KR20080110993A - 과립, 정제 및 그들의 제조방법 - Google Patents
과립, 정제 및 그들의 제조방법 Download PDFInfo
- Publication number
- KR20080110993A KR20080110993A KR1020087019647A KR20087019647A KR20080110993A KR 20080110993 A KR20080110993 A KR 20080110993A KR 1020087019647 A KR1020087019647 A KR 1020087019647A KR 20087019647 A KR20087019647 A KR 20087019647A KR 20080110993 A KR20080110993 A KR 20080110993A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- calcium silicate
- parts
- granules
- oily substance
- Prior art date
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- 239000008187 granular material Substances 0.000 title claims abstract description 92
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000000126 substance Substances 0.000 claims abstract description 86
- 239000000378 calcium silicate Substances 0.000 claims abstract description 74
- 229910052918 calcium silicate Inorganic materials 0.000 claims abstract description 74
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims abstract description 74
- 239000000843 powder Substances 0.000 claims abstract description 39
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (22)
- 유상(油狀)물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 전분류 10 내지 65중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 천연 유래의 액상물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 전분류 10 내지 65중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 유상물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 10 내지 65중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 천연 유래의 액상물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 10 내지 65중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 저융점 물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 10 내지 65중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 유상물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 5 내지 33중량부, 전분류 5 내지 33중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 천연물 유래의 액상물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 5 내지 33중량부, 전분류 5 내지 33중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 저융점 물질 5 내지 40중량부, 다공성 규산칼슘 5 내지 35중량부, 당류 5 내지 33중량부, 전분류 5 내지 33중량부에 의하여 구성되는 이완부피밀도 0.30 내지 0.80g/㎖의 과립.
- 제1항 내지 제7항 또는 제8항에 있어서, 이완부피밀도 0.35 내지 0.55g/㎖인 과립.
- 제1항 내지 제7항 또는 제8항에 있어서, 다공성 규산칼슘이 꽃잎결정구조를 가진 자이롤라이트형 규산칼슘인 과립.
- 제1항 내지 제7항 또는 제8항에 있어서, 전분류가 덱스트린인 과립.
- 제3항 내지 제7항 또는 제8항에 있어서, 당류가 당알코올인 과립.
- 제1항 내지 제7항 또는 제8항의 과립을 압축성형한 정제.
- 유상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지(擔持)시키고, 해당 유상물질 담지 규산칼슘과 전분류를 혼합하여 얻어진 혼합분말 조성물을 조립(造粒)하는 제1항의 과립 제조방법.
- 천연물 유래의 액상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 전분류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제2항의 과립 제조방법.
- 유상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제3항의 과립 제조방법.
- 천연물 유래의 액상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제4항의 과립 제조방법.
- 저융점 물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제5항의 과립 제조방법.
- 유상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류 및 전분류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제6항의 과립 제조방법.
- 천연물 유래의 액상물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류 및 전분류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제7항의 과립 제조방법.
- 저융점 물질을 유기용매에 용해 또는 분산시킨 용액과, 다공성 규산칼슘을 혼합하여 유상물질을 규산칼슘 분말에 흡착, 담지시키고, 해당 유상물질 담지 규산칼슘과 당류 및 전분류를 혼합하여 얻어진 혼합분말 조성물을 조립하는 제8항의 과 립 제조방법.
- 제14항 내지 제20항 또는 제21항의 제조방법에 의하여 만들어진 과립에 고분자 첨가물, 활택제를 첨가하고, 그 후 압축성형하는 정제의 제조방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2006-00042906 | 2006-02-20 | ||
JP2006042906 | 2006-02-20 |
Publications (1)
Publication Number | Publication Date |
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KR20080110993A true KR20080110993A (ko) | 2008-12-22 |
Family
ID=38437373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020087019647A KR20080110993A (ko) | 2006-02-20 | 2007-02-20 | 과립, 정제 및 그들의 제조방법 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100285157A1 (ko) |
EP (1) | EP1990062A1 (ko) |
JP (1) | JPWO2007097333A1 (ko) |
KR (1) | KR20080110993A (ko) |
CN (1) | CN101384281A (ko) |
CA (1) | CA2643054A1 (ko) |
WO (1) | WO2007097333A1 (ko) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101497508B1 (ko) * | 2013-12-20 | 2015-03-03 | 한국유나이티드제약 주식회사 | 펠라고니움 시도이데스 추출물 및 규산 화합물을 포함하는 고형 제제 및 이의 제조 방법 |
KR101533286B1 (ko) * | 2013-12-09 | 2015-07-03 | 주식회사한국파마 | 콜린알포세레이트를 함유하는 경구용 약학 조성물 및 이의 제조 방법 |
WO2020009394A1 (ko) * | 2018-07-03 | 2020-01-09 | 한국유나이티드제약 주식회사 | 펠라고니움 시도이데스 추출물을 포함하는 약학 조성물 및 이의 제조방법 |
