KR102633741B1 - Dressing material with excellent adhesion and absorption - Google Patents

Abstract

The disclosed content relates to a dressing material that has an excellent effect on wound recovery because it is easy to quickly absorb exudate generated from a wound and has excellent adhesion to the skin.
The disclosed content includes a base layer; An absorbent layer formed at the bottom of the base layer and including a first rubber absorber or an acrylic absorber; and an adhesive layer formed at the bottom of the absorbent layer and containing a second rubber absorbent or an acrylic absorbent. A dressing material having excellent adhesion and absorbency is presented as an example.

Description

Dressing material with excellent adhesion and absorption}

The disclosed content relates to a dressing material with excellent adhesion and absorbency.

Unless otherwise indicated herein, the matters described in this identification are not prior art to the claims of this application, and are not admitted to be prior art by being described in this identification.

The skin is a body organ that protects the human body from external stimuli, prevents moisture loss, regulates body temperature, and performs important life-protection functions such as preventing bacterial invasion. When the skin loses its function due to various traumas, it suffers from various damage due to moisture loss, etc. It causes side effects and external bacterial infections, making it difficult to treat the affected area, or causes additional side effects such as secondary dysfunction, which in severe cases can even affect life extension. Therefore, in order to quickly heal wounds occurring on the skin and minimize secondary side effects, wound healing using dressings must be performed.

Conventionally, a gauze method in a dry environment was used as a wound healing method, but currently, a dressing method in a wet environment is in the spotlight. The ideal requirements for a dressing for healing such wounds include maintaining a moist environment, preventing infection, protecting, moisture permeability, visibility, non-irritating, and ease of use.

There is a need for research into an adhesive composition that satisfies the ideal requirements of a dressing material for wound healing, has high exudate absorption, and has excellent skin fixation.

Patent Document 1: Korean Patent Publication No. 10-2014-0089412 Patent Document 2: Korean Patent Registration No. 10-2152455

The disclosed invention seeks to provide a dressing material with excellent adhesion and absorbency that is capable of rapid absorption of exudate generated from a wound and has excellent adhesion to the skin, thereby providing an excellent effect on wound recovery.

Additionally, it is not limited to the technical challenges described above, and it is obvious that other technical challenges may be derived from the description below.

The disclosed content includes a base layer; An absorbent layer formed at the bottom of the base layer and including a first rubber absorber or an acrylic absorber; and an adhesive layer formed at the bottom of the absorbent layer and containing a second rubber absorbent or an acrylic absorbent. A dressing material having excellent adhesion and absorbency is presented as an example.

According to the features of the disclosed content, the first rubber absorbent or the second rubber absorbent may include rubber and sodium croscarmellose.

In addition, the sodium croscarmellose contained in the first rubber absorbent may be 30 to 40% by weight, and the sodium croscarmellose contained in the second rubber absorbent may be 15 to 25% by weight.

Additionally, the acrylic absorbent may include a water-soluble acrylic resin, sodium croscarmellose, a curing agent, and a solvent, and the sodium croscarmellose contained in the acrylic absorbent may be 25 to 35% by weight.

In addition, the absorbent layer may further include a functional ingredient selected from the group consisting of borneol, limonene, Asian pennywort herb, tea tree oil, menthol, lavender oil, and mixtures thereof.

Additionally, the water-soluble acrylic resin may include 40 parts by weight of n-butylacrylate, 30 to 50 parts by weight of 2-ethylhexyl acrylate, and 5 to 80 parts by weight of 2-hydroxyethyl acrylate.

Additionally, the water-soluble acrylic resin may include 80 parts by weight of n-butylacrylate and 5 to 80 parts by weight of 2-hydroxyethyl acrylate.

Additionally, the water-soluble acrylic resin may have a weight average molecular weight of 600,000 to 800,000 g/mol.

According to the dressing material according to an embodiment of the disclosed content, it has the advantage of being able to quickly absorb exudate generated from a wound and having excellent adhesion to the skin, thereby having an excellent effect on wound recovery.

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description of the claims.

Figure 1 is a schematic diagram showing a dressing material with excellent adhesion and absorbency according to an embodiment of the content disclosed in the present specification.

Hereinafter, the configuration and effects of preferred embodiments of the disclosed content will be examined with reference to the attached drawings. For reference, in the drawings below, each component is omitted or schematically shown for convenience and clarity, and the size of each component does not reflect the actual size. In addition, the same reference numerals refer to the same components throughout the specification, and reference numerals for the same components in individual drawings will be omitted.

