KR102455793B1 - Shampoo composition for companion animal and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a shampoo composition for companion animals and a method for preparing the same. The shampoo composition for companion animals, according to the present invention, may comprise, with respect to 100 parts by weight of a shampoo composition, 40-50 parts by weight of purified water, 10-20 parts by weight of complex extract, 10-20 parts by weight of houttuynia cordata extract, 5-15 parts by weight of coco betaine, 5-20 parts by weight of glucoside, 1-5 parts by weight of lecithin, 1-5 parts by weight of saponin, etc. According to the present invention, skin irritation and inflammation of companion animals can be alleviated.

Description

Shampoo composition for companion animals and manufacturing method thereof

The present invention relates to a shampoo composition for companion animals and a method for preparing the same, and more particularly, to a shampoo composition for companion animals having an effect of alleviating skin irritation and relieving inflammation of companion animals, and a method for preparing the same.

In general, humans have slightly acidic skin with a pH of 4 to 6, but animals such as dogs have slightly alkaline skin with a pH of 7 to 7.5.

In addition, the epidermal layer of human skin consists of 10 to 15 layers, whereas animal skin is very thin with 3 to 5 layers. Because bacteria thrive in neutral and alkaline environments, it is for this reason that animals often suffer from skin diseases caused by bacterial growth.

Shampoo is used as a method to prevent skin diseases of companion animals.

Among the main ingredients of existing shampoos for companion animals, surfactants that clean sebum, wastes, and dust are Sodium Lauryl Sulfate (SLS, Sodium Lauryl Sulfate), Sodium Laureth Sulfate (SLES, Sodium Laureth Sulfate), and Ammonium Lauryl. Among petroleum-based surfactants such as sulfate (ALS, Ammonium Lauryl Sulfate), these chemically synthesized surfactants are highly toxic, so they may have the side effect of inducing protein denaturation in cells by melting the fat film of the skin, and in the long term, Accumulation can cause inflammation and allergic reactions.

In addition, unlike humans, the skin condition of companion animals, which is always in a dry state regardless of environmental factors, is very vulnerable to dry eczema and pruritus and is easily exposed to these diseases. They are exposed to the problem of a vicious cycle of disease.

Examples of such a technique are disclosed in Documents 1 to 2 below.

Patent Document 1 includes a surfactant, glycerin, vegetable oil, and saccharides, and when the detergent weight is 100 parts by weight, the surfactant is 30 to 50 parts by weight as a vegetable surfactant or amphoteric surfactant, and the glycerin is 10 to 20 parts by weight, 5 to 10 parts by weight of vegetable oil, and 5 to 13 parts by weight of saccharides including xanthan gum in an amount of more than 0 and 3 parts by weight or less is disclosed for a cleaning agent for pets.

Patent Document 2 discloses floral water, polyquater, glucamate, LES, apple surfactant, yucca extract, propolis extract, chamomile extract, panthenol, silk amino acid, germanium and essential oil for pets. is disclosed for

However, the conventional shampoo composition for companion animals as described above has a problem in that it cannot reliably prevent bacterial skin diseases that frequently occur in companion animals.

Republic of Korea Patent Publication No. 10-1534384 (2015.07.09. Announcement) Korean Patent Publication No. 10-2022-0032352 (published on March 15, 2022)

The present invention has been devised to solve the problems described above, and uses a shampoo composition for companion animals containing a mixture of a hibiscus extract and an eosinth extract as an active ingredient to relieve skin irritation and inflammation of companion animals, An object of the present invention is to provide a shampoo composition for companion animals capable of inhibiting or eradicating the growth of various microorganisms, pathogens, viruses, bacteria, and the like by using ethyllauroyl alginate, which is an antibacterial substance, and a method for manufacturing the same.

In addition, an object of the present invention is to provide a shampoo composition for companion animals capable of preventing bacterial propagation without chemical components and a method for preparing the same by additionally adding allspice when preparing the hibiscus extract to prepare a complex extract.

