KR20120046564A - Compositions for scalp-care and hair restoration containing extracts of melia azedarach fruits as an effective ingredient - Google Patents

Abstract

PURPOSE: A composition containing Melia azedarach L. var. japonica Makino extract for hair and scalp care is provided to suppress conversion of testosterone into dehydrotestosterone. CONSTITUTION: A composition for hair and scalp care contains 0.5-20.0 wt% of plant extract isolated from Melia azedarach L. var. japonica Makino fruits. The composition is manufactured in the form of a shampoo, rinse, hair gel, hair mousse, hair spray, hair tonic, or hair pack. The solvent is ethanol, propylene glycol, butylene glycol, polyol, or purified water.

Description

Compositions for scalp-care and hair restoration containing extracts of Melia Azedarach fruits as an effective ingredient}

The present invention is a combination of a conventional hair cosmetic composition with an extract obtained from the safe fruit of St. Pauline in humans as an active ingredient and inhibits the activity of testosterone, a male hormone, which is not produced by the active male hormone dihydrotestosterone and at the same time scalp Prevents hair loss by promoting excessive sebum secretion, promotes hair growth and cleansing the scalp to prevent itching, excessive sebum secretion and dandruff due to keratinogenesis. It relates to a composition for management.

The human hair has about 100,000 to 150,000 hairs, and each hair has a different hair cycle, which is produced, grown, and dropped out by repeating anagen, catagen, and telogen. About 15% of the hair is placed in the resting and degenerative stages, so that on average 50-100 hairs fall out and reproduce normally. This hair growth cycle repeats about 3-6 years. In general, alopecia refers to a period in which the anagen phase of the hair cycle is shortened due to various causes, so that the ratio of degenerative and resting hair increases relatively, resulting in more hair falling out than the average value. Genetic androgen hormone action, nutritional disorders caused by local blood flow disorders, autonomic nervous system disorders, autoimmune disorders, endocrine disorders, but there is no clear cause of hair loss until now, and the aforementioned causes It is known to occur by action.

In recent years, the population that causes abnormal hair loss due to changes in diet, lifestyle changes, and excessive stress caused by social environment is gradually increasing. Especially, the hair loss population of the young, middle-aged and female is increasing. On the other hand, hair loss, which means less or no normal condition due to hair or hair, is distinguished from general hair loss phenomenon (telogen effluvium) in which hair falls out of the resting state and anagen effluvium (abnormal hair loss). In general, the term alopecia refers to the latter. Types of alopecia include alopecia areata, premature alopecia, and alopecia alopecia in women, syphilis alopecia, and male pattern baldness. In male expression, testosterone is involved in male impulse, skeletal muscle increase, male external genital development, scrotum growth, and spermatogenesis, and dehydrotestosterone is involved in acne, sebum increase, hair loss and prostatic hyperplasia. It is known that [J. Invest. Dermatol. (1995) 105 (2): 209-214. Among them, male-type hair loss in male hormone-dependent diseases has serious mental pain for men in the modern society, which focuses on beauty. Therefore, studies are being actively conducted to identify and improve the mechanism of hair loss. Testosterone, a male hormone that is biosynthesized in testes, is a dihydrotestosterone (DHT) that is activated by 5 alpha-reductase, which is present in male hormone-reactive tissues such as sebaceous glands, hair follicles, prostate, or epididymis. As a reductase involved in the conversion, NADPH is known to be used as a coenzyme. Excessive secretion of dihydrotestosterone after puberty acts as a major causative agent in the production of sebum in sebocytes, causing acne and male hair loss. In particular, many hair follicle cells provide a cause for hair loss because dehydrotestosterone binds to hormone receptors better than testosterone. Accordingly, studies are being actively conducted to develop a substance that inhibits the activity and production of 5-alpha-reductase, which promotes the production of dihydrotestosterone, and to use it as a hair regrowth or hair loss prevention agent.

Conventionally, female hormones such as estrogen have been used for the treatment of androgenetic alopecia, but female hormones have been reported to cause skin inflammation and side effects due to hormone administration. I'm using it. Recently, Merck of the United States has synthesized finasteride (finasteride, proscar), a drug that inhibits the action of 5 alpha-reductase and inhibits the production of dihydrotestosterone, and is commercially available as a hair regrowth for oral administration, but it is expensive and for scalp application. If manufactured and applied directly, the effect is limited and other side effects of oral administration occurs, such as the use is limited. In addition, there is Minoxidil of Upjohn Co., Ltd. disclosed in U.S. Patent No. 4,596,812 as a representative hair growth promoting agent that has been used to promote hair growth. Minoxidil was used as an antihypertensive agent. As a side effect, the human hair is increased by focusing on the hair growth promoting agent, which increases the blood flow of the scalp where the hair follicles are located to promote hair growth. However, when minoxidil is used as a hair growth promoter for a long time, its effect is halved, and as a side effect due to chemical vasodilation, it has been reported that anxiety and sebum increase are reported.

