KR20110103604A - Composition for protecting and improving skin - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a plant extract as the main active ingredient, the cosmetic composition of the present invention is excellent whitening, wrinkle improvement by containing at least one species selected from Sanjoin, baby fish, horse riding horse extract as the main active ingredient , Anti-aging effect.

Description

Composition for protecting and improving skin

The present invention relates to a composition for skin protection and improvement.

Skin is the body's primary protective film that protects organs in the body from changes in temperature and humidity, irritation from the external environment such as UV and pollutants, and plays an important role in maintaining homeostasis such as body temperature control. However, cell damage stimuli, such as excessive physical and chemical stimuli and stress from outside the cell, malnutrition, ultraviolet radiation, sudden temperature changes, ozone from environmental pollution, or other harmful substances present in the atmosphere, induce various biochemical changes in cells. Cause cell damage. In particular, the skin is susceptible to damage by free radicals and nonspecific proteases released by stimulation.

In addition, pigments affecting skin color include melanin, melazoid, carotene, and hemoglobin, the most important of which determines the skin color, melanin, the skin color is determined according to the amount, nature and distribution of melanin. Melanogenesis inhibitors directly inhibit tyrosinase itself, the main enzyme of melanogenesis, or do not show direct inhibition of tyrosinase but inhibit melanogenesis in the newly formed cells. Among them, tyrosinase deactivation experiments have been adopted in the early stages of development of melanin inhibitors. Ascorbic acid, kojic acid, arbutin, hydroquinone, benzoic acid, corticosteroids, retinoids, glutathione and derivatives thereof, and some extracts have tyrosinase inhibitory activity. Its stability is poor and its color is degraded, or its use is limited due to the occurrence of odor, efficacy at the biological level, unclear effect and safety problems. Hydroquinone exerts a predetermined whitening effect but severe skin irritation has a problem to limit the amount to a very small amount, ascorbic acid and kojic acid has a strong whitening effect, but it is difficult to use due to problems such as product safety and economics. Thiol-based compounds such as glutathione and cysteine not only have a characteristic unpleasant odor, but also have problems with transdermal absorption, and glycosides and derivatives thereof have a high polarity and thus have a problem in being used as a component of cosmetics. Placenta extract, which is used frequently these days, has no skin irritation but lacks a whitening effect.

It is an object of one embodiment of the present invention to provide a composition for skin protection and improvement.

Another object of an embodiment of the present invention is to provide a cosmetic composition that is recognized for skin protection and improvement efficacy.

The composition according to an embodiment of the present invention includes one or more or an extract thereof selected from the group consisting of sanjoin, baby lychee and horseback riding as an active ingredient. In addition, it provides a cosmetic composition comprising the composition.

The composition according to the present invention can be safely used without side effects on the skin, and has excellent effects such as skin whitening, anti-wrinkle effect, prevention of skin aging and promotion of collagen biosynthesis.

The composition for protecting and improving the skin according to an embodiment of the present invention includes one or more or an extract thereof selected from the group consisting of sanjoin, baby fowl and horseback riding as active ingredients. More specifically, the composition according to the present invention is free of skin irritation and exerts a skin protection and improvement effect by using at least one natural product selected from sanjoin, baby squirrel or horseback riding or an extract prepared therefrom.

In one embodiment, the composition may further comprise a baby pig or its extract. The active ingredient contained in Aeggi slush has a synergistic effect with other active ingredients. By adding baby sorghum or its extract, skin protection and improvement effect can be enhanced.

Hereinafter, the sanjoin, baby flies, horseback riding, and baby fowl, according to an embodiment of the present invention will be described in more detail.

Sanjoin in the present invention means a medicinal herb made from the seeds of Zizyphus jujuba Miller of the sea buckthorn family, and in some cases includes the seeds of Sanjoin ( Zizyphus jujuba var . Sanjoin's appearance is oval, and the outer surface is yellowish brown or reddish brown, smooth and glossy. On one side there is a point, on the other side there is a point, and the barges are around one side of the point along the margin. Seed hulls are slightly pliable and enclose gray oil and pale yellow cotyledons. Sanjoin has a mild smell of oil, tastes sweet and sour, and has a flat and unbiased nature. It is used for nerve hypersensitivity, insomnia, forgetfulness, and cold sweat. Pharmacological effects include sedation (Sanjoin's sedation and psychotropic effects, Park Chan-sung et al., Korean Journal of Pharmacy, 23 (3), p53-63, 1971), hypnosis, blood pressure lowering, analgesic, lowering body temperature, antioxidant Actions, immune hyperactivity, uterine excitement, burn lesion edema suppression, etc. have been reported.