The dressing material with excellent adhesion and absorbency disclosed herein includes a base layer (10); An absorbent layer 20 formed at the bottom of the base layer and including a first rubber absorber or an acrylic absorber; and an adhesive layer 30 formed at the bottom of the absorbent layer and including a second rubber absorbent or an acrylic absorbent. The dressing material contains sodium croscarmellose in the absorbent layer and the adhesive layer, so it has excellent adhesion to the wound area and excellent absorption of exudate.

Hereinafter, the components included in the dressing material will be described in more detail.

(1) Base layer (10)

The base layer 10 is used as a support matrix for the dressing material. The base layer 10 includes a paper-based base material such as paper; Fibrous base materials such as cloth, non-woven fabric, and net; Metal base materials such as metal foil and metal plate; Plastic base materials such as plastic films and sheets; Rubber-based substrates such as rubber sheets; Appropriate thin materials such as foams such as foam sheets and laminates thereof (in particular, laminates of plastic base materials and other substrates, laminates of plastic films (or sheets), etc.) can be used.

Preferably, a plastic base material such as a plastic film or sheet can be used. Materials for such plastic films and sheets include, for example, polyethylene (PE), polypropylene (PP), ethylene-propylene copolymer, ethylene-vinyl acetate copolymer (EVA), polyurethane (PU), and polyethylene terephthalate ( PET), polyethylene naphthalate (PEN), polybutylene terephthalate (PBT), polyvinyl chloride (PVC); Polyphenylene sulfide (PPS), polyamide (nylon), fully aromatic polyamide (aramid), polyether ether ketone (PEEK), etc. can be used. These materials can be used individually or in combination of two or more types. Polyurethane (PU) is most preferable from the viewpoint of properties such as elastic elongation recovery rate.

The base layer 10 may further include a UV blocking agent to add a UV blocking function. The type of the sunscreen is not particularly limited, but may be composed of one or a mixture of a plurality of substances selected from arbutin, zinc oxide, and titanium oxide.

Additionally, the base layer 10 may further include additional materials to provide additional functions.

Hereinafter, the components included in the absorbent layer 20 and the adhesive layer 30 will be described in more detail.

(2) Rubber absorbent material

The rubber absorbent is a material that can be included in both the absorbent layer 20 and the adhesive layer 30, and may include rubber and sodium croscarmellose. The rubber absorbent included in the absorbent layer 20 is referred to as a first rubber absorbent, and the rubber absorbent included in the adhesive layer 30 is referred to as a second rubber absorbent. The composition contained in the first and second rubber absorbents is the same as rubber and sodium croscarmellose, but there is a difference in the proportion of the composition as described below.

The types of rubber are not particularly limited, and include natural rubber and various synthetic rubbers (e.g., polyisoprene rubber, polybutadiene rubber, polyisobutylene rubber, styrene/butadiene (SB) rubber, styrene/isoprene (SI) Rubber, styrene, isoprene, styrene block copolymer (SIS) rubber, styrene, butadiene, styrene block copolymer (SBS) rubber, styrene, ethylene, butylene, styrene block copolymer (SEBS) rubber, styrene, ethylene, propylene, Styrene block copolymer (SEPS) rubber, styrene·ethylene·propylene block copolymer (SEP) rubber, recycled rubber, butyl rubber or modified forms thereof, etc.]. Preferably polybutadiene or polyisobutylene can be used. The first rubber absorbent includes the rubber

The sodium croscarmellose sodium (Croscarmellose sodium) is a cross-linked polymer of sodium carboxymethyl cellulose and is an additive to promote absorption. It is preferable to use those produced by FMC Company, but it is not limited to this. By including the sodium croscarmellose in the rubber absorbent and the acrylic absorbent, it has the effect of effectively absorbing exudate generated from the wound.

Sodium croscarmellose included in the first rubber absorbent may be included in an amount of 30 to 40% by weight. If it is less than 30% by weight, the exudate absorption effect of the dressing material is low, and if it exceeds 40% by weight, it becomes difficult to secure the mechanical properties of the absorbent layer. Additionally, sodium croscarmellose included in the second rubber absorbent may be included in an amount of 15 to 25% by weight. If it is less than 15% by weight, the exudate absorption effect of the dressing material is low, and if it exceeds 25% by weight, the adhesion of the adhesive layer is low and it becomes difficult to secure mechanical properties.

