KR20100093151A - The composition having the prevention effect of atopy - Google Patents

Abstract

PURPOSE: A composition containing natural herb extract for preventing atopic dermatitis is provided to ensure anti-inflammatory and antibacterial activities. CONSTITUTION: A composition with an effect of preventing atopic dermatitis contains natural herb extract containing 1-35 weight parts of Sanguisorba officinallis L., 1-35 weight parts of Aquilaria agallocha Roxb, and 1-35 weight parts of Vitis vinifera L. The herb extract is prepared through hot water extraction, filtration, and decompression.

Description

The composition having the prevention effect of atopy}

The present invention relates to a composition having an excellent preventive effect against atopic dermatitis containing a herbal plant extract composed of fat milk, aroma, grape skin and rice bran as main ingredients.

The present invention relates to a composition having a prophylactic effect of atopic dermatitis, and more particularly, to a composition capable of providing a prophylactic effect of atopic dermatitis containing a herbal plant extract consisting of fat, aroma, grape skin, and rice bran. will be.

Many skin diseases, such as atopic dermatitis, a recurrent chronic dermatitis with severe pruritus, are still known as incurable diseases that humanity must solve with cancer, AIDS, and dementia in the 21st century.

In other words, the cause of atopic dermatitis is a genetic disease that has not yet been clearly identified, and its onset and deterioration are known to be greatly involved in environmental factors.

Atopic dermatitis, also known as fever, is accompanied by allergic diseases such as asthma and hay fever. Allergy is one of the factors that can cause atopic dermatitis.

In other words, when a skin test for protein antigens is performed, urticaria responses to a large number of antigens appear well, and anaphylactic shock, urticaria and angioedema, wheezing and respiration within minutes to several hours when the body is exposed to these protein antigens. Immediate-type reactions such as difficulty, nasal congestion, runny nose, sneezing, conjunctival hyperemia and swelling, vomiting, diarrhea, and abdominal pain occur well in the skin, respiratory, eye, and intestinal mucosa, and these abnormal and inappropriate reactions have family-specific characteristics.

Immune abnormalities in atopic dermatitis include immunoglobulins attached to the surface of mast cells around blood vessels or skin in the body, and when antigens invade the body again, they bind to immunoglobulins and activate mast cells to secrete chemicals such as histamine. It is known to make. Atopic dermatitis may be aggravated by dry skin, ambient temperature and humidity, severe exercise and sweating, scouring, wool and fiber, skin irritation, food, drugs, house dust, animal hair, irritating chemicals, infections or mental Stress and the like. It is also argued that chlorine residues in tap water interfere with skin maturation, causing atopic dermatitis.

Atopic dermatitis is a recurrent chronic dermatitis with severe itching. About 10 to 15% of children have atopic dermatitis, and 90% report an improvement within 5 years. Such atopic dermatitis generally improves in adulthood, and about 30 to 40% of the dermatitis does not reappear in appearance, but the rest is known to cause severe dermatitis such as skin dryness, skin irritation caused by irritant substances, and housewife eczema. The ratio is increasing with the progress of industrialization and the increase of environmental pollution.

Dry and sensitive skin has low water retention and recovery ability, and thus, skin keratinization, itching, etc. tend to appear, and in severe cases, dermatitis such as atopic dermatitis develops.

Other causes of atopic dermatitis have to be cured in different ways, most often with some overlap. In particular, atopic dermatitis is a skin disease in which immunity is extremely degraded due to frequent use of steroid ointments and antihistamines when the fever does not radiate and accumulates on the skin, causing rashes and itching.

Several compositions have been proposed as a method for treating dry skin and itching, such as atopic dermatitis, but these compositions are pharmaceutical compositions, and most of them contain steroid agents or antibiotics as active ingredients. There is a concern that serious side effects such as capillary dilatation or stratum corneum increase or enlargement are caused.

Also related to the composition for atopic dermatitis is a cosmetic composition containing hair vulgaris, rosacea, gardenia, ephedra root extract, benzoyl peroxide, retinoic acid, beta glycyretin acid, salicylic acid as an active ingredient, but atopic dermatitis is known. There are many problems, such as not providing a satisfactory effect on the skin and causing a lot of irritation to the skin.

Oyster oil ( Sanguisorba officinallis L.) is a perennial herbaceous herbaceous flower, 50-150 cm tall, with purple flower spikes on the ends of branches. When you rub a leaf, it smells like cucumber or watermelon and is called cucumber or watermelon. The roots are cut and washed in water to make fat. The leaves of this plant are similar to elm trees and freshly sprouted root leaves are called fat oil because they crawl on the ground. There are mixed tannins (12-20%) in the roots and roots, and the roots contain more tannins than elsewhere. It is known that there are acidic assets, ellagic acid, and saponin (2-4%), and saponin is known to include acidic sorbine, acidic sorbogenin (tomentosolic acid), and porterine. There is also an anti-inflammatory action and an antibacterial action against E. coli.

