KR20100005538A - Composition for treating skin injury - Google Patents

Abstract

PURPOSE: A composition containing steroid, anti-histamine agent and vasopressors for treating skin injury is provided to promote collagen synthesis and skin sedation effect. CONSTITUTION: A composition for treating skin injury contains steroid, anti-histamine agent and vasopressors as active ingredient. The steroid and vasopressors are contained in 0.0001-1 weight parts and 0.00001-1 weight parts, respectively, based on total 100 weight parts. The vasopressors are epinephrine. The composition further contains local anesthetic, vitamin, moisturizer or antiseptic. The vitamin is retinoid or ascorbic acid. The composition formulated in liquid-phase. A composition for anti-inflammation contains the steroid, anti-histamine agent, and vasopressors as active ingredient.

Description

Composition for the treatment of skin damage {COMPOSITION FOR TREATING SKIN INJURY}

The present invention relates to a composition for treating skin damage, comprising a steroid, an antihistamine and a vasoconstrictor as an active ingredient.

The human body protects internal tissues and organs by the skin, and this skin serves as the primary protective film of the human body to protect the organs of the body from temperature and humidity changes, and ultraviolet and pollutants.

The skin consists of two parts: the epidermis, which is the outer shallower layer, and the dermis, the deeper layer beneath the epidermis, and a separate layer of connective tissue (subcutaneous tissue) under the dermis called ) (See FIGS. 1A and 1B). The dermis is particularly related to skin health, skin aging, and wrinkles. Corium is composed mainly of collagen, which is a connective tissue, and consists of fibroblasts and melanocytes that make collagen. There are cells, such as inflammatory cells (histocytes), and stem cells that can differentiate into these various cells. When the dermis is stimulated due to physical force or other factors, various cells are stimulated and activated, thereby regenerating the dermis and activating collagen regeneration, thereby regenerating the skin.

Using this principle, there are treatments that induce skin regeneration through collagen synthesis by causing artificial puncture damage vertically to the dermis layer to prevent or improve wrinkles and maintain skin elasticity. Such treatments include a MESOROLLER, a Fraxel laser using an ARBIUM LASER, and a fractional laser using a CO ₂ GAS LASER. Multi-acupuncture treatment is used to treat scars and acne scars by inducing collagen synthesis by injecting drugs that can damage the skin vertically to a depth of about 0.3-3mm and apply drugs that can be applied to various skins. And to treat stretch marks. Laser treatment causes vertical skin damage (skin perforation) of about 0.5-1mm and collagen synthesis around the laser perforation area due to the heat energy from the laser, resulting in scar treatment, stretch marks, acne scar treatment and pore shrinkage. How to achieve the purpose. The principle of the treatment is that damage to the skin, the surrounding cells release cytokines (cytokine), the fibroblasts are induced by the cytokines, the fibroblasts produce a substrate containing procollagen (procollagen), The resulting procollagen is in that it is cleaved and crosslinked to the size of the collagen molecule and converted into new collagen of damaged dermal tissue. Thus, by damaging the dermal tissue, it promotes new collagen formation to regenerate new skin.

However, these treatments are based on the premise of destroying the cells that make up the general skin by puncturing normal skin, causing the cells to cause non-bacterial inflammatory reactions, which can cause bleeding, pain, edema, Symptoms such as flushing increase pain and discomfort in patients undergoing the procedure. In addition, the inflammatory response lasts for several days to several weeks, thereby increasing side effects such as infection and pigmentation after inflammation. Therefore, after the treatment, there may be pain, redness, bleeding, edema, dry skin, pigmentation after inflammation in the late stage, infection, and the like. Therefore, post-treatment management to solve the problem is important.

