KR20090078662A - Calcium compound containing natural product composition for curing a hangover and preparation method thereof - Google Patents

Abstract

A composition for curing alcoholic hangover containing calcium compound as an active ingredient is provided to shorten remaining time of acetealdehyde in the body and reduce the alcohol concentration in blood in a short time. A method for manufacturing a composition for curing alcoholic hangover comprises: a first step of adding water or ethanol in a mixture and compress-drying; a second step of adding water and ethanol in to another mixture and compression-drying; and a third step of mixing together the extracts obtained from the first and second steps and resolving sugar, glucose, maleic acid, lactic acid or its salt. The calcium compound is shell ionized calcium, ostreae Testa calcium, calcium from seaweed, calcium lactate or the calcium salt. The mixture of the first step comprises 500-800 weight part of calcium compound, 200-400 weight part of black bean, 200-400 weight part of mung bean, 200-400 weight part of Hoveniae Semen cum Fructus, 200-400 weight part of Puerariae Radix, 100-200 weight part of glycyrrhizae radix. The another mixture of the second step comprises 400-500 weight part of Puerariae Flos, 400-600 weight part of Oenanthe javanica, 400-600 weight part of radish, 400-600 weight part of bean sprout, and 30-60 weight part of Zingiberis Rhizoma crudus.

Description

Hangover-relieving composition of natural raw materials based on calcium compounds and its manufacturing method {CALCIUM COMPOUND CONTAINING PRODUCT COMPOSITION FOR CURING A HANGOVER AND PREPARATION METHOD THEREOF}

The present invention relates to a hangover-relieving composition and a method for producing the same having excellent effects in promoting alcohol decomposition and relieving hang-over.

Drinking alcohol, which is the most popular drink in Korea, causes excessive social problems, both personally and mentally and physically. When about 10% of alcohol absorbed by drinking It is excreted through the urine and most of the remaining 90% is metabolized in the gastric mucosa or liver. Alcohol metabolism occurs mainly in the liver and is metabolized to acetaldehyde by Zn-containing alcohol dehydrogenase (ADH), which requires nicotinamide adenine dinucleotide (NAD). The reaction by ADH is achieved by zero order kinetics and the reaction rate is constant. Acetaldehyde is converted to acetic acid by alcohol dehydrogenase (ALDH), and NAD is also required in this process (Jae-Yeol Cho , 29 (1), 167-172 (1997) ). This reaction is very fast when a sufficient amount of ALDH is produced, and the concentration of acetaldehyde in the blood is extremely low even when a large amount of alcohol is ingested.

However, before a sufficient amount of ALDH is produced, especially in the early stages of drinking, the reaction is very slow, acetaldehyde accumulates and causes a hangover.

The resulting acetate is converted back to acetyl coenzyme A (acetyl Coenzyme A), through the TCA (tricarboxylic acid cycle) CO ₂ And H ₂ O (Cho Jaeyeol et al .; Lieber CS and Leo MA, In Progress in liver diseases, Popper, H. and Schaffner, F. (Ed), Grune amd Stration, New York, p.253 (1986)); And Linder MC).

Chronic ethanol uptake causes hyperlipidemia and fatty liver, leading to increased liver and intracellular NADH / NAD ⁺ ratios as a result of ethanol metabolism by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Theorem has been shown to increase fatty acid oxidation and TCA cycle activity in hepatocytes, resulting in fatty liver (Murray RK et al., Haper's Biochemistry, Appleton & Lange, Connechcut, USA. 3rd ed, p260 (1993)).

In hangovers, acetaldehyde produced by alcohol consumption acts as a major toxic substance, and a large amount of free radicals are generated in alcohol metabolism process, which is a major cause of alcoholic disorders.

In vivo, a variety of enzymes, including aldehyde dehydrogenase (ALDH), are used to accelerate the degradation of acetaldehyde in order to rapidly decompose acetaldehyde after drinking alcohol (Lieber, CS: Hepatology, 4: 1243-1260, 1984). One of the treatment methods for alcoholism is the administration of disulfiram, an ALDH inhibitor, which concentrates high concentrations of acetaldehyde in the blood so that the patient feels strong discomfort and nausea when they ingest alcohol. It is a way. In particular, discomfort and nausea are similar to hangover symptoms, suggesting that hangover is caused by acetaldehyde (Gessa GL Guidelines for the drug therapy of alcoholism Recenti). Prog Med 1990 Mar; 81 (3): 171-5).

In particular, ethanol is first decomposed into acetaldehyde in the body and then to acetic acid. Acetaldehyde, a high concentration of active compound, is sweat, rapid pulse, skin flushing, nausea and vomiting. may cause vomiting (Rosser BG and Gores GJ, Gastroenterology , 108, 252 (1995)). For this reason, most modern researchers believe that acetaldehyde, the alcohol breakdown product, is the cause of hangovers. Sherif, S., Wahlstrom, G., Oreland, L. Alcohol , Clin . Exp . Res . 17 (6): 1313-1318, 1993).

The hangover experience is very dependent on personal preferences and circumstances and the type and amount of alcohol consumed. Physical hangover symptoms are accompanied by headaches, fatigue, light and sound sensitivity, myalgia, hyperemia, thirst, nausea, vomiting and stomach pain. Hangovers can also cause rapid heartbeat, excitement, increased blood pressure and sweating. Mental symptoms associated with a hangover include sleep deprivation, changes in sleeping places, decreased attention, decreased concentration, depression, dizziness, anxiety, and irritability.

These detrimental phenomena are due to the peroxidation reactions occurring in the production of acetaldehyde and the destruction of hepatocytes by excess NADH formed by the catalyst of MEOS, inhibition of hepatocyte chemical equilibrium, metabolic abnormalities and function of mitochondria (Bunsel RG and Lehmann AG, Behav. Vrain Res . 1, 351 (1980); And State Chung, Chemical World, 34 , 767 (1994)).

The production of these intracellular free radicals is formed from enzymes in the cytoplasm and various oxidases. These free radicals damage DNA and mitochondria and promote fatty oxidation in the plasma membrane, causing fatty liver (Said EM et al., European Jounal of obsterics and gynecology and reproductive biology , 89 , 1-6 (2000)). On the other hand, the generated free radicals are converted to H ₂ O ₂ by Cu-Zn peroxide dismutase (Cu-Zn SOD), which in turn is converted to glutathione reductase 5 (GPX 5) or antioxidant enzyme catalase. ₂ O and O ₂ are separated. Therefore, it can be said that Cu-Zn SOD, GPX 5 and the like play a secondary role in restoring cellular oxidation (Said EM, etc.).