Aquilaria agallocha Roxb (Aquilaria agallocha Roxb) is an evergreen tree of the Thymelaceae family, and has a resin-deposited tree. In the past, timber was buried in water or soil, so that sapwood was decayed and only the heartwood remained as water, but now it hurts the trees and deposits resin on the neck. In China, Aquilaria sinensis is used as the same herbal medicine. The herbal name is called aroma. Acupuncture has traditionally been used as herbal medicines such as soothing, healthy, breathing, and asthma. Anitic acid, agarosspirol, benzyl acetone, and the like have been reported through the component study on aroma.

Grapes (Vitis vinifera L.) are native to Western Asia and are one of the oldest fruit trees with cultivation history. The grape variety is very diverse, especially about 10 genera and 500 species in the tropics, and 4 genera and 6 species in Korea. Most vines with tendrils are wooden. In particular, resveratrol contained in grape skin has the effect of preventing various diseases such as antioxidant activity, anticancer action, anti-inflammatory action. Resveratrol also has a cholesterol-lowering effect that helps prevent cardiovascular disease.

Rice bran is composed of fat, protein, and dietary fiber, a large part of the nutrients, vitamin A, thiamin, pyridoxine, niacin, such as vitamin B group, and calcium, zinc, iron and other minerals.

Rice bran contains a large amount of lysine, an essential amino acid lacking in grains, and more than 70% of constituent fatty acids are unsaturated fatty acids such as oleic acid, linoleic acid, and linolenic acid, which are excellent in natural moisturizing action.

Therefore, an object of the present invention is to solve the problems of the prior art as described above, by conducting research to develop a composition having a preventive effect of atopic dermatitis using herbal plant-derived components, sterilization for the prevention of secondary infection Composition for the prevention of atopic dermatitis containing natural herbal mixed extract consisting of fat, aroma, grape skin and rice bran, which have the effect, moisturizing for dry and keratinized skin, nourish for damaged skin, and sedative effect of itching To provide.

The present invention for achieving the above object is characterized by a composition containing a natural herbal mixed extract from fat, aroma, grape skin, rice bran and the effect of preventing atopic dermatitis.

Hereinafter, the present invention will be described in detail.

The present invention is a composition for preventing atopic dermatitis, moisturizing action to replenish moisture on dry skin and anti-inflammatory action to alleviate the signs of inflammation and inhibiting the itching of atopic dermatitis, the skin with weakened immunity exposed to bacterial infection In order to prevent antibacterial activity, a combination of extracts of fat, aroma, grape skin and rice bran is used.

In the composition according to the present invention, the composition of each herbal plant component is 1 to 35 parts by weight of fat, 1 to 35 parts by weight of aroma, 1 to 35 parts by weight of grape skin, and 1 to 35 parts by weight of rice bran, based on the respective dry weight. It consists of.

10 times of distilled water was added to the natural herbal plant extracts mixed at the above compounding ratio, extracted twice at 100 ° C. for 6 hours, filtered, concentrated under reduced pressure, and added to make cosmetics.

The composition according to the invention is characterized in that the herbal plant extract prepared as described above contains 0.1 to 5 parts by weight, preferably 2 parts by weight.

The composition having a prophylactic effect of atopic dermatitis according to the present invention may have a conventional formulation, for example, to be formulated with softening longevity, astringent longevity, nourishing longevity, nutrition cream, body lotion, body oil, body essence, etc. Can be. The composition of each of these formulations may contain a variety of bases and additives necessary for the formulation of the formulation and are suitable, and the types and amounts of these components can be readily selected by those skilled in the art. Hereinafter, as a typical application example of the composition having a prophylactic effect of atopic dermatitis, a skin lotion and a milk nutrition cream composition will be described as an example.

In addition, the composition having a prophylactic effect of atopic dermatitis according to the present invention can be used according to a conventional method of use, and the number of times of use may vary depending on the user's skin condition or taste.

The composition of the present invention has a prophylactic effect of atopic dermatitis.

Hereinafter, a composition having a prophylactic effect of atopic dermatitis of the present invention will be described in more detail with reference to examples of the present invention, but the present invention is not limited to these examples.

Example 1 Preparation of Natural Herbal Plant Extracts

Natural herbal plants were used to finely powder the dried form for each member.

10 times of distilled water was added to each dried mixed plant material configured as shown in Table 1, followed by repeated extraction for 6 hours at 100 ° C., followed by filtration and concentration under reduced pressure to obtain 10.0 g of herbal plant extract.

turn Kinds Weight before extraction (g) Weight after extraction (g) One Oil 35 2 Aroma 5 3 Grape 25 4 Rice bran 35 Sum 100 10.0

Example 2: Preparation of skin lotion having a prophylactic effect of atopic dermatitis according to the present invention

A skin lotion was prepared at the composition ratio as shown in Table 2 below. The alcohol part was produced by dissolving in the order of MP, tween 20, NP-12 in 78 distilled alcohol, and the purified water part was glycerin, 1,3-BG, DC-193, hyaluronic acid, The skin lotion was prepared by dissolving allantoin, citric acid and sodium citric acid in this order and then mixing the herbal plant extract prepared in Example 1 above.