Families Citing this family (12)
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CA2650498A1 (en) | 2006-03-31 | 2007-10-11 | Rubicon Research Private Limited | Orally disintegrating tablets |
LT2487162T (lt) | 2007-02-23 | 2016-11-10 | Gilead Sciences, Inc. | Terapinių agentų farmakokinetinių savybių moduliatoriai |
EP2213306A4 (en) * | 2007-09-19 | 2012-08-29 | Asahi Group Holdings Ltd | PROCESS FOR PRODUCTION OF PELLETS CONTAINING NATURAL MATTER, SUCH AS AN EXTRACT PROPOSED BY TRADITIONAL CHINESE MEDICINE, A CRUDE MEDICINE EXTRACT, A NATURAL EXTRACT OR A MIXTURE THEREOF, AND METHOD FOR PRODUCING TABLETS FROM PELLETS |
KR20100075599A (ko) | 2007-10-03 | 2010-07-02 | 아사히비루 가부시키가이샤 | 과립, 정제 및 이들의 제조 방법 |
JP5249568B2 (ja) * | 2007-12-06 | 2013-07-31 | 旭化成ケミカルズ株式会社 | 成形用粉末、およびこれを用いた圧縮成形組成物、ならびに成形用粉末の製造方法 |
HUE026380T2 (en) * | 2008-05-02 | 2016-06-28 | Gilead Sciences Inc | Use of solid carrier particle |
JP2010189337A (ja) * | 2009-02-19 | 2010-09-02 | Asahi Breweries Ltd | 難溶性物質を含有する顆粒、錠剤、及び難溶性物質の可溶化方法 |
KR20210009441A (ko) * | 2009-04-01 | 2021-01-26 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법 |
US20110244031A1 (en) * | 2010-03-31 | 2011-10-06 | Lifecycle Pharma A/S | Porous tablets as carriers for liquid formulations |
JP6056114B2 (ja) * | 2015-05-30 | 2017-01-11 | 富田製薬株式会社 | 油状物質含有粉末組成物 |
EP3294269A1 (en) * | 2015-06-12 | 2018-03-21 | Santa Farma Ilaç Sanayi A.S. | Oral pharmaceutical composition comprising otilonium bromide and simethicone with certain bulk density and improved dissolution characteristics |
CN115671056A (zh) * | 2022-10-14 | 2023-02-03 | 南通大学 | 一种维生素e颗粒及其制备方法和应用 |
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JP2626975B2 (ja) * | 1987-03-30 | 1997-07-02 | エーザイ株式会社 | 低融点油性物質含有錠剤 |
JPH0352823A (ja) * | 1989-07-21 | 1991-03-07 | Tokuyama Soda Co Ltd | 固形剤 |
JPH05238930A (ja) * | 1992-02-28 | 1993-09-17 | Eisai Co Ltd | 持続性薬剤 |
JPH10114655A (ja) * | 1996-10-09 | 1998-05-06 | Kyowa Hakko Kogyo Co Ltd | 固形製剤 |
JPH10279475A (ja) * | 1997-04-07 | 1998-10-20 | Maruko Seiyaku Kk | 安定なテプレノン含有組成物 |
JP2000016934A (ja) * | 1998-06-30 | 2000-01-18 | Eisai Co Ltd | テプレノンを含有した錠剤 |
JP4400941B2 (ja) * | 1998-10-15 | 2010-01-20 | 木村産業株式会社 | 漢方含有錠剤および漢方充填カプセル剤および生薬含有錠剤および生薬充填カプセル剤および漢方含有錠剤の製造方法および漢方充填カプセル剤の製造方法および生薬含有錠剤の製造方法および生薬充填カプセル剤の製造方法 |
JP4467678B2 (ja) * | 1999-09-30 | 2010-05-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テプレノン含有固形製剤 |
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JP5027375B2 (ja) * | 2002-02-20 | 2012-09-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 改良製剤 |
JP2005104934A (ja) * | 2003-10-01 | 2005-04-21 | Eisai Co Ltd | 新規組成物及びその製造方法 |
JP4643922B2 (ja) * | 2004-03-29 | 2011-03-02 | 第一三共ヘルスケア株式会社 | パンテチン含有粒状物 |
JP4717414B2 (ja) * | 2004-11-08 | 2011-07-06 | 富田製薬株式会社 | 低融点薬剤含有顆粒、およびこれを用いて製造した錠剤 |
-
2007
- 2007-02-20 JP JP2008501725A patent/JPWO2007097333A1/ja active Pending
- 2007-02-20 CA CA002643054A patent/CA2643054A1/en not_active Abandoned
- 2007-02-20 CN CNA2007800059198A patent/CN101384281A/zh active Pending
- 2007-02-20 WO PCT/JP2007/053093 patent/WO2007097333A1/ja active Application Filing
- 2007-02-20 EP EP07714596A patent/EP1990062A1/en not_active Withdrawn
- 2007-02-20 KR KR1020087019647A patent/KR20080110993A/ko not_active Application Discontinuation
- 2007-02-20 US US12/279,980 patent/US20100285157A1/en not_active Abandoned
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101533286B1 (ko) * | 2013-12-09 | 2015-07-03 | 주식회사한국파마 | 콜린알포세레이트를 함유하는 경구용 약학 조성물 및 이의 제조 방법 |
KR101497508B1 (ko) * | 2013-12-20 | 2015-03-03 | 한국유나이티드제약 주식회사 | 펠라고니움 시도이데스 추출물 및 규산 화합물을 포함하는 고형 제제 및 이의 제조 방법 |
WO2015093899A1 (en) * | 2013-12-20 | 2015-06-25 | Korea United Pharm. Inc. | Solid preparations containing pelargonium sidoides extracts and silicic acid compound, and preparing method thereof |
RU2612085C1 (ru) * | 2013-12-20 | 2017-03-02 | Кореа Юнайтед Фарм. Инк. | Твердые препараты, содержащие экстракты pelargonium sidoides и соединение кремниевой кислоты, и способ их получения |
WO2020009394A1 (ko) * | 2018-07-03 | 2020-01-09 | 한국유나이티드제약 주식회사 | 펠라고니움 시도이데스 추출물을 포함하는 약학 조성물 및 이의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
WO2007097333A1 (ja) | 2007-08-30 |
US20100285157A1 (en) | 2010-11-11 |
CN101384281A (zh) | 2009-03-11 |
EP1990062A1 (en) | 2008-11-12 |
CA2643054A1 (en) | 2007-08-30 |
JPWO2007097333A1 (ja) | 2009-07-16 |
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