KR20070069105A - Sustained-release formulations - Google Patents

Abstract

Sustained-release formulations are provided to block burst release of a drug during an initial period of an oral administration, improve production convenience by removing additional coating device for forming coating films, and inhibit environmental pollution by using water system coating method. The sustained-release formulation comprises (a) a sustained-release nucleus containing an active component and a polymer having corrosion and swelling properties in mammal intestinal juice and being selected from hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, polyethylene oxide, wax, sodium alginate, povidone, polyvinylalcohol, sodium carboxymethylcellulose, xanthan gum and alginate, (b) an enteric film coating layer which coats the sustained-release nucleus, and (c) an active component-containing film coating layer which coats the enteric film coating layer, and contains the same active component and a hydrophilic polymer for film coating selected from polyvinylalcohol, polyethyleneglycol, polypropyleneglycol, acrylic acid copolymer, hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose and ethylcellulose.

Description

Sustained-release formulations

Figure 1 shows the structure of a sustained release formulation according to an embodiment of the present invention.

Figure 2 shows the dissolution test results of the sustained release formulation of the present invention prepared in Examples 3, 4, and 5.

Figure 3 shows the dissolution test results of the sustained release formulation of the present invention prepared in Examples 5, 6, and 7.

Figure 4 shows the dissolution test results of the sustained release formulation of the present invention prepared in Example 8.

The present invention relates to a sustained release formulation which controls the release of the active ingredient in two stages over a long time in the gastrointestinal tract upon oral administration.

Circulatory system drugs, such as β-sympathetic receptor blockers and arrhythmia drugs, are often observed with circulatory side effects such as orthostatic disorders. There is a need for a sustained release composition capable of controlling dissolution accordingly.

Matrix formulations using hydrophilic polymers in conventional sustained-release preparations have the advantage of being simple and easy to prepare. However, there is a disadvantage in that excessive drug release occurs initially due to the absorption of water from the digestive tract immediately after administration. In addition, the drug is initially released by the concentration gradient of the drug, but there is a problem that the speed decreases due to a decrease in the concentration gradient and an increase in the diffusion distance as the drug is dissolved. Because of this, matrix preparations using such hydrophilic polymers are difficult to obtain zero-order release of the drug, and are not suitable for drugs that exhibit orthostatic disorders, such as circulatory therapy such as β-sympathetic receptor blockers and arrhythmia drugs. It can be said.

US Pat. No. 4,252,786 discloses a formulation in which the swellable matrix is coated with hydrophobic and hydrophilic polymers to have an initial drug release delay and zero release rate. Such formulations may initially delay release of the drug by coating during the gelation of the drug-containing matrix, but after the coating layer is broken, the drug may rely on the concentration gradient of the drug as seen in the general matrix formulation. There is this.

U. S. Patent 5,464, 633 discloses a method for initially suppressing rapid drug release by introducing a compressed tablet layer rather than a coating layer into a matrix having swelling and erosion properties. However, this method has the disadvantage that the production process is very complicated.

Korean Patent Publication No. 1998-85592 discloses a sustained release formulation that controls drug release by forming a bilayer coating layer using two or more polymer materials in a core containing a drug (ie, a bilayer system ), It is designed as a system for suppressing swelling of the primary coating film with the secondary coating film. However, such tablets have the disadvantage that the manufacturing process is complicated.

Osmotic pumps around the nucleus with a water-insoluble hard membrane such as cellulose acetate show zero-emissions, but in organic film coatings, organic solvents must be used and the osmotic discharge holes can be There are process difficulties that need to be drilled (US 1999-1713).

Thus, there is a need for a sustained release formulation that can effectively control early rapid drug release to near zero-order release.

The present invention is to solve the problems of the prior art, it is an object of the present invention to provide a sustained-release formulation capable of dissolution control close to the zero-order release without the initial rapid drug release.

In order to achieve the above object, the present invention

(a) a sustained release nucleus comprising the active ingredient and a polymer having erosion and swelling properties in the intestinal fluid of a mammal;

(b) an enteric film coating layer coated on the sustained release nucleus; And

(c) an active ingredient-containing film coating layer comprising an active ingredient and a hydrophilic polymer for film coating and coated on the enteric film coating layer;

It provides a sustained release formulation comprising a.

The sustained release preparation may further include an outer coating layer coated on the active ingredient-containing film coating layer, including a polymer selected from the group consisting of a hydrophilic polymer, a hydrophobic polymer, a pH dependent polymer, and a combination thereof.