In alcohol metabolism, other toxic substances are produced besides acetaldehyde, which are highly reactive oxygen compounds called active oxygen. In the process of alcohol metabolism, active oxygen appears due to the reaction of dehydrating enzymes such as alcohol dehydrogenase, ALDH, etc. It is also caused by the action of direct oxidase such as microsomal ethanol oxidizing system, xanthine oxidase, and aldehyde oxidase.

In addition, in connection with the elimination of hangovers, various dietary supplements containing ingredients extracted from natural foods or herbal medicines have been developed (Kim Jung-han et al . , 38 (6): 549-553, 1995). As part of this research, a composition containing choline acids, which have an effect of edema, hepatic detoxification, hepatic blood flow improvement, promoting fat absorption, and excretion of waste products through fine bile ducts, is commercially available. Examples of such choline acid include ursodeoxycholic acid, which is known to be effective in improving liver function of liver disease, systemic malaise due to liver dysfunction, indigestion, anorexia, physical fatigue, and the like; Tauroursodeoxycholic acid, which is commercially available as a gallstone dissolving agent and is effective in treating fatty liver, which has an effect of improving liver function and reducing liver fat mass when orally administered; Chenodeoxycholic acid sold as a gallstone dissolving agent; And dehydrocholic acid. However, the composition containing choline acids is effective in the general symptoms caused by stress, such as increase in adrenal weight by stress and prevention of spleen atrophy, inhibition of ascorbic acid content of adrenal gland and suppression of blood biochemical changes This has been proven, and there is no report on the effects of relieving hangovers or protecting the liver.

In addition, as a herbal medicine or a folk remedy, various types of medicines have been developed, which are mainly composed of ingredients such as ginseng and thorny ginseng, which are known to be useful in relieving hangovers. Among these, many nourishment tonic drink agents based on ginseng are commercially available, and drinks containing various herbal medicines are commercially available for removing hangover after drinking alcohol. These drinks are used alone after drinking, and in addition to alcohol with high alcohol content before drinking. However, a drink containing some herbal medicines may not only cause systemic boredom, abdominal bloating, vomiting or abdominal pain, but also some drink may be sold at high prices by using expensive herbal medicines.

However, despite various efforts to resolve hangovers after drinking as described above, the development of therapeutic agents or beverages that can effectively alleviate or eliminate hangovers has not been successful until now.

An object of the present invention is to provide a new hangover-relieving composition having an excellent effect on the overall hangover resolved by drinking without side effects in the human body to solve the above problems.

Hangover composition according to the present invention for solving the above problems, the present invention as the active ingredient calcium compound 500 to 800 parts by weight, black bean 200 to 400 parts by weight, mung bean 200 to 400 parts by weight, red bean 200 to 400 weight Part, 200 to 400 parts by weight, 200 to 400 parts by weight, 100 to 200 parts by weight, licorice 100 to 200 parts by weight, five to 200 parts by weight, 150 to 250 parts by weight of dermis, 10 to 20 parts by weight of ginseng, 30 to 60 parts by weight of jujube Parts, 400 to 500 parts by weight, 400 to 600 parts by weight of buttercup, 400 to 600 parts by weight of radish, 400 to 600 parts by weight of bean sprouts (soybean yellow soybean), 30 to 60 parts by weight of ginger using alcohol or hot water as a solvent To provide a hangover composition for dissolving sugar or glucose, maleic acid, lactic acid or salts thereof in the extract.

At this time, the calcium compound is preferably a compound having high absorption in the human body, and shell ionized calcium, cured calcium, seaweed calcium, whey calcium, other calcium salts, for example calcium acetate, calcium ascorbate ( calcium ascorbate, calcium gluconate, calcium iodate, calcium iodide, calcium nitrate, calcium oxalate, calcium oxide oxide, calcium (calcium phosphate), calcium pyrophosphate (calcium pyrophosphate), calcium silicate (calcium silicate), calcium sulfate (calcium sulfate), calcium sulfite (calcium sulfite) and the like can be used alone or in combination.

The hangover composition may be diluted to 3 to 6 times the volume of the extract, distilled water is preferred as a diluent to dilute the extract.

In addition, the hangover relief composition according to the present invention, in addition to the active ingredient as described above, as an auxiliary component for reinforcing the bioactive effect of the composition, vitamin B ₁ , B ₂ , B ₆ , B ₁₂ , C, pantothenic acid, nicotinic acid It may further contain a mixture of amide, folic acid, biotin, zinc, iron, calcium, magnesium or yeast extract for the purpose of supplying various vitamins and minerals.

At this time, the composition of the present invention preferably contains an auxiliary component such as vitamins in an amount of 0.01 to 10% by weight based on the total weight of the composition, especially in the case of containing vitamins B ₁ , B ₂ and C, Most preferably, the amount is contained in an amount of 0.01 to 3% by weight, 0.01 to 3% by weight and 0.01 to 4% by weight, respectively.

In addition, the hangover composition of the present invention may further contain a pharmaceutically or physiologically acceptable carrier. As the carrier, it may contain all carriers pharmaceutically or physiologically acceptable according to the preparation method of the functional composition known in the art, for example, lactose, dextrose, sucrose, sorbitol, Mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzo Eights, talc, magnesium stearate, mineral oil and the like. In addition, the hangover composition of the present invention may further contain a filler, anti-coagulant, lubricant, wetting agent, fragrance, emulsifier or preservative.

In addition, the composition of the present invention, natural flavors such as plum flavor, lemon flavor, pineapple flavor or herbal flavor, natural fruit juice, natural pigments such as chlorphyllin, sweeteners such as fructose, honey, sugar alcohol, sugar and / or It may further contain an acidulant such as citric acid, sodium citrate or a mixture thereof.