In order to achieve the above object, the shampoo composition for companion animals according to the present invention, based on 100 parts by weight of the shampoo composition, 40-50 parts by weight of purified water, 10-20 parts by weight of the complex extract, 10-20 parts by weight of the eosincho extract, and culantro Extract 0.5 to 1 parts by weight, ethyl lauroyl arginate 0.05 to 0.1 parts by weight, cocobetaine 5 to 15 parts by weight, glucoside 5 to 20 parts by weight, lecithin 1 ~5 parts by weight, saponin 1-5 parts by weight, sodium carbonate 0.5-1 parts by weight, 1, 3-propanediol 0.5-1 parts by weight, glycerin 0.5 ~1 part by weight, ε-polylysine (ε-polylysine) 0.5 to 1 parts by weight, and EDTA (ethylenediaminetetraacetic acid) 0.5 to 1 parts by weight, the complex extract is a mixture of hibiscus leaves and purified water, it is 80 ~ 100 ℃ After extraction for 2 to 6 hours at a temperature of 40 to 50°C, allspice is additionally added to the hibiscus extract prepared by filtration, extracted at 80-100°C for 2-4 hours, and cooled to 40-50°C. And characterized in that it is prepared by filtration.

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The manufacturing method of the shampoo for companion animals according to the present invention comprises the steps of mixing hibiscus leaves and purified water, extracting it at 80-100° C. for 2-6 hours, cooling it to 40-50° C., and filtering it to prepare a hibiscus extract ; preparing a complex extract by additionally adding allspice to the hibiscus extract, extracting it at 80-100° C. for 2-4 hours, cooling it to 40-50° C., and filtering; Mixing eoseongcho and purified water, extracting it at 80-100 ℃ for 2-6 hours, cooling to 40-50 ℃ and filtering to prepare a eoseongcho extract; preparing a coolant extract by adding a solvent 5 to 15 times the weight of the dried coolant and extracting it at 40 to 80° C. for 2 to 6 hours; And mixing the complex extract, eoseongcho extract, culantro extract and shampoo base; characterized in that it comprises a.

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In addition, the shampoo base is ethyl lauroyl arginate, cocobetaine, glucoside, lecithin, saponin, sodium carbonate, 1, 3- It is characterized in that at least one component selected from the group consisting of propanediol (1, 3-propanediol), glycerin, ε-polylysine, and ethylenediaminetetraacetic acid (EDTA).

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As described above, the shampoo composition for companion animals according to the present invention and a manufacturing method thereof have the effect of alleviating skin irritation and inflammation of companion animals while inhibiting or eradicating the growth of various microorganisms, pathogens, viruses, bacteria, and the like.

In addition, there is an effect of maintaining the preservation period of the composition for a long time by preventing bacterial propagation even without chemical components.

In addition, it excludes irritating chemical components and is made with natural extracts, so that it is harmless to companion animals even when ingested shampoo while washing companion animals.

Hereinafter, the most preferred embodiment of the present invention will be described in detail in order to be described in detail enough to allow those of ordinary skill in the art to easily carry out the present invention.

Companion animals are not limited to dogs or cats, and can be used comprehensively if they are animals that are vulnerable to skin irritation or have skin or hair that is easily dry.

The shampoo composition for companion animals of the present invention includes a mixture of a hibiscus extract and an extract of seaweed extract as an active ingredient. Here, the mixture is preferably a mixture of the hibiscus extract and the eosinthia extract in a weight ratio of 1-2:1-2.

Hibiscus is a dicotyledonous plant belonging to the genus Mallow and Mugunghwa. The leaves are alternate phyllotaxis, have petioles, are broad egg-shaped, have sharp tips, and have irregular sawtooths. The leaf surface is glossy and dark green. Flowers are broad funnel-shaped, hanging one at a time on the armpit of the upper part of the new branch, and have small flower branches. It blooms from summer to autumn, but blooms all year round when the temperature is moderate. In winter, due to the low temperature, flowering is stopped.

Hibiscus contains effective physiologically active substances in the human body, and it is known to be effective in excreting waste products quickly when drinking, and being effective in arteriosclerosis, anticancer component, enteritis, bronchitis, and the like.