The polymer having erosion and swelling properties in the intestinal fluid of the mammal included in the sustained-release nucleus may be a polymer having a viscosity of 1 mPa.s to 100,000 mPa.s, preferably 3,500 mPa.s to 100,000 mPa.s It may be a polymer having a viscosity. Specific examples of the polymer include hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, polyethylene oxide, waxes (carnauba wax), sodium alginate, povidone, polyvinyl alcohol and sodium carboxy. It may be selected from the group consisting of methyl cellulose, xanthan gum, alginate or derivatives thereof, and combinations thereof, but is not limited thereto. Most preferably hydroxypropylmethyl cellulose can be used.

The content of the polymer included in the sustained-release nucleus is preferably about 1 to 99% by weight based on the total weight of the sustained-release nucleus.

Meanwhile, the hydrophilic polymer for film coating included in the active ingredient-containing film coating layer may be a polymer having a viscosity of 1 mPa.s to 100,000 mPa.s, and preferably a viscosity of 3,500 mPa.s to 100,000 mPa.s. It may be a polymer having. Specifically, the polymer may be selected from the group consisting of polyvinyl alcohol, polyethylene glycol, polypropylene glycol, acrylic acid copolymer, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, and combinations thereof. But it is not limited thereto.

In the sustained-release formulation, the polymer used for the enteric film coating layer coated on the sustained-release nucleus may be an enteric polymer that is dissolved at about pH 5 or higher. The enteric polymer which is used in the outer coating layer of the sustained release formulation may also be dissolved at about pH 5 or more.

The enteric polymer used in the enteric film coating layer and the outer coating layer of the sustained release formulation is selected from the group consisting of cellulose polymer, polyvinyl polymer, maleic acid-vinyl polymer, polymethacrylate copolymer, and combinations thereof. Can be used, but is not limited thereto. Preferably, a 1: 1 copolymer of methacrylic acid and ethyl acrylate may be used as the enteric polymer.

The active ingredient contained in the sustained-release preparations provided by the present invention may be used for treating hypertension, treating diabetes, treating hyperlipidemia, treating the cardiovascular system, expectorant, antibiotic, sedative, steroid compound, treating asthma, nonsteroidal anti-inflammatory agent, treating prostatic hypertrophy, It may be selected from the group consisting of antidepressants, antihistamines, and combinations thereof, but is not limited thereto.

Specifically, the active ingredient may be nifedipine, felodipine, citrizine, pseudoephedrine, tamsulosin, or a pharmaceutically acceptable salt thereof, and particularly, tamsulosin or a hydrochloride thereof.

When the active ingredient contained in the sustained release preparation is tamsulosin or a hydrochloride thereof, 60 to 99 wt% of the tamsulosin contained in the sustained release preparation is present in the sustained release nucleus, and 1 to 40 wt% It is preferably present in the active ingredient-containing film coating layer.

Hereinafter, the present invention will be described in more detail.

Sustained release formulations provided by the present invention are intended to enable control of dissolution close to zero-order release without the initial rapid release of the drug, for which the drug is separated into two layers and an enteric film between the two layers. Sustained release formulations containing a coating and optionally forming an outer coating layer to control initial drug release.

Therefore, the sustained release formulation provided by the present invention

(a) a sustained release nucleus comprising the active ingredient and a polymer having erosion and swelling properties in the intestinal fluid of a mammal;

(b) an enteric film coating layer coated on the sustained release nucleus; And

(c) an active ingredient-containing film coating layer comprising an active ingredient and a hydrophilic polymer for film coating and coated on the enteric film coating layer.

The mammalian intestinal fluid is a concept encompassing liquids present in the duodenum, small intestine, and large intestine of the mammalian digestive organs, and particularly refers to liquids present in the small and large intestine.

The sustained release nuclei in the sustained release formulation comprise 5 to 99% by weight of the total drug contained in the formulation.

The polymer having erosion and swelling properties in the intestinal fluid of the mammal used in the sustained-release nucleus may use a conventional polymer known to have such properties in the pharmaceutical field, and the active ingredient is slowly and preferably at zero order rate. The polymer to release can be used preferably. In addition, the viscosity of the high molecular compound may be 1 mPa.s to 100,000 mPa.s, preferably 3,500 mPa.s to 100,000 mPa.s, more preferably 4,000 mPa.s to about 20,000 mPa.s.

Polymers having such viscosity and erosion and swelling properties include hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, polyethylene oxide, waxes (carnauba wax), sodium alginate, and povidone , Polyvinyl alcohol, sodium carboxymethyl cellulose, xanthan gum, alginate or derivatives thereof, and one or more of these components can be used in combination.

Among the polymers, hydroxypropyl methylcellulose is most preferably used, and commercially available Methocel K4M CR Premium (Methocel K4M CR Premium, Dow Chemical, USA) may be used.

The polymer included in the sustained-release nucleus may vary depending on the type of polymer, but may be contained in an amount of 1 to 99% by weight based on the total weight of the sustained-release nucleus, and preferably 1 to 50% by weight. .