Hangover-relieving compositions containing the natural medicinal herb or extracts thereof according to the present invention are well known in the art to control the release rate of the active ingredient (eg, rapid, sustained or delayed release) after administration. It can be formulated in a known manner. The formulations may be in the form of tablets, pills, powders, sachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, soft or hard gelatin capsules, sterile injectable solutions, sterile powders and the like.

In addition, hangover relieving agent according to the present invention can be administered through various routes such as oral, transdermal, subcutaneous, intravenous or intramuscular, it is most preferred to use an oral administration method.

The single human dose of the composition for relieving hangover according to the present invention is preferably 15 g to 25 g in the case of a composition containing a natural medicine, and 3 g to 10 g in the case of a composition containing an extract of the natural medicine. And more preferably in the range of 4 to 6 g, the actual dosage should be determined in consideration of several factors such as the route of administration, the age, sex, weight of the patient and the severity of the symptoms, the dosage being in any way It does not limit the scope of the invention.

In addition, the present invention provides a method for preparing the hangover relief composition, the method for preparing a hangover relief according to the present invention 500 to 800 parts by weight calcium compound, 200 to 400 parts by weight black beans 200 to 400 parts by weight mung beans , Red bean 200 to 400 parts by weight, earth 200 to 400 parts by weight, brown root 200 to 400 parts by weight, licorice 100 to 200 parts by weight, omega 200 to 400 parts by weight, dermis 150 to 250 parts by weight, ginseng 10 to 20 parts by weight 30 to 60 parts by weight of jujube, 70 to 95% of ethanol is added in an amount of 4 to 8 times the weight of the mixture, and then at 40 ° C. to 90 ° C., preferably at 60 ° C. to 85 ° C., for 2 hours to Extracting for 6 hours, preferably 4 hours, and drying under reduced pressure to obtain a concentrated natural extract, 400 to 500 parts by weight, 400 to 600 parts by weight of buttercup, 400 to 600 parts by weight of radish, 400 to 600 parts by weight of bean sprouts (soybean yellow bean) 400 to 600 parts by weight, ginger 70 to 95% of ethanol is added to 30 to 60 parts by weight in an amount of 4 to 8 times the weight of the mixture, followed by 10 to 30 minutes at 40 ° C to 90 ° C, preferably 60 ° C to 85 ° C, Preferably, the method comprises extracting for 20 minutes and drying under reduced pressure to obtain a concentrated natural extract, and mixing the extracts of the two steps and dissolving sugar or glucose with maleic acid, lactic acid or salts thereof in the extract. According to the above method, when the total weight of the natural medicine mixture of 20 kg is extracted and dried under reduced pressure, approximately 5.5 kg of concentrated extract can be obtained.

In addition, the method for producing a hangover relief composition of the present invention, 500 to 800 parts by weight of calcium compound, 200 to 400 parts by weight of black bean, 200 to 400 parts by weight of mung bean, 200 to 400 parts by weight of red beans, 200 to 400 parts by weight , 200-400 parts by weight, 100-200 parts by weight of licorice, 200-400 parts by weight of ume, 150-250 parts by weight of dermis, 10-20 parts by weight of ginseng, 30-60 parts by weight of jujube, water of the mixture 4 To an amount of 8 to 8 times, followed by extracting at 90 ° C. to 120 ° C., preferably at 110 ° C. for 2 to 6 hours, preferably 4 hours, and drying under reduced pressure to obtain a concentrated natural extract; To 500 parts by weight, buttercup 400 to 600 parts by weight, radish 400 to 600 parts by weight, 400 to 600 parts by weight of bean sprouts (soybean yellow soybean), 30 to 60 parts by weight of ginger in an amount of 4 to 8 times the weight of the mixture After addition, 490 ° C to 120 ° C, Preferably at 110 ° C., extraction for 10 minutes to 30 minutes, preferably 20 minutes, and drying under reduced pressure to obtain a concentrated natural extract.

When the two step extracts are combined by the above method, it is preferable to extract 20 kg of the natural medicinal herb mixture, and to heat and concentrate to obtain a concentrated extract of about 5.9 kg. At this time, the amount of alcohol or water used for extraction in the production method of the present invention, the extraction temperature and extraction time should be in the above range to obtain an extract of the appropriate concentration.

The present invention is characterized in that the composition of the additives, such as natural ingredients and vitamins containing calcium compounds as a main component exhibits an excellent hangover relief effect without adverse effects on the human body.

According to the mechanism of alcohol metabolism and excretion, by controlling the ratio of hyper-NAD and NADH in the metabolic process when drinking alcohol, it accelerates the decomposition of alcohol and inhibits the concentration of acetaldehyde as much as possible, The present invention also provides a health functional composition and a method for producing the same, which inhibits a large amount of active oxygen generated, thereby ultimately eliminating the phenomenon caused by alcohol absorption and the following hangover phenomenon.

When alcohol is inhaled into the body, it is oxidized through the following metabolic pathways, which are metabolized by the action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) present in the liver and gastrointestinal tract.

The present inventors have studied in depth the mechanism of absorption, distribution, metabolism and excretion of alcohol (ADME), and as a result, it is very important that the hangover caused by alcohol is absorbed by alcohol absorbed within 30 minutes of the start of drinking. Was found.

In the early stages of drinking, the human body produces alcohol, a primary metabolic process that produces acetaldehyde. The second metabolic process is the oxidation of acetaldehyde with acetic acid by the ALDH enzyme. However, since the human body does not always have a sufficient amount of ALDH, the secondary metabolic reaction of oxidizing acetaldehyde, which is a hangover-causing substance, may have a slower reaction rate than the primary metabolism. Therefore, until the body produces a sufficient amount of ALDH enzyme (transcription) it is inevitably accompanied by the accumulation of a large amount of acetaldehyde in accordance with the absorption of alcohol.

The present inventors have therefore invented a method of inhibiting the rate of primary metabolic reaction of early alcohol. In other words, in order to suppress the primary metabolic reaction of alcohol, calcium compounds with high absorption are used as active ingredients in the composition to activate the signal transduction system of the human body, thereby rapidly producing ALDH, and administering sugar or glucose to By using these methods to preferentially metabolize, NAD, an essential coenzyme of the primary metabolic reaction, is prevented from participating in alcohol for a certain period of time during the first metabolic process.

