused by fungi (fungi). The incidence of skin fungus is most common among skin fungi belonging to incomplete fungi. Actinomycetes are currently classified as fungi, but conventionally skin lesions caused by the fungi are treated as skin fungus. Most modern people often wear shoes or socks for a long time, and skin fungus such as athlete's foot, ringworm, etc. is likely to develop.

Tinea pedis, one of the skin fungus, is one of the most frequently observed fungal infections. It is a skin disease in which fungus dissolves the keratin of the skin to become parasitic and multiply as nutrients. In addition, athlete's foot is able to develop in most parts of the body in a rich, moist and warm place (mold, toes, soles, claws, fingernails, groin, Generally, it is easy to think of only a foot athlete's foot as a foot athlete's foot. However, not only feet and hands, but also all of the white nails (nail athlete's foot) . In Korea, more than 10% of the population is suffering from athlete's foot, and it is reported that the most cases occur in the 20s to 40s, and the problem is serious. It has also been reported to infrequently occur in children.

In addition, the groin line is mainly caused by high temperature and high humidity environment, obesity, friction between clothes and skin, and it is most often caused by infection with foot and foot athlete's foot. It occurs mostly in men and spreads to the scrotum, hips, thighs. In humid summers, the condition of the disease worsens. In relatively dry winters, only black pigmentation remains and most of the symptoms disappear. Most of the groin occurs in both groin. The beginning of the groin begins at the site of the testicles and spreads to both groin, and the red keratinization begins at the testis or penis pubis without involvement of the groin. The reason why the groin is more common in men than in women is that men wear more closed clothes than women, and because the testicles are more closed, groin is more frequent than women.

Currently, there are methods for treating such skin fungus, such as external preparation for skin, antifungal agent, steroid, etc. However, all of these methods have disadvantages of high economic costs. In addition, the external preparation for skin should only be used for at least several months, and the effect can not be cured. In the case of antifungal agents and steroid agents, the antifungal effect is superior to the external preparation for skin, but there is a problem in safety that hepatotoxicity and nephrotoxicity can be induced depending on the patient. Skin fungus should be used for a long time because it is inevitable for long-term treatment and it is highly likely to recur if treatment is discontinued. However, most of the antifungal products currently available have a high toxicity and thus can not be used for a long period of time. In addition, conventional antifungal products can only treat fungal infections of localized sites, and when the sites of mutual related pathogenic infections are different, they can not be treated at the same time.

Accordingly, the present inventors have researched the above-mentioned problems and studied a formulation with high safety that can be used for a long period of time. The inventive complex contains hizclein or hizclein and clotrimazole, Itching, odor and the like are excellent, and the present invention has been completed.

It is an object of the present invention to provide a skin cleansing composition containing, as an active ingredient, a complex of Hizclein or Hizclein and Clotrimazole having antifungal activity.

The present invention provides an antifungal cleanser composition comprising, as an active ingredient, a complex of hecinin or heislean and clotrimazole represented by the following formula (1).

The chlorotrimazole represented by the above formula (1) has the chemical name 1 - [(2-chlorophenyl) diphenylmethyl] imidazole, the molecular formula is C22H17CIN2, and the molecular weight is 344.84.

Hereinafter, the present invention will be described in detail.

The heisclean used in the preparation of the complex as an active ingredient of the present invention is a male cleanser and is a cleanser for a special site developed to suit the care of the inguinal cleansing by mixing raw materials having low skin irritation and high cleansing power. The hygizin cleanses the sweat, secretions, sweat and the like of the groin, and contains flavonoid components of the Cubuckton oil. Since the natural ingredients are used as the main ingredients, the skin irritation is small. In addition, the hygizin contains a large amount of ingredients beneficial to the skin including the ginseng stem cell culture fluid, mushroom extract and the like.