Horseback riding ( Cimicifuga acerina (S. et Z.) TANAKA ) is a perennial herb of the dicotyledon plant Ranunculus. Underground stems grow to the side. Stems grow straight, about 30-100 cm in height, with branched branches from above. The leaves run with 3 leaflets once in a long sack. Circular leaves are 5-9, somewhat irregularly split, with irregular sawtooth at the end. In July-August, a white flower runs as a plural picture at the end of the main stem. Goldolwain fruit is a single sack. It is a perennial herb distributed in Jeju, Gyeongnam, and Jeonnam, Korea, and also distributed in Japan.

Baby Fly ( Polygala) chameabuxus var . grandiflora ) is a plant grown in the Carpathian Mountains, strong and fragrant. The flowering period is from December to April, also called polygara.

It grows in the forests and mountains of the mountainous region, with stems extending laterally, with stems coming out from several places, branches not splitting, 15 ~ 20 cm high. The tip of the young branch has a hairline and the leaves are displaced but the upper one or two layers are turned, the long oval is thick, glossy, and the sawtooth is on the edge. Flowers bloom in June, bisexual, white or pale red, and bloom downward from the axilla. The corolla is deeply divided into 5 branches and has a branch, 5 surgeries and 1 pistil. Fruits are berry, ripen round and red in September, and remain until flowering next year. It is distributed in Korea, Japan, Taiwan, and China. Coral water (A.pusilla) is similar, but has thick teeth and hair on both sides. Baby babies are small species of babies.

 In one embodiment, the content of one or more or the extract thereof selected from the group consisting of Sanjoin, baby fish and horseback riding, 0.001 to 50% by weight, specifically 0.01 to 20% by weight, based on the total weight of the composition, More specifically, it is 0.05-5 weight%. If the content is less than the above range, the efficacy by the active ingredient is insignificant, and if it exceeds the above range, the formulation stability may be lowered or the content of other additional ingredients may be limited.

In another embodiment, the content of the baby porridge or extract thereof is 0.01 to 20% by weight, more specifically 0.05 to 5% by weight based on the total weight of the composition. If the content is less than the above range, the synergistic effect due to mixing with other active ingredients is insignificant, and if it exceeds the above range, the formulation stability may be lowered or the content of other additional ingredients may be limited.

The method for extracting plant extracts such as sanjoin, baby fowl, horseback riding, and horseradish cow extract used in the present invention is not particularly limited unless it limits the efficacy of the active ingredient. In one embodiment, the extract is a leaching material leaching raw material; Concentrated concentrate of leachate; Or dry powder of the leachate or concentrate. For example, it may be a leaching solution obtained by leaching and transferring sanjoin, baby fly, horseback riding, and baby fundraising. In addition, it may be in the form of a concentrated extract obtained by concentrating a part or all of the leaching solution, or extract extract, extract or dry powder prepared by drying the concentrate. The plant extract according to the present invention includes the extract prepared through various methods, and the active ingredient itself having the main effect included in the formulation of the extract.

In addition, the present invention provides a cosmetic composition comprising the composition for protecting and improving the skin, and specifically, may be a composition for skin whitening, wrinkle improvement and / or anti-aging. The cosmetic composition according to the present invention exhibits a whitening effect by inhibiting melanin synthesis, which is a substance causing blemishes, freckles and skin pigmentation, as well as promoting the proliferation and collagen biosynthesis of skin cells, thereby improving wrinkles and preventing aging. Indicates.

Skin aging progresses or promotes skin aging by the action of highly reactive free radicals such as free radicals. Specifically, highly reactive free radicals such as hydrogen peroxide, hydroxy radicals, or active oxygen such as superoxide radicals peroxidize lipids constituting the cell membrane to destroy the cell membrane and oxidize proteins. It can also attack nucleic acids, causing oxidative damage. Thus, anti-aging or retardation of the skin is made possible by eliminating free radicals in the skin.