(3) Acrylic absorbent material

The acrylic absorbent material disclosed herein includes a water-soluble acrylic resin, sodium croscarmellose, a curing agent, and a solvent.

The water-soluble acrylic resin is not particularly limited, but includes methyl acrylate, ethyl acrylate, n-propyl acrylate, isopropyl acrylate, n-butyl acrylate, t-butyl acrylate, sec-butyl acrylate, and pentyl acrylate. It may be one or more selected from the group consisting of acid, octyl acrylate, 2-ethylhexyl acrylate, 2-ethylbutyl acrylate, 2-hydroxyethyl acrylate, acrylic acid, and methacrylic acid. Preferably, it may be at least one selected from the group consisting of n-butylacrylate, 2-ethylhexyl acrylate, and 2-hydroxyethyl acrylate, and more preferably n-butylacrylate or 2-hydroxyethyl acrylate. There may be one or more selected from the rate.

The water-soluble acrylic resin may include 40 parts by weight of n-butylacrylate, 30 to 50 parts by weight of 2-ethylhexyl acrylate, and 5 to 80 parts by weight of 2-hydroxyethyl acrylate. Additionally, the water-soluble acrylic resin may include 80 parts by weight of n-butylacrylate and 5 to 80 parts by weight of 2-hydroxyethyl acrylate.

The water-soluble acrylic resin may have a weight average molecular weight of 600,000 to 800,000 g/mol, and the cohesion of the water-soluble acrylic resin can be sufficiently secured within the weight average molecular weight range.

The sodium croscarmellose is the same as that used in (2) rubber absorbent described above. However, in terms of proportion, the sodium croscarmellose contained in the acrylic absorbent may be 25 to 35% by weight. If it is less than 25% by weight, the exudate absorption effect of the dressing material is low, and if it exceeds 35% by weight, it becomes difficult to secure the mechanical properties of the absorbent layer and adhesive layer.

The type of curing agent is not particularly limited as it is an additive used to harden the water-soluble acrylic resin and provide mechanical strength such as hardness and elasticity and chemical stability. For example, in addition to isocyanate-based curing agents, epoxy-based curing agents, melamine-based curing agents, and peroxide-based crosslinking agents, urea-based curing agents, metal alkoxide-based curing agents, metal chelate-based curing agents, metal salt-based curing agents, carbodiimide-based curing agents, oxazoline-based curing agents, and ajiri. Examples include dine-based curing agents and amine-based curing agents, and isocyanate-based curing agents and epoxy-based curing agents can be preferably used. Examples of the isocyanate-based curing agent include lower aliphatic polyisocyanates such as 1,2-ethylene diisocyanate, 1,4-butylene diisocyanate, and 1,6-hexamethylene diisocyanate; Alicyclic polyisocyanates such as cyclopentylene diisocyanate, cyclohexylene diisocyanate, isophorone diisocyanate, hydrogenated tolylene diisocyanate, and hydrogenated xylene diisocyanate; and aromatic polyisocyanates such as 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, 4,4'-diphenylmethane diisocyanate, and xylylene diisocyanate. Examples of the epoxy-based curing agent include N,N,N', N'-tetraglycidyl-m-xylenediamine, diglycidylaniline, 1,3-bis(N,N-glycidylaminomethyl )Cyclohexane, 1,6-hexanediol diglycidyl ether, neopentyl glycol diglycidyl ether, ethylene glycol diglycidyl ether, propylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, poly Propylene glycol diglycidyl ether, sorbitol polyglycidyl ether, glycerol polyglycidyl ether, pentaerythritol polyglycidyl ether, polyglycerol polyglycidyl ether, sorbitan polyglycidyl ether, trimethylolpropane Polyglycidyl ether, adipic acid diglycidyl ester, o-phthalic acid diglycidyl ester, triglycidyl-tris(2-hydroxyethyl)isocyanurate, resorcinol diglycidyl ether, bisphenol In addition to -S-diglycidyl ether, epoxy resins having two or more epoxy groups in the molecule can be mentioned.

The solvent is not particularly limited as long as it is a component that serves to exhibit homogeneous physical properties, and may be at least one selected from water, ethanol, propanol, butanol, and acetone, and is preferably ethanol.