Recently, for post-treatment care, skin cooling, packs, ointments, skin care cosmetics and the like have been proposed. However, the effect of skin cooling using ice or cooling gas is very temporary, ranging from a few seconds to several minutes, and the soothing effect lasts for several tens of minutes even when the pack is used. In addition, conventional ointments used to reduce the inflammatory response of the skin, most of which are steroids, have long-term side effects such as capillary dilator, skin softening, reduced skin immune function, as an emulsion component contained in the ointment Due to the problem that a secondary infection may occur in the skin perforation site. In addition, almost all of the skin care agents being used contain emulsions, which increases the risk of infection of damaged skin, such as when the ointment is used. That is, even with skin cooling, packs, and conventional ointments, symptoms such as pain, flushing, bleeding, and skin drying persist for a short time from several days to weeks. There is a problem that can cause deposition, infection or extensive skin damage.

The present invention has been made in view of the above-described point, and an object of the present invention is to provide a therapeutic agent for skin damage containing an active ingredient having an excellent effect on promoting inflammation and collagen synthesis.

The present invention for achieving the above object, provides a composition for treating skin damage containing a steroid, an antihistamine and a vasoconstrictor as an active ingredient.

In addition, the present invention provides a composition for treating skin damage, further comprising a local anesthetic.

The present invention also provides a composition for treating skin damage further comprising at least one component among vitamins, humectants, and preservatives.

The present invention also provides an anti-inflammatory composition containing a composition according to the present invention as an active ingredient, a composition for enhancing collagen synthesis, and a composition for treating perforated skin damage.

As described above, the composition for treating skin damage containing steroid, antihistamine, and vasoconstrictor as an active ingredient has an effect of relieving inflammation and promoting collagen synthesis better than the composition for treating skin damage.

In addition, the composition for treating skin damage of the present invention, which further contains a local anesthetic, also has an effect of reducing pain.

Hereinafter, the present invention will be described in detail.

The composition for treating skin damage according to the present invention is characterized by including steroid, antihistamine and vasoconstrictor as an active ingredient.

Conventional ointments for the treatment of skin damage, most of which contain steroids or antihistamines, to date, no composition for treating skin damage, including a vasoconstrictor as an active ingredient has not been produced. The present inventors, through numerous studies and experiments to produce a composition having an excellent inflammation-reducing or collagen synthesis promoting effect, in the case of a composition comprising the steroids, antihistamines, vasoconstrictors of the present invention at the same time, comprising the respective components It was found that the effect of alleviating inflammation and promoting collagen synthesis was better than that.

Accordingly, the present invention provides a composition for treating skin damage, comprising a steroid, an antihistamine and a vasoconstrictor as an active ingredient.

In the present invention, the 'steroid' may be prepared and used according to a known method, or a commercially available one may be purchased and used, and also includes derivatives having the same efficacy. Steroids stabilize the cell membrane in damaged cells or normal skin cells, and have an anti-inflammatory effect that reduces and reduces the cascading inflammatory response of damaged skin cells, and has an effect of relieving edema. Thus, the steroid may play an important role in reducing the initial inflammatory response of damaged skin. Dexamethasone, prednisolone, triamcinolone, cortisone, hydrocortisone, tretinoin, prednisone, methylprednonelone, methylthadnoneone, betamethasone And the like, but are not limited thereto. The steroid may be included in an amount of 0.0001 to 1 part by weight, preferably 0.001 to 0.01 part by weight, based on 100 parts by weight of the total composition for treating skin damage according to the present invention.