In other words, by suppressing the rate of primary metabolic processes until a sufficient amount of ALDH (Alcohol Decomposition Second Enzyme) is produced at the beginning of drinking, the absorption of sugar, glucose, etc. is very rapid for the purpose of preventing excess acetaldehyde from being produced. Carbohydrate was added to the composition. These carbohydrates are rapidly metabolized along the corresponding Glycolytic Pathway (FIG. 1), which is well known in the body, such as glucose 6-phosphate, fructose 6-phosphate, and fructose. Glyceraldehyde 3-phosphate is produced through 1,6-bisphosphate (Fructose1,6-phosphate).

The resulting glyceraldehyde-3-phosphate is converted directly to 1,3-biphosphoglycerate, where NAD acts as the main enzyme (Lubert Stryer, Biochemistry 4th Ed. P. 490). ).

Therefore, NAD is preferentially used for metabolism of administered sugar or glucose, and thus cannot be used for alcohol metabolism, thereby inhibiting the primary metabolic reaction of alcohol and suppressing the production of excessive amount of acetaldehyde at the beginning of drinking. Absorbed alcohol is more likely to be excreted in the kidneys without being metabolized into urine. The greater the amount of ethanol released into the body without metabolism, the less acetaldehyde is produced, and of course, the hangover is also reduced.

In addition to sugar and glucose, glucose 6-phosphate, fructose 6-phosphate, fructose 1,6-bisphosphate, which are intermediates in the glucose metabolic pathway Like sugar, etc., NAD has the effect of using NAD over alcohol metabolism, so it can be added instead.

In addition, the present inventors studied the reaction in which NAD is preferentially used in in vivo reactions other than the glucose metabolic pathway, indicating that maleic acid and its salts (Maleic acid and maleate salts) and lactic acid and its salts (Lactic acid and lactate salts) use NAD. Figured out. Therefore, these acids and salts have the effect of using NAD in preference to alcohol in addition to sugar and glucose, which delays the metabolism of alcohol and releases it out of the body, and inhibits primary metabolism of alcohol until sufficient ALDH is produced. Prevention (Citric acid cycle, Lubert Stryer, Biochemistry 4th Ed.p. 513, Glyoxalate cycle, Lubert Stryer, Biochemistry 4th Ed.p. 523, Glycolysis, Lubert Stryer, Biochemistry 4th Ed.p. 497).

Calcium compound, the main component, activates the signal transduction system of the human body, and promotes the production of ALDH in the early stage of drinking, thereby rapidly progressing the secondary metabolic reaction of acetaldehyde produced in primary metabolism.

Calcium is the most abundant inorganic element in the human body, and the human body holds about 1,200 g, which is about 2% of the human body, and plays a very important role in the activation of various enzymes and signal transduction systems within and between cells.

In other words, the addition of calcium compounds inhibits the absorption of alcohol by converting the pH in the stomach into alkali, and simultaneously activates various enzymes such as ion balance, NAD, NADH, ADH, and ALDH, and glucose metabolism in the human body. (Maria V. Zamaraeva) et al. ^{Ca 2 + -dependent glycolysis activation mediates apoptotic} ATP elevation in HeLa cells, Biochemical and Biophysical Research Communications Vol. 363, (3), 2007, pp 687-693)

 In addition, by activating the signal transduction system within the body and between cells, it facilitates the smooth production and supply of various enzymes, coenzymes, and co-factors related to alcohol metabolism, thereby preventing the accumulation of acetaldehyde and harmful oxygen. Mechanisms prevent hangovers.

In particular, the lack of calcium leads to acidification of cells and generation of harmful oxygen, which provides another cause of hangover, such as headache caused by brain cell destruction, so the composition of the main ingredient of this calcium compound is a major toxic substance acetase produced by alcohol consumption during hangover. In addition to inhibiting aldehyde production, active oxygen is generated in a large amount in the process of alcohol metabolism, which has the effect of preventing them from causing alcoholic disorders.

In the present invention, the calcium compound is preferably a compound having high absorption to the human body, and has a high degree of ionization, thereby providing a highly ionizable calcium absorption rate to the recipient, and also providing beneficial elements such as essential elements (New Carry). On formulation, Korean Patent Publication No. 2006-0034085), chopped calcium extracted from oyster shell, seaweed calcium produced in sea red algae with high digestion absorption rate, whey calcium extracted from milk containing ingredients that enhance calcium absorption, Other calcium salts, such as calcium acetate, calcium ascorbate, calcium gluconate, calcium iodate, calcium iodide, calcium tight Calcium nitrate, calcium oxalate, calcium oxide, calcium phosphate, Calcium pyrophosphate, calcium silicate, calcium sulfate, calcium sulfite, or the like may be used alone or in combination.

In addition to the main calcium components, as an auxiliary component, water or alcohol extracts such as black bean, green bean, red bean bean, earthworm, brown root, licorice, ume, dermis, ginseng and jujube, and water such as browning, buttercup, radish, bean sprouts (soybean rhubarb) and ginger or After the alcohol extract is added, the composition is finally prepared by dissolving 10-30% sugar or glucose with respect to the weight of the extract, and 2-5% by weight of maleic acid, lactic acid or each salt thereof.

The components used in the present invention will be described as follows.

Glycine max (L.) Merrill refers to black beans, which are said to have a good effect on the metabolism of the kidney system. People with weak kidneys are cold body and metabolism is not smooth, so the body will accumulate extra moisture or fat. When you eat black beans, the kidneys are active and moisture and fat do not accumulate, thereby promoting the metabolism and excretion of alcohol to prevent hangovers.

Black beans contain 36-45% protein and 17-22% oil. There are also triterpenoids saponins, nitrogen compounds, carbohydrates, candy, pectins, minerals and vitamins. 80-90% of the protein consists of essential amino acids: arginine, methionine, threonine, leucine, isoleucine and valine.

The ash contains K, Mg, Cu, Fe, Mn, Ni, Zn and trace Co and phosphoric acid. Seeds also contain vitamins A, B ₁ , B ₂ , D, E, K and isoflavone glycosides such as diazine, heistin, and rovinin.