The hibiscus extract is prepared by mixing hibiscus leaves and purified water, extracting it at 80-100° C. for 2-6 hours, cooling it to 40-50° C., and filtering.

It is preferable to add 10-20 parts by weight of the hibiscus extract, and when the content of the hibiscus extract is less than 10 parts by weight, the skin irritation and inflammation alleviation effect is insignificant, and when it exceeds 20 parts by weight, skin irritation is caused, etc. There is a problem with stability.

Meanwhile, in the present invention, allspice is additionally added to the hibiscus extract, extracted at 80-100° C. for 2-4 hours, cooled to 40-50° C., and filtered to use a composite extract. The manufacturing method and action thereof will be described in detail in the manufacturing method of shampoo for companion animals to be described later.

Eoseongcho is also called yakmomil, jungyak or tenyak. Eoseongcho is called eoseongcho because it contains various essential oils and gives off a unique smell like fishy smell. Eoseongcho, belonging to the family Trifolium, is a perennial herb that blooms in May-July, and is mainly grown along the coast. In Japan, it is distributed nationwide and is the most widely used as a folk herbal method. Eoseongcho contains a large amount of protein of 12.8% in leaves and stems, and minerals are 25 times higher than rice, 10 times higher than brown rice, and in particular, calcium, etc., is 20 times higher than rice. There are also many B vitamins, which are rare in plants. Eoseongcho is known to be effective against gonorrhea, enteritis, urinary tract infections, pneumonia, and bronchitis.

Eoseongcho extract is prepared by mixing eoseongcho and purified water, extracting it at 80~100℃ for 2~6 hours, cooling it to 40~50℃ and filtering.

It is preferable to add 10 to 20 parts by weight of the eosincho extract content, and when the content of the hibiscus extract is less than 10 parts by weight, the skin irritation and inflammation alleviation effect is insignificant, and when it exceeds 20 parts by weight, skin irritation is caused, etc. There is a problem with stability.

On the other hand, the shampoo composition for companion animals according to the present invention may additionally add a culantro extract and a graviola extract along with the above-mentioned hibiscus extract and eosengcho extract.

The culantro is a plant belonging to the buttercup family, and its leaves are used as spices. The country of origin is used in Latin America such as Puerto Rico and Asian countries such as the West Indies, Thailand and Vietnam. In some Latin American countries, it has been used as a medicinal plant since ancient times for stopping convulsions and seizures, and among them, in Jamaica, it was used to treat colds, flu, and digestive symptoms. On the other hand, the elongated green leaves of culantro grow from the root like lettuce, and the maximum length is about 30cm and the width is about 5cm. The edges of the leaves are serrated and have fine yellow hairs.

When the plant is fully matured, green flowers with thick stems bloom. In this state, the scent of the leaves fades and the leaves themselves become rough, so the leaves are harvested before flowers appear.

Coolantro contains vitamins A, B, and C, which protect eyesight, improve night blindness, relieve fatigue, improve immunity, and beautify skin. It also contains calcium and iron, which helps prevent osteoporosis and alleviate anemia.

The culantro extract can be extracted using a conventional solvent under conditions of constant temperature and pressure. The extraction solvent is preferably water, ethanol, or a mixture thereof. As the extraction method, hot water extraction, immersion extraction, reflux cooling extraction, ultrasonic extraction, and the like can be used.

The extraction solvent is preferably extracted by adding 5 to 15 times the weight of the dried coolant, and the extraction temperature is preferably 40 to 80°C. In addition, the extraction time is preferably 2 to 6 hours.

The content of the culantro extract is preferably 0.5 to 1 part by weight, and when the content of the culantro extract is less than 0.5 parts by weight, the skin improvement effect is insignificant, and when it exceeds 1 part by weight, there is a problem in that a pungent smell is generated.

Graviola is a tree fruit native mainly to humid and hot lowlands, originally native to Central America and the Caribbean, but is now widely grown in tropical and subtropical climates. In particular, the leaves of graviola have been used to treat malaria using the extract, and when applied to the wound with the extract of the leaf, it has the effect of healing the wound and reducing inflammation. In addition, it is known that it helps to improve immunity because it contains a pyhtochemical component. On the other hand, acetogenin contained in graviola is known to be effective in lung cancer, breast cancer, pancreatic cancer, colorectal cancer or liver cancer, etc. due to its excellent anticancer effect.