In the present invention, 'antihistamine' generally refers to a drug having affinity for histamine receptors and antagonizing histamine by blocking or inhibiting the action of histamine. Therefore, the kind is not particularly limited as long as it can block or inhibit the action of histamine. Skin cells damaged by physical or other stimuli release histamine, leukotriene, etc., which secondaryly secrete inflammation-inducing substances to other cells, and at the same time, lymphocytes and multinuclear leukocytes, which are involved in the inflammatory response. It also induces blood cells, such as monocytes. As described above, it is the initial non-bacterial inflammatory response after injury that continues the chain reaction in which the cells involved in the inflammatory response induce another inflammatory inducer. In such a chain reaction, histamine causes itching and pain. Therefore, since it is important to block the reaction of histamine, the composition for treating skin damage of the present invention may contain an antihistamine as an active ingredient. In the present invention, the antihistamine may be prepared and used according to a known method, or a commercially available one may be purchased and used, and also include derivatives having the same efficacy. Flacon, chlorpheniramine, clemastine, triprolidine, diphenhydramine, diphenhydramine hydrochloride, hydroxyzine hydrochloride, doxy Doxylamine, cetirizine, gelatin (azelastine), loratadine, ebastine, epinastine, fexofenadine, levocetirizine, etc. May be, but is not limited thereto. The antihistamine may be included in an amount of 0.00001 to 0.01 parts by weight, preferably 0.0001 to 0.001 parts by weight, based on 100 parts by weight of the total composition for treating skin damage according to the present invention.

In the present invention, the "vascular contractor" means a drug capable of contracting capillaries of the skin, and may be prepared and used according to a known method or purchased commercially. The vasoconstrictor includes epinephrine and the like. Epinephrine is also called adrenaline or epirenamine, and the formula is C ₉ H ₁₃ O ₃ N. Epinephrine stimulates the sympathetic nerve to constrict capillaries, so it can be used as a vasoconstrictor in the present invention. Thus, it may be replaced with or used with other substances having vasoconstrictive efficacy.

 When applying a composition for treating skin damage comprising a component such as a steroid or an antihistamine according to the present invention to damaged skin, the composition is absorbed into the skin by capillary action, which causes edema due to a non-bacterial inflammatory reaction prior to application of the composition. Active ingredients in the composition can be transferred to the systemic circulation system, including blood, through blood vessels expanded by damage. That is, not only the local effect of the active ingredients on the skin damage site is reduced, but there is a possibility of causing side effects on the parts other than the damaged skin. Therefore, in order to reduce the amount of the active ingredient absorbed into the circulation system or the like other than the damage site, a vasoconstrictor such as epinephrine may be used. On the other hand, the vascular contractors such as epinephrine shrink the capillaries, thereby preventing subcutaneous bleeding (spot) to point bleeding that may be caused by skin damage. Subcutaneous bleeding or pointed bleeding may cause secondary inflammatory reactions, so it is useful to use vasoconstrictors such as epinephrine. The vasoconstrictor such as epinephrine may be included in an amount of 0.000001 to 1 part by weight, preferably 0.000001 to 0.00002 part by weight, based on 100 parts by weight of the total composition for treating skin damage according to the present invention.

The composition containing the steroid, the antihistamine and the vasoconstrictor has an excellent anti-inflammatory effect and the collagen synthesis promoting effect, compared to the composition containing one to three of the above components, so that the steroid, antihistamine and blood vessel The composition according to the present invention containing a shrinkage agent is useful as a composition for treating skin damage.

In the present invention, the 'composition for treating skin damage' means a composition for treating skin damage. The damage to the skin refers to the destruction of skin cells by other stimuli such as physical stimulation, chemical stimulation, and the like, and also includes punctured skin damage by saliva (multi-ring needle, microneedles, etc.) or laser. The perforated skin refers to skin having a channel (needle hole) formed by a microneedle or the like, and the diameter of the needle of the microneedle may be 0.01 mm to 3.0 mm, and the needle length is not limited. The composition means that the skin may be damaged by physical stimulation or the like, and may be used for skin in which an inflammatory response has occurred or skin that needs skin regeneration.

In the present invention, the steroid, the antihistamine and the vasoconstrictor, each of the components may be sequentially contained in the composition according to the present invention, may be contained in a state in which each component is mixed.

On the other hand, the composition for treating skin damage according to the present invention may further contain a local anesthetic. Skin damaged by physical stimulation or the like, or skin damage caused by skin puncture treatment (multi-acupuncture needle, laser, etc.) causes pain, sometimes extreme pain. Therefore, the present inventors can provide a composition for treating skin damage further comprising a local anesthetic. By using the composition, the patient may reduce or alleviate the pain resulting from the treatment, and thus, the treatment of the laser or the like may be possible.