Mung bean (Phaseolus aureus, Phaseolus radiatus, Mung bean, Green bean) is a perennial herb that belongs to the dicotyledonous rosewood legume, and its origin is estimated to be India and is mainly distributed in Asia such as Korea, China and India. Mung beans grow well on warm climate loam (壤土: black soil mixed with sand and clay) and are about 30-80 cm in height. The stem has a thin, vertical vein, about 10 nodes, and branches. The leaves come in pairs of cotyledons and freshly formed leaves, followed by three leaflets. Flowers are yellow and bloom in August, gathering several on axilla, but only 3-4 pairs bear fruit. Fruits are edible, initially green, but ripened and covered with long, coarse fur. It is 5-6 cm long and contains 10-15 seeds in one pod. Seeds are often green, but yellow, greenish brown, and blackish brown. The varieties are divided into yellow, greenish brown, and blackish brown mung beans, depending on the color of the seeds, but green mung beans make up 90% of the total. The ingredients are 53-54% starch and 25-26% protein.

Mung beans have been documented to have a skin cosmetic effect, such as Dongbobogam. Mung bean protein and mung bean flavonoids are particularly effective in face washing, while bioactive ingredients, bitexin and isobitexin, have excellent antioxidant effects and prevent skin aging. It is known that such facts.

Mung bean is written in the medicinal herb, 'It is good for freshness, harmonizes five intestines, stabilizes the mind, controls the wind, and makes the skin beautiful.' In addition, it is effective for summer symptoms and anorexia, and it is good for fever, high blood pressure, hangover, and various skin diseases such as blemishes, sweat bands and acne, and whitening. It is used as main raw material

Red bean is red bean (phaseolus angularis) is a perennial plant of legumes, has diuretic effect and has been used as a folk remedy to calm species. Diuretic, moist, bleeding, drainage, detoxification, etc. Efficacy in treating species, each, jaundice, hari, and other symptoms.

The earth vulgaris (haven) is known to be effective in many diseases after drinking alcohol, and detoxification, sputum (diabetes), hemorrhoids, alcoholism, jaundice, fatty liver caused by alcohol, jaundice, hepatitis, cirrhosis, etc. Due to the large intestine, stomach, brain disease is effective. Recent studies have demonstrated that the extract of Hovenia dulis Thunb has an excellent effect on the hangover and liver function and protection.

Among the various parts of the bark tree, the most effective part of protection against liver function is known as the fruit part. Hollow trees include Hoduloside I, II, III, IV, V, Hovenine A, Hovenolactone, Hovenoside D, G, I, Saponin C2, E, It consists of components, such as H, lamanose, mannose, glucose, galactose, and arabinose. These ingredients contain substances that are beneficial to the human body and have been found to have the effects of alcohol detoxification, fatigue recovery, diabetes, nausea, indigestion, intoxication, and various diseases.

Earth's Earth contains Hovenodulinol, which accelerates alcohol breakdown and decomposes acetaldehyde, and Ferulric acid, which improves liver function.

In the Ming Dynasty, the Sichuan River, written by Yi Shijin, said, "In autumn, the bark tree grows in the shape of a coral, and the fruit becomes large. It is used as a medicine and tastes sweet so that people eat it. It protects you. " It has been reported that hawthorn has the effect of inhibiting glutamate-induced brain damage. Hazel tree has the effect of inhibiting carbon tetrachloride-induced liver injury (Hase K et al., Biol. Pharm. Bull. 20 (4): 381-385, 1997), and dihydroflavonol isolated from the fruit of Hazel tree (dihydroflavonols), hovenitins I, II and III have been reported to have the effect of inhibiting alcohol-induced liver damage (Yoshikawa M et al., Yakugaku Zasshi 117 (2): 108-118, 1997). Phenolic compounds isolated from the fruit of the bark have the effect of inhibiting glutamate-induced brain damage (Li G et al., Arch. Pharm. Res. 28 (7): 804-809, (2005), it has been reported that barberry fruit has an effect of promoting alcohol degradation upon acute alcohol administration (Ji Y. et al., Zhong Yao Cai 24 (2): 126-128, 2001).

It is known for its detoxification and recovery of fatigue as it contains beneficial ingredients such as glucose, malic acid, calcium, furangurinine, hobenin, hobenoside, and habenic acid in the fruit, leaf and branches. It is known to use leaves, stems, and roots as medicinal herbs (Information and Shinmingyo, Hyangjedae, Yeonglimsa, pp 291-292, 1998).

Brown root (Pueraria lobata Ohwi) is a legume (Leguminosae), the roots of the bark of Pueraria lobata OHWI. The root roots are isoflavonoids, which include diazin, daidzin, and formonetinm genistein. It also contains triterpenoids, soyasapogenol A and kuzusapogenol B. These ingredients are known to have a sedative, hypothermic and vascular relaxing effect. Reed root is one of the drugs that inhibit the production of fatty liver due to alcohol (Kwon HJ et al., World J. Gastroenterol. 11 (35): 5512-5516, 2005). And remove the disorder of antioxidant enzymes (Lee JS. Et al., Clin. Chim. Acta. 347 (1-2): 121-128, 2004). Diazine, one of the isoflavonoids contained in the roots, has the effect of lowering the concentration of alcohol in the blood after the administration of alcohol (Xie CI et al., Alcohol Clin.Exp. Res. 18 (6): 1443-1447, 1994) Also, root canal has an inhibitory effect on alcohol consumption with phosphoric acid (Carai MA et al., Fitoterapia Aug; 71 Suppl 1: S38-42, 2000).

There are many researches on the functionalities of ume, mainly in Japan, and reports on improving the resistance of the living body, promoting fatigue recovery, and enhancing the biological function with various effects. Organic acids such as citric acid and citric acid promote the secretion of the stomach wall in the body, which stimulates appetite, helps digestion, promotes liver activity, and promotes metabolism.

Citric acid (19%), citric acid (15%), malic acid (15%), succinic acid, carbohydrate, carbohydrate, triterpenoids, oleanol acid, sitosterol are known as citric acid. It has been reported about the anticancer effect such as the component promotes the secretion of gastric juice in the body (Jaewoong Lim, Study on the antimicrobial activity and physiological activity of plum, thesis, 1999).

When combined with honey, maeja sweats a lot of sweat and reduces the thirst when it acts to quench thirst. Tea leaves are diuretic, and it is excellent in treating thirst and especially active poisoning (酒 毒 除去).