The sustained-release nucleus may include, in addition to the active ingredient and the polymer, conventional additives. As a diluent, for example, microcrystalline cellulose (e.g. Avicel, etc.), dextrose, starch, sucrose, lactose, sorbitol, mannitol, calcium phosphate (dicalcium or tricalcium) and the like can be used. Talc, corn starch and the like can be used as a release. As the binder, polyvinylpyrrolidone, magnesium aluminum silicide, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxy methylcellulose and / or hydroxypropylcellulose, copovidone and the like can be used, and as a solvent, Lower alcohols such as water, ethanol and isopropanol can be used, and light lubricants such as light silicic anhydride, talc, stearic acid and zinc, magnesium or calcium salts, polyethylene glycol and the like can be used. In addition, it may contain disintegrants, boiling mixtures, absorbents, colorants, flavors, sweeteners and the like, such as sodium starch glycolate (eg Primojel), starch, alginic acid, or sodium salts thereof.

When microcrystalline cellulose is used as the diluent, it may be contained in the range of about 10 to 90% by weight, preferably about 60 to 90% by weight, based on the total weight of the sustained release core. Glidants can be used in the range of 0.2 to 2% by weight, preferably about 1% by weight, relative to the total weight of the sustained release core. Disintegrants may be used in the range of 0.2 to 5% by weight, preferably about 2% by weight, relative to the total weight of the sustained release core. In addition, if necessary, polyvinylpyrrolidone may be used in the amount of 1 to 20% by weight, preferably about 2 to 10% by weight, based on the total weight of the sustained-release core.

The sustained release formulation of the present invention includes an enteric film coating layer coated on the sustained release nucleus. The enteric film coating blocks the release of the active ingredient present in the sustained release nucleus in the stomach and allows only the active ingredient present in the active ingredient-containing film coating layer to be continuously released initially without excessive release.

The enteric polymer used in the enteric film coating layer may be a commonly used enteric polymer, it is preferable that the enteric polymer is dissolved at about pH 5 or more. The enteric polymers that can be used may be selected from the group consisting of cellulose polymers, polyvinyl polymers, maleic acid-vinyl polymers, polymethacrylate copolymers, and combinations thereof.

Examples of the cellulose polymer include cellulose acetate phthalate, cellulose acetate succinate, methylcellulose phthalate, hydroxymethylethyl cellulose phthalate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethylcellulose acetate succinate, and the like. Examples of the polyvinyl polymer include polyvinyl alcohol phthalate, polyvinyl butyrate phthalate, polyvinyl acetoacetyl phthalate, and the like. Examples of the maleic acid-vinyl polymer include poly (vinyl acetate, maleic anhydride), poly (vinylbutyl ether, maleic anhydride), poly (styrene, maleic acid monoester), and the like. In addition, the polymethacrylate copolymer includes a copolymer of one or two copolymers of ethyl methacrylate, methyl methacrylate, or triethylaminoethyl group in polymethacrylate, polymethacrylate.

The enteric polymer dissolved at a pH of 5 or higher is more preferably selected from the group consisting of cellulose acetate phthalate, polyvinylacetate phthalate, hydroxypropylmethylcellulose phthalate, polymethacrylate copolymer, and combinations thereof. Particular preference is given to 1: 1 copolymers of ethyl acrylate (poly (methacrylic acid, ethyl acrylate) 1: 1). Commercially available Eudragit L100, L12.5, L12.5P, 30D-55, L100-55, etc. may be used as the 1: 1 copolymer of methacrylic acid and ethyl acrylate, and double Eudragit L100- It is preferred to use 55.

The enteric film coating layer may include a plasticizer commonly used in addition to the enteric polymer. Such plasticizers include polyethylene glycols and derivatives thereof (eg PEG 6000), fatty acids, substituted triglycerides, glycerides, castor oil, and hydrogenated castor oil. The amount of plasticizer in the coating solution for forming the enteric film coating layer may be 5 to 50%. In addition, the coating solution may contain 0.1 to 2% by weight of sodium hydrogen carbonate and / or sodium lauryl sulfate, if necessary.

The enteric film coating layer may be about 1 to about 20% by weight, preferably about 8 to 12% by weight relative to the total weight of the sustained release formulation.

On the other hand, as described above, the sustained-release preparation of the present invention comprises a part of the active ingredient contained in the formulation and a hydrophilic polymer for film coating, and includes an active ingredient-containing film coating layer coated on the enteric film coating layer.

As the polymer used in the drug-containing film coating layer, a conventional hydrophilic polymer capable of forming a film coating may be used, and the amount thereof is preferably kept to a minimum in order to limit the size of the formulation and to effectively manufacture the film. It may be about 1 to 10% by weight, preferably about 3 to 8% by weight relative to the total weight of the formulation.

