KR20020040687A - Cosmetic method - Google Patents

Abstract

According to the present invention there is provided a make-up method comprising:

(i) applying to the skin a composition comprising:

(a) one or more quaternary ammonium preparations; And

(b) wetting agents; And

(ii) rinsing the skin.

The method of the present invention has a low level of negative aspects such as slipperiness, stickiness or stickiness, and provides a good skin care effect such as good moisturizing property, good hydration, good skin feel, good skin softness and / or good smoothness. .

Description

Makeup method {COSMETIC METHOD}

The skin consists of several layers of cells that coat and protect keratin and collagen fibrous proteins that form the framework of its structure. The outermost layer, called the stratum corneum, is known to consist of a 25 nm protein bundle surrounded by an 8 nm thick layer. Anionic surfactants and organic solvents usually penetrate the stratum corneum and disrupt its integrity by degreasing (ie, removing lipids from the stratum corneum). This disruption of skin surface topography can cause a rough feel and, consequently, irritation, allowing the surfactant or solvent to interact with keratin.

It was now recognized that the maintenance of an appropriate water gradient across the stratum corneum was important for his sensuality. Most of the water, sometimes considered to be a plasticizer of the stratum corneum, comes from the interior of the body. If the humidity is too low, such as in cold climates, insufficient water remains in the outer layer of the stratum corneum to adequately plasticize the tissue, and the skin starts scaling and itching. Skin permeability is also somewhat reduced if there is inadequate water across the stratum corneum. On the other hand, too much water on the outside of the skin ultimately causes the stratum corneum to absorb three to five times the weight of the water itself. This swells and wrinkles the skin, resulting in an increase of approximately two to three times the skin's permeability to water and other polar molecules.

Thus, there is a need for compositions that will assist the stratum corneum to maintain its boundary wall and water retention action in optimal performance despite the deleterious interactions that the skin may encounter during washing, working and recreation.

In past methods of treating skin, compositions containing one or more 'skin benefit agents' have often been used. For example, one method of delivering high moisture to the skin is to incorporate a polyhydric alcohol-like humectant material such as glycerin into the composition. However, skin compositions having high levels of polyhydric alcohols and having high levels of moisturizing can often feel tacky when applied to the skin and may be perceived by the user as annoying. There will be a direct relationship between the effectiveness of the composition and the amount of skin active agent in delivering benefits to the skin. However, the higher the level of skin active agent, the higher the risk of associated negative aspects. One way to alleviate this problem is to rinse your skin with water. However, if the active agent is water soluble, rinsing the skin will also wash out the skin active agent.

Quaternary ammonium preparations are also known for use in cosmetic compositions. See, eg, WO-A-99 / 27904, WO-A-96 / 32089 and EP-A-789,076. See also US Pat. No. 5,804,205, which discloses the claimed skincare composition to provide a high level of moisturization without remaining "sticky" or "sticky". The composition contains quaternary ammonium compounds having two alkyl groups of 16 to 22 carbon atoms, wetting agents and non-irritating hydrophobic microspheres having an average particle size of less than 50 μm. It is claimed that hydrophobic polymeric microspheres significantly reduce the "tackiness" associated with high wetting agent levels. The compositions of US-A-5,804,205 may contain low levels of softeners such as mineral or mineral oils. However, quaternary ammonium preparations conventionally used in the prior art are often not readily biodegradable and are therefore harmful to the environment.

Now, a cosmetic method comprising treating the skin with a composition containing one or more quaternary ammonium preparations and wetting agents and then rinsing the skin provides benefits such as good moisturizing, hydration, skin feel, skin softness and skin smoothness. And negative aspects such as low levels of slipperiness, stickiness or stickiness.

Without being bound by theory, it is believed that in the compositions used in the methods of the present invention, the quaternary ammonium preparations of the present invention can vesicle wetting agents and deposit onto the skin. This allows for a smooth and uniform application of the humectant to the skin with minimal stickiness / stickiness / slipiness on the skin. This rinse step is believed to further reduce the negative side by washing away the excess wetting agent that causes the skin to have a sticky or slippery feel. Prior art methods comprising a rinse step wash out most of the active agent. However, the method of the present invention is believed to delay the loss of the active agent while assisting the quaternary ammonium preparations to alleviate the usual negative aspects. The compositions used in the process of the present invention have low levels of conventional negative aspects, even when they contain very high percentages of wetting agent, for example 30% by weight. Quaternary ammonium preparations are also believed to assist in reducing the loss of humectant from the skin due to environmental factors such as water from the rinsing step or friction from clothing or during washing. Moreover, quaternary ammonium formulations deliver skin care benefits such as good moisturizing, good skin feel, good skin softness and the like.

Summary of the Invention

According to the present invention there is provided a make-up method comprising:

(i) applying to the skin a composition comprising:

(a) one or more quaternary ammonium preparations; And

(b) wetting agents

(ii) rinsing the skin.

The method of the present invention provides a good skin care effect, such as good moisturizing properties, good hydration, good skin feel, good skin softness and / or good smoothness, with a low level of negative aspects such as slipperiness, stickiness or stickiness.

The present invention relates to a makeup method. In particular, the present invention relates to a cosmetic process of skin treatment that provides good moisturizing, hydrating, skin feel, skin softness and / or skin smoothness benefits.

The methods of the present invention comprise applying a composition containing one or more quaternary ammonium preparations and wetting agents to the skin, followed by rinsing the skin.

Makeup method

The methods of the present invention comprise applying a composition containing one or more quaternary ammonium preparations and wetting agents to the skin, followed by rinsing the skin. Compositions for use in the methods of the invention are described in more detail below.

The method of the present invention provides a good skin care effect, such as good moisturizing property, good hydration, good skin feel, good skin softness and / or good skin smoothness, with a low level of negative aspects such as slipperiness, stickiness or stickiness. . In particular, the method of the present invention provides the skin with good moisturizing and hydrating effects but does not leave a slippery feel to the skin. The method of the present invention should include the following steps:

(i) applying to the skin a composition comprising:

(a) one or more quaternary ammonium preparations; And

(b) wetting agents;

(ii) rinsing the skin.