The kind of local anesthetic agent included in the composition of the present invention is not particularly limited, but cocaine analogues such as amino acids anilide such as lidocaine, prolycaine, cocaine, and tropacocaine; Water-soluble amino benzoic acid esters such as procaine and tetracaine; Benzoic acid esters such as piperocaine and stovane; Alkoxy benzoic acid esters such as cyclomethycaine and parethoxycaine; Amino ketones such as diclonine and falicaine; amino ethers such as pramoxine; Benzofuranone derivatives such as amolanone; Amidine or guanidine derivatives such as phenacaine; Urethane derivatives such as diperodon; Quinoline or isoquinoline derivatives such as dibucaine; Amino benzoic acid alkyl esters, such as ethyl benzoic acid, etc. are mentioned. The local anesthetic may generally be used in the form of a physiologically acceptable salt, for example, in the form of an inorganic acid salt such as hydrochloride or sulfate. Preferably, at least one selected from the group consisting of lidocaine and prorikain can be used. The local anesthetic may be included in an amount of 0.001 to 2 parts by weight, preferably 0.001 to 0.5 parts by weight, based on 100 parts by weight of the total composition for treating skin damage according to the present invention.

In addition, the composition for treating skin damage according to the present invention may further include one or more components of vitamins, moisturizers and preservatives.

The vitamin can be used without limitation as long as it can promote collagen production. Retinoids, ascorbic acid, and the like can be used. The retinoid is meant to include retinol, retinoic acid, retinal, retinyl esters, retinyl palmitate and derivatives thereof. Preferably retinyl palmitate can be used. Retinoids can help prevent skin aging and promote the synthesis of collagen to get rid of wrinkles. In particular, it is possible to prevent the production of wrinkles by reducing the production of collagenase. The retinoid content may be about 0.01 to 1 parts by weight based on 100 parts by weight of the total composition. If the content of the retinoid is too small, it is difficult to expect the effect by the retinoid, and if the content is too high, side effects such as cracking or dryness of the skin may be caused, so the content is adjusted as described above.

The ascorbic acid includes an ascorbic acid derivative. Ascorbic acid; Esters of ascorbic acid such as ascorbyl palmitate, ascorbyl acetate, ascorbyl propionate and ascorbyl stearate; Salts of ascorbic acid, such as sodium ascorbate, calcium ascorbate, magnesium ascorbate and zinc ascorbate, and the like. It is not. Ascorbic acid not only activates hydroxylase, an enzyme necessary for the synthesis of collagen, but also inhibits melanin production in melanocytes of the epidermis, brightens color by reducing oxidized melanin, and prevents skin aging. can do. The ascorbic acid may be included in an amount of 0.01 to 1 part by weight based on 100 parts by weight of the total composition. If the content of ascorbic acid is too small, it is difficult to expect the hydroxylase activation effect by ascorbic acid, and if too much content can cause side effects, the content can be adjusted as described above.

Moisturizing agent that may be included in the composition of the present invention, means a substance that increases the moisture content of the skin or stores moisture, the type is not limited. Polyol compounds such as sodium hyaluronate, polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol, butylene glycol, glycerin, sorbitol, malitol, sodium pyrrolidone carboxylic acid, etc. can be used. have.

As the preservative which may be included in the composition of the present invention, chlorobutanol and the like may be used, but the present invention is not limited thereto, and any preservative may be used as an ointment or a skin external preparation. The chlorobutanol may lower the viscosity of the composition of the present invention to help the active ingredient is better absorbed by the skin. Preservatives such as chlorobutanol may be included in an amount of 0.01 to 2 parts by weight, and preferably 0.1 to 0.5 parts by weight, based on 100 parts by weight of the total composition.