The viscosity of the conventional hydrophilic polymer compound used in the active ingredient-containing film coating layer may be 1 mPa.s to 100,000 mPa.s, preferably 3,500 mPa.s to 100,000 mPa.s, more preferably 4,000 mPa.s to about 20,000 mPa.s.

Polymers having such viscosity properties and erosion and swelling properties include cellulose such as acrylic acid copolymers, polyoxyethyiene sorbitan esters, or hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, and ethylcellulose. It is preferable that it is a compound. In addition, the amount of polymer included in the active ingredient-containing film coating layer is preferably kept to a minimum in order to limit the size of the final formulation, for example tablets and to make the production effective.

The active ingredient-containing film coating layer may further include a plasticizer such as polyethylene glycol, for example, PEG 6000, creacetin, etc., and may include talc and titanium dioxide to facilitate the coating process.

The sustained release formulation of the present invention may contain the drug appropriately divided into the sustained release nucleus and the drug-containing film coating layer. For example, when using tamsulosin or its hydrochloride, 60 to 90% by weight of tamsulosin or its hydrochloride in the formulation is present in the sustained-release nucleus and 10 to 40% by weight of the drug-containing film It is preferably present in the coating layer.

Sustained release formulations of the present invention can form an additional envelope coating layer on the drug-containing film coating layer so as to suppress the rapid rise in blood levels in vivo at the beginning of administration and at the same time exhibit sustained release characteristics. This allows only the drug present in the drug-containing film coating layer to be continuously and initially released, and may also play a role in providing anti-abrasion, stability, and functionality of the drug present in the drug-containing film coating layer. The sustained release formulation according to one embodiment of the present invention having an outer coating layer is shown in FIG. 1.

The polymer used for the outer coating layer includes at least one component selected from the group consisting of hydrophilic, hydrophobic and pH dependent polymers used for film coating. In particular, it can be used selected from the group consisting of cellulose polymer, polyvinyl polymer, maleic acid-vinyl polymer, polymethacrylate copolymer, and combinations thereof. Particularly preferred is one copolymer (poly (methacrylic acid, ethyl acrylate) 1: 1). Commercially available Eudragit L100, 30D-55, L100-55 and the like can be used as the 1: 1 copolymer of methacrylic acid and ethyl acrylate, and in particular, Eudragit L100-55 is preferably used.

The skin coating layer may further include plasticizers that are commonly used, and may include, for example, plasticizers such as polyethylene glycol and derivatives thereof, fatty acids, substituted triglycerides, glycerides, castor oil and hydrogenated castor oil. Can be. And, if necessary, may include 0.1 to 2% by weight of sodium bicarbonate and / or sodium lauryl sulfate.

The content and type of the polymer contained in the skin coating layer may be used in accordance with the desired dissolution pattern. That is, as the content of the polymer increases, the dissolution rate of the active ingredient contained in the formulation is lowered, and in particular, the initial release rate is significantly lowered. That is, the sustained release formulation of the present invention can effectively control the initial drug release by controlling the coating amount of the outer coating layer. Although different depending on the desired elution pattern, the content of the polymer contained in the outer coating layer, i.e. the coating amount, is about 0.1 to 20% by weight, preferably about 0.1 to 5% by weight, based on the total weight of the sustained-release core.

The coating may be carried out according to a conventional coating method, but is preferably coated by an aqueous coating by a pan coating method used for tablet coating. That is, it is preferable to carry out the coating of the sustained release preparation while spraying the aqueous suspension of the polymer. In this case, since the coating is performed using an aqueous suspension without using an organic solvent, it may not cause problems such as environmental pollution due to the use of the organic solvent.

The pharmaceutical composition of the present invention may be formulated into various types of oral preparations so as to have the ingredients and contents described above. Preferably, it may be prepared in the form of a tablet, and when formulated into a tablet formulation, a specific manufacturing method is as follows.

The sustained release nucleus contained in the sustained release formulation of the present invention can be produced by a direct tableting method or a compressed granulation method.

When the sustained-release nucleus is produced by a direct tableting method (direct spun method), after mixing the active ingredient, swellable polymer such as methocel K4M CR Premium, direct excipient such as Avicel PH102, and disintegrating agent such as Primojel, A sustained release core can be manufactured by further mixing and tableting a lubricant such as a rate.

When prepared by the compressed granulation method, active ingredients, swellable polymers such as Methocel K4M CR Premium, excipients such as AVICEL PH101, disintegrants such as L-HPC, binders such as HPC-L, glidants such as magnesium stearate After mixing the agent, the granules may be prepared by a compression granulator (for example, a roller compacter), sieved to about 20 mesh, and then compressed into tablets to prepare a sustained release nucleus.