Step (i) can be carried out on wet or dry skin. It is preferred that step (i) be carried out on dry skin for a separate moisturizing and / or hydrating effect. Therefore, one preferred aspect of the present invention includes:

(i) applying a composition containing at least one quaternary ammonium agent and a humectant to dry skin;

(ii) rinsing the skin.

Another preferred aspect of the invention includes the method above with the additional application of the composition to wet skin. Therefore, preferred methods include the following:

(i) applying a composition containing at least one quaternary ammonium agent and a humectant to dry skin;

(ii) rinsing the skin under a shower;

(iii) further applying the composition;

(iv) additional rinsing.

Many damages to human skin are caused by repeated exposure to compositions containing surfactants during the washing procedure. It has been found that such damage can be mitigated by the method of the present invention. Therefore, another preferred aspect of the present invention includes:

(i) washing the skin using a composition containing a surfactant;

(ii) rinsing the skin;

(iii) applying to the wet skin a composition containing at least one quaternary ammonium agent and a humectant;

(iv) rinsing the skin.

In addition, the method of the present invention has been found to be particularly useful when included as part of a conventional procedure. Therefore, another preferred aspect of the present invention includes:

(i) applying to the skin a composition comprising:

(a) at least one quaternary ammonium compound;

(b) wetting agents; And

(ii) rinsing the skin;

(iii) repeating steps (i) and (ii) within 48 hours.

In addition, the method of the present invention has been found to be useful when included as part of a conventional shaving procedure. Therefore, another preferred aspect of the present invention includes:

(i) shaving the skin;

(ii) optionally rinsing the skin;

(iii) applying to the skin a composition comprising:

(a) at least one quaternary ammonium compound;

(b) wetting agents; And

(iv) rinsing the skin.

The method of the invention is also caused by damage caused by exposure of the skin to ultraviolet radiation, damage caused by exposure of the skin to water during swimming or similar water based exposure, or exposure of the skin to water during bathing. It can be useful for mitigating damage.

Composition

Preferably the composition used in the process of the invention comprises a vesicle containing a quaternary ammonium preparation and a wetting agent. As used herein, the term “vesicle” means one or more bilayers arranged in a closed, typically spherical geometry, which contain the quaternary ammonium preparations described below. Preferably, the vesicle contains a quaternary ammonium preparation and a wetting agent. In the compositions of the present invention, the vesicles are preferably substantially spherical. The presence of vesicles in the compositions of the invention can be detected by microscopic analysis (polarized optical microscope at x60 magnification using a Nikon Eclipse E800 microscope).

The number average size of the vesicles of the present invention is preferably 0.01 μm to 30 μm, more preferably 0.1 μm to 15 μm.

Preferably the composition used in the process of the invention may be in the form of a cream, lotion, gel or the like. The composition used in the process of the invention preferably comprises that each oil phase contains a single oil component or a mixture of oil components in a miscible or homogeneous form, said different oil phases comprising different substances or combinations of different substances from each other, One or more oil phase oil-in-water emulsions in the aqueous continuous phase.

Preferably the composition used in the process of the invention contains less than 10% by weight, preferably less than 5% by weight, more preferably less than 3% by weight, even more preferably 0% by weight of anionic surfactant. .

Preferably, the composition of the present invention is at least about 1,000 mPa · s, preferably from about 1,000 to about 300,000 mPa · s, more preferably from about 2,500 to about 250,000 mPa · s, in particular from about 5,000 to about 200,000 mPa · s. Formulated to have product viscosity (26.8 ° C., neat, Brookfield DV-II + Spindle CP52 / CP41).

Quaternary Ammonium Formulations

The composition of the present invention should contain at least one quaternary ammonium preparation. Any quaternary ammonium formulation suitable for use in cosmetic compositions can be used in the present invention. As used herein, the term "quaternary ammonium preparation" means a compound or mixture of compounds having a quaternary nitrogen atom substituted by one or more, preferably two or more, carbon 6 or more parts. Preferably quaternary ammonium preparations for use in the present invention are readily biodegradable. As used herein, the term "easy biodegradable" means that at least 60% of the compounds are mineralized within 28 days according to the OECD 301 test. Preferably, the quaternary ammonium preparations used in the present invention are selected from those having quaternary nitrogen substituted in two parts each having at least 10 additional carbon atoms, preferably at least 12 carbon atoms. Highly preferred quaternary ammonium preparations for use in the present invention are selected from those capable of forming vesicles in polar solvents detected by microscopic analysis (polarized optical microscope at x60 magnification using a Nikon Eclipse E800 microscope). .

Preferably, the composition of the present invention contains at least 0.01% by weight, more preferably at least 0.1% by weight, even more preferably at least 1.5% by weight, even more preferably at least 3% by weight of quaternary ammonium preparation.

Preferably the quaternary ammonium preparation used in the present invention is selected from:

(a) quaternary ammonium compounds of formula I:

Wherein R ₁ and R ₂ are each C ₁ -C ₄ alkyl or C ₁ -C ₄ hydroxyalkyl group or hydrogen, and R ₃ and R ₄ are each an alkyl or alkenyl group having from about 8 to about 22 carbon atoms. . X ⁻ is a salt forming anion and is compatible with quaternary ammonium compounds and other additional ingredients.

Preferred quaternary ammonium compounds of this kind are those in which R ₁ and R ₂ are methyl or hydroxyethyl and R ₃ and R ₄ are linear or branched alkyl or alkenyl chains having at least 11 carbon atoms, preferably at least 15 carbon atoms. Quaternized amine with

(b) quaternary ammonium compounds of formula II or III:

[Wherein each R ₅ unit is hydrogen, branched or linear chain C ₁ -C ₆ alkyl, branched or linear chain C ₁ -C ₆ hydroxyalkyl and mixtures thereof, preferably methyl and hydroxyethyl Independently selected from; Each R ₆ unit is independently linear or branched C ₁₁ -C ₂₂ alkyl, linear or branched C ₁₁ -C ₂₂ alkenyl, and mixtures thereof; X ⁻ is an anion that is compatible with the skin care active agent and additional ingredients; m is 1 to 4, preferably 2; n is 1 to 4, preferably 2 and Q is a carbonyl unit selected from:

(Wherein R ₇ is hydrogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ hydroxyalkyl, and mixtures thereof).