The term " clotrimazole "used in the preparation of the composite of the present invention is a compound having the chemical structure of the above formula (1), bis- phenyl [(2- chlorophenyl) -1-imidazole] 1- (O-chloro-a, -diphenyl-benzyl) imidazole. The clotrimazole is a water-insoluble trityl imidazole derivative of colorless crystals. Clotrimazole was first described by Plempel et al. (Bayer AG, Germany) in 1969, and many studies have confirmed that it has excellent antifungal activity. Also, it is known that clotrimazole has a broad spectrum of antimicrobial spectrum including most pathogenic fungi such as dermatophytic fungi, yeast fungi, mold fungi, dysplastic fungi, and gram-positive bacteria, thus causing antigen-inserting action.

The antifungal mechanism of clotrimazole has not yet been clarified, but it is known that it acts as a mediator that directly interacts with phospholipids at high concentrations and inhibits ergosterol synthesis at low concentrations. However, there is a disadvantage in that clotrimazole is toxic to the drug, and therefore, systematic administration is not possible at present and there is a limitation that it can be used locally only for superficial mycoses.

As used herein, the term "cleanser " refers to light gray powdery detergent used for polishing cleaning of kitchen utensils and wash basins, etc., and most people use it as a skin cleanser or a skin condition used as a cosmetic The skin is interpreted only as an entrapment agent.

Wherein the complex comprises 4 to 6% by weight of Cybergton oil, 0.05 to 0.15% by weight of anhydrous ginseng stem cell extract, 0.01 to 0.05% by weight of an epithelial growth factor, 2 to 4% by weight of mushroom extract, 10 to 20% by weight of glucopone, It is preferable that the composition contains 18 to 28 wt% of water, 5 to 10 wt% of plant component 1, 22 to 32 wt% of plant component 2, 5 to 10 wt% of plant component 3 and 5 to 15 wt% of plant component 4 However, it is not limited thereto, and may be added and added at a range lower than or equal to the upper limit of the range according to the ordinary judgment of a person skilled in the art.

The components of the composite

1) Plant component 1 is an alkaloid or saponin, which is isolated and purified from royal jellyfish, snowballs, flower buds, and honeysuckle flower extract;

2) Plant component 2 is a mixed medicinal herb extract containing herbal medicines;

3) Plant component 3 is a plant extract including fermented soybean, oregano, whitening, golden, flowering and marigold;

4) Plant component 4 is preferably a herbal complex consisting of rosemary, lavender, oregano, and time, but is not limited thereto and can be suitably produced by the judgment of a person skilled in the art.

Since the complex of the present invention contains Hizclein or Hizclein and Clotrimazole, it is excellent in the effect of removing skin itching, odor and the like caused by dermatophytes, so that it can be effectively used for treating skin fungus.

Preferably, the composition inhibits the growth of fungi that cause skin mycosis.

The fungi include, but are not limited to, skin fungi including ringworm, yolk, swollen, superficial, skin candidiasis, spolotricosis, chromomycosis and mycobacteria.

The composition preferably improves athlete's foot and groin pain.

The composition preferably contains a natural surfactant. Further, it is preferable that the composition contains hydrogen ion water.

It is preferable that the composition is manufactured by a formulation of an external skin cleansing agent, a scalp cleansing agent, a crotch cleansing agent, a dedicated cleansing agent and a cleansing agent for removing odors, and it is preferably made of a cleansing gel or a cleansing formulation.

The composition of the present invention may further comprise an aging agent, a surfactant, a known kaolin neutralizing agent and a foaming aid to achieve the formulation of the cleanser.

Wherein the thickener is selected from the group consisting of an acrylate copolymer, an acrylate / vinylneodecanoate crosspolymer, an acrylate / stearth-20 methacrylate crosspolymer, and an acrylate / C10-30 alkyl acrylate crosspolymer. Or more species. The thickening agent is preferably contained in an amount of 0.1 to 10% by weight, more preferably 0.3 to 7% by weight, based on the total weight of the composition. If the thickener is contained in an amount of less than 0.1% by weight, it is difficult to expect an increasing effect, and when it is contained in an amount of more than 10% by weight, the viscosity is too high.