The enteric film coating layer can be formed using a conventional coating method. For example, when using a water-based coating method according to the general pan coating method, commercially available coatings of acrylic (coating agent with Eudragit L100-55, Calcon) are suspended in water, and the suspension is passed through the coating solution. After the preparation, the sustained-release nuclei are filled in a fan coater (e.g., Hi-coater), and the coating is performed at an inlet temperature of 50 to 80 ° C and an exhaust air temperature of about 30 to 45 ° C. By drying (for example, drying for 30 minutes with dry air), an enteric film coating layer can be formed.

The active ingredient-containing film coating layer may also be formed using conventional coating methods such as an enteric film coating layer. For example, in the case of using a water-based coating method by a general pan coating method, the coating solution is prepared by dissolving a drug in water and then suspending a commercially available Opadry (Coating agent containing 45.52% PVA, Colorcon) coating agent in the drug solution. Then, the sustained-release nucleus on which the enteric film coating layer was formed was filled in a fan coater (for example, a Hi-coater), and the coating was performed at an inlet temperature of 50 to 80 ° C and an exhaust air temperature of about 30 to 45 ° C. And the active ingredient-containing film coating layer can be formed by drying in a conventional manner (eg, drying with dry air for 30 minutes).

The outer coating layer may also be prepared using a coating method such as an enteric film coating layer.

The sustained-release preparation prepared as described above may be a tablet, in which case it may be stored and filled in a container through which water vapor does not pass, such as a blister pack (alu-alu) (PVDC, PE, PVC-alu). In addition, the sustained-release preparation prepared as described above may be formulated into a hard capsule by filling a hard capsule or the like.

The sustained-release preparation of the present invention prepared as described above releases the drug in two stages, and after the drug present in the active ingredient-containing film coating layer is continuously released from the gastric juice at the beginning of oral administration, the enteric film coating layer in the small intestine within minutes. This disintegration and continuous release of the drug allows dissolution control to be close to zero-order release without an initial rapid drug release.

The sustained-release preparation of the present invention can be applied to a drug that needs to exhibit sustained-release properties while suppressing a rapid increase in blood concentration in vivo as an active ingredient, for example, a diabetes therapeutic agent (glymepyride) , Glipizide, glyclazide, metformin and its therapeutically equivalent salts), antihypertensive agents (irbesaltan, fosinopril, felodipine, lercanidipine, rasididipine, nicardipine, amosululul, perrin Dopril, Krizazryl, Imidapril, Ricinopril, Rosaltan, Doxazosin, Candesaltan), Hyperlipidemia (simvastatin, lovastatin), Cardiovascular drugs, expectorants, Antibiotics, Sedatives, Steroids, Asthma, Non- Steroidal anti-inflammatory agents, and the like, and particularly, may be more preferably applied to tamsulosin or its hydrochloride salt, which is widely used as a therapeutic agent for enlarged prostate.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, this is for illustrating the present invention, and the present invention is not limited by these examples.

Example  One

(1) Preparation of Sustained Release Nuclei

Sustained release nuclei were prepared according to the composition (weight: mg) of the active ingredients and additives as shown in Table 1 below.

Furtherance Weight (mg) Felodipine 4.17 Hydroxypropylmethyl cellulose 70 Avicel PH102 35.2 Magnesium stearate 2 Weight of sustained-release nuclei 111.42

Pelodipine, hydroxypropylmethylcellulose (hypromellose 2903 mPa.s), and a direct-type excipient Avicel PH102 were mixed in a mixer in accordance with the composition ratios shown in Table 1. Magnesium stearate was added and mixed thoroughly. The resulting mixture was compressed in a rotary press (Korsch PH 106) to produce 100,000 white tablets (ie sustained release nuclei) each 111.42 mg.

(2) enteric film coating layer

The enteric film coating layer was Eudragit L 30 D-55 (30% aqueous suspension, 14.3 kg), PEG 6000 (10% aqueous solution, 4.15 kg), talc (1.1 kg), and cremophor EL (0.05). kg) was slowly added to water, followed by stirring until complete dissolution to prepare an enteric film coating solution. The sustained-release nucleus prepared in (1) was filled in a coating pan (ie, Glatt-type GC-750), and warmed with air so that the exhaust air temperature was about 30 to 40 ° C. The enteric film coating solution was sprayed by applying to the core with a spray device operated by air pressure. At the end of heating the heating was stopped, but the air supply was continued for about 30 minutes to dry the tablets. The coated core was extracted and stored in the apparatus, which was dried with dry air and left at room temperature for 24 hours.