In the example of the quaternary ammonium compound, unit -QR ₆ comprises a fatty acyl unit typically derived from a triglyceride source. The triglyceride source is preferably a resin, partially hydrogenated resin, lard, partially hydrogenated lard, vegetable oil and / or partially hydrogenated vegetable oil such as canola oil, safflower oil, peanut oil, rapeseed oil, sunflower oil , Corn oil, soybean oil, tall oil, rice bran oil, and the like, and mixtures of these oils.

The counterion X ⁻ in the compound is any compatible anion, preferably a strong acid, such as chloride, bromide, methylsulfate, ethylsulfate, sulfates, nitrates, etc., more preferably anions of chlorite or methyl sulfates. to be. In addition, the anion may carry a double charge, less preferably when X ⁻ represents a half group.

Preferred quaternary ammonium compounds of the present invention are diester and / or diamide quaternary ammonium (DEQA) compounds wherein the diesters and diamides are of formula (II) wherein the carbonyl group Q is selected from:

Resins, canola and palm oil are sources of convenient and inexpensive fatty acyl units suitable for use as R ₆ units in the present invention.

The counterion X ⁻ may be chloride, bromide, methylsulfate, formate, sulfate, nitrate and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

As used herein, when diesters are specified, they will include monoesters and triesters which are usually present as a result of the manufacturing process.

(c) quaternary ammonium compounds of formula IV or V:

[Wherein R ₉ is a bicyclic aliphatic C ₁₅ -C ₂₁ hydrocarbon group and R ₁₀ is a C ₁ -C ₆ alkyl or alkylene group].

Such ammonium compounds having pKa values of about 4 or less can induce cationic charges when dispersed in aqueous solutions, resulting in a pH of about 6 or less in the final composition.

(d) quaternary ammonium compounds of formula VI or VII:

Wherein R ₉ and R ₁₀ are as specified above and R ₁₁ is selected from C ₁ -C ₄ alkyl and hydroxyalkyl groups.

The counterion X ⁻ may be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

(e) quaternary ammonium compounds of formula VIII or IX:

[Wherein n is 1 to 6, R ₉ is selected from bicyclic aliphatic C ₁₅ -C ₂₁ hydrocarbon groups, and R ₁₂ is selected from C ₁ -C ₄ alkyl and hydroxyalkyl groups].

Such ammonium compound (V) having a pKa value of about 4 or less, when dispersed in an aqueous solution, can generate a cationic charge inherently, resulting in a pH of about 6 or less in the final composition.

Counterion X ^- (IX) may be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

(f) diquaternary ammonium compounds of formula X, XI, XII or XIII:

[Wherein R ₅ , R ₆ , Q, n and X ⁻ are as defined above in connection with formulas II and III, R ₁₃ is a C ₁ -C ₆ alkylene group, preferably an ethylene group, z is 0 to 4].

(g) a mixture of said quaternary ammonium compounds.

Preferred quaternary ammonium preparations for use in the present invention are those described in section (b) above. Especially preferred are diesters of formula (II) and / or diamide quaternary ammonium (DEQA) compounds. Preferred diesters for use in the present invention are those of formula II wherein R ₅ , R ₆ , and X ⁻ are as defined above and Q is

Preferred diamides for use in the present invention are those of formula II wherein R ₅ , R ₆ , and X ⁻ are as defined above and Q is

Preferred examples of quaternary ammonium compounds suitable for use in the compositions of the present invention are N, N-di (canolyl-oxy-ethyl) -N, N-dimethyl ammonium chloride, N, N-di (canolyl-oxy- Ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium methyl sulfate, N, N-di (canolyl-oxy-ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium chloride and Mixture of them. Particularly preferred for use in the present invention is N, N-di (canolyl-oxy-ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium methyl sulfate.

While it is preferred that the quaternary ammonium compound is derived from a "canolyl" fatty acyl group, another suitable example of a quaternary ammonium compound is derived from a fatty acyl group, in which the term "canolyl" is derived from a fatty acyl unit. Replaced with the term “resin, cocoyl, palmyl, lauryl, oleyl, ricinoleyl, stearyl, palmityl”, corresponding to triglycerides. Such alternative fatty acyl sources may contain fully saturated, or preferably at least partially unsaturated chains.

Humectant

The second essential element of the composition of the process of the invention is to contain a humectant. As used herein, the term "wetting agent" means a substance that provides a water-retaining benefit to the skin. Preferably, the composition of the present invention is at least 1% by weight, more preferably at least 5% by weight, even more preferably at least 10% by weight, even more preferably at least 20% by weight, even more preferably 30% by weight. The above wetting agent is included.

Any humectant suitable for use in the cosmetic composition may be used in the present invention. Non-limiting examples of wetting agents suitable for use in the present invention are described in WO98 / 22085, WO98 / 18444 and WO97 / 01326. Preferably the humectant for use in the present invention is selected from, but is not limited to: amino acids and derivatives thereof such as proline and arginine aspartate, 1,3-butylene glycol, propylene glycol and water and kodium tomento Codium tomentosum extracts, collagen amino acids or peptides, creatinine, diglycerol, biosaccharide gum-1, glucamine salts, glucuronates, glutamate salts, polyethylene glycol ethers of glycerine (e.g. glycereth 20), Glycerin, Glycerol Monopropoxylate, Glycogen, Hexylene Glycol, Honey, and Extracts or Derivatives thereof, Hydrogenated Starch Hydrate, Hydrolyzed Mucopolysaccharides, Inositol, Keratin Amino Acids, Urea, LAREX A-200 (available commercially) Cosaminoglycans, methoxy PEG 10, methyl gluecet-10 and -20 (both Amerchol, Edison, NJ) Plates), methyl glucose, 3-methyl-1,3-butanediol, N-acetyl glucosamine salt, polyethylene glycol and derivatives thereof (e.g. PEG 15 butanediol, PEG 4, PEG 5 pentaerythritol, PEG 6, PEG 8 , PEG 9), pentaerythritol, 1,2 pentanediol, PPG-1 glyceryl ether, PPG-9, 2-pyrrolidone-5-carboxylic acid and its salts such as glyceryl pca, saccharide iso Isomerate, SEACARE (commercially available from Secma), sericin, silk amino acids, sodium acetylhyaluronate, sodium hyaluronate, sodium poly-aspartate, sodium polyglutamate, sorbeth 20, sorbeth 6, Sugars and sugar alcohols and derivatives thereof such as glucose, mannose and polyglycerol sorbitol, trehalose, triglycerol, trimetholpropane, tris (hydroxymethyl) amino methane salts, and yeast extracts, and mixtures thereof.