Generally, among the incremental agents used in the cleanser composition, cellulose type, carbomer, alginic acid type, and inorganic thickening agents exhibit a uniform amorphous form, so that the effect of the thickening agent added to the composition of the present invention is similar, The effect of granulating and stabilizing carbon dioxide can not be expected, which is not preferable.

In the present invention, the thickening agent acts to form a polymer matrix of a wall structure and to contain carbon dioxide in its structure, so that the phenomenon of carbon dioxide bubbles being generated and blown can be suppressed as much as possible.

The surfactant is added to exhibit the cleansing effect of the composition. The surfactant is preferably selected from the group consisting of phage-7 glyceryl cocoate, phage-6 caprylic / capric glyceride, olive oil phage-7 ester and polyglyceryl Stearate, and the like. The surfactant is preferably contained in an amount of 5 to 25% by weight, more preferably 7 to 20% by weight based on the total weight of the composition. If the surfactant is contained in an amount of less than 5% by weight, the cleansing effect is markedly deteriorated. If the surfactant is contained in an amount exceeding 25% by weight, irritation to the skin may occur and skin stability can not be guaranteed.

The composition of the present invention may further include a bubble generating auxiliary agent.

The term "bubbling aid" in the specification of the present invention can be used interchangeably with "auxiliary agent ", and acts to increase the toxic effect generated when the detergent of the present invention is applied to skin.

The bubble generating auxiliary may include at least one selected from the group consisting of methyl perfluoroisobutyl ether / methyl perfluorobutyl ether, disiloxane and trisiloxane.

The bubbling aid is preferably contained in an amount of 0.5 to 15% by weight, more preferably 2 to 10% by weight, based on the total weight of the composition. If the bubbling aid is contained in an amount of less than 0.5% by weight, it is difficult to exhibit bubbling effect, and if it is contained in an amount exceeding 15% by weight, the viscosity of the composition is lowered.

The antifungal detergent composition according to the present invention forms a composite containing a hyposcreen or hyposcreen and a clotrimazole phorbol, and may contain at least one known active ingredient having a cleansing effect.

The cleanser composition of the present invention can be used as a cosmetic product in the form of a general emulsified formulation and a solubilized formulation, and can be variously used as a cleanser cosmetic having a cleansing effect. Emulsifier-type cosmetics include nutritional lotion, cream, and essence, and cosmetics of the solubilized formulation have softening longevity. Suitable cosmetic formulations include, for example, solutions, gels, solid or kneaded anhydrous products, emulsions obtained by dispersing the oil phase in water, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) In the form of a dispersing agent, in the form of a cream, a skin, a lotion, a powder, an ointment, a spray or a conical stick. It can also be prepared in the form of a foam or an aerosol composition further containing a compressed propellant. Cleansing cosmetics include, for example, cleansing lotions, cleansing creams, cleansing sprays, cleansing oils, cleansing gels, and cleansing bars.

The cleanser composition of the present invention is not limited to the face, hands, and feet, and can be applied to all skin tissues constituting the body.

The cleanser cleanser composition according to the present invention contains hydrogen ion water having an antioxidative effect that inhibits skin aging due to active oxygen, and preferably contains 0.01 to 20% by weight based on the total weight of the cleanser cleanser composition.

Since the complex of the present invention contains Hizclein or Hizclein and Clotrimazole, it is excellent in the effect of removing skin itching, odor and the like caused by dermatophytes, so that it can be effectively used for treating skin fungus. In addition, the conventional antifungal agent is an ointment type, but the antifungal cleanser composition according to the present invention can be made of a gel-type cleaning flow, so that the user can easily and easily remove the fungus by washing.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined by the appended claims. It will be obvious to you.

That is, the present invention relates to an external skin cleansing agent containing an antifungal agent, a scalp containing the same, and a cleansing gel composition acting on itching, whitening and odor removal.