(3) Preparation and Coating of Drug-Containing Film Coating Suspension

Water (35.007 kg) was heated to about 70 ° C., to which hydroxypropylmethylcellulose 2910 5 mPa · s (12.99 kg), talc (0.45 kg) and triacetin (1.5 kg) were added slowly with stirring. Then water (17.503 kg) was added thereto, followed by slowly adding felodipine (0.85 kg). The suspension was homogenized and then cooled to room temperature with continued stirring. The sustained-release nucleus coated with the enteric film prepared in (2) was filled in a coating pan, and warmed with air so that the discharge air temperature was about 40-50 占 폚. The drug coating suspension was sprayed into the enteric film-coated sustained-release nuclei, the air supply was continued for about 10 minutes to dry the drug-coated tablets, and then the tablets were extracted from the device and stored.

The average weight of the sustained-release tablet prepared as described above was 145.81 mg, and included a total of 5 mg of felodipine.

Example  2

(1) Preparation of Sustained Release Nuclei

The composition and preparation method of the core component of the sustained-release nucleus of Example 2 are as follows.

Furtherance Weight (mg) Nifedipine 27.5 Hydroxypropylmethyl cellulose 70 Avicel PH102 35.2 Magnesium stearate 2 Nuclear weight 134.75

Nifedipine, hydroxypropylmethylcellulose (hypromellose 2903 mPa.s) and a direct excipient Avicel PH102 were mixed in a mixer in accordance with the composition ratios described in Table 5. Magnesium stearate was added and mixed thoroughly. The resulting mixture was compressed in a rotary press (Korsch PH 106) to produce 100,000 white tablets (ie, sustained release nuclei) of 134.75 mg each.

(2) enteric film coating

The enteric film coating layer was Eudragit L 30 D-55 (30% aqueous suspension, 14.3 kg), PEG 6000 (10% aqueous solution, 4.15 kg), talc (1.1 kg), and cremophor EL (0.05). kg) was slowly added to water, followed by stirring until complete dissolution to prepare an enteric film coating solution. The sustained-release nucleus prepared in (1) was filled into a coating pan (ie, Glatt-type GC-750) and warmed with air so that the exhaust air temperature was about 30 to 40 ° C. The enteric film coating solution was sprayed by applying to the core with a spray device operated by air pressure. At the end of heating the heating was stopped, but the air supply was continued for about 30 minutes to dry the tablets. The coated core was extracted and stored in the apparatus, which was dried with dry air and left at room temperature for 24 hours.

(3) Preparation and Coating of Drug-Containing Film Coating Suspension

Water (35.007 kg) was heated to about 70 ° C. and slowly added thereto while stirring hydroxypropylmethylcellulose 2910 mPa · s (12.99 kg), talc (0.45 kg), and triacetin (1.5 kg). After addition of water (17.503 kg) nifedipine (5.5 kg) was added slowly. The suspension was homogenized and then cooled to room temperature with continued stirring. The sustained-release nucleus coated with the enteric film prepared in (2) was filled in a coating pan, and warmed with air so that the discharge air temperature was about 40-50 占 폚. The drug coating suspension was sprayed onto the enteric film-coated sustained-release nuclei, the air supply was continued for about 10 minutes to dry the drug-coated tablets, and then the tablets were extracted from the device and stored.

The average weight of the sustained-release tablet prepared as above was 174.75 mg, which included a total of 33 mg of nifedipine.

Example  3 to 5

(1) Preparation of Sustained Release Nuclei

The composition and preparation method of the core component of the sustained-release nucleus of Examples 3 to 5 are shown in Table 3 below.

Furtherance Weight (mg) Example 3 Example 4 Example 5 Tamsulosin hydrochloride 0.15 0.15 0.15 Methocel K4M CR Premium 50 20 70 Avicel PH102 47.85 77.85 27.85 Magnesium stearate One One One Primojel One One One Quantity of nuclear 100 100 100

In a mixer, 15 g of tamsulosin hydrochloride, Methocel K4M CR Premium (Methocel K4M CR Premium, Dow Chemical, USA), and the right-handed excipient Avicel PH102, Primojel were mixed in accordance with the composition ratios shown in Table 1. Magnesium stearate was added to mix thoroughly and then compressed in a rotary press (Korsch PH 106) to produce approximately 100,000 white sustained-release nuclei of 100 mg each.

(2) enteric film coating

5 kg of the sustained-release nucleus prepared in (1) was filled into a coating pan (Hi-coater), and warmed with air so that the exhaust air temperature was about 30 to 40 ° C. A coating solution prepared by suspending 500 g of acrylide (coating agent containing 40% of Eudragit L100-55, Calcon) in 4 times of water was sprayed into the sustained-release nucleus with a spray device operated by air pressure, The air supply was continued to dry for about 10 minutes. The coating amount of the acrylate (the coating agent containing 40% of Eudragit L100-55, Calcon) of the tablet obtained here was 10% with respect to the sustained-release nucleus.