More preferably, the humectant for use in the present invention is selected from glycerin, urea, butylene glycol, polyethylene glycol and derivatives thereof, or mixtures thereof. Even more preferably, the humectant for use in the present invention is selected from glycerin, urea and mixtures thereof, in particular glycerin.

Random ingredient

The composition of the present invention may contain various optional ingredients suitable to make the composition more cosmetically or aesthetically acceptable or to provide additional use advantages thereto. Such conventional optional ingredients are known to those skilled in the art. This includes any cosmetically acceptable ingredients such as those listed in the CTFA International Cosmetic Ingredient Dictionary and Handbook, Rev. 7, Wenninger and McEwen, (The Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC, 1997). do. Some non-limiting examples of such optional components are given below.

Polar solvent

The composition of the present invention may also contain a polar solvent. Any polar solvent suitable for use in the cosmetic composition may be used in the present invention. However, the polar solvent must be polar enough to cause the formation of vesicles in the present invention. Preferably, the polar solvent used in the composition of the present invention is water.

Preferably, the composition will contain from 10% to 90% by weight, more preferably from 20% to 80% by weight, even more preferably from 30% to 60% by weight of a polar solvent.

Softener

Another very preferred optional ingredient of the composition of the present invention is a softener. Softeners tend to lubricate the skin, increase the smoothness and suppleness of the skin, prevent or relieve dryness of the skin and / or protect the skin. A wide variety of suitable softeners are known and can be used in the present invention. Sagarin, Cosmetics, Science and Technology, 2nd Revision, Vol 1, pp. 32-43 (1972) include examples of numerous materials suitable for use as softeners. Preferably the composition of the present invention comprises more than 1% by weight, more preferably at least 5% by weight, even more preferably at least 10% by weight of emollient.

Preferably the emollient for use in the present invention is selected from:

i) linear and branched chain hydrocarbons having about 7 to about 40 carbon atoms, such as dodecane, squalane, mineral oil, cholesterol and derivatives thereof, hydrogenated polyisobutylene, isohexadecane and C ₇ -C ₄₀ branched hydrocarbons C ₇ -C ₄₀ isoparaffin.

ii) C ₁ -C ₃₀ alcohol esters of C ₁ -C ₃₀ carboxylic acids and C ₂ -C ₃₀ dicarboxylic acids such as isononyl isononanoate, isopropyl myristate, myristyl propionate, isopropyl Stearate, behenyl behenate, dioctyl maleate, diisopropyl adipate, and diisopropyl dilinoleate.

iii) mono-, di- and tri-glycerides of C ₁ -C ₃₀ carboxylic acids and ethoxylated derivatives thereof. Suitable polyethylene glycol derivatives of glycerides include PEG-20 almond glycerides, PEG-60 almond glycerides, PEG-11 avocado glycerides, PEG-6 capric acid / caprylic acid glycerides, PEG-8 capric acid / caprylic acid glycerides, PEG-20 corn glycerides, PEG-60 corn glycerides, PEG-60 evening primrose glycerides, PEG-7 glyceryl cocoate, PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-12 glyceryl dioleate, PEG-15 glyceryl isostearate, PEG-20 glyceryl isostearate, PEG-30 glyceryl isostearate, PEG-75 cocoa butter glycerides , PEG-20 hydrogenated palm oil glycerides, PEG-70 mango glycerides, PEG-13 mink glycerides, PEG-75 shorea butter glycerides, PEG-10 olive glycerides, PEG-12 palm fruit el) glycerides, PEG-45 palm fruit glycerides, PEG-8 glyceryl laurate and PEG-30 glyceryl laurate. Mixtures of polyethylene glycol derivatives of glycerides may also be used in the present invention.

iv) alkylene glycol esters of C ₁ -C ₃₀ carboxylic acids, such as ethylene glycol mono- and di-esters, and propylene glycol mono- and di-esters of C ₁ -C _3O carboxylic acids, such as ethylene glycol distea Rate.

v) organopolysiloxane oils. The organopolysiloxane oil may be volatile, nonvolatile, or a mixture of volatile and nonvolatile silicones. As used herein, the term "nonvolatile" refers to silicone that is liquid under ambient conditions and has a flash point of about 100 ° C. or higher (under 1 atmosphere). As used herein, the term "volatile" refers to all other silicone oils. Suitable organopolysiloxanes can be selected from a variety of silicones, ranging from a wide range of volatility and viscosity. Nonvolatile polysiloxanes are preferred. Suitable silicone is U.S. Patent 5,069,897, issued December 3, 1991. Organopolysiloxanes selected from polyalkylsiloxanes, alkyl substituted dimethicones, dimethiconols, polyalkylarylsiloxanes, and mixtures thereof are preferred for use in the present invention. Polyalkylsiloxanes and cyclomethicones are more preferred for use in the present invention. Preference is given to dimethicone in polyalkylsiloxanes.

vi) vegetable oils and hydrogenated vegetable oils. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, palm oil, cottonseed oil, menhaden oil, palm fruit oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, and rice bran oil. , Pine oil, sesame oil, sunflower seed oil, partial and total hydrogenated oils from the above, and mixtures thereof.

vii) animal fats and oils such as cod liver oil, lanolin and derivatives thereof such as acetylated lanolin and isopropyl lanoleate. Lanolin oil is preferred.

viii) C ₄ -C ₂₀ alkyl ethers of polypropylene glycol, C ₁ -C ₂₀ carboxylic acid esters of polypropylene glycol, and di-C ₈ -C ₃₀ alkyl ethers such as PPG-14 butyl ether, PPG-15 ste Aryl ethers, dioctyl ethers, dodecyl octyl ethers, and mixtures thereof are also useful.

ix) polyol carboxylic acid esters.

x) mixtures of the above.