On the other hand, dandruff, a measure of scalp health, refers to a form in which all forms of keratin or dead cells do not come off the scalp in a comprehensive sense. Normally, the normal cell regeneration cycle is 28 days, but due to skin aging stress, such cell regeneration cycles lengthen dead cells that need to fall off in time, forming a stratum corneum, that is, dandruff. White dandruff as seen in general is the top layer of this stratum corneum. There are dry dandruff and gin dandruff. When it is scratched, it is dry dandruff and when it is scratched it is dry dandruff. In other words, dry dandruff is a type of dry scalp that does not fall well because of dandruff attached to the scalp. In addition, gin dandruff is oily and moist dandruff, many types of oily scalp. Especially dandruff can be dangerous because it causes itching.

. Because of this, scratching the scalp is easy to hurt, and if the wound on the scalp causes inflammation to cause seborrheic scalpitis. Such symptoms, such as increased dandruff and itchy scalp appear about 6 months to 2 years and then suddenly disappear. However, this is not a phenomenon caused by the disappearance of dandruff, it is a time when the symptoms of full-scale hair loss appear. Severe dandruff causes itching, severe cases of tingling and cracking of the skin, and redness of the forehead or forehead. Especially for patients with seborrheic scalp infection, dandruff is an invisible visitor every winter. Most dandruff itself does not cause hair loss. However, if you do not manage the scalp cleanly when dandruff occurs, the dandruff layer of the scalp is formed, and sebum, waste products, and sweat are combined to block the hair follicle inlet, and when the hair root is hardened by such waste products, hair is made. Naturally, hair roots cannot grow hair well, and this poor scalp environment is a major cause of hair loss, whether primary or secondary. The symptoms of seborrheic scalp on the other hand are reddish skin on the skin, scaly white scales (like dandruff), itching, but no pain unless there are complications caused by infection. In addition, when the head is itchy scratching bleeding out and secondary bacterial infections occur, so caution is required. As the disease worsens, the same symptoms occur on the face, ears, armpits, abdomen, chest, and back and are more likely to recur. As a treatment for this, in general, when the redness is severe on the skin, corticosteroids are applied, when a thick scab sits, apply zinc ointment, etc., and when a secondary bacterial infection occurs, antibiotic drugs are used. However, it is a premise that these drugs have other side effects.

Although the above methods for preventing hair loss and scalp health have achieved some results, there are still some problems in terms of effectiveness and skin safety. In other words, finasteride, which is a drug to solve these problems, is expensive and ineffective when manufactured and applied directly to the scalp, and other side effects occur due to oral administration, and when minoxidil is used as a hair growth promoter for a long time, the effect is halved. As a side effect due to chemical vasodilation, asthenia, sebum increase, etc. have been reported that the use is limited. In addition, corticosteroids or antibiotics used in the treatment of dandruff or seborrheic scalp have many problems such as the fact that there are many other side effects.

The present invention has been made in view of the above problems, which have been effective in the treatment of hair loss, but many side effects have occurred in the past, and the active male hormone dihydrotestosterone (Dihydrotestesterone), which is known as the main cause of hair loss, in particular male hair loss, To prevent hair loss and promote hair growth by preventing the formation of sebum and keratin formation, which prevents the formation of seborrheic scalp or dandruff to prevent the occurrence of seborrheic scalp and to develop a substance that is safe for the human body for long-term use. As a result of research, the person skilled in the art, through the exploration and experiment on the efficacy of many plants in nature, found that the polyhydric alcohol extract obtained from the medicinal fruit has an effective effect on hair loss prevention and scalp health. Therefore, an object of the present invention is to find that the extract extracted from the punja fruit using a polyol has an inhibitory effect of the testosterone and ultimately prevents it from being produced by the active male hormone dihydrotestosterone, thereby preventing hair loss and scalp health. It is to provide a composition having an effect of promoting the. Thus, by containing this plant extract in a conventional hair composition to develop a composition having an effective effect on hair loss prevention and scalp health, which will be described in detail with an embodiment of the present invention as follows.

The effect on the sebum production inhibition and hair growth promotion of the composition for hair growth and scalp management containing the extract according to the present invention as an active ingredient was measured.