The graviola extract is extracted by mixing purified water and graviola leaves, and heating it at 100~120°C. The graviola extract preferably uses water, ethanol, or a mixture thereof as an extraction solvent. In addition, the extract used in the present invention includes not only the extract by the above-described extraction solvent, but also an extract that has undergone a conventional purification process.

It is preferable to add 1 to 2 parts by weight of the graviola extract, and when the content of the graviola extract is less than 1 part by weight, the skin improvement and antibacterial effect is insignificant, and when it exceeds 2 parts by weight, mixing with other components is difficult. There is an impediment problem.

On the other hand, the shampoo composition for companion animals according to the present invention further comprises a shampoo base in addition to active ingredients such as hibiscus extract and Eoseongcho extract.

The shampoo base used in the present invention is a mixture of basic materials used to prepare shampoo, and refers to a composition comprising an antibacterial agent, a surfactant, an auxiliary additive, a moisturizing agent, a preservative, a stabilizer, etc., 100 parts by weight of the shampoo composition With respect to, ethyl lauroyl arginate 0.05 to 0.1 parts by weight, cocobetaine 5 to 15 parts by weight, glucoside 5 to 20 parts by weight, lecithin 1 to 5 parts by weight , 1-5 parts by weight of saponin, 0.5-1 parts by weight of sodium carbonate, 0.5-1 parts by weight of 1, 3-propanediol (1, 3-propanediol) 0.5-1 parts by weight of glycerin , ε-polylysine (ε-polylysine) 0.5 to 1 parts by weight and EDTA (ethylenediaminetetraacetic acid) 0.5 to 1 parts by weight is preferred.

The ethyl lauroyl arginate (ethyl lauroyl arginate) is an antibacterial agent, and is a broad-spectrum antibacterial material consisting of a condensation reaction of an amino acid, arginine, a fatty acid, lauric acid, and ethanol. It is registered as a food sterilizing preservative and cosmetic sterilizing preservative, and has high biodegradability that is rapidly decomposed into arginine, lauric acid and ethanol when ingested or absorbed. Inhibits or eradicates the growth of microorganisms, pathogens, viruses, bacteria, etc.

Preferably, the content of ethyl lauroyl alginate is added in an amount of 0.05 to 0.1 parts by weight, and when the content of ethyl lauroyl alginate is less than 0.05 parts by weight, the effect of inhibiting microbial growth is insignificant, and when it exceeds 0.1 parts by weight, it is a high price. As a result, there is a problem in that economic efficiency is lowered.

In particular, the ethyl lauroyl alginate is an amino acid-based antibacterial substance and its performance deteriorates when mixed with anionic surfactants, so the main surfactants used are as follows.

The cocobetaine (cocobetaine) is a cationic surfactant, a naturally-derived surfactant made by synthesizing coconut oil, has an antibacterial effect because it has cationic property, and has an antistatic effect and thus has an excellent conditioning effect.

The glucoside is a non-ionic surfactant, which helps in cleaning and thickening without irritation.

The lecithin (lecithin) is a nonionic surfactant, which facilitates the cleansing action and absorption of nutrients.

The saponin relieves skin irritation and serves to impart moisturizing power to the skin.

The sodium carbonate is a sodium salt of carbonic acid, usually called soda or sodium carbonate, and has a function of adsorbing contaminants.

The 1, 3-propanediol (1, 3-propanediol) is colorless, viscous, and miscible with water. It improves skin moisturizing power, and especially when mixed with glycerin in a 1:1 weight ratio, viscosity occurs and acts as a natural preservative, such as having an antibacterial effect.

The glycerin (glycerin) is a moisturizer, preventing the skin from drying out, making the skin soft and moist.