Preferred emollients for use in the compositions of the present invention include dodecane, squalane, cholesterol and derivatives thereof, isohexadecane, isononyl isononanoate, mineral oil, lanolin and derivatives thereof, safflower oil, castor oil, palm oil, cottonseed oil, Palm fruit oil, palm oil, peanut oil, soybean oil, polyol carboxylic acid esters and mixtures thereof. More preferred emollients for use in the present invention are selected from polyol carboxylic acid esters, mineral oils and mixtures thereof.

The ester is derived from sugar or polyol moieties and one or more carboxylic acid moieties. Depending on the constituent acids and sugars, the esters may be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannose tetraester of mixed soybean oil fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylose tetra Linoleate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate Eights, sucrose octaoleate, and mixtures thereof. Examples of solid esters include: sorbitol hexaester, which is a palmitate and arachidate carboxylic acid ester addition in a 1: 2 molar ratio; Octaester of raffinose, which is a phenolic ester addition 1: linoleate and behenate in a 1: 3 molar ratio; Heptaester of maltose which is an esterified carboxylic acid addition 3: 4 molar ratio of sunflower seed oil fatty acid and lignocerate; Octaester of sucrose, which is an esterified carboxylic acid addition of 2: 6 molar ratio of oleate and behenate; And octaesters of sucrose which are esterified carboxylic acid additions in a 1: 3: 4 molar ratio of laurate, linoleate and behenate. Preferred solid materials are sucrose polyesters having a degree of esterification of 7-8 and C18 mono- and / or di-unsaturated and behenic with a molar ratio of fatty acid addition unsaturated: behenic 1: 7 to 3: 5. Particularly preferred solid sugar polyesters are octaesters of sucrose, having about 7 behenic fatty acid moieties and about 1 oleic acid moiety in the molecule. Other substances include cottonseed oil or soybean oil fatty acid esters of sucrose. Ester materials are also described in U.S. Patent 2,831,854, U.S. Patent 4,005,196 (Jandacek, issued January 25, 1977); U.S. Patent 4,005,195 (Jandacek, issued January 25, 1977), U.S. Patent 5,306,516 to Letton et al., Issued April 26, 1994; U.S. Patent 5,306, 515 to Letton et al., Issued April 26, 1994; U.S. Patent 5,305,514 to Letton et al., Issued April 26, 1994; U.S. Patent 4,797,300 (Jandacek et al., Issued January 10, 1989); U.S. Patent 3,963,699 (Rizzi et al., Issued June 15, 1976); U.S. Patent 4,518,772 (Volpenhein, issued May 21, 1985); And U.S. Patent 4,517,360 (Volpenhein, issued May 21, 1985).

Suitable polyol fatty acid polyesters for use in the present invention can be prepared by a variety of methods known to those skilled in the art. Such methods include: transesterification of polyols with methyl, ethyl or glycerol fatty acid esters using various catalysts; Acylation of polyols with fatty acid chlorides; Acylation of fatty anhydrides and polyols; And acylation of polyols using fatty acids themselves. For example, U.S. Patent number 2,831,854; U.S. See patent 4,005,196 (Jandacek, issued January 25, 1977).

Particularly preferred materials are known under the INCI name sucrose polycottonseedate.

Other skin effective agents

Other skin benefit agents may be useful in the compositions of the present methods. Examples of other skin active agents that can be used in the compositions include the following:

(a) vitamin compounds

The composition may comprise vitamin compounds, precursors, and derivatives thereof. Such vitamin compounds may be in natural or synthetic form. Suitable vitamin compounds include vitamin A (e.g. beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate, etc.), vitamin B (e.g. niacin, niacinamide, riboflavin, pantothenic acid, etc.) C (e.g. ascorbic acid, etc.), vitamin D (e.g. ergosterol, ergocalciferol, cholecalciferol, etc.), and vitamin K (e.g. phytonadione, menadione, pthiocol, etc.) compounds. have. Preferred vitamin compounds for use in the compositions of the present invention are vitamin B ₃ compounds. Vitamin B ₃ compounds are particularly useful for regulating skin conditions as described in WO-A-97 / 39733. When present, the composition of the present invention is preferably from about 0.01% to about 50% by weight, more preferably from about 0.1% to about 10% by weight, even more preferably from about 0.5% to about 5% by weight Contains vitamin B ₃ compounds.

"Vitamin B ₃ compound" as used herein, means a compound having the formula:

[Wherein R is -CONH ₂ (ie niacinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinyl alcohol); Derivatives thereof; And salts of any of the above.

Typical derivatives of the vitamin B ₃ compounds include nicotinic acid esters including non-vascular expanding esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides and niacinamide N-oxides.

Examples of suitable vitamin B ₃ compounds are well known in the art and include Sigma Chemical Company (St. Louis, Missouri); ICN Biomedicals, Inc. (Urban, California) and Aldrich Chemical Company (Milwaukee, Wisconsin).

Vitamin compounds may be included as substantially pure substances, or as extracts obtained by appropriate physical and / or chemical isolation from natural (eg, plant) sources.