Test Example 1 Measurement of Sebum Production in Cells Promoted by Testosterone

The sebum production of the scalp can be used as a measure of scalp health. Excess sebum production by male hormone testosterone leads to excessive scalp keratin formation, which in turn leads to the development of seborrheic scalpitis and dandruff. The SZ95 human sebaseous gland cell line, which has the characteristics of primary human sebocytes, has been observed to observe sebum production inhibitory effects of scalp extracts and anti-androgenic anti-androgenic effects on sebum overproduced by testosterone. The effect was observed. That is, 1 × 10 ⁵ SZ95 cells were dispensed in 10 cm culture vessels, and testosterone (10 ⁻⁶ M) and P. pellucida extract were incubated at 100 μg / ml and 200 μg / ml for 5 days, followed by total sebum. As a result of quantifying the production amount, the total amount of the control group was 25.4 ± 0.2mg / ml, the testosterone treatment group was 39.5 ± 0.2mg / ml. However, the testosterone and puncture extracts showed 25.1 ± 0.3mg / ml and 22.2 ± 0.2mg / ml, respectively, in the 100㎍ / ㎖ and 200㎍ / ㎖ treated groups, which were significantly decreased compared to the testosterone treated group. It is explained by the decrease of the back. From this, it can be seen that the extract of Rhizophylla significantly inhibits the activity of testosterone (see figure below).

<Test Example 2> Measurement of scalp improvement effect through clinical

In order to clinically measure the effect of improving the scalp health, the composition containing the puncture extract according to the present invention (prescription example 4) and the composition of the conventional prescription (control formulation 1) as shown in the formulation example 1 of Table 5 Each one was manufactured and clinically tested in people with dandruff or seborrheic scalp. In other words, 10 subjects with dandruff and 10 persons with seborrheic scalp disease were tested using the two compositions twice daily for 30 days and the male and female ratios were 10 to 10. Observations were made to determine the overall improvement status such as the effects (sedation of dripping dandruff, rash of seborrheic dermatitis and sedation or treatment of inflammatory state), and the results as shown in Table 1 were obtained.

                     <Scalp Improvement>-Formulation Example 1   A noticeable effect     Slightly effect    no effect     Worse Prescription Example 4 (invention) 10 people  8 people 2 people 0 people Conventional prescription (for control)      0 people       5 people      12 people      3 people

As described above, the composition of Formulation Example 1 of Formulation Example 1 containing a puncture extract showed a superior effect of improving the dandruff and seborrheic scalp compared to the composition of Control Formula 1.

Test Example 3 Measurement of Hair Growth Promoting Effect Using Animals

 The composition (prescription example 1-4) and the composition of the conventional prescription (control prescription example 2) containing the puncture extract according to the present invention were prepared in liquid form as shown in the formulation example 2 of Table 6, respectively, and the effect of using the animal Was measured. To this end, hairs from the back of 42-56 day-old mice (C57BL / 6, male) were removed, and 10 rats each of the composition of Formulation Examples 1-4 and Control Formulation 1 of Formulation Example 2 were placed on the back for 1 day. Once, 100 μl was applied for 28 days. The results were compared by calculating the rate at which new hairs were grown with respect to the area from which hair was removed by using an image analyzer, and when the ratio was 70% or more, it was judged that the hair growth promoting effect was found. .

                    <Hair growth promoting effect>-Formulation Example 2 Formulation Example 1 Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 2 Formulation Example 1 55 79.7 85.6 88.7 40.5

As described above, the compositions of Formulation Examples 1-4 of Formulation Example 2 containing the puncture extract were approximately two times higher hair growth promoting effect depending on the content of the puncture extract compared to the composition of Control Formula 2. And other supplementary ingredients showed higher hair growth promoting effect than otherwise.

Test Example 4 Clinical Measurement of Hair Loss Prevention Effect

In order to confirm the hair growth promoting effect shown in the animal experiment confirmed in Test Example 3 in the clinical use by humans, a subject with alopecia was selected and the clinical effect of hair loss prevention was measured. In other words, a clinical trial of hair growth promotion was conducted using Formulation Examples 1 to 4 of Formulation Example 2 containing a Stellar extract and Control Formulation 2 containing no extract. A total of 10 men and women with alopecia and male hair loss between 30 and 50 years old were selected. The method of use was to apply about 2ml about 2 ~ 3 times a day to the hair loss site, and it was used for at least 1 month up to 3 months depending on the degree of effect checking, and more than that was not effective. To determine the effect, the average daily hair loss at trituration, gross findings, and the degree of improvement of subjective symptoms were evaluated in five stages according to the following Table 3, and overall improvement was taken as the average of the evaluation scales. The final judgment was that the overall improvement was 3.0 points or more, and the results are shown in Table 4 below.