(4) Functional ingredients

The functional ingredient is an ingredient that provides wound healing, acne care and prevention, anti-itching, antibacterial properties, etc., but is not limited to this and is an ingredient that can be added to provide other functions. Additionally, the weight of the functional ingredient added to the absorbent layer may vary depending on the function.

The functional ingredient may be any one or more selected from the group consisting of borneol, limonene, Asian pennywort herb, tea tree oil, menthol, piperine, lavender oil, spike essential oil, and mixtures thereof. Preferably, it may be one or more selected from the group consisting of borneol, limonene, Asian pennywort herb, tea tree oil, menthol, lavender oil, and mixtures thereof.

The borneol, menthol, and lavender oil are preferably produced by SigmaAldrich, but are not limited thereto. The Asian pennywort herb and tea tree oil are preferably produced in Elgin, but are not limited thereto. It is preferable to use the limonene produced by Sinopharm, but it is not limited to this.

In addition to the functional ingredients, other additives such as moisture absorbents, antimicrobial agents, wound healing agents, etc. can be additionally added depending on the function to be given to the dressing material.

The present invention may be better understood by the following examples, which are for illustrative purposes only and are not intended to be limited or limited by the appended claims.

[Example 1]

In a mixer capable of applying heat, add 40 parts by weight of polybutadiene (RH9000, Kilupetrochemical), 40 parts by weight of polyisobutylene (Ophanol B-12 SFN, BASF), and 20 parts by weight of sodium croscarmellose (FMC). Add and mix at 80°C for 2 hours. The mixture is placed on the surface of a 50 micrometer-thick polyethylene terephthalate film release layer, and the same polyethylene terephthalate film with a 50 micrometer thickness is placed on the upper surface of the mixture so that the release layer surface is located on the mixture. Afterwards, it was placed in a press capable of heating and pressed at 70°C to prepare an adhesive layer with a thickness of 100 micrometers. The absorbent layer contains 35 parts by weight of polybutadiene (RH9000, Chylupetrochemical), 35 parts by weight of polyisobutylene (Ophanol B-12 SFN, BASF), and 30 parts by weight of sodium croscarmellose (FMC). It was prepared in the same manner as the adhesive layer above, except that it was manufactured in the same manner as above. Afterwards, the release film on one side of the manufactured absorbent layer was removed, a 20 micrometer polyurethane base layer was laminated at 50°C, the release film on the opposite side of the absorbent layer was removed, and the release film on one side of the adhesive layer was removed. Afterwards, the surfaces were facing each other and laminated at 50°C to prepare a dressing material.

[Example 2]

The composition ratio of the absorbent layer was changed to 30 parts by weight of polybutadiene (RH9000, Chylupetrochemical), 35 parts by weight of polyisobutylene (Ophanol B-12 SFN, BASF), and 35 parts by weight of sodium croscarmellose (FMC). A dressing material was prepared in the same manner as in Example 1 except that.

[Example 3]

The composition ratio of the absorbent layer was changed to 25 parts by weight of polybutadiene (RH9000, Chylupetrochemical), 35 parts by weight of polyisobutylene (Ophanol B-12 SFN, BASF), and 40 parts by weight of sodium croscarmellose (FMC). A dressing material was prepared in the same manner as in Example 1 except that.

[Example 4]

A dressing material was prepared in the same manner as in Example 1, except that 5 parts by weight of functional ingredients borneol (Sigma-Aldrich) and 0.5 parts by weight of limonene (Sinopharm) were added to the absorbent layer.

[Example 5]

A dressing material was prepared in the same manner as in Example 1 except that 5 parts by weight of Asian pennywort herb (Elgin), 2 parts by weight of tea tree oil (Elgin), and 1 part by weight of menthol (Sigma-Aldrich) were added to the absorbent layer. did.

[Example 6]

A dressing material was prepared in the same manner as in Example 1, except that the functional ingredients 2 parts by weight of lavender oil (Sigma-Aldrich), 2 parts by weight of tea tree oil (Elgin), and 1 part by weight of menthol (Sigma-Aldrich) were added to the absorbent layer. .

[Example 7]

Acrylic resin (made by polymerizing 40 parts by weight of n-butylacrylate, 40 parts by weight of 2-ethylhexyl acrylate, and 20 parts by weight of 2-hydroxyethyl acrylate, GPC weight average molecular weight is 700,000), 70 parts by weight, sodium cloth A mixture of 30 parts by weight of carmellose (FMC), 0.5 parts by weight of hardener (epoxy), and 100 parts by weight of solvent (ethanol) was coated to a thickness of 100 micrometers using the comma coating method and dried at 120°C to form an absorbent layer. A dressing material was prepared in the same manner as in Example 1 except for one thing.