The biggest contributors to pigmentation in the skin are UV exposure and hormone secretion in the body, such as estrogen and prostaglandins. When the skin is exposed to ultraviolet rays, the activity of an enzyme called tyrosinase in melanocytes in the base layer increases. Tyrosinase acts on tyrosine, a type of amino acid present in skin tissue, to produce dopas, which, in turn, convert to dopaquinone, forming melanin, which causes skin pigmentation. On the other hand, the resulting melanin pigment is widely distributed to the surrounding keratinocytes through the dendritic projections of melanocytes, thereby changing the color of the skin. In normal skin, keratinocytes containing melanin pigment are differentiated into keratinocytes without nuclei through the keratinization process for about 4 weeks, and naturally fall away from the skin naturally. However, skin pigment abnormalities such as blemishes, freckles, and senile plaques are caused by abnormally excessive melanogenesis in melanocytes, but do not fall off normally. The melanin production mechanism is characterized by the involvement of an enzyme called tyrosinase, which inhibits tyrosinase activity and prevents melanin production.

The cosmetic composition according to the present invention comprises a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing the oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases, and It may be provided in the form of a nonionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray or cone stick. These compositions may be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition may contain, in addition to the plant extract, other ingredients which can preferably give a synergistic effect to the main effect within the range of not impairing the main effect of the present invention. For example, in cosmetics, conventionally acceptable substances in fats and oils, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols It may include one or more additives selected from the group consisting of pigments, flavorings, blood circulation promoters, cooling agents, limiting agents, purified water and carriers.

The cosmetic composition according to the present invention is not particularly limited in the formulation, for example, lotion, gel, water-soluble liquid, cream, essence, emulsion, pack, powder, makeup products, oil-in-water (O / W) type and oil At least one selected from the heavy water (W / O) formulations. The cosmetic composition as described above may be applied in a form applied to the skin, or may be applied in a form that is absorbed into the skin using a microneedle or the like.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the following Examples and the like are for illustrating the present invention, and the scope of the present invention is not limited thereto.

Example  1: sanjoin, Baby fish , Baby money  Preparation of Extract

The dried natural plant material was chopped and extracted in 10-20 times of reverse osmosis water at 60 ° C. for 24 hours and then cooled. After cooling, the components were centrifuged at 15000 rpm for 10 minutes, and the supernatant was filtered using filter paper (Advantec No. 5C). The extract in powder form was prepared by lyophilization through a concentration process, based on lyophilized weight, to prepare 1 wt%.

Example  2: Horseback riding  Preparation of Extract

The finely dried natural plant material was extracted with 20 times of ethyl alcohol at 60 ° C. for 3 hours and cooled. After cooling, the components were centrifuged at 15000 rpm for 10 minutes, and the supernatant was filtered using filter paper (Advantec No. 5C). The filtrate was separated and concentrated to prepare a concentrate. The prepared concentrate was used by diluting in dimethyl suloxoxide in 10% by weight based on the weight of the concentrate.

Test Example  One: Tyrosinase  Measurement of inhibitory activity

20 ul of sample solution was added to a mixed solution of 180 ul of distilled water, 200 ul of 0.1 M potassium dihydrogen phosphate, and 200 ul of substrate solution, and 20 ul of enzyme solution was mixed and shaken to react at 37 ° C for 10 minutes. The reaction solution was left in ice for 5 minutes and absorbance was measured at 490 nm (absorbance B).

20 ul of distilled water was used instead of the sample solution, and the absorbance was measured using the solution obtained in the same manner as the test solution as the blank test solution (absorbance A). 20 ul of enzyme solution was added to a mixed solution of 380 ul of distilled water and 200 ul of 0.1 M potassium dihydrogen phosphate, and the solution obtained by the same method as the test solution was used as a control (blank). In this case, 100 uM of kojic acid was used as a positive control that inhibits tyrosinase. The tyrosinase inhibition rate (%) was calculated through Equation 1 below, and the calculated tyrosinase inhibition rate (%) is shown in Table 1 below.