The dermis is the mature rind of the tangerine (Citrus unshiu Markovich) or its plant (Riaceae). Contains essential oils such as d-limonene, linalool and linalilacetate, and flavonoids hesperidin, naringin and porcirin ) And nobiletin and alkaloid synephrine. These dermis have antiallergic activity and have been reported to improve sedative, antiviral and serotonin action. The researchers reported that Chinese herbal prescription containing root and dermis lowered alcohol absorption and decreased serum alcohol concentration after drinking alcohol (Shin BS et al., J. Toxicol. Environ. Health A. 68 (23-24) : 2219-2226, 2005), it has been reported that dermis has the effect of minimizing liver damage in hepatitis C (Cyong JC et al., Am. J. Chin.Med. 28 (3-4): 351-360, 2000).

Galhwa (葛花, Pueraria thunbergiana) refers to the flower of the ,, a medicine that relieves the poison and removes the intestinal poison. It is effective in fever, ill feeling, loss of appetite and hemostasis caused by resident wine (Jebo Bo-seop and Shin Mingyo, Hyangjeomsa, Yeonglimsa, pp704-705, 1998).

Soybean hwangwon (大豆 黃 卷, leguminosae) is a soybean sprout, a year-old herb that belongs to the legumes, usually refers to bean sprouts. Sprouts are foods made by germinating soybeans, but they are much better for our bodies than eating soybeans, and have the effect of preventing and treating various adult diseases. What's noteworthy about soybean sprouts is the production of vitamin C and vitamin B2, nisin and vitamin K, which are not found in soybean sprouts. In addition, it contains high amounts of minerals such as potassium and calcium and dietary fiber, so bean sprouts are highly regarded as a valuable source of vitamins and minerals. Soybean sprouts have a low digestive absorption rate, but soybean sprouts have digestive enzymes such as amylase and invertase, and have high digestive absorption rates. .

Soybean yellow soybeans are soaked in soybean sprouts for about a day, germinated, and then dried for 5 days at room temperature in a cool place. The soybean yellow area gives mental and physical vitality, and it cures hangover, abdominal pain, diarrhea and skin disease caused by hangover effect and cold.

Hangover composition of the present invention has the effect of significantly reducing blood alcohol concentration within a short time not only in animal experiments but also in human experiments. This rapid decrease in blood alcohol levels indicates a rapid rate of alcohol metabolism, which means that the residence time of acetaldehyde, an alcohol metabolite intermediate, acting as a toxic substance is shortened. It can be confirmed that it has an excellent effect.

As can be seen in animal experiments and human experiments, the alcohol concentration reduction and hangover relieving effects of the compositions of the present invention can be obtained both in the case of extraction by alcohol and in case of extraction by hot water. have.

That is, the natural product composition according to the present invention is easy to manufacture the method using the basic medicine as a raw material, and shows a superior hangover resolution effect than conventional products as demonstrated in animal experiments and human tests.

Hereinafter, the present invention will be described in detail by the following examples, but these examples are only for illustrating the present invention, and the scope of the present invention is not limited to these examples.

The composition ratio of the raw material medicines used in this example is shown in Table 1 below.

Natural products Composition ratio (wt.%) Calcium Compound 12.5 Black bean 6.24 green gram 6.24 Small cow 6.24 Earth 6.24 Rooting 6.24 licorice 3.12 Hawk 6.24 dermis 4.16 Ginseng 0.31 Jujube 0.94 Gala 9.37 Buttercup 10.41 radish 10.41 Bean sprouts 10.41 ginger 0.94 Sum 100

Example  1: Preparation of Composition containing Natural Extracts- Liquid

(1) Alcohol Extract A Preparation

Among the kinds shown in Table 1 above, natural compounds of calcium compounds, black bean, green bean, red bean bean, earthworm, brown root, licorice, ume, dermis, ginseng and jujube are prepared, and the whole plant, leaves or berries are washed and finely cut. After mixing at the weight ratio shown in Table 1, 75% ethanol was added to the mixture in an amount of 3 times based on the weight, followed by heating by attaching a reflux condenser at 80 ° C. for 4 hours in a round bottom flask. Extracted by reflux.

The obtained extract was passed through a filter paper (No. 1001100 manufactured by Whatman) or a conventional filtration apparatus in a hot state without cooling to remove solids. The filtered filtrate was dried under reduced pressure using a rotary evaporator or a conventional concentrator to prepare a final extract.

(2) Alcohol Extract B Preparation

Of the kinds shown in Table 1 above, natural herbs such as brown, buttercup, radish, bean sprouts (soybean sprouts) and ginger are prepared, the entire plant, leaves or berries are thoroughly washed and finely cut, and then mixed in the weight ratio shown in Table 1 Thereafter, 75% ethanol was added to the mixture in an amount of 3 times by weight, followed by heating and refluxing by attaching a reflux condenser at 80 ° C. for 20 minutes in a round bottom flask.

The obtained extract was passed through a filter paper (No. 1001100 manufactured by Whatman) or a conventional filtration apparatus in a hot state without cooling to remove solids. The filtered filtrate was dried under reduced pressure using a rotary evaporator or a conventional concentrator to prepare a final extract.

A total of 20 kg of the natural medicinal herb mixture of Table 1 was extracted and depressurized to obtain a 5.5 kg concentrated extract (alcohol extract A + alcohol extract B).

(3) Hydrothermal  Extract A manufacture

Calcium compound, black bean, mung bean, red bean bean, earthworm, brown root, licorice, ume, dermis, ginseng, jujube among the medicinal herbs of the kind shown in Table 1 above, and prepared by mixing in the weight ratio shown in Table 1, the obtained medicinal mixture Into the amount of water 3 times the weight of the mixture, the first extraction and filtration for 240 minutes at 100 ℃ to obtain a primary extract, to the remaining solid content of 1/2 of the weight of the solid content of fresh water was added at 100 ℃ A reflux condenser was attached for 4 hours, heated and refluxed to obtain a second extract.

After filtering the primary extract and the secondary extract to remove solids, the filtrate was concentrated by heating.