According to the present invention, a composition for treating skin damage containing a steroid, an antihistamine and a vasoconstrictor, or a composition according to the present invention further comprising a local anesthetic, or a vitamin, a humectant and a preservative further comprising at least one component. The composition according to the invention can be used as a therapeutic agent for skin damage, skin external preparation, cosmetics, face wash, etc. for the effect of alleviating inflammation or promoting collagen synthesis, and constituting the composition as long as it does not have a detrimental effect on inflammation reduction or collagen synthesis. It may further comprise an active substance.

The composition for treating skin damage according to the present invention can be used as an external preparation for skin. The formulation of the external preparation for skin is not particularly limited. For example, it may have a formulation such as liquid, powder, gel, ointment, cream, aerosol, or the like. Preferably, it may be prepared in liquid form. The composition according to the present invention prepared in liquid form can be well absorbed by capillary action in damaged pores or fine pores produced by skin perforation, so as to reduce inflammation or collagen of damaged skin as compared to conventional high-viscosity ointments for treating skin damage. Synthetic effect is excellent. In addition, since the liquid composition serves as a barrier to prevent contact between damaged dermis and air, it may serve to prevent moisture evaporation and dry skin of the skin, which may be caused by skin damage or perforation of the skin. When the viscosity of the composition is high, the capillary phenomenon may not occur or may be too weak, so that the viscosity of the composition may be adjusted in some cases.

In addition, the composition for treating skin damage according to the present invention can be used as a cosmetic. The formulation of the cosmetic is not particularly limited, and may have, for example, a formulation such as a nourishing cream, astringent lotion, a flexible lotion, a lotion, an essence, a nourishing gel or a massage cream. When used as the cosmetic, the composition according to the present invention may be added to the material selected arbitrarily according to the formulation or purpose of use of the cosmetic. For example, purified water, oil, surfactants, moisturizers, higher alcohols, thickeners, chelating agents, pigments, fatty acids, antioxidants, preservatives, waxes, pH adjusters, flavoring agents and the like can be added.

The oils include mineral oil, cyclomethicone, squalane, octyldodecyl myristate, olive oil, macadamia nut oil, glycerol octanoate, castor oil, ethylhexyl isononanoate, dimethicone, cyclopentasiloxane, Sunflower seed oil and the like can be used.

The surfactants include sorbitan sesquinolate, polysorbate 60, glyceryl stearate, lipophilic glyceryl stearate, sorbitan oleate, sorbitan stearate, die-cetyl phosphate, sorbitan stearate / Sucrose cocoate, glyceryl stearate / polyethylene glycol-100 stearate, ceteareth-6 oleate, arachidyl alcohol / behenyl alcohol / arachidyl glucoside. Polypropylene glycol-26-butes-26 / polyethylene glycol-40 hydrogenated castor oil and the like can be used.

As the moisturizing agent, glycerin, sorbitol, propylene glycol, butylene glycol, hexylene glycol, diglycerin, betaine, glycerin-26, methylgluse-20 and the like may be used.

Cetyl alcohol, stearyl alcohol, octyldodecanol, isostearyl alcohol and the like may be used as the higher alcohol.

Xanthan gum, carbomer, magnesium aluminum silicate, cellulose gum, dextrin palmitate may be used as the thickener.

As the chelating agent, disodium idieti, tetrasodium idieti and the like may be used.

As the dye, Blue No. 1, Red No. 40, Yellow No. 4, Yellow No. 5, etc. may be used.

As the fatty acid, stearic acid, mystic acid, palmitic acid, isostearic acid, lauric acid, or the like may be used.

Tocopheryl acetate, butylated hydroxytoluene, etc. may be used as the antioxidant.

As the preservative, methyl paraben, butyl paraben, propyl paraben, phenoxyethanol, imidazolidinyl urea, chlorphenesin and the like may be used.

Carnauba wax, candenilla wax, beeswax, braze and the like may be used as the wax.

As the pH adjusting agent, triethanolamine, citric acid, or the like may be used.

As the fragrance, natural fragrance, combination fragrance, or the like may be used. In a specific embodiment of the present invention was used pine needle extract which is a liquid fragrance having a specific fragrance.