(b) anti-wrinkle and anti-skin atrophy actives

Examples of anti-wrinkle and anti-skin atrophy actives that can be used in the compositions of the present invention include lactic acid and its derivatives, retinoic acid and its derivatives (eg cis and trans); Retinol; Retinyl esters; Niacinamide, salicylic acid and derivatives thereof; Sulfur-containing D and L amino acids and derivatives and salts thereof, particularly N-acetyl derivatives, including but not limited to, preferred examples thereof include N-acetyl-L-cysteine; Thiols such as ethane thiol; Hydroxy acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin release agents (e.g., phenol and the like).

(c) antimicrobial and antifungal actives

Examples of antimicrobial and antifungal actives that may be used in the compositions of the invention include β-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'-trichloro -2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarvanide, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, Oxytetracycline, clindamycin, ethambutol, hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linenemycin, metacycline, metheneamine, minocycline, neomycin, netylmycin, paromomycin, Streptomycin, tobramycin, myconazole, tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin estholate, erythromycin Tearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride , Metronidazole hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, linenemycin hydrochloride, methacycline hydrochloride, metheneamine hypofurlate, metheneamine mandelate, minocycline hydrochloride, neomycin sulphate Pate, Netylmycin Sulfate, Paromomycin Sulfate, Streptomycin Sulfate, Tobramycin Sulfate, Myconazole Hydrochloride, Amanpadin Hydrochloride, Amanpadin Sulfate, Octopy Scotland, para-chloro-meta-xylenol, you statins, toll-naphthyl lactate, zinc pyrithione and clotrimazole but are included, and the like.

(d) sunscreen actives

The composition of the present invention also contains a sunscreen active agent. Various sunscreen agents are useful in the present invention. Such sunscreen actives include both organic compounds and salts thereof as well as inorganic particulate materials. Without being bound by theory, it is believed that sunscreen agents provide protection from ultraviolet radiation by one or more mechanisms including absorption, dispersion and reflection of ultraviolet radiation. Non-limiting examples of such sunscreen agents are described in US Pat. No. 5,087,445 to Haffey et al., Feb. 11, 1992; U.S. Patent 5,073,372 (Turner et al., Issued Dec. 17, 1991); U.S. Patent 5,073,371 (Turner et al., Issued Dec. 17, 1991); US Patent No. 5,160,731 (Sabatelli et al., Issued Nov. 3, 1992); US Patent No. 5,138,089 to Sabatelli, issued August 11, 1992; US Patent No. 5,041,282 (Sabatelli, issued August 20, 1991); U.S. Patent No. 4,999,186, issued to Sabatelli et al., March 12, 1991; US Patent No. 4,937,370 (Sabatelli, issued June 26, 1990); And in Segarin et al., Chapter VII, p. 189, Cosmetics Science and Technology . Preferred among the sunscreen agents are 2-ethylhexyl p-methoxycinnamate, octyl salicylate, octocrylene, oxybenzone, 2-ethylhexyl N, N-dimethylaminobenzoate, p-aminobenzoic acid, 2-phenyl- Benzimidazole-5-sulfonic acid, homomentyl salicylate, DEA p-methoxycinnamate, 4,4'-methoxy- t -butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3- (4- Methylbenzylidene) camphor, 3-benzylidene camphor, 4-N, N-dimethylaminobenzoic acid ester with 2,4-dihydroxybenzophenone, 2-hydroxy-4- (2-hydroxyethoxy 4-N, N-dimethylaminobenzoic acid ester with benzophenone, 4-N, N-dimethylaminobenzoic acid ester with 4-hydroxydibenzoyl-methane, 4- (2-hydroxyethoxy) dibenzoylmethane 4-N, N-dimethylaminobenzoic acid ester with, 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with 2,4-dihydroxybenzophenone, 2-hydroxy-4- (2 -Hydroxyethoxy) benzo 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with phenone, 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with 4-hydroxydibenzoylmethane, 4- (2 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with -hydroxyethoxy) dibenzoylmethane, 4-N, N- (2-ethylhexyl with 2,4-dihydroxybenzophenone ) Methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester with 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, and 4-hydroxydibenzoylmethane 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester with 4- (2-hydroxyethoxy) dimenzoylmethane , Titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.

More preferred for use in the compositions described herein are 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, 2-ethylhexyl p-methoxycinnamate, octocrylene, octyl salicylate, homomentyl Salicylate, p-aminobenzoic acid, oxybenzone, 2-phenylbenzimidazole-5-sulfonic acid, DEA p-methoxycinnamate, 4,4'-methoxy- t -butyldibenzoylmethane, 4-isopropyl 4-N, N- (2-ethylhexyl) with dibenzoyl methane, 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor, 4- (2-hydroxyethoxy) dibenzoylmethane Sunscreen agents selected from the group consisting of methylaminobenzoic acid esters, titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.

The exact amount of sunscreen that can be used will depend on the sunscreen chosen and the desired Sun Protection Factor (SPF) to be achieved. SPF is a commonly used measure of photoprotection of sun protection against erythema. Federal Register , Vol. 43, No. 166, pp. 38206-38269, August 25, 1978].

Thickener

The composition of the present invention preferably contains a thickener. Any thickener suitable for use in the cosmetic composition may be used in the present invention. Preferred thickeners are selected from nonionic water soluble polymers, fatty alcohols and mixtures thereof. Suitable nonionic polymers include cellulose ethers (e.g., hydroxybutyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxy ethyl cellulose, hydrophobically modified hydroxyethyl cellulose and hydroxyethyl cellulose). Such water-soluble polymers, poly (ethylene oxide), polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl guar gum, amylose, hydroxyethyl amylose, starch and starch derivatives. Suitable fatty alcohols are high molecular weight, nonvolatile, primary alcohols having the formula:

RCH ₂ OH

_Wherein R is C _8-20 alkyl.

They can be prepared from natural fats or oils by reduction of fatty acid COOH-groups to hydroxyl functionality. Alternatively, fatty alcohols of the same or similar structure may be prepared according to conventional synthesis methods known in the art. Suitable fatty alcohols include behenyl alcohol, C ₉ -C ₁₁ alcohol, C ₁₂ -C ₁₃ alcohol, C ₁₂ -C ₁₅ alcohol, C ₁₂ -C ₁₆ alcohol, C ₁₄ -C ₁₅ alcohol, caprylic alcohol, cetea Contains ryl alcohol, coconut alcohol, decyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, oleyl alcohol, palm fruit alcohol, stearyl alcohol, cetyl alcohol, tallow alcohol, tridecyl alcohol or myristyl alcohol However, it is not limited to this.

