KR20130077912A - Composition for treating and preventing diabetes containing cedrela sinensis jussieu extracts - Google Patents

Abstract

PURPOSE: A composition containing a Cedrela sinensis Jussieu extract as an active ingredient for preventing and treating diabetes is provided to promote insulin secretion, reduce blood glucose without toxicity in the body, and be used as a pharmaceutical product and a health functional food for preventing or treating diabetes. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes contains a Cedrela sinensis Jussieu extract as an active ingredient. The extract is prepared using C1-C4 alcohols or a mixture thereof. The diabetes is type 2 diabetes. A health functional food for preventing or treating diabetes contains the extract as an active ingredient.

Description

Composition for the prevention and treatment of diabetes mellitus comprising the oak extract as an active ingredient {Composition for treating and preventing diabetes containing Cedrela sinensis Jussieu extracts}

The present invention relates to a composition for the prevention and treatment of diabetes mellitus, including the oak extract as an active ingredient.

Diabetes is a disease in which glucose in the blood is excreted through the urine and is one of the chronic degenerative diseases that does not heal fundamentally. In modern times, due to changes in diet and lack of exercise, a great change occurred in the body's own energy metabolism process, and thus chronic degenerative diseases such as diabetes are increasing. In Korea, the prevalence of diabetes is known to reach 5-10% and shows a continuous increase. In the United States, diabetes has increased six-fold over the last 40 years, and this increase is expected to reach 26 million patients by 2050.

The etiology of type 2 (insulin-independent) diabetes, which accounts for more than 95% of diabetes, is known to be a combined disorder of two causes: insulin secretion disorder and insulin resistance. Diabetes mellitus is a disease with chronic hyperglycemia due to this complex disorder.

Insulin secretion disorder refers to a situation in which an appropriate amount of insulin is not secreted from the beta cells of the pancreas according to the blood glucose level, which includes both a quantitative decrease in insulin secreting beta cells and a functional distribution disorder. Insulin resistance refers to a situation in which secreted insulin has reached the target organ through the bloodstream but its insulin action and sensitivity are decreased in the target cell. , Obesity, decreased physical activity and hyperglycemia or dyslipidemia. Insulin resistance requires higher levels of insulin to overcome resistance, and conversely, hyperglycemia caused by insufficient insulin secretion may worsen insulin resistance again.

Currently, the treatment of insulin-independent diabetes mellitus, diet therapy, exercise therapy, sulfonurea drug, biguanide drug, α-glucosidase inhibitor, insulin, etc. are used. Linidin- or thiazolidinidione-based drugs, insulins with various action times have been developed and applied in clinical practice. However, these therapeutic agents have a problem of causing low side effects or many side effects such as liver dysfunction, hypoglycemia, lactic acidosis and the like. Therefore, it is necessary to reduce the side effects, improve the metabolic disorders, and the like, and to develop an excellent diabetes treatment agent for long-term use.

Accordingly, the present inventors have completed the present invention by confirming that the oak extract promotes the secretion of insulin in cells and has a hypoglycemic effect in an animal model, as a result of research for developing a diabetes treatment.

It is an object of the present invention to provide a pharmaceutical composition for the prevention and treatment of diabetes mellitus, including the oak extract as an active ingredient.

In addition, it is an object of the present invention to provide a health functional food for the prevention and improvement of diabetes mellitus containing the oak extract as an active ingredient.

In order to achieve the above object, the present invention provides a pharmaceutical composition for the prevention and treatment of diabetes mellitus comprising an oak tree extract as an active ingredient.

In addition, the present invention provides a health functional food for the prevention and improvement of diabetes mellitus containing the oak extract as an active ingredient.

According to the present invention, the oak tree extract promotes the secretion of insulin in cells without being toxic to cells, and has an effect of lowering blood sugar in an animal model, thereby having a significant therapeutic effect of diabetes.

Hereinafter, the present invention will be described in more detail.

According to one aspect of the invention, there is provided a pharmaceutical composition for the prevention and treatment of diabetes mellitus comprising an oak tree extract as an active ingredient.

The composition of the present invention is prepared by the following method.

The oak tree is washed with water to remove debris, dried in the shade and crushed. Oak tree can be used without limitation, such as cultivated or commercially available. Appropriate amount of solvent is added to the ground oak tree to ensure complete immersion. The oak tree extract is extracted using a solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.

The composition of the present invention may contain at least one known active ingredient having an inhibitory and therapeutic effect of diabetes along with elder tree extract.

The composition of the present invention can be administered orally or parenterally during clinical administration and can be used in the form of general pharmaceutical preparations. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants are usually used. Solid preparations for oral administration are prepared by mixing tablets, pills, powders, granules and capsules. In addition to simple excipients, lubricants such as magnesium stearate talc are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions and syrups. Various excipients such as wetting agents, sweeteners, fragrances and preservatives may be included in addition to water and liquid paraffin, which are commonly used simple diluents. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations and suppositories. Examples of the non-aqueous solvent and the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin butter, glycerol, gelatin and the like can be used.

Dosage units may include, for example, one, two, three or four times the individual dosage or may include one, two, one third or one quarter times. Individual dosages preferably include the amount in which the effective drug is administered at one time, which usually corresponds to all, 1/2, 2/3 or 1/4 times the daily dose. The effective dose of the composition of the present invention is 0.1 to 1000 mg / kg (body weight), may be administered 1 to 6 times a day.