In addition, the composition for treating skin damage according to the present invention can also be used as a face wash. The formulation of the detergent is not particularly limited. For example, it may be a formulation such as a solid soap, liquid soap, shampoo, body cleanser, cleansing foam, cleansing oil, cleansing cream or cleansing lotion.

1 shows the structure of skin cells.

Claims (39)

A composition for treating skin damage containing steroids, antihistamines and vasoconstrictors as an active ingredient. The method of claim 1, wherein the steroid is dexamethasone, prednisolone, triamcinolone, cortisone, hydrocortisone, tretinoin, prednisone, prednisone, methyl Prednisolone (methylprednisolone) and betamethasone (bethamethasone) at least one selected from the composition for treating skin damage. According to claim 1, wherein the antihistamine is flacon, chlorpheniramine (chlorpheniramine), clemastine (clemastine), triprolidine, (diphenhydramine), diphenhydramine hydrochloride (diphenhydramine hydrochloride), Hydroxyzine hydrochloride, doxylamine, cetirizine, gelatin (azelastine), loratadine, ebastine, efinastine, fexofenadine And levocetirizine (levocetirizine) at least one selected from the composition for treating skin damage. The composition of claim 1, wherein the vasoconstrictor is epinephrine. The composition of claim 1, further comprising a local anesthetic. The method of claim 5, wherein the local anesthetic agent is lidocaine, procaine, cocaine (cocaine), tropacocaine (tropacocaine), procaine (procaine), tetracaine (piperocaine), piperocaine (storbine), stovine ( stovaine, cyclomethycaine, parethoxycaine, diclonine, palycaine, pramoxine, amolanone, aphenanine, phenacaine, dife A composition for treating skin damage, characterized in that at least one selected from rodon (diperodon), dibucaine (dibucaine) and ethyl amino benzoate. The composition for treating skin damage according to claim 1, further comprising at least one component among vitamins, humectants, and preservatives. 8. The composition of claim 7, wherein the vitamin is a retinoid or ascorbic acid. According to claim 7, wherein the moisturizing agent is a polyol-based compound such as sodium hyaluronate, polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol, butylene glycol, glycerin, sorbitol, malitol and pyrroli A composition for treating skin damage, characterized in that at least one selected from sodium doncarboxylic acid. According to claim 1, wherein the composition is a composition for treating skin damage, characterized in that to reduce the inflammation by blocking the reaction of histamine. The composition of claim 1, wherein the composition treats skin damage by promoting collagen synthesis to regenerate the skin. The composition for treating skin damage according to any one of claims 1 to 11, which has a liquid dosage form. The composition for treating skin damage according to any one of claims 1 to 11, wherein the composition is for treating punctured skin damage in which a needle hole is formed by being stuck by a microneedle. An anti-inflammatory composition containing steroids, antihistamines and vasoconstrictors as active ingredients. The method of claim 14, wherein the steroid is dexamethasone, prednisolone, triamcinolone, cortisone, hydrocortisone, tretinoin, prednisone, methyl prednisone, or methyl. Prednisolone (methylprednisolone) and betamethasone (bethamethasone) at least one selected from the composition for anti-inflammatory. 15. The method according to claim 14, wherein the antihistamine is flacon, chlorpheniramine, clemastine, triprolidine, diphenhydramine, diphenhydramine hydrochloride, Hydroxyzine hydrochloride, doxylamine, cetirizine, gelatin (azelastine), loratadine, ebastine, efinastine, fexofenadine And levocetirizine (levocetirizine) is at least one selected from the composition for anti-inflammatory. 15. The anti-inflammatory composition according to claim 14, wherein the vasoconstrictor is epinephrine. 15. An anti-inflammatory composition according to claim 14 further comprising a local anesthetic. 