[ Example One. Hizklin And Of clotrimazole Complex composition]

Hizzlein or hizclein and clotrimazole were purchased and placed in a homogenizer and mixed. Thereafter, a viscous complex of the present invention was prepared by adding siqbutton oil, wild ginseng stem cell extract, epithelial growth factor, mushroom extract, glucupone, plant components 1 to 4, and hydrogen water. The composition of each component in the composite is shown in Table 1 below.

Main ingredients percentage(%) Seabuckthorn oil 3 Wild ginseng stem cell extract (cultured ginseng callus) 0.05 Epidermal Growth Factor (EGF) 0.01 Mushroom extract 1.2 Glucopon 8 Hydrogen water 12.2 Botanical Ingredients 1 (Arugacea, Saponin, etc.) 4 Plant Component 2 (10 herbs) 14.5 Plant component 3 (fermented soybeans, oregano, white, golden, broiler, etc.) 4 Plant ingredient 4 (herbal complex consisting of rosemary, lavender, oregano, thyme, etc.) 5

As shown in the above Table 1, it can be seen that the complex of the present invention contains a large amount of plant components, so that it has less side effects than a chemical agent and can inhibit various fungi than a single product.

[Production Example 1: Preparation of detergent]

The formulation examples of the detergent prepared with the complex of the present invention are shown in Table 2 below.

No . Compound name ( ICID Name ) Furtherance(%) function One Purified water (hydrogen ion water) Q.S 12.210 Solvent 2 Disodium laureth sulfosuccinate Q.S 10,000 Surfactant 3 Acrylate copolymer Q.S 10,000 Viscosity 4 Cocamidopropyl betaine Q.S 10,000 Surfactant 5 Decyl glucoside (ecocert certified) Q.S 8.000 Conditioning 6 ethanol Q.S 4.000 Active Ingredient 7 Gosam extract Q.S 3.000 Conditioning 8 Lily extract Q.S 3.000 Conditioning 9 Rosemary extract Q.S 2.000 Conditioning 10 Lavender extract Q.S 2.000 Conditioning 11 Basil flower / leaf extract Q.S 2.000 Conditioning 12 Marshmallow leaves / root extract Q.S 2.000 Conditioning 13 Horsetail extract Q.S 2.000 Conditioning 14 Chamomile flower extract Q.S 2.000 Conditioning 15 Fennel extract Q.S 2.000 Conditioning 16 Number of apples Q.S 2.000 Conditioning 17 Peony extract Q.S 1.500 Conditioning 18 Licorice extract Q.S 1.500 Conditioning 19 Sashou extract Q.S 1.500 Conditioning 20 Mushroom extract Q.S 1.500 Conditioning 21 Eucalyptus extract Q.S 1.500 Conditioning 22 Horse riding extract Q.S 1,000 Conditioning 23 Black sesame extract Q.S 1,000 Conditioning 24 Angelica extract Q.S 1,000 Conditioning 25 Golden extract Q.S 1,000 Conditioning 26 Lavender extract Q.S 1,000 Conditioning 27 Oregano leaf / flower / stem extract Q.S 1,000 Conditioning 28 Sun Thyme Extract Q.S 1,000 Conditioning 29 Royal roe extract Q.S 1,000 Conditioning 30 Snowball Pocket Extract Q.S 1,000 Conditioning 31 Flower extract Q.S 1,000 Conditioning 32 Sweetpotato flower extract Q.S 1,000 Conditioning 33 Lactobacillus / soybean fermented extract Q.S 1,000 Conditioning 34 White Willow bark extract Q.S 0.500 Conditioning 35 Broiler extract Q.S 0.500 Conditioning 36 Oregano leaf extract Q.S 0.500 Conditioning 37 Prunus persicae leaf extract Q.S 0.500 Conditioning 38 Marchia extract Q.S 0.500 Conditioning 39 Golden extract Q.S 0.500 Conditioning 40 Propylene glycol Q.S 0.500 Conditioning 41 PIGGY-40 Hydrogenated Castor Oil Q.S 0.300 Surfactant 42 menthol Q.S 0.200 Conditioning 43 Triethanolamine Q.S 0.200 pH Adjuster 44 Ginseng cultured root extract Q.S 0.050 Conditioning 45 Human Oligopeptide-1 Q.S 0.010 Conditioning 46 Chlorhexidine di gluconate Q.S 0.010 Active Ingredient 47 Spices Q.S 0.010 Fragrance 48 Ascorbic acid Q.S 0.010 Conditioning

The present invention having the above-described constitutions and effects can be modified in various ways, and the above description is not intended to limit the scope of the present invention. That is, the present invention described above is preferably used in the storeroom tank, but the present invention is not necessarily limited thereto, and various applications are possible within the scope of achieving the same purpose and function. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope thereof.