[Example 8]

The resin of the adhesive layer was prepared in the same manner as Example 7, except that the same resin used in the absorbent layer of Example 7 was used.

[Example 9]

The acrylic resin of the absorbent layer and the adhesive layer is changed to the following acrylic resin (80 parts by weight of n-butylacrylate, 20 parts by weight of 2-hydroxyethyl acrylate, GPC weight average molecular weight is 700,000). A dressing material was prepared in the same manner as in Example 8 except that.

[Example 10]

A dressing material was prepared in the same manner as in Example 8, except that the same functional ingredients as in Example 6 were added to the absorbent layer.

[Comparative Example 1]

A dressing material was manufactured in the same manner as Example 1, except that the absorbent layer was not formed and the adhesive layer was manufactured to a thickness of 200 micrometers.

[Comparative Example 2]

A dressing material was manufactured in the same manner as Comparative Example 1, except that the absorbent layer was manufactured to a thickness of 100 micrometers and the adhesive layer was manufactured to a thickness of 100 micrometers.

[Comparative Example 3]

A dressing material was manufactured in the same manner as Comparative Example 1, except that the functional ingredient of Example 6 was added to the absorbent layer.

[Experimental Example 1] Absorption evaluation

Prepare a sample of the dressing material cut into sizes of 50 x 50 mm, measure the initial weight, and place it in a beaker. Afterwards, add distilled water equivalent to 40 times the weight of the sample and seal to prevent the distilled water from volatilizing. Then, the sample is left in an oven at 37±1°C for 24 hours, then the sample is recovered and its weight is measured.

Absorption (%) = (Initial weight after absorption) / Initial weight

[Experimental Example 2] Adhesion evaluation

A sample of the dressing material was prepared by cutting it into 25mm

[Experimental Example 3] Transfer rate evaluation

A sample was prepared by cutting the dressing material to a size of 100

item Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Absorption (%) 191 227 252 195 197 193 Adhesion (gf/25mm) 800 800 800 800 800 800 Transition rate (%) 0 0 0 0 0 0

item Example 7 Example 8 Example 9 Example 10 Comparative Example 1 Comparative Example 2 Comparative Example 3 Absorption (%) 197 203 199 207 154 236 121 Adhesion (gf/25mm) 800 1000 900 1000 800 600 200 Transition rate (%) 0 0 0 0 0 0 5

Looking at the experimental results according to Table 1 and Table 2, it was confirmed that the absorbency (%) of the dressing material increased as the weight ratio of sodium croscarmellose in the absorbent layer increased in Examples 1 to 3, and Examples 7 to 10 It was confirmed that the adhesive strength (gf/25mm) of the dressing material increased when the adhesive layer was manufactured with an acrylic absorbent material.

Although preferred embodiments of the present invention have been described above with reference to the accompanying drawings, the embodiments described in this specification and the configuration shown in the drawings are only one of the most preferred embodiments of the present invention and do not represent the entire technical idea of the present invention. Since this is not the case, it should be understood that there may be various equivalents and modifications that can replace them at the time of filing this application. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive, and the scope of the present invention is indicated by the claims described later rather than the detailed description, and the meaning and scope of the claims and their All changes or modified forms derived from the equivalent concept should be construed as falling within the scope of the present invention.

10: Base layer
20: absorption layer
30: Adhesive layer

Claims (9)

A base layer having a thickness of 20 ㎛ and composed of polyurethane,
An absorbent layer formed on the lower surface of the base layer,
It includes an adhesive layer formed on the lower surface of the absorbent layer,
The absorbent layer is composed of 30 parts by weight of polybutadiene, 35 parts by weight of polyisobutylene, and 35 parts by weight of sodium croscarmellose,
The adhesive layer has a thickness of 100 ㎛, and is composed of 40 parts by weight of polybutadiene, 40 parts by weight of polyisobutylene, and 20 parts by weight of sodium croscarmellose. A dressing material with excellent adhesion and absorbency. According to paragraph 1,
The absorbent layer is a dressing material with excellent adhesion and absorbency, further comprising at least one selected from the group consisting of borneol, limonene, Asian pennywort herb, tea tree oil, menthol lavender oil, and mixtures thereof. delete delete delete delete delete delete delete