Wherein A is the absorbance obtained from the blank and B is the absorbance obtained from the test solution.

division Baby money Sanjoin Baby fish Horseback riding Treatment concentration (%) 0.03 0.03 0.03 0.03 Tyrosinase
% Inhibition 45 36 41 45

Test Example  2: DPPH Antioxidant activity measurement

A 500 uM DPPH (2.2-diphenyl-1-picryl hydrezyl) solution was dissolved in ethyl alcohol, filtered and used immediately. The prepared DPPH solution and the sample solution were mixed 1: 1 and mixed vigorously, and left in a dark room for 20 minutes. After measuring the absorbance at 540 nm, DPPH radical removal rate (%) was calculated through Equation 2 below, and the calculated DPPH radical removal rate is shown in Table 2 below. At this time, 1 mM of ascorbic acid was used as a positive control for removing radicals.

Wherein A is the absorbance obtained from the blank and B is the absorbance obtained from the test solution.

division Baby money Sanjoin Baby fish Horseback riding Horseback riding
(EtOH) Treatment concentration (%) 0.1 0.1 0.1 0.1 0.1 Radical
% Removal 96 43 92 93 61

Examples of the formulation of the composition according to the present invention are described below, but are also applicable to various other formulations, which are intended to explain in detail only and not intended to limit the present invention.

Formulation Example 1 Flexible Cosmetic (Skin Lotion)

According to the composition described in Table 3 below to prepare a flexible longevity in a conventional manner.

Compounding ingredient Content (% by weight) Sanjoin Extract 0.1 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 2 Nutritious Longevity (Milk Lotion)

Nutritional longevity was prepared according to the conventional composition described in Table 4 below.

Compounding ingredient Content (% by weight) Baby Fly Extract 0.1 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 3 Nutrition Cream

Nutritional cream was prepared in a conventional manner according to the composition described in Table 5.

Compounding ingredient Content (% by weight) Horseback riding extract 0.1 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 4 Massage Cream

To prepare a massage cream in a conventional manner according to the composition shown in Table 6.

Compounding ingredient Content (% by weight) Sanjoin, Baby Litter, Horseback Riding Horse, and Baby Piglet Extract 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Beeswax 4.0 Cetearyl Glucoside 1.5 Sesqui oleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Quantity Purified water Balance

[Formulation Example 5] Pack

To prepare a pack in a conventional manner according to the composition described in Table 7.

Compounding ingredient Content (% by weight) Sanjoin, Baby Litter, Horseback Riding Horse, and Baby Piglet Extract 0.3 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl Phenyl Ether 0.4 Polysorbate 60 1.2 ethanol 6.0 Preservative, coloring, fragrance Quantity Purified water Balance

The above examples and formulations are provided only for the purpose of understanding the present invention, but the scope of the present invention is not limited thereto.

Claims (10)

Skin protection and improvement composition comprising one or more or an extract thereof selected from the group consisting of Sanjoin, baby fish and horseback riding as an active ingredient. According to claim 1, wherein the composition is a skin protection and improvement composition further comprises a baby pig or extract thereof. The method of claim 1,
The content of at least one selected from the group consisting of the sanjoin, baby fish and horseback riding horse or its extract, 0.01 to 20% by weight based on the total weight of the composition, the composition for skin protection and improvement. The method of claim 2,
The content of the baby pig or its extract, based on the total weight of the composition, 0.01 to 20% by weight of the composition for skin protection and improvement. The method according to claim 1 or 2,
The extract is a leaching material which leached raw materials; Concentrated concentrate of leachate; Or a dry powder of the leachate or concentrate. Cosmetic composition containing the composition of any one of Claims 1-4. The method according to claim 6,
The cosmetic composition is a cosmetic composition for skin whitening. The method according to claim 6,
The cosmetic composition is a cosmetic composition for improving wrinkles. The method according to claim 6,
The cosmetic composition is a cosmetic composition for preventing skin aging. The method according to claim 6,
Formulation of the cosmetic composition is a cosmetic composition of one or more selected from the lotion, gel, water-soluble liquid, cream, essence, oil-in-water (O / W) type and water-in-oil (W / O) type.