(4) Hydrothermal  Extract B manufacturer

Among the medicinal herbs of the type described in Table 1, browning, buttercup, radish, bean sprouts (soybean rhubarb) and ginger are prepared and mixed in a weight ratio shown in Table 1, and then the obtained medicinal mixture is added to water in an amount three times the weight of the mixture. Primary extract and filtered to obtain a primary extract for 20 minutes at ~ 100 ℃, and add water of 1/2 the weight of the solid content to the remaining solids to reflux condenser (reflux condenser) for 20 minutes at 100 ℃ The mixture was heated, refluxed, and extracted to obtain a secondary extract.

After filtering the primary extract and the secondary extract to remove the solids, the filtrate was concentrated by heating.

(5) Preparation of Final Composition

A total of 20 kg of the natural medicinal herb mixture of Table 1 was extracted and depressurized to obtain a concentrated extract of 5.9 kg (hydrothermal extract A + hydrothermal extract B).

To 5 g of the alcohol extract or 5 g of the hydrothermal extract obtained above, 20% by weight of sugar or glucose, 3.5% by weight of maleic acid and lactic acid were added, and 15 times the volume of distilled water was mixed to prepare a single-dose liquid composition. It was.

Example  2: Preparation of Compositions Containing Natural Extracts- Pill

The raw materials were purchased at the composition ratios of Table 1, and powdered by a conventional method, and 20% by weight of honey was added to prepare a ring. At this time, the single dose was prepared in 25g.

Example  3: Animal testing to confirm the efficacy of alcohol metabolism promotion

(1) Test group setting

In order to confirm the alcohol metabolism promoting effect of the composition prepared in Example 1 above, the effect of reducing the blood alcohol concentration of the composition in the animal was tested.

Thirty male Sprague-Dawley rats (weights 270-300 g), 8 weeks of age, were acclimated to a laboratory at a temperature of 21 ± 3 ° C, 50 ± 5% relative humidity, and roughness 200-300 lux for 7 days. Afterwards, only 10 healthy animals were selected and used for testing. Distilled water was freely consumed as drinking water and experimental animal feed was freely consumed. After weighing the subjects who had no health problems during the adaptation period, 10 animals near the mean weight were selected. Thus selected animals were divided into two groups of five by random selection method, the first group was administered only distilled water as a negative control, the second group was the final composition prepared in Example 1 of the present invention as a test group (natural extract) The composition using the hot water extract in (sugar + distilled water) was administered.

(2) Composition and ethanol administration

In the first group, which is a negative control, 4 g / kg of distilled water was injected into the stomach of the rat by an oral administration method using a syringe. The second group, which is a positive control group, was orally administered a composition using hot water extract in the final composition of Example 1 of the present invention in an amount of 4 g / kg. After administration of distilled water and the composition of the present invention as described above, after 15 minutes, 5.3 g / kg of a 30% ethanol solution was orally administered, and blood ethanol concentration of the subject was measured after 1 hour and 2 hours.

(3) Measurement of blood ethanol concentration

After oral administration of 5.3 g / kg of a 30% ethanol solution, 1 hour and 2 hours later, the animals were anesthetized with ethyl ether, and 3 ml of blood were collected by cardiac puncture. After refrigeration in a sealed tube, the blood alcohol concentration was measured at the SCL Lab.

The test method is an enzymatic assay, which uses NAD and AH (alcohol dehydrogenase) as shown in the following scheme.

Formation of NADH can be quantified by increased absorbance at 378 nm. At this time, 1,3-diamino-2-hydroxypropane is a reagent for trapping aldehyde, and serves as an effective buffer. This reagent system is ethanol quantitative determination using alcohol dehydrogenase is more stable than other test methods.

The measurement results are shown in Table 2 and FIG. 2. Table 2 shows the blood alcohol concentrations of the rats in which the composition was not ingested and the rats in which the composition was obtained, and the averages of the measurements obtained in the five rats of each group were described.

1 hour after drinking 2 hours after drinking Non-dosing composition Average (mg / dl) 76.8 53.2 SEM. (Standard deviation) 7.2 12.5 No. 5 5 Taking composition Average (mg / dl) 28.2 3.2 SEM. (Standard deviation) 6.1 2.5 No. 5 5

Looking at the results of Table 2, after one hour of drinking the composition of the present invention was measured 63.3% decrease in blood alcohol concentration compared to the non-dosing group, after 2 hours of drinking shows that the alcohol almost metabolized to 94.0% decrease.

This is indicative of the pronounced alcohol metabolism promoting efficacy of the compositions of the present invention in animals.

In addition, in order to evaluate the toxicity of the composition for relieving hangover of the present invention, 50% lethality was measured in an ICR mouse using the tablet prepared in Example 1 below, and the value was 5 g / kg (body weight) or more. It can be seen from these results that the composition of the present invention is very safe.

Example  4: human test to confirm alcohol metabolism promoting effect

In order to confirm the effect of promoting alcohol metabolism in the human body of the composition of the present invention, 25 healthy adult males were measured for ethanol concentration after ethanol ingestion and observed the symptoms appearing the day after drinking.

1) human subjects

   24 men

2) Ethanol concentration measuring instrument

   Digital Alcohol Detector CA 2000 (manufactured by TNT Tech)

3) test method

24 healthy adults were allowed to drink without administering the composition of the present invention on the first day, and after 45 minutes of alcohol consumption, the primary respiratory alcohol concentration was measured using an alcohol meter, and the alcohol was continued and the alcohol was measured again by alcohol meter after 120 minutes. Measured.

One week later, the same subject was administered 15 minutes before the start of drinking, and the alcohol was measured in the same manner as the above method.

The dose per adult male was 100 ml (active ingredient: 4-6 g) for the compositions of the present invention. At 45 and 120 minutes after the start of drinking, breathing alcohol concentration was measured using a breathalyzer CA 2000. Jujong was made with soju, and snacks served pork ribs.