Other optional ingredients

The composition of the present invention may contain a wide variety of other optional ingredients. The additional ingredient should be pharmaceutically acceptable. Non-limiting examples of functional groups suitable for use in the compositions of the present invention include: abrasives, absorbents, anti-acne actives, cake formers, antidandruffs, antiperspirants, antioxidants, anti-viral actives, Artificial tanning actives and accelerators, biological additives, bleaching agents, bleaching agents, brighteners, builders, buffers, chelating agents, chemical additives, colorants, cosmetics, cleansers, cosmetic astringents, cosmetic biocides, denaturants, Deodorant, Epidermal Deactivator, Hair Loss, Drug Astringent, Dye, Dye Transfer Agent, Enzyme, External Anesthetic, Foam Generator, Flavoring Agent, Membrane Formant, Aromatic Ingredients, Insect Repellent, Flavoring Agent, Nonsteroidal Anti-Inflammatory, Oxidizing dyes, oxidizing agents, pest control ingredients, pH adjusting agents such as citric acid, pH buffers, pharmaceutical actives, plasticizers, preservatives, radical scavengers, skin, hair or Nail bleach, skin, hair or nail conditioner, skin, hair or nail penetration enhancer, stabilizer, surfactant, surface conditioner, reducing agent, temperature lowering agent, viscosity modifier, and warming generator, such as pyrogenic zeolites. Also useful in the present invention are aesthetic components such as colorants, essential oils, and skin healing agents. In the present invention, other optional materials include pigments. Pigments suitable for use in the compositions of the present invention may be organic and / or inorganic. The term also includes pigments having low coloration or gloss, such as matte finishes, and also light scattering agents. Examples of suitable pigments are iron oxide, acylglutamate iron oxide, titanium dioxide, ultramarine blue, D & C dyes, carmine, and mixtures thereof.

Formulation Method

Preferably the composition of the method is prepared in such a way that the quaternary ammonium compound forms a vesicle. It is preferred that the vesicle also contains a humectant. Preferably, the vesicle contains a softener. Even more preferably the vesicle contains a sunscreen active agent. In order to ensure optimal performance properties, it is preferred that the compositions of the present invention be prepared as follows:

(Iii) mix all or part of the quaternary ammonium formulation with a humectant, a water soluble skin care active agent (if included), and preferably at a temperature above the melting point of the quaternary ammonium formulation with the polar solvent;

(Ii) optionally, stirring the mixture vigorously;

(Iii) preparing an emulsion in a separation vessel as follows; The oil phase containing the softener, if the thickener is fat-soluble, the appropriate thickener, and any remaining quaternary ammonium preparation, are mixed together at a temperature above the melting point of the quaternary ammonium compound. Prepare by separating the aqueous phase. If water, the thickener is water soluble, suitable thickeners, and any remaining water soluble components are heated to the same temperature as the oil phase.

(Iii) Then, the temperature of the aqueous phase of the oil and the emulsion is made approximately equal, and the aqueous phase is combined with the oil phase under stirring.

(Iii) The mixture formed in step (iii) in the preparation of the emulsion is added to the abovementioned emulsion with stirring.

The following examples further illustrate preferred embodiments within the scope of the present invention. The examples are provided for illustrative purposes only and many modifications of the invention are possible without departing from the spirit or scope thereof and should not be construed as limiting the invention. Unless otherwise indicated, all ingredients are in percent by weight of active ingredient.

One; Croda commercially available

2; Floratech (AZ, USA) commercially available

3; Hoffman La Roche (NJ, USA) commercially available

4; Amerchol (NJ, USA) commercially available

5; Rhodia, (NJ, USA) commercially available

In Formulations 1, 4, 7, 9, 17, 20, 22, 24, 28, 36, 38, 47, 49, 53, 56, the quaternary ammonium compounds used are supplied by Goldschmidt under the trade name Varisoft TA100. Distearyl dimethyl ammonium chloride.

Example 2, 3, 5, 6, 8, 10, 15, 16, 18, 19, 21, 23, 26, 27, 31, 33, 34, 35, 37, 41, 45, 46, 48, 50 , 51, 52, 54, 55, the quaternary ammonium compounds used are N, N-di (canolyl-oxy-ethyl) -N-methyl, N- (2-, supplied under the trade name Rewoquat V3620 by Goldschmidt. Hydroxyethyl) ammonium methyl sulfate.

In Example 11, the quaternary ammonium compound used is N, N-di (canolyl-oxy-ethyl) -N methyl, N- (2-hydroxyethyl) ammonium supplied by Goldschmidt under the trade name Rewoquat WE18. Methyl sulfate.

In Example 12, the quaternary ammonium compound used was N, N-di (canolyl-oxy-ethyl) -N methyl, N- (2-hydroxyethyl), a developing material (WE25) supplied by Goldschmidt. Ammonium chloride.

In Example 13, the quaternary ammonium compound used is methylbis (hydrogenated tallowamidoethyl) (2-hydroxyethyl) ammonium methyl sulfate, supplied under the trade name Varisoft 110 by Goldschmidt.

In Example 14, the quaternary ammonium compound used is methylbis (tallowamidoethyl) (2-hydroxyethyl) ammonium methyl sulfate, supplied under the trade name Varisoft 222 by Goldschmidt.

In Example 25, the quaternary ammonium compound used is methyl-1-tallowoilethyl-2-tallowimidazoline, a developing material supplied by Goldschmidt.

In Example 29, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallowimidazoline, which is a developing material supplied by Goldschmidt.

In Example 30, the quaternary ammonium compound used is methyl-1-tallowoilethyl-2-tallowimidazolinium methyl sulphate supplied by Goldschmidt.