The composition of the present invention may be used alone or in combination with methods using surgery, radiation therapy, hormone therapy, chemotherapy and biological response modifiers for the prevention and treatment of diabetes.

According to another aspect of the present invention, it provides a health functional food for the prevention and improvement of diabetes comprising an oak extract as an active ingredient.

In the present invention, "health functional food" refers to a food having a bioregulatory function, such as prevention and treatment of diseases, biological defense, immunity, recovery of symptoms, inhibition of aging, and should be harmless to the human body when taken in the long term.

When the composition of the present invention is used as a food additive, the composition can be added as it is or can be used together with other food or food ingredients, and can be suitably used according to a conventional method. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or therapeutic treatment). In general, the composition of the present invention is added in an amount of not more than 15% by weight, preferably not more than 10% by weight based on the raw material, in the production of food or beverage. However, in the case of long-term intake for the purpose of health and hygiene or for the purpose of controlling health, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range.

There is no particular limitation on the kind of the food. Examples of foods to which the above substances can be added include dairy products including meats, sausages, breads, chocolates, candies, snacks, confectionery, pizza, ramen noodles, gums, ice cream, soups, drinks, tea, Alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense.

The health beverage composition of the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. Such natural carbohydrates include monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and natural sweeteners such as dextrin and cyclodextrin, synthetic sweeteners such as saccharine and aspartame, and the like . The ratio of the natural carbohydrate is generally about 0.01 to 10 g, preferably about 0.01 to 0.1 g per 100 ml of the composition of the present invention.

In addition to the above, the composition of the present invention may further contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, A carbonating agent used in a carbonated beverage, and the like. In addition, the composition of the present invention may include a pulp for the production of natural fruit juice, fruit juice drinks and vegetable drinks. These components may be used independently or in combination. The proportion of such additives is not critical but is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the examples.

Example  One: Oak  Obtaining Extracts

The oak tree is washed with water to remove debris, dried in the shade and crushed. Then extracted in 80% EtOH.

Example  2: Anti-diabetic  Check the effect

As a result of confirming the anti-diabetic effect of the oak extract obtained in Example 1, it was confirmed that there is an excellent hypoglycemic effect and insulin secretion promoting effect.

Hereinafter will be described a pharmaceutical composition containing the composition of the present invention and a preparation example of a health functional food, but is not intended to limit the present invention only intended to be described in detail.

Formulation example  One. Sanje  Produce

True Oak Extract 20 mg

Lactose 100 mg

Talc 10 mg

The above components are mixed and filled in airtight bags to prepare powders.

Formulation example  2. Preparation of tablets

Oak Tree Extract 10 mg

Corn starch 100 mg

Lactose 100 mg

Magnesium stearate 2 mg

After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

Formulation example  3. Preparation of capsules

Oak Tree Extract 10 mg

Crystalline cellulose 3 mg

Lactose 14.8 mg

Magnesium stearate 0.2 mg

The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Formulation example  4. Preparation of injections

Oak Tree Extract 10 mg

180 mg mannitol

Sterile sterilized water for injection 2974 mg

Na ₂ HPO _{4 ?} 2H ₂ O 26 mg

(2 ml) per 1 ampoule in accordance with the usual injection preparation method.

Formulation example  5. Liquid  Produce

True Oak Extract 20 mg

10 g per isomer

5 g mannitol

Purified water quantity

Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was added with purified water to adjust the total volume to 100 ml, And sterilized to prepare a liquid preparation.

Formulation example  6. Manufacture of health food

Oak Tree Extract 100 mg

Vitamin mixture quantity

Vitamin A acetate 70 μg

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

0.15 mg of vitamin B2

Vitamin B6 0.5 mg

Vitamin B12 0.2 μg

Vitamin C 10 mg

Biotin 10 μg

Nicotinic acid amide 1.7 mg

Folic acid 50 μg

Calcium pantothenate 0.5 mg

Mineral mixture quantity

1.75 mg of ferrous sulfate

0.82 mg of zinc oxide

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Secondary calcium phosphate 55 mg

Potassium citrate 90 mg

Calcium carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

Formulation example  7. Health drink  Produce

Oak Tree Extract 100 mg

Vitamin C 15 g

Vitamin E (powder) 100 g

19.75 g of ferrous lactate

3.5 g of zinc oxide

Nicotinic acid amide 3.5 g

Vitamin A 0.2 g

Vitamin B1 0.25 g

Vitamin B2 0.3g

Water quantification

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The solution thus prepared was filtered and sterilized in a sterilized 2 liter container, It is used in the production of the health beverage composition of the invention.

Although the compositional ratio is relatively mixed with a component suitable for a favorite drink, it is also possible to arbitrarily modify the compounding ratio according to the regional or national preference such as the demand class, the demanding country, and the use purpose.

Claims (4)

A pharmaceutical composition for the prevention or treatment of diabetes mellitus, comprising an oak tree extract as an active ingredient.
The composition according to claim 1, wherein the extract is extracted with a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof.
The composition of claim 1, wherein the diabetes is type 2 diabetes.
Health functional foods for the prevention or improvement of diabetes mellitus containing oak tree extract as an active ingredient