The ε-polylysine (ε-polylysine) is a preservative for inhibiting microorganisms, and 25 to 35 strong basic amino acids (L-Lysine) generated by streptomyces albulus are combined. Polylysine, which is charged with a cation, has an antibacterial effect that inhibits the growth of microorganisms by ionically binding to the cell membrane of a microorganism having an anion charge, thereby inhibiting the growth of microorganisms.

The EDTA (ethylenediaminetetraacetic acid) is a stabilizer, and serves to prevent discoloration, corrosion, decay, rancidity, bacterial infection, and deposits. When combined with metallic ions such as iron or copper, the metallic ions are inactivated and absorbed into the skin. make sure it doesn't happen

In addition, the shampoo base used in the present invention may include a thickener in order to increase the viscosity of the shampoo, and the thickener may be Xanthan Gum, hydroxypropyl methylcellulose, and the like.

On the other hand, Figure 1 is a method for producing a shampoo for companion animals according to the present invention includes a hibiscus extract preparation step, Eoseongcho extract production step and mixing step.

The step of preparing the hibiscus extract is a step of preparing a hibiscus extract by mixing and extracting hibiscus leaves and purified water, cooling it, and filtering it.

Specifically, in the hibiscus extract preparation step, hibiscus leaves are mixed with purified water 6 times the weight by weight, extracted at 80-100° C. for 2-6 hours, cooled to 40-50° C., and filtered to prepare a hibiscus extract do. In particular, the active ingredient of the hibiscus leaf is eluted in a large amount by slowly cooling the extract.

Meanwhile, the present invention may further include adding allspice to the hibiscus extract, extracting it at 80-100° C. for 2-4 hours, cooling it to 40-50° C., and filtering to prepare a complex extract. have.

The allspice is a kind of spice, and the production area is Jamaica, Mexico, Antiier Island and South America. It is a fruit the size of a red bean and is known to have a fragrance mixed with cinnamon and cloves, and it is used for spicy or sweet dishes and liqueurs. Used to add flavor to varieties.

The All Spice is a dried fruit, mixed with a hibiscus extract in a weight ratio of 1:0.1, and extracted by heating. The complex extract prepared in this way acts as a natural preservative and prevents bacterial propagation without chemical components, thereby maintaining the preservation period of the composition for a long time.

The eoseongcho extract preparation step is a step of preparing eoseongcho extract by mixing and extracting eoseongcho and purified water, cooling it and filtering it.

Specifically, in the step of preparing the eoseongcho extract, eoseongcho and purified water are mixed, extracted at 80-100 ℃ for 2-6 hours, cooled to 40-50 ℃ and filtered to prepare eoseongcho extract.

On the other hand, prior to preparing the eoseongcho extract, it is preferable to go through a step of washing the eoseongcho. Eoseongcho should be cleaned thoroughly because the root itself has a lot of soil and bacteria, etc. are present.

That is, the antibacterial and deodorizing performance of eoseongcho is greatly improved by adding brewing vinegar, which is a natural antibacterial material, to the water used to wash eoseongcho.

The brewing vinegar is obtained by fermenting grains and fruits such as rice with yeast or acetic acid bacteria, and inhibits the growth of various bacteria. Here, water and brewing vinegar are mixed in a weight ratio of 2:1 and used, and when the content of the brewing vinegar is insufficient, the antibacterial and deodorizing effect is deteriorated.

In the mixing step, the prepared hibiscus extract, eoseongcho extract and shampoo base are mixed to prepare a shampoo for companion animals.

Here, the shampoo base is ethyl lauroyl arginate, cocobetaine, glucoside, lecithin, saponin, sodium carbonate, 1, 3-propane Diol (1, 3-propanediol), glycerin (glycerin), ε- polylysine (ε-polylysine) and EDTA (ethylenediaminetetraacetic acid) contains one or more components selected from the group consisting of.

Hereinafter, the present invention will be described in more detail by way of Examples. However, the following examples are only illustrative of the present invention, and the content of the present invention is not limited to the following examples.