                 <Measurement to Measure Hair Loss Prevention> Phase division One 2 3 4 5 Tricycle
Daily hair loss
Visual judgment
Subjective symptoms worse immutability Light reduction decrease A marked decrease

                 <Hair Loss Prevention Effect>-Formulation Example 2 Phase division Tricycle Daily hair loss Subjective symptoms Visual judgment Comprehensive Improvement Diagram Prescription Example 4 4.1 4.8 4.2 4.5 4.4 A control prescription 1.3 2.5 2.3 2.5 2.15

As shown in the above results, the composition of Formulation Example 4 containing the puncture extract showed a significant hair loss improvement effect compared to the composition of Control Formula 2, and no adverse effects were found in all subjects during the use period. Also found to be a safe composition. Through the above test examples 1 to 4, the extract of the Stylus Japonica strongly inhibits the activity of testosterone and inhibits the growth of dihydrotestosterone, thereby promoting hair growth and maintaining the scalp health of the composition containing the same. I could see the superiority.

As described above through the preparation examples and test examples, the present invention has the effect that the extract extracted from the fruit of the cheonnyeonja inhibits sebum secretion by inhibiting the process of converting testosterone to dihydrotestosterone to maintain the scalp normally healthy Not only it is revealed, in particular, by preparing a composition for preventing hair loss or promoting hair growth containing the same, there is an excellent effect of effectively treating and preventing male hair loss. In conclusion, as a result of clinically measuring the effect of the composition according to the present invention, the composition for hair growth and scalp management containing the extract of the cheonnyeonja as an active ingredient has an excellent effect on the hair growth and scalp health compared to the conventional similar composition Has

The present invention is a conventional herbal composition for hair, by inhibiting the production of the active male hormone dihydrotestosterone to maintain the scalp health and effective hair growth promotion, while the long-term use of the fruit of the puncture of the medicinal herb in the form of dry medicinal herbs The extract obtained by extraction with a polyol solvent is composed of a certain amount according to the formulation of the composition for hair growth and scalp care.

Referring to the contents related to the present invention of the trainer used in the present invention are as follows. The physicist refers to the fruit of Melia azedarach L. var. Japonica Makino in Korea. In China, it refers to Melia toosendan Sied. Et Zucc. In Japan, it was not loaded with fair herbs. It was named Yeon, meaning that the leaves gently polished things, and because the fruit looks like a small drop and becomes yellow when ripe, the name Geumnyeong (金鈴) was also obtained. Root bark is called the cinnamon. This drug has a peculiar smell, taste is bitter, cold and has a little poison [苦寒 小 毒]. Chunjaun is a symptom that is not scattered due to the gathering of the liver is used for narrowing, abdominal pain, testicles, etc. It is used to remove parasites and psoriasis dermatitis. Circulates the liver, relieves pain and has a pesticidal effect. Pharmacological action has been reported to inhibit skin fungi and staphylococcus aureus, insecticidal action such as roundworm, earthworm, leech. The appearance is round, the outer side is yellowish brown, glossy and wrinkled. The side cut horizontally is pale yellow, divided into 4 ~ 5 rooms, each containing 1 seed. The outer shell is golden and the flesh is yellowish white. Other names include Geumnja (金鈴 子), curious, Yeonsu, Yeonsil, Yeonsu, Seoksu, Yeonsil, Artificial, and Cheonnyeonja.

The medicinal herb used in the present invention is dried, finely powdered and extracted by the fruit by a conventional lyophilization method. The extraction solvent used to prepare the plant extract used in the present invention is ethanol or a polar solvent in which a small amount of polyols such as propylene glycol, butylene glycol is added thereto, or a mixed solution of them and purified water. The extraction method may be a conventional method, for example, by adding 5 to 10 times the amount of the extraction solvent to the dried Magnolia fruit powder by immersion extraction at room temperature for 1-7 days or at 40-60 ℃ under 1 atmosphere The extract is obtained by warming for 1 to 5 hours.

In the present invention, when the composition for hair growth and scalp management is applied to the scalp, the blending amount of the puncture extract in the product is preferably 0.01 to 50.0% by weight, particularly 0.1 to 20.0% by weight.