Table 3 and Table 4 show the average blood alcohol concentrations of 24 people in each group after 45 minutes and 120 minutes after drinking, respectively.

specimen age Non-dosing composition Taking composition Blood alcohol reduction rate (%) One 26 0.17 0.10 41.1 2 29 0.33 0.13 60.6 3 23 0.18 0.09 50.0 4 27 0.26 0.15 42.3 5 24 0.32 0.12 62.5 6 19 0.14 0.17 21.4 increase 7 33 0.18 0.04 77.8 8 30 0.10 0.04 60.0 9 32 0.16 0.11 31.3 10 27 0.10 0.09 10.0 11 29 0.17 0.34 100 increase 12 29 0.12 0.06 50.0 13 29 0.16 0.09 43.8 14 30 0.14 0.06 57.1 15 28 0.10 0.03 70.0 16 29 0.08 0.01 87.5 17 28 0.13 0.39 200 increase 18 26 0.23 0.20 13.0 19 28 0.29 0.19 34.5 20 44 0.22 0.14 36.3 21 54 0.07 0.05 28.6 22 50 0.21 0.16 23.8 23 48 0.29 0.21 27.6 24 40 0.18 0.07 61.1 Average 32 0.18 0.127

name age Non-dosing composition Taking composition Blood alcohol reduction rate (%) One 26 0.36 0.02 94.4 2 29 0.34 0.15 55.9 3 23 0.24 0.09 62.5 4 27 0.11 0.03 72.7 5 24 0.19 0.12 36.8 6 19 0.14 0.14 0.0 7 33 0.19 0.03 84.2 8 30 0.11 0.09 18.2 9 32 0.16 0.25 56.3 increment 10 27 0.08 0.16 100.0 increase 11 29 0.23 0.03 87.0 12 29 0.18 0.07 61.1 13 29 0.15 0.08 46.7 14 30 0.25 0.06 76.0 15 28 0.04 0.00 100.0 16 29 0.07 0.00 100.0 17 28 0.17 0.11 35.3 18 26 0.39 0.20 48.7 19 28 0.24 0.18 25.0 20 44 0.22 0.24 9.1 increase 21 54 0.09 0.07 22.2 22 50 0.23 0.16 30.4 23 48 0.25 0.17 32.0 24 40 0.18 0.07 61.1 Average 32 0.192 0.105

Table 5 and FIG. 3 show the results of summarizing the results of Tables 3 and 4.

Non-dosing composition Taking composition 45 minutes after drinking Average Alcohol Concentration (%) 0.180 0.127 SEM. 0.015 0.019 No. 24 24 120 minutes after drinking Average Alcohol Concentration (%) 0.192 0.105 SEM. 0.018 0.015 No. 24 24

As can be seen in Table 5, looking at the clinical test results of the hangover relief composition according to the present invention 45 minutes after drinking the composition of the present invention group was measured 29.4% blood alcohol decrease compared to the non-dose group, drinking 2 After time there was a 45.3% reduction, indicating that almost half of the alcohol was metabolized. This indicates a result that is very consistent with the pronounced alcohol metabolism promoting efficacy of the composition of the present invention in animals, i.e., the efficacy of the inventive subjectivity increases over time.

1 is a flow chart showing the glucose metabolism pathway.

Figure 2 is a graph of animal experiments to determine the effect of promoting alcohol metabolism of the composition of the present invention.

Figure 3 is a human experiment result graph to determine the alcohol metabolism promoting effect of the composition of the present invention.

Claims (5)

As active ingredients, 500 to 800 parts by weight of calcium compounds which are at least one of shell ionized calcium, cured calcium, seaweed calcium, whey calcium and calcium salts, 200 to 400 parts by weight of black bean, 200 to 400 parts by weight of mung bean, 200 to 400 parts by weight of red bean Part, 200 to 400 parts by weight, 200 to 400 parts by weight, 100 to 200 parts by weight, licorice 100 to 200 parts by weight, five to 200 parts by weight, 150 to 250 parts by weight of dermis, 10 to 20 parts by weight of ginseng, 30 to 60 parts by weight of jujube To 400 parts by weight, 400 to 500 parts by weight, 400 to 600 parts by weight of parsley, 400 to 600 parts by weight of radish, 400 to 600 parts by weight of bean sprouts (soybean yellow soybean), 30 to 60 parts by weight of ginger is extracted using alcohol or hot water as a solvent. , Hangover dissolution composition dissolved sugar or glucose, maleic acid, lactic acid or salts thereof in the extract. The method of claim 1, Vitamin B ₁ , B ₂ , B ₆ , B ₁₂ , C, pantothenic acid, nicotinic acid amide, folic acid, biotin, zinc, iron, calcium, magnesium and yeast extract, characterized in that the composition further comprises at least one. The method of claim 2, Sugar or glucose dissolved in the extract is 10-30% by weight of the extract, maleic acid, lactic acid or its salt is 2-5% by weight of the extract, characterized in that hangover relief composition. Calcium compound 500 to 800 parts by weight, black bean 200 to 400 parts by weight, mung bean 200 to 400 parts by weight, red bean 200 to 400 parts by weight, earth 200 to 400 parts by weight, brown root 200 to 400 parts by weight, licorice 100 to 200 parts by weight , 200 to 400 parts by weight, dermis 150 to 250 parts by weight, ginseng 10 to 20 parts by weight, jujube to 30 to 60 parts by weight, water or ethanol is added as a solvent, followed by extraction and drying under reduced pressure to obtain a concentrated natural extract A first step; 400 to 500 parts by weight of gallium, 400 to 600 parts by weight of buttercup, 400 to 600 parts by weight of radish, 400 to 600 parts by weight of bean sprouts (soybean yellow soybean), 30 to 60 parts by weight of ginger, after adding water or ethanol as a solvent, Extracting and drying under reduced pressure to obtain a concentrated natural extract; And And a third step of mixing the extract of the first step and the second step and dissolving sugar or glucose, maleic acid, lactic acid or its salts in the extract. The method of claim 4, wherein When the solvent is water, the first step is to add 4 to 8 times the water of the mixture of the first step, and then extracted at 90 ℃ to 120 ℃, 2 hours to 6 hours and dried under reduced pressure, the second step Is added 4 to 8 times the weight of the second stage mixture, followed by extraction at 490 ° C. to 120 ° C. for 10 to 30 minutes and drying under reduced pressure, When the solvent is ethanol, the first step is after adding 70 to 95% of ethanol of 4 to 8 times the weight of the mixture of the first step, extracted at 40 ℃ to 90 ℃, 2 hours to 6 hours and dried under reduced pressure And, the second step is after adding 70 to 95% of ethanol of 4 to 8 times the weight of the mixture of the second step, at 40 ℃ to 90 ℃, characterized in that extracted for 10 to 30 minutes and dried under reduced pressure Hangover relieving composition manufacturing method.

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