19. The method of claim 18, wherein the local anesthetic agent is lidocaine, prolycaine, cocaine (cocaine), tropacacaine (tropacocaine), procaine (procaine), tetracaine (piperocaine), piperocaine, stovine ( stovaine, cyclomethycaine, parethoxycaine, diclonine, palycaine, pramoxine, amolanone, aphenanine, phenacaine, dife Anti-inflammatory composition, characterized in that at least one selected from rodon (diperodon), dibucaine (dibucaine) and ethyl amino benzoate. The anti-inflammatory composition according to claim 14, further comprising at least one component among vitamins, humectants, and preservatives. 21. The anti-inflammatory composition of claim 20, wherein the vitamin is a retinoid or ascorbic acid. The method of claim 20, wherein the moisturizing agent is a polyol-based compound, such as sodium hyaluronate, polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol, butylene glycol, glycerin, sorbitol, malitol and pyrroli Anti-inflammatory composition, characterized in that at least one selected from sodium doncarboxylic acid. 15. The anti-inflammatory composition of claim 14, wherein the composition relieves inflammation by blocking the reaction of histamine. 15. The anti-inflammatory composition of claim 14, wherein the composition treats skin damage by promoting collagen synthesis to regenerate the skin. The anti-inflammatory composition according to any one of claims 14 to 24, which has a liquid dosage form. 25. The anti-inflammatory composition according to any one of claims 14 to 24, wherein the composition is for treating punctured skin damage in which a needle hole is formed by being stuck by a microneedle. Collagen synthesis enhancing composition containing a steroid, an antihistamine and a vasoconstrictor as an active ingredient. The method of claim 27, wherein the steroid is dexamethasone, prednisolone, triamcinolone, cortisone, hydrocortisone, tretinoin, prednisone, prednisone, methyl Prednisolone (methylprednisolone) and betamethasone (bethamethasone) is a composition for enhancing collagen synthesis, characterized in that at least one selected. 28. The method of claim 27, wherein the antihistamine is flacon, chlorpheniramine, chlorpheniramine, clemastine, triprolidine, diphenhydramine, diphenhydramine hydrochloride, Hydroxyzine hydrochloride, doxylamine, cetirizine, gelatin (azelastine), loratadine, ebastine, efinastine, fexofenadine And levocetirizine (levocetirizine) is a composition for enhancing collagen synthesis, characterized in that at least one selected. The composition for enhancing collagen synthesis according to claim 27, wherein the vasoconstrictor is epinephrine. The composition for enhancing collagen synthesis according to claim 27, further comprising a local anesthetic. 32. The method of claim 31, wherein the local anesthetic agent is lidocaine, prolycaine, cocaine (cocaine), tropacocaine (tropacocaine), procaine (procaine), tetracaine, piperocaine (piperocaine), stovine ( stovaine, cyclomethycaine, parethoxycaine, diclonine, palycaine, pramoxine, amolanone, aphenanine, phenacaine, dife A composition for enhancing collagen synthesis, characterized in that at least one selected from rodon (diperodon), dibucaine (dibucaine) and ethyl amino benzoate. The composition for enhancing collagen synthesis according to claim 27, further comprising at least one component among vitamins, humectants, and preservatives. The composition of claim 33, wherein the vitamin is a retinoid or ascorbic acid. The method of claim 33, wherein the moisturizing agent is a polyol-based compound such as sodium hyaluronate, polyethylene glycol, polypropylene glycol, dipropylene glycol, propylene glycol, butylene glycol, glycerin, sorbitol, malitol and pyrroli Collagen synthesis enhancing composition, characterized in that at least one selected from sodium doncarboxylic acid. The composition for enhancing collagen synthesis according to claim 27, wherein the composition reduces inflammation by blocking the reaction of histamine. The composition for enhancing collagen synthesis according to claim 27, wherein the composition treats skin damage by promoting collagen synthesis and regenerating the skin. The composition for enhancing collagen synthesis according to any one of claims 27 to 37, which has a liquid dosage form. The composition for enhancing collagen synthesis according to any one of claims 27 to 37, wherein the composition is for treating punctured skin damage formed by puncture by microneedle.

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