Claims

An antifungal cleanser composition comprising as an active ingredient a complex of heislean and clotrimazole represented by the following formula (1);
[Chemical Formula 1]

At this time, the chlorotrimazole represented by Chemical Formula 1 is chemically named 1 - [(2-chlorophenyl) diphenylmethyl] imidazole, the molecular formula is C22H17CIN2, and the molecular weight is 344.84.

The composition of claim 1, wherein the complex comprises 4 to 6% by weight of siembourg oil, 0.05 to 0.15% by weight of ginseng stem cell extract, 0.01 to 0.05% by weight of epithelial growth factor, 2 to 4% 5 to 10% by weight of plant component 1, 22 to 32% by weight of plant component 2, 5 to 10% by weight of plant component 3 and 5 to 10% by weight of plant component 4, 18 to 28% By weight, based on the total weight of the composition;
At this time, the component
1) Plant component 1 is an alkaloid or saponin, which is isolated and purified from royal jellyfish, snowballs, flower buds, and honeysuckle flower extract;
2) Plant component 2 is a mixed medicinal herb extract containing herbal medicines;
3) Plant component 3 is a plant extract including fermented soybean, oregano, whitening, golden, flowering and marigold;
4) Plant component 4 is a herbal complex consisting of rosemary, lavender, oregano and thyme.

The antifungal cleanser composition of claim 1, wherein the composition inhibits the growth of fungi that cause skin mycosis

[Claim 4] The method according to claim 3, wherein the fungus has an antifungal activity against at least one skin fungus selected from the group consisting of white, yellow, topical, superficial skin, candidiasis, spolotricosis, chromomycosis, Characterized by an antifungal cleanser composition

The antifungal cleanser composition according to claim 1, wherein the composition is a composition for improving athlete's foot and groin pain.

The antifungal cleanser composition of claim 1, wherein the composition comprises a natural surfactant

The antifungal cleanser composition of claim 1, wherein the composition contains hydrogen ion water

The antifungal cleanser composition according to claim 1, wherein the composition is prepared by formulating an external skin cleansing agent, a scalp cleansing agent, a crotch cleansing agent, a scouring cleanser and a malodor removing cleansing agent

The antifungal cleanser composition of claim 1, wherein the composition is formulated as a cleaning gel or a wash flow formulation

(Ecocert certified), Ethanol, Gossam Extract, Rosaceae Extract, Rosemary Extract, Lavender Extract, Basil Phytophthora, Lactobacillus acidophilus, Lactobacillus sp. / Leaf extract, marshmallow leaf / root extract, horsetail extract, chamomile flower extract, fennel extract, apple water, peony extract, licorice extract, moss extract, mushroom extract, manganese extract, horse riding extract, black sesame extract, ginseng extract, golden Extracts, Lavender Extracts, Oregano Leaf / Flower / Stem Extract, Sun Thyme Extract, Royal Cordoba Extract, Snowball Pouch Extract, Flower Bud Extract, Sweet Potato Extract, Lactobacillus / Soybean Fermented Extract, White Willow Shell Extract, Broiler Extract, Oregano Leaf Extract, Leaf Extract, Lime Extract, Golden Extract, Propylene Glycol, Phage-40 Hydrogenated Cass An antifungal cleanser composition, which comprises, as an active ingredient, terry oil, menthol, triethanolamine, ginseng root extract, human oligopeptide-1, chloxydinediglycinate, fragrance and ascorbic acid