KR20110060154A - Oral composition containing fermented herb extract - Google Patents

Abstract

PURPOSE: A dental composition containing medicinal herb fermentation extract is provided to effectively suppress gingival disease bacteria and to prevent gingival diseases. CONSTITUTION: A dental composition contains 0.01-10 weight% of medicinal herb fermentation extract which is obtained by fermenting medicinal herb of Taraxacum platycarpum H. Dahlstedt, Gardenia jasminoides Ellis, Pulsatilla koreana Nakai, Pueraria thunbergiana Bentham, or Scutellaria baicalensis Georgi by yeast. The composition is used for treating marginal gingivitis. A method for preparing the medicinal herb fermentation extract comprises: a step of putting medicinal herb ingredients in a fermentation device together with purified water and dried yeast; a step of fermenting at room temperature for 24 hours; a step of performing thermal treatment; and a step of filtering.

Description

Oral composition containing fermented herb extract

The present invention relates to a composition for oral cavity containing herbal fermentation extract, and more particularly, by reducing the inflammation of the gums and effective gum disease bacteria by fermenting and containing a herbal raw material having anti-inflammatory, antibacterial, antioxidant and blood circulation promoting effect with yeast It relates to an oral composition which is excellent in inhibiting gum disease prevention effect. In addition, the herbal fermented extract of the present invention is very excellent in feeling by improving the bitterness and aroma unique to herbal raw materials.

In general, oral compositions designed to prevent gum disease were composed mainly of synthetic raw materials such as sodium chloride, allantoin chlorohydroxy aluminum, aminocaproic acid, tocopherol acetate. However, as interest in natural extracts has recently increased, studies on various plants have been actively conducted, and as the effects on oral cavity are known, many extracts have been applied to oral compositions related to gum disease prevention and bad breath control.

Many plant extracts have been used in combination to promote oral hygiene, but in most cases they have poor antibacterial effects or simply prevent the occurrence of periodontal disease through abstract effects such as anti-inflammatory, convergence, hemostasis and blood circulation. It only shows the degree.

In addition, it is known that herbal ingredients are helpful in the prevention of oral diseases, but the effect is not great and there is a problem that the feeling of use is not good because of the bitter taste and aroma unique to herbal ingredients.

Thus, the present inventors steadily studied the herbal ingredients suitable for the oral cavity by removing the bitter taste and aroma while showing an excellent effect on the prevention of oral disease, the herbal fermentation extract has a good feeling of use by improving the bitter taste and aroma unique to the herbal ingredients The disease prevention effect was also found to be excellent and completed this invention.

Accordingly, it is an object of the present invention to provide a composition for oral cavity which is excellent in feeling of use and has high oral disease prevention effect.

In order to achieve the above object, the present invention provides a composition for oral cavity containing the herbal fermented extract of fermented herbal ingredients as yeast.

The composition for oral cavity of the present invention is effective in preventing gum disease by effectively reducing gum inflammation and effectively inhibiting gum disease by containing fermented herbal ingredients having anti-inflammatory, antibacterial, antioxidant and blood circulation promoting effects with yeast. In addition, by fermenting the herbal raw materials, the bitterness and aroma unique to the herbal raw materials are improved, and the feeling is very excellent.

The present invention provides a composition for oral cavity containing the herbal fermented extract obtained by fermenting the herbal raw material into yeast.

Hereinafter, the present invention will be described in more detail.

Herbal fermentation extract of the present invention is prepared by fermenting herbal raw materials into yeast. The herbal raw materials are those having anti-inflammatory, antibacterial, antioxidant and blood circulation promoting effects, and are one or more selected from the group consisting of pogongyoung, gardenia, baekduong, brown root and gold, which can be used.

Pogongyoung is an outpost of Dandelion (Taraxacum platycarpum H. Dahlstedt) and the same plant (Asteraceae). It has antibacterial and antifungal action and is used for various inflammations in oriental medicine.

Gold is the root of the skin of Scutellaria baicalensis Georgi (Lamiaceae), which has antibacterial, antiviral, antifungal and sedative effects. Used for

Gardenia is the fruit of the gardenia (Gardenia jasminoides Ellis) tree and the same plant (Gapilioaceae), which has hemostasis, antibacterial and sedative effects, and is used in various medicines including stomatitis and bleeding caused by inflammation.

Baekduong is the root of Pulsatilla koreana Nakai and the same plant (Mariaceae), which has antibacterial, antifungal and astringent effects, and is used for toothache and various inflammations in oriental medicine.

Root is the root of the skin removed from Pueraria thunbergiana Bentham (Soybean). It has analgesic and anti-inflammatory action. In oriental medicine, it is combined with golden lamp and used for toothache and oral inflammation.

Herbal fermentation extract of the present invention can be prepared by a conventional manufacturing method in the art, the method is not particularly limited. For example, the herbal raw material may be added to a fermentor, and purified water and dry yeast may be added thereto, followed by stationary culturing at room temperature for 24 hours, followed by removal of natural products, followed by heat treatment (80 to 90 ° C., 30 minutes) and filtration.

Herbal fermentation extract of the present invention is contained in 0.01 to 10% by weight based on the total weight of the composition. If it is less than 0.01% by weight, the effect is insignificant, and if it exceeds 10% by weight, the bitterness peculiar to herbal ingredients is increased and the feeling of use decreases.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not necessarily limited to these examples.