In Example 32, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallowimidazolinium methyl sulphate supplied by Goldschmidt under the trade names Varisoft 475, Varisoft 445.

In Example 39, the quaternary ammonium compound used is N, N-dimethyl-N- (canolyl-oxy-ethyl) -N- (canolamidoethyl) amine supplied by Kao.

In Example 40, the quaternary ammonium compound used is N, N-dimethyl-N- (canolyl-oxy-ethyl) -N- (canolamidoethyl) ammonium methyl sulfate supplied by Kao.

In Example 42, the quaternary ammonium compounds used are N, N'-bis (2-taloyloxyethyl) -N, N, N, disclosed in Ciba-Geigy Corporation Patents US 4728337, US 4721512, US 4906413. ', N'-tetramethylene diammonium dichloride.

In Example 43, the quaternary ammonium compounds used are N, N'-bis (2-canolyloxyethyl) -N, N-dimethyl-N, N, disclosed in Goldschmidt-Witco Patents EP 0503155A1 & EP 0803498. '-(2-hydroxyethyl) -1,6-hexane diammonium methyl sulfate.

In Example 44, the quaternary ammonium compounds used are quaternized following the reaction of fatty acids, difunctional (or multifunctional) acids and triethanolamines, as described in WO98 / 49132 by Kao and US 5880289 by Henkel. Di and oligo ester quaternaries prepared.

fair

In an embodiment comprising component C:

1. Premix 1: The components of group A are mixed together at a temperature higher than the transition temperature of the selected quaternary ammonium compound, leaving a pre-determined portion of the quaternary ammonium compound and water. The premix is stirred vigorously.

2. Premix 2: Combine the components of groups B and C with some of the remaining quaternary ammonium compound and water not previously used in premix 1. Heat above the melting point of the quaternary and oil.

3. Combine the premixes 1 & 2, cool to 40 ° C. and stir in the perfume.

In an embodiment comprising component D:

1. Premix 1: Combine the components of group A together at a temperature higher than the transition temperature of the selected quaternary ammonium compound, leaving a pre-determined portion of water. The premix is stirred vigorously.

2. Premix 2: Combine the components of group D with water which was not used previously in premix 1 with stirring.

3. Combine the components of premixes 1 & 2 and groups B and E. Stir vigorously.

Example

1. After applying Formulations 1 to 56 to the skin, it may be rinsed off to further moisturize the skin.

2. After washing with a composition containing a surfactant, the formulations 1 to 56 can be applied to the skin. After rinsing off the surfactant based product, the product should be applied directly to the moist skin. The composition must then be rinsed off. This moisturizes the skin with little damage caused by the composition comprising the surfactant.

3. Formulations 1 to 56 above should be used as part of the general procedure, therefore the composition should be applied to wet skin, the skin should be rinsed and the product used in the same manner within 48 hours. This moisturizes the skin and protects against damage from surfactant based products.

4. Formulations 1 to 56 may be applied to the dry skin area in question prior to wetting the skin. After a short time, the skin can be moistened and washed with a surfactant. The composition is applied successively, followed by rinsing, to strongly moisturize the skin area. This "pretreatment step" is particularly effective for very dry skin or simplifies enhanced benefits from the product.

5. The formulations 1 to 56 can be applied to the dry skin area in question before wetting the skin. After a short time, the skin can be rinsed off. The composition is applied successively, followed by rinsing, to strongly moisturize the skin area. This "pretreatment step" is particularly effective for very dry skin or simplifies enhanced benefits from the product.

6. The formulations 1 to 56 may be applied to wet skin before shaving. The pre shaving product is applied to wet skin and is used in place of conventional shaving foam. After shaving, rinse the skin. This moisturizes the skin after shaving.

7. The formulations 1-56 can be used during shaving care. After shaving, the product should be applied to the skin and the skin subsequently rinsed. This makes the skin softer and more moisturized after shaving.

8. Formulations 1 to 56 may be applied after swimming. The product must first be rinsed with water containing a large amount of chlorine. After application, the skin should be rinsed. It will moisturize your skin and minimize the damage caused by chlorine.

The method of this embodiment provides good skin care benefits, such as good moisturizing, good hydration, good skin feel, good softness and / or good skin smoothness, with a low level of negative aspects such as slippery, sticky or tacky.

Claims (10)

Makeup method for treating skin comprising the following steps: (i) applying to the skin a composition comprising: (a) one or more quaternary ammonium preparations; And (b) wetting agents; And (ii) rinsing the skin. The method of claim 1 wherein said composition contains greater than 1% by weight, preferably at least 2% by weight, of quaternary ammonium preparations. The process according to claim 1 or 2, wherein the composition contains more than 4% by weight, preferably more than 5% by weight, more preferably at least 10% by weight. The method of claim 1, wherein the composition comprises a vesicle containing a quaternary ammonium agent and a humectant. The method of any one of claims 1 to 4, comprising the following steps: (i) applying a composition containing the following to dry skin: (a) one or more quaternary ammonium preparations; (b) wetting agents; And (ii) rinsing the skin. The method of any one of claims 1 to 5 comprising the following steps: (i) applying a composition containing at least one quaternary ammonium agent and a humectant to dry skin; (ii) rinsing the skin under a shower; (iii) further applying the composition; And (iv) additional rinsing. The method according to any one of claims 1 to 6, wherein the composition contains a humectant selected from glycerin, urea, butylene glycol, polyethylene glycol and derivatives thereof, or mixtures thereof. 8. The method of any one of claims 1 to 7, wherein the quaternary ammonium preparation is readily biodegradable. The method of any one of claims 1 to 8 comprising the following steps: (i) applying to the skin a composition comprising: (a) at least one quaternary ammonium compound; (b) wetting agents; And (ii) rinsing the skin; (iii) repeating steps (i) and (ii) within 48 hours. The method of any one of claims 1 to 9 comprising the following steps: (i) washing the skin using a composition containing a surfactant; (ii) rinsing the skin; (iii) applying to the wet skin a composition containing at least one quaternary ammonium agent and a humectant; (iv) rinsing the skin.