(3) Preparation and Coating of Drug-Containing Film Coating Suspension

In the dried tablet prepared in (2), which was filled in a coating pan (Hi-coater), the exhaust air temperature was maintained at about 30 to 40 ℃. 2.5 g of tamsulosin hydrochloride and 240 g of Opadry (coating agent containing 45.52% PVA) were coated in 4 times of water to prepare a coating solution, and then the dried tablets were sprayed with an air pressure spray device. After spraying, the air supply continued to dry for about 10 minutes. The coating amount of the Opadry (coating agent containing 45.52% PVA, Calcon) coating agent of the tablet obtained was 4% with respect to the tablet.

(4) Preparation and Coating of Outer Film Coating Suspensions

In the tablet dried in (3), which was filled in a coating pan (Hi-coater), the exhaust air temperature was maintained at about 30 to 40 ℃. 12 g of an acrylic (coating agent containing 40% of Eudragit L100-55, Calcon) coatings were suspended in 4 times of water to prepare a coating solution, which was then sprayed onto the dried tablet with an air pressure spray device. The air supply was then continued to dry for about 10 minutes. In the tablets obtained here, the coating amount of the acrylic agent (coating agent containing 40% of Eudragit L100-55, Calcon) was 2% relative to the tablet.

The resulting tablets (Examples 3-5) had an average weight of 116-117 mg.

(5) Dissolution test

A dissolution test was conducted on the tablets prepared above. The dissolution test was conducted in accordance with the Dissolution Test No. 2 method of the general test method of KP. However, 1 ml of polysorbate 80 solution (1.5% a.q.) was accurately added to 500 ml of pH 1.2 for 2 hours at 37 ° C. and 100 rpm. The remaining 3 hours were carried out in 500 ml of phosphate buffer pH 7.2 at 37 ℃, 100 rpm conditions. Dissolution test results are shown in Table 4 and FIG. 2.

The amount of tamsulosin hydrochloride eluted (% by weight) time Example 3 Example 4 Example 5 0 0 0 0 2 25.32 28.56 22.34 3 74.89 97.69 60.23 5 99.785 100.43 101.45

As can be seen in Table 4 and FIG. 2, 0.05 mg, which corresponds to about 25% of the 0.2 mg of the drug included in the tablet, is slowly released during the initial 2 hours, and 0.15 mg is slowly released during the remaining 3 hours. Able to know.

Example  6 to 7

Effect test of outer coating layer

Example 6 produced the tablets in the same composition and method as in Example 5, with only 1% of the coating amount of the skin coating layer on the tablets of Example 5.

Example 7 produced the tablets in the same composition and method as in Example 5, except that the coating amount of the outer coating layer was 3% relative to the tablets of Example 5.

Dissolution Test

The dissolution test of the tablet prepared above was carried out in the same manner as the dissolution test of Examples 1 to 3. Dissolution test results are shown in Table 5 and FIG.

The amount of tamsulosin hydrochloride eluted (% by weight) time Example 5 Example 6 Example 7 0 0 0 0 0.5 13.5 18 3 One 16 21 7 1.5 18 23 11 2 22.34 25 15 3 60.23 58 62 5 101.45 99 99.5

As can be seen in Table 5 and FIG. 3, about 0.05 mg of the 0.2 mg of the drug contained in the tablet is slowly released during the initial 2 hours, and it can be seen that the release rate depends on the amount of the outer coating layer.

Example  8

Manufacture of tablets

The composition of the tablet of Example 8 is shown in Table 6 below.

Furtherance Weight (mg) Example 6 Hydrochloric acid pseudoephedrine 120 Hydrochloric Acid Citrizine 5 Hypromellose 99 HPC 30 Magnesium stearate One HPMC 2910 14.75 Talc 0.45 Triacetin 1.5 Tablet weight 271.7

(1) Preparation of Sustained Release Nuclei

In a mixer, 120 kg of pseudoephedrine hydrochloride, 99 kg of hydroxypropylmethylcellulose (hypromellose 2903 mPa · s), and 30.0 kg of binder HPC (hydroxypropylcellulose) were mixed. Magnesium stearate (500 g) was then added and mixed thoroughly. Then, ribbon-shaped granules were manufactured by a roller compacter, and sieved through a 20-mesh sieve. Magnesium stearate (500 g) was added thereto, mixed, and then compressed in a rotary press (Korsch PH 106) to prepare 100,000 white tablets of 250.0 mg each.

(2) enteric film coating

A 10% coating was performed on the white tablets in the same manner as in Examples 3 to 7.