Preparation Example 1 Preparation of Herbal Fermented Extract

Pogongyoung, golden, and gardenia were selected and adjusted according to theft in the Pharmacopoeia, 400g of ginseng, 600g of green tea, 400g of black bean were weighed in a fermentor and placed in fermented water: 15Kg and 100g of dry yeast. After the incubation was completed, the primary product was first removed, heat treated (80 to 90 ° C. for 30 minutes) for extraction and deactivation of the active ingredient of the cultured yeast, and diatomaceous earth was filtered to obtain about 8 kg of yeast fermentation broth. After mixing 136kg of ionized water, 6kg of a solution of phenonip dissolved in 1,3-butylene glycol was mixed and stirred. About 150 kg of herbal fermentation extract was prepared by pre-filtering using a 1.0 μm filter and micro-filtering using a 0.45 μm filter.

Preparation Example 2 Preparation of General Herbal Extract

Pogongyoung, golden, and gardenia were selected and adjusted according to theft in the Pharmacopoeia, 400g of ginseng, 600g of green tea, 400g of black bean were weighed and placed in a reactor. 15Kg of purified water was placed at 25 ° C for 24 hours. Natural products were removed first, heat treatment (80 ~ 90 ℃, 30 minutes), and then filtered through diatomaceous earth to obtain an extract of about 8kg. After mixing 136 kg of ionized water, a solution in which a preservative (Phenonip) was dissolved in 1,3-butylene glycol was mixed and stirred. About 150 kg of general herbal extracts were prepared by pre-filtering using a 1.0 μm filter and micro-filtering using a 0.45 μm filter.

Example 1 and Comparative Examples 1 and 2

To Example 1 and Comparative Examples 1-2 of the toothpaste formulations were prepared according to the composition of Table 1 below. Example 1 contains the herbal fermented extract, Comparative Example 1 contains a general herbal extract and Comparative Example 2 was prepared not to contain the herbal extract.

ingredient Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Sodium fluoride 0.30 0.30 0.30 Precipitated silica 15.00 15.00 15.00 Herbal Fermentation Extract (Manufacturing Example 1) 1.0 - - General Herbal Extract (Manufacturing Example 2) - 1.0 - Sorbitol solution 50.00 10.00 10.00 Carboxymethyl Cellulose Sodium 1.00 1.00 1.00 Zaccarin Sodium 0.25 0.10 0.10 Paraoxybenzoic Acid Methyl 0.20 0.20 0.20 Spices 1.00 1.00 1.00 Sodium Lauryl Sulfate 2.00 2.00 2.00 Purified water To 100 To 100 To 100

[Test Example 1] Measurement of gum disease prevention effect

The gingival index was measured to determine the effect of preventing gum disease. First, 60 subjects were screened, and during the experiment period, the administration of antibiotics and the receipt of oral medical treatments that may affect the experiment were prohibited. Twenty subjects were divided into each of Example 1 and Comparative Examples 1 and 2, and the gingivitis index was measured according to the following evaluation criteria. The results are shown in Table 2 below.

<Evaluation of Loe's Gingivitis Index Modified by Talbott, Mandel and Chilton>

0: no inflammation

1: Mild gingivitis (weak change of color and weak edema)-no bleeding during periodontal cyst measurement

2: moderate gingivitis (redness, edema)-bleeding during periodontal cystic measurement

3: highly gingivitis (ulcer)-tendency to bleed spontaneously

division Example 1 Comparative Example 1 Comparative Example 2 Initial value 0.85 ± 0.21 0.91 ± 0.33 0.87 ± 0.18 4 Weeks 0.41 ± 0.34 0.76 ± 0.27 0.74 ± 0.25 8 Weeks 0.15 ± 0.19 0.56 ± 0.21 0.67 ± 0.21 Improvement Index 0.71 ± 0.22 0.33 ± 0.26 0.14 ± 0.23

In the results of Table 2, Comparative Example 2 containing no herbal extracts had almost no gingivitis alleviating effect, Comparative Example 1 containing a common herbal extract showed some gingival improvement effect, but containing herbal fermentation extract The gingival improvement effect of Example 1 was much better than the comparative example 1. Therefore, it was found that the herbal fermentation extract obtained by fermenting the herbal raw material of the present invention with yeast is much more effective in preventing gum disease than the general herbal extract.

[Test Example 2] Bitter taste sensory evaluation

Thirty test subjects (10 males and 25 females, aged 25-35 years) who were trained to taste sensory evaluation by applying 1g of toothpaste of Comparative Example 1 and Example 1 to saliva soaked with saliva after one week of manufacture Myeong) was brushed for 3 minutes, washed five times with water, and the degree of toothpaste bitterness was evaluated immediately after brushing on a five-point scale. The results of sensory evaluation on toothpaste bitterness are shown in Table 3 below. At this time, the food intake was prohibited during the measurement time after brushing.

division Example 1 Comparative Example 1 Bitterness 1.2 3.9

Criteria: Very Write (5 points), Slightly Write (4 points), Write (3 points), Slightly Write (2 points), Not Write (1 point)

Looking at the results of Table 3, the bitter taste was significantly reduced in Example 1 in which the herbal fermentation extract in the toothpaste than Comparative Example 1 containing the common herbal extract. Therefore, the herbal fermented extract of the present invention was found to reduce the unique bitter taste of the herbal raw material has excellent usability.

Claims (3)

Oral composition containing herbal fermented extracts obtained by fermenting at least one herbal ingredient selected from the group consisting of pogongyoung, gardenia, baekduong, brown root and gold with yeast The oral composition according to claim 1, wherein the herbal fermented extract is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. According to claim 1, wherein the composition is a composition for oral cavity for improving gingivitis.