[Example 1]

50 parts by weight of purified water, 20 parts by weight of hibiscus extract, 0.1 parts by weight of ethyl lauroyl arginate, 10 parts by weight of cocobetaine, 15 parts by weight of glucoside, 3 parts by weight of lecithin , 3 parts by weight of saponin, 1 part by weight of sodium carbonate, 1 part by weight of 1,3-propanediol (1, 3-propanediol) 1 part by weight, 1 part by weight of glycerin, ε-polylysine (ε-) 1 part by weight of polylysine) and 1 part by weight of EDTA (ethylenediaminetetraacetic acid) were mixed and stirred to prepare a shampoo for companion animals.

[Example 2]

50 parts by weight of purified water, 20 parts by weight of eosincho extract, 0.1 parts by weight of ethyl lauroyl arginate, 10 parts by weight of cocobetaine, 15 parts by weight of glucoside, 3 parts by weight of lecithin , 3 parts by weight of saponin, 1 part by weight of sodium carbonate, 1 part by weight of 1,3-propanediol (1, 3-propanediol) 1 part by weight, 1 part by weight of glycerin, ε-polylysine (ε-) 1 part by weight of polylysine) and 1 part by weight of EDTA (ethylenediaminetetraacetic acid) were mixed and stirred to prepare a shampoo for companion animals.

[Example 3]

50 parts by weight of purified water, 20 parts by weight of hibiscus extract, 20 parts by weight of eosincho extract, 0.1 parts by weight of ethyl lauroyl arginate, 10 parts by weight of cocobetaine, 15 parts by weight of glucoside, lecithin (lecithin) 3 parts by weight, saponin 3 parts by weight, sodium carbonate 1 part by weight, 1, 3-propanediol 1 part by weight, glycerin 1 part by weight, ε -Polylysine (ε-polylysine) 1 part by weight and EDTA (ethylenediaminetetraacetic acid) 1 part by weight were mixed and stirred to prepare a shampoo for companion animals.

[Example 4]

50 parts by weight of purified water, 20 parts by weight of a complex extract prepared by additionally adding allspice to the hibiscus extract, 20 parts by weight of eosincho extract, 0.1 parts by weight of ethyl lauroyl arginate, 10 parts by weight of cocobetaine parts by weight, glucoside 15 parts by weight, lecithin 3 parts by weight, saponin 3 parts by weight, sodium carbonate 1 part by weight, 1, 3-propanediol (1, 3-propanediol) 1 A shampoo for companion animals was prepared by mixing parts by weight, 1 part by weight of glycerin, 1 part by weight of ε-polylysine, and 1 part by weight of EDTA (ethylenediaminetetraacetic acid) and stirring.

[Comparative Example 1]

In Example 3, a shampoo for companion animals was prepared in the same manner except that the hibiscus extract and the eoseongcho extract were not used.

[Comparative Example 2]

"Noirment Premium Pet Shampoo" manufactured by "Dongbang Cosmetics" and sold on the market by "Kukje Pharm" was purchased and prepared.

[Experimental Example 1] Skin irritation relief and inflammation relief effect

After selecting 20 dogs suffering from skin diseases, the shampoo for companion animals prepared in Examples and Comparative Example 1 and the pet shampoo prepared in Comparative Example 2 were shampooed by the dog owner for 2 months to relieve skin irritation and inflammation was tested. In particular, prior to conducting the experiment, information on whether the selected dogs caused ① itchiness and ② skin inflammation in the process of using the existing product was investigated in advance.

The evaluation criteria for skin irritation alleviation, inflammation relief, and acceptance were evaluated by applying a 9-point scale method.

skin irritation relief relieve inflammation symbol Example 1 7.1 6.8 7.0 Example 2 7.1 6.7 6.9 Example 3 7.5 7.1 7.2 Example 4 7.6 7.2 7.3 Comparative Example 1 6.4 5.2 5.6 Comparative Example 2 7.0 6.6 6.8

As can be seen from Table 1, it was confirmed that Examples 1 to 4 were relatively superior in all items of skin irritation and inflammation compared to Comparative Examples 1 and 2.

In particular, Examples 3 and 4 using both the hibiscus extract and the eoseongcho extract were relatively excellent in evaluation compared to Example 1 and Example 2 not using the hibiscus extract.

In terms of overall preference, it was confirmed that Examples 1 to 4 were overall superior to those of Comparative Examples 1 and 2.