(3) Preparation and Coating of Drug Coating Suspensions

Water (35.007 kg) was heated to about 70 ° C., to which HPMC 2910 mPa · s (14.75 kg), talc (0.45 kg), and triacetin (1.5 kg) were added slowly with stirring. After adding water (17.503 kg), citric acid hydrochloride (5 kg) was added slowly. The suspension was homogenized and then cooled to room temperature with continued stirring. In (2), the enteric film-coated sustained-release nucleus was filled in a coating pan, and warmed with air so that the discharge air temperature was about 40 to 50 ° C. The prepared drug coating suspension was sprayed onto the enteric film-coated tablets, the air supply was continued for about 10 minutes to dry the tablets on which the drug-containing layer was formed, and then the tablets were taken out of the device and stored.

By treatment as described above, a tablet containing a total of 120 mg of pseudoephedrine hydrochloride and 5 mg of citric acid hydrochloride having an average weight of 271.7 mg can be obtained.

(4) Dissolution test

A dissolution test was performed on the prepared formulation. The test was conducted according to the Dissolution Test No. 2 method of the Korean Pharmacopoeia General Test Method. However, elution was performed for 12 hours at 37 degreeC and 100 rpm conditions. The experimental results are shown in Table 7.

time Example 8 Hydrochloric acid pseudoephedrine (%) Citric Acid Hydrochloride (%) 0 0 0 One 8.3 100 2 17 - 4 49 - 6 70 - 8 84 - 12 100 -

In the tablets prepared above, pseudoephedrine hydrochloride, a drug contained in the sustained-release nucleus, showed 10-20% release for 1-2 hours, and citric acid hydrochloride in the active ingredient-containing film coating layer was 100% for 1-2 hours. Release. And 90-80% hydroephedrine hydrochloride was slowly released for the remaining 10-11 hours.

According to the present invention, it is possible to provide a sustained release formulation that effectively blocks initial rapid release of the drug upon oral administration and releases the drug continuously for a long time. In addition, the coating process of the enteric film coating layer and the outer coating layer used in the preparation of the sustained-release preparation of the present invention can be prepared using a general coating process does not require a special device in the manufacturing process, by employing a water-based coating method Since it can be manufactured, there is an advantage to avoid problems such as environmental pollution due to the use of organic solvents.

Claims (10)

(a) Active ingredient and hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, polyethylene oxide, waxes (carnauba lead), sodium alginate, povidone, polyvinyl alcohol, sodium carboxy Sustained-release nuclei comprising a polymer having erosion and swelling properties in the intestinal fluid of a mammal selected from the group consisting of methylcellulose, xanthan gum, alginate or derivatives thereof, and combinations thereof; (b) an enteric film coating layer coated on the sustained release nucleus; And (c) the same active ingredient as the active ingredient, and polyvinyl alcohol, polyethylene glycol, polypropylene glycol, acrylic acid copolymer, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, and combinations thereof An active ingredient-containing film coating layer comprising a hydrophilic polymer for film coating selected from the group and coated on the enteric film coating layer; Sustained release formulation comprising a. The sustained-release preparation according to claim 1, wherein the polymer contained in the sustained-release nucleus is hydroxypropylmethyl cellulose. The sustained-release preparation according to claim 1, wherein the content of the polymer contained in the sustained-release nucleus is 1 to 99% by weight based on the total weight of the sustained-release nucleus. The sustained-release preparation according to claim 1, wherein the polymer used in the enteric film coating layer is an enteric polymer dissolved at a pH of 5 or higher. The sustained-release preparation according to claim 4, wherein the enteric polymer is selected from the group consisting of cellulose polymer, polyvinyl polymer, maleic acid-vinyl polymer, polymethacrylate copolymer, and combinations thereof. The sustained-release preparation according to claim 4, wherein the enteric polymer is a 1: 1 copolymer of methacrylic acid and ethyl acrylate. According to claim 1, wherein the active ingredient is a hypertension, diabetes, hyperlipidemia, cardiovascular, expectorant, antibiotic, sedative, steroid compound, asthma, nonsteroidal anti-inflammatory, prostatic hypertrophy, antidepressant, antihistamine, And a drug selected from the group consisting of a combination thereof. The sustained-release preparation according to claim 7, wherein the drug is nifedipine, felodipine, citrizine, pseudoephedrine, tamsulosin, or a pharmaceutically acceptable salt thereof. The sustained-release preparation according to claim 8, wherein the active ingredient is tamsulosin or a hydrochloride thereof. 10. The method according to claim 9, wherein 60 to 99% by weight of tamsulosin or a hydrochloride thereof contained in the formulation is present in the sustained-release nucleus, and 1 to 40% by weight is present in the active ingredient-containing film coating layer. Sustained release formulation.

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