Classification Raw material name Weight (% by weight) Alcohol part ethanol 7 Methylparahydroxybenzoic acid 0.1 tween-20 0.2 Nonylphenylether-12 0.2 Purified water Purified water 89.01 glycerin 0.1 1,3-butylene glycol 0.2 Alanine 193 0.1 Hyaluronic acid 0.5 Allantoin 0.05 Citric acid 0.01 Citric acid 0.03 Herbal medicine Korean anti-corrosive extract (Example 1) 2.5 Sum 100

Example 3 Preparation of Milk Nourishing Cream Having Preventive Effect of Atopic Dermatitis According to the Present Invention

Milk nutrition cream was prepared in the same manner as in Example 2.

Classification Raw material name Weight (% by weight) Alcohol part Stearic acid 2.1 Cetanol 1.3 Liquid paraffin 7.0 Squalene 0.5 Isopropyl myristate 1.0 Glyceryl Monostearate 0.5 Arasel-60 0.85 tween-20 0.1 Isostearyl-isostearate 0.5 Propylparaben 0.1 Alanine 200F / 100CS 0.1 Purified water Purified water 72.65 Triethanolamine 0.7 Propylene glycol 7.0 glycerin 3.0 Methylparahydroxybenzoic acid 0.1 Herbal medicine Korean anti-corrosive extract (Example 1) 2.5 Sum 100

Experimental Example 1: Skin irritation test of the skin lotion according to the present invention

Twenty healthy men and women (10 males, 10 females) were applied to the forearm of the skin lotion prepared in Example 2 by a predetermined amount (10 m / 5), and the rest was shielded with aluminum foil for 30 minutes. Long-wavelength ultraviolet rays were irradiated at a dose of 10.2 J / using an ultraviolet irradiator and skin conditions (erythema, edema, papules, etc.) were observed after 24 hours. As a result of the observation, no side effects such as erythema occurred on the skin, and thus the skin lotion was confirmed that there is no skin irritation.

Experimental Example 2: Skin irritation test of milk nutrition cream according to the present invention

Apply the milk nourishment cream prepared in Example 3 (10 m / 5) to the forearm of 20 healthy men and women (10 males and 10 females) and shield the rest with aluminum foil for 30 minutes. Subsequently, long wavelength ultraviolet rays were irradiated at a dose of 10.2 J / using an ultraviolet irradiator, and skin conditions (erythema, edema, papules, etc.) were observed 24 hours later. As a result, the side effects such as erythema did not occur on the skin, and thus the milk nutrition cream was confirmed that there is no skin irritation.

Experimental Example 3: Test for irritation confirmation of atopic dermatitis of skin lotion according to the present invention

The skin lotion prepared in Example 2 was applied twice a day to the site of atopic dermatitis on 20 adult men and women (10 males, 10 females) showing atopic dermatitis symptoms. The treatment effect was judged after 2 weeks of application. As shown in Table 4, 15 out of 20 patients showed no effect or irritation in improving the symptoms of atopic dermatitis, and there were no side effects from long-term administration.

Experimental Example 4: Irritation confirmation test for atopic dermatitis of milk nutrition cream according to the present invention

Milk nourishment cream prepared in Example 3 was applied twice a day to the site of atopic dermatitis on 20 adult men and women (10 males, 10 females) showing atopic dermatitis symptoms. The treatment effect was judged after 2 weeks of application. As shown in Table 4, 16 out of 20 patients showed no effect or irritation in improving the symptoms of atopic dermatitis, and no side effects from long-term administration.

sample Very good Good No change Bad Skin lotion 2 7 6 5 Milk Nutrition Cream 2 8 6 4

Claims (3)

A composition having a prophylactic effect of atopic dermatitis, comprising a natural herbal plant extract composed of fat, aroma, grape skin, and rice bran The method of claim 1, Each herbal plant composition is composed of 1 to 35 parts by weight of fat milk, 1 to 35 parts by weight, 1 to 35 parts by weight of grape skin, 1 to 35 parts by weight of rice bran based on each dry weight Composition having a prophylactic effect of atopic dermatitis The composition of each herbal plant material is composed of 1 to 35 parts by weight of fat milk, 1 to 35 parts by weight of aroma, 1 to 35 parts by weight of grape skin, and 1 to 35 parts by weight of rice bran based on each dry weight. Herbal plant extracts mixed in a blending ratio of hot water extract, filtered and concentrated under reduced pressure to prepare a composition having a prophylactic effect of atopic dermatitis, characterized in that it contains 0.1 to 5 parts by weight in a cosmetic composition