[Experimental Example 2] Skin inflammation relief test

Skin inflammation was induced by exposing the excrement of house dust mites to the skin of 1,2,3 beagle dogs (4-5 years old females), which are experimental animals. Thereafter, the composition prepared in Example 3 was sprayed twice a day at intervals of 6 hours on the inflammation site of Beagle Dog 1, purified water was sprayed on the inflammation site of Beagle Dog 2, and no action was taken on Beagle Dog 3 Did not do it.

For beagle dogs 1,2,3 induced by skin inflammation, the size of inflammation induced in the skin was measured over the 1st, 2nd, and 3rd days from the experimental day. As a result of the measurement, as shown in Table 2 below, in Beagle Dog 1, the inflammation of 6 mm was gradually reduced on the 1st day, and it was measured to be 3 mm on the 3rd day. In Beagle Dog 3 without treatment, 7 mm of inflammation was measured as 10 mm.

Therefore, it was confirmed that the size of inflammation in Beagle Dog 1 was reduced compared to that of Beagle Dog 2 and 3, and thus the composition of the present invention alleviated the size of inflammation induced in the skin of Beagle dog.

pro-inflammatory laboratory animal Inflammation size (mm)
mite excrement Day 1 Day 2 Day 3 beagle dog 1 6 5 3 beagle dog 2 7 8 9 beagle dog 3 7 9 10

Although the present invention has been mainly described with reference to the accompanying drawings, it will be apparent to those skilled in the art that various modifications can be made without departing from the scope of the present invention from these descriptions. Accordingly, the scope of the present invention should be construed by the appended claims including examples of many such modifications.

Claims (13)

Based on 100 parts by weight of the shampoo composition, 40-50 parts by weight of purified water, 10-20 parts by weight of the complex extract, 10-20 parts by weight of the eoseongcho extract, 0.5-1 part by weight of the culantro extract, ethyl lauroyl arginate 0.05-0.1 parts by weight, cocobetaine 5-15 parts by weight, glucoside 5-20 parts by weight, lecithin 1-5 parts by weight, saponin 1-5 parts by weight, sodium carbonate ( sodium carbonate) 0.5-1 parts by weight, 1, 3-propanediol (1, 3-propanediol) 0.5-1 parts by weight, glycerin 0.5-1 parts by weight, ε-polylysine 0.5-1 It contains 0.5 to 1 part by weight and EDTA (ethylenediaminetetraacetic acid),
The complex extract is obtained by mixing hibiscus leaves and purified water, extracting it at 80-100° C. for 2-6 hours, cooling it to 40-50° C., and adding allspice to the hibiscus extract prepared by filtration, and 80- A shampoo composition for companion animals, characterized in that it is extracted at 100°C for 2-4 hours, cooled to 40-50°C, and filtered.
delete delete delete delete delete delete delete delete Preparing a hibiscus extract by mixing hibiscus leaves and purified water, extracting it at 80-100° C. for 2-6 hours, cooling it to 40-50° C., and filtering;
preparing a complex extract by additionally adding allspice to the hibiscus extract, extracting it at 80-100° C. for 2-4 hours, cooling it to 40-50° C., and filtering;
Mixing eoseongcho and purified water, extracting it at 80-100 ℃ for 2-6 hours, cooling to 40-50 ℃ and filtering to prepare a eoseongcho extract;
preparing a coolant extract by adding a solvent 5 to 15 times the weight of the dried coolant and extracting it at 40 to 80° C. for 2 to 6 hours; and
A method of producing a shampoo for companion animals, comprising: mixing the complex extract, the eosinth extract, the culantro extract and the shampoo base.
delete 11. The method of claim 10,
The shampoo base is ethyl lauroyl arginate, cocobetaine, glucoside, lecithin, saponin, sodium carbonate, 1, 3-propanediol (1, 3-propanediol), glycerin (glycerin), ε- polylysine (ε-polylysine) and EDTA (ethylenediaminetetraacetic acid) A method for producing a shampoo for companion animals, characterized in that at least one component selected from the group consisting of.
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