On the other hand, the composition for hair growth and scalp care containing the cheonnyeonja extract of the present invention as an active ingredient in a variety of formulations, such as topical application such as ointment, cream, lotion, liquid, spray, etc. when used for its original purpose. It is available. The compositions of the present invention are preferably formulated into topical application preparations such as ointments, lotions, sprays and the like and applied directly to the scalp site or hair loss site in question. The composition of the present invention may also further include one or more known herbal ingredients that may enhance the hair growth effect as needed. Plant ingredients that may be included for this purpose include, for example, baekbaek, baekbaek, ginseng, licorice, cloves, safflower, dermis, cheongho, green tea, dried branches, dermis, flaxseed, pomegranate, cornus, wolfberry, ringworm, fig leaf There is an extract or oil extracted from the back. When such additional components are included in the composition of the present invention, their content is preferably within 5% based on the total weight of the composition. In addition, the composition of the present invention includes a composition for antibacterial hair. The composition for hair regrowth may include the usual compounding ingredients hinokithiol, pepper tink, tocopherol acetate, nico acid amide nicotinic acid benzine, pyrotonolamine, salicylic acid, el-menthol, shampoo, hair conditioner, hair lotion, liquid All formulations that can be applied to the scalp, such as hair growth promoter type, are possible. The cosmetic composition for hair may include alpha hydroxy acid (α-Hydroxy acid), beta hydroxy acid (β-Hydroxy acid), fragrances, colorants, fungicides, antioxidants, preservatives, moisturizers, etc., shampoo as a cosmetic or cleaning agent Formulations of soap, cream, and the like are possible. The present invention is described in more detail by the following examples and experimental examples, but the present invention is not limited in any way by these.

 Referring to the preparation method of the present invention cheonnyeonja through Example 1 as follows.

<Preparation Example 1>-Method of producing a Stirrup extract according to the present invention

400 g of pulverized fruit (dried medicinal herb) was added to 3,000 ml of ethanol, immersed at room temperature for 10 days, and filtered. The filtrate was evaporated under reduced pressure and evaporated to obtain 30 g of concentrate.

In addition, the composition for improving the scalp or hair regrowth liquid containing the puncture extract of the present invention using the puncture extract according to Preparation Example 1 and other auxiliary ingredients by the solubilization method in the composition ratios shown in Formulations 1 to 4 below. A control composition was also prepared.

               <Formulation Example 1>-Liquid composition for scalp improvement     Name  Content (% by weight) Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 1 Extract of Preparation Example 1
Cornus extract
March extract
Red ginseng extract
Tocopherol Acetate
Salicylic acid
L-menthol
POE sorbitan fatty acid ester
Spices
antiseptic
Purified water 0.1
-
-
-
-
-
0.1
0.4
Suitable amount
Suitable amount
to 100 1.0
-
-
-
-
-
0.1
0.4
Suitable amount
Suitable amount
to 100 5.0
-
-
-
-
-
0.1
0.4
Suitable amount
Suitable amount
to 100 5.0
0.5
0.5
0.5
0.5
0.15
0.1
0.4
Suitable amount
Suitable amount
to 100 -
0.5
0.5
0.5
0.5
0.15
0.1
0.4
Suitable amount
Suitable amount
to 100

                <Formulation Example 2>-Liquid composition for hair regrowth    Name Content (% by weight) Prescription Example 1 Prescription Example 2 Prescription Example 3 Prescription Example 4 Prescription 2 Extract of Preparation Example 1
Cornus extract
Pepper tink
Red ginseng extract
Tocopherol Acetate
Salicylic acid
L-menthol
POE sorbitan fatty acid ester
Spices
antiseptic
Purified water 1.0
-
-
-
-
-
0.1
0.3
Suitable amount
Suitable amount
to 100 0.1
-
-
-
-
-
0.1
0.3
Suitable amount
Suitable amount
to 100 5.0
-
-
-
-
-
0.1
0.3
Suitable amount
Suitable amount
to 100 5.0
0.5
0.5
0.5
0.5
0.15
0.1
0.3
Suitable amount
Suitable amount
to 100 -
0.5
0.5
0.5
0.5
0.15
0.1
0.3
Suitable amount
Suitable amount
to 100

Claims (2)

A composition for hair growth and scalp management, comprising as an active ingredient a cheonnyeon extract, characterized in that it contains 0.5 to 20.0% by weight of the plant extract extracted from the fruit of the cheonnyeon. The method of claim 1, wherein the composition for hair growth and scalp care has a formulation such as shampoo, rinse, hair gel, hair mousse, hair spray, hair tonic, hair essence, hair liquid, hair treatment cream, hair pack, etc. A composition for hair growth and scalp care containing the extract of Chunjaun as an active ingredient.