KR102430389B1 - Hydrogen-carbon dual cylinder rail shape MRI coil for small animal - Google Patents

Abstract

In the equipment for acquiring Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), which is an aspect of the present invention, carbon ( ¹³ C) MRI and MRS of an object disposed inside the equipment an internal structure to obtain; and an external structure for obtaining the proton ( ¹ H) MRI and MRS of the object, wherein the internal structure can be inserted, and the carbon ( ¹³ C) MRI and MRS are obtained inside the inner structure It further includes at least one first coil for doing, and at least one second coil for acquiring the proton ( ¹ H) MRI and MRS on the outside of the external structure, wherein the internal structure is the external structure It may be inserted into and in a state in which the internal structure and the external structure are combined, carbon ( ¹³ C) and proton ( ¹ H) MRI and MRS of the object may be sequentially obtained.

Description

Multi-nuclide (hydrogen-carbon) fusion cylinder-rail shape MRI coil for small animals {Hydrogen-carbon dual cylinder rail shape MRI coil for small animal}

The present invention sequentially acquires proton ( ¹ H) MRI/MRS and carbon ( ¹³ C) MRI/MRS as one coil fused through a rail, without replacing the coil and moving the animal compared to the existing single nuclide coil. It relates to a device and method that can acquire proton-based excellent anatomical properties and carbon-based molecular biological properties in one fusion image.

Magnetic Resonance Imaging (MRI) is a representative imaging technique that can measure the brain function of the human body. It is used in various ways along with spectroscopy (MRS, Magnetic Resonance Spectroscopy).

Magnetic resonance imaging is one of the medical imaging technologies that uses the principle of nuclear magnetic resonance. That is, when a human body is placed in a magnetic resonance imaging device that generates a strong magnetic field and a high frequency is generated, the spins of hydrogen atomic nuclei aligned in the direction of the main magnetic field are resonated. By reconstructing and imaging through a computer, a magnetic resonance image can be created.

Unlike X-ray computed tomography (CT), which uses X-rays, which is harmful to the human body, magnetic resonance imaging is harmless to the body. have.

Nuclear Magnetic Resonance Spectroscopy or magnetic resonance spectroscopy uses the interaction of the spin of specific (1H, 13C, 23Na, 31P) atomic nuclei with the main magnetic field and high frequency to determine the state of biomolecules and metabolites composed of the atoms, etc. way to investigate.

In the magnetic resonance spectroscopy method, in particular, the hydrogen atom ( ¹ H), which is abundantly present in the human body and has high sensitivity, is widely used in the medical field.

Proton ( ¹ H) magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques are imaging of functional and metabolic pathophysiological characteristics that serve as biomarkers of various diseases as well as anatomical structures of the human body. And due to the characteristics that can be quantitatively evaluated, the importance of early diagnosis of various diseases, observation of conditions, and evaluation of drug efficacy has emerged.

In particular, the carbon ( ¹³ C) magnetic resonance/spectroscopy technique labels ¹³ C, an isotope, on a metabolite that exhibits disease-specific pathophysiological metabolic changes, and its effectiveness in diagnosing specific diseases and evaluating drug efficacy at the molecular biology level. and effectiveness were highlighted.

However, in addition to the method of obtaining ( ¹ H) MRI/MRS and ( ¹³ C) MRI/MRS through separate procedures, the method of obtaining MRI/MRS of two (proton-carbon) nuclides through a single process and device is It does not exist, so a solution is required.

Korean Intellectual Property Office Registration No. 10-1461099

The present invention sequentially acquires proton ( ¹ H) MRI/MRS and carbon ( ¹³ C) MRI/MRS as one coil fused through a rail, without replacing the coil and moving the animal compared to the existing single nuclide coil. An object of the present invention is to provide a user with a device and method that can acquire proton-based excellent anatomical properties and carbon-based molecular biological properties in one image.

Specifically, the present invention enables acquisition/fusion of multi-nuclide images at the same location without replacing the coil and moving the animal, so that the possibility of positional error and diagnostic error is low compared to the existing method, so reliability can be increased. In addition to multi-nuclide MRI/MRS as well as simple proton ( ¹ H) MRI/MRS, it is manufactured in a rail type that can be used efficiently and time-efficiently. has a purpose

On the other hand, the technical problems to be achieved in the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned are clearly to those of ordinary skill in the art to which the present invention belongs from the description below. can be understood

In the equipment for acquiring Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), which is an aspect of the present invention for achieving the above technical problem, internal structures for obtaining carbon ( ¹³ C) MRI and MRS; and an external structure for obtaining the proton ( ¹ H) MRI and MRS of the object, wherein the internal structure can be inserted, and the carbon ( ¹³ C) MRI and MRS are obtained inside the inner structure It further comprises at least one first coil for performing, and at least one second coil for acquiring the proton ( ¹ H) MRI and MRS on the outside of the external structure, wherein the internal structure is the external structure It may be inserted into and in a state in which the internal structure and the external structure are combined, carbon ( ¹³ C) and proton ( ¹ H) MRI and MRS of the object may be sequentially obtained.

In addition, the internal structure inserted into the external structure may be detachable, and in a state in which the internal structure is separated, the external structure may acquire only proton ( ¹ H) MRI and MRS for the object.

In addition, a fine rail is provided on the inside of the external structure along the long axis, and a rail coupling part having a protrusion structure insertable into the rail is further included on the outside of the internal structure, and by inserting the rail coupling part into the rail, the inside A structure and an external structure may be combined.

In addition, the rail coupling part is provided in a "T" shape, the "ㅣ" part of the "T" shape rail coupling part is inserted into the rail, and the "ㅡ" part of the "T" shape rail coupling part is The inner structure and the outer structure may be coupled to each other by being exposed to the outside of the rail.

In addition, the internal structure includes a groove formed in a specific region, the external structure includes a hole formed corresponding to the position of the groove, and in a state in which the internal structure and the external structure are combined, the hole passes through the hole It may further include; a screw inserted into the groove to support the coupling.

In addition, the inner structure and the outer structure may have a cylindrical shape, and the outer structure may have an inner diameter and a major axis length greater than that of the inner structure.

In addition, the internal structure may have an acrylic structure having an inner diameter of 50 mm, a thickness of 5 mm, and a major axis length of 140 mm, and the external structure may have an acrylic structure having an inner diameter of 60 mm, a thickness of 5 mm, and a major axis length of 100 mm.

In addition, the inner structure and the outer structure may have a cylindrical shape, the first coil and the second coil may be plural, and the first coil and the second coil may be vertically disposed so as not to overlap each other.

In addition, each of the first coil and the second coil is eight, the first coil is disposed inside the internal structure so as to be spaced apart at an angle of 45°, and the second coil vertically overlaps with the first coil. It may be disposed on the outside of the external structure so as not to be spaced apart at an angle of 45°.

In addition, the first coil and the second coil may be spaced apart from each other at an angle of 22.5° and may not vertically overlap each other.

On the other hand, another aspect of the present invention for achieving the above technical problem, carbon ( ¹³ C) an internal structure for obtaining magnetic resonance imaging (Magnetic Resonance Imaging, MRI) and magnetic resonance spectroscopy (MRS); and an external structure for obtaining the proton ( ¹ H) MRI and MRS of the object, wherein the internal structure can be inserted, and the carbon ( ¹³ C) MRI and MRS are obtained inside the inner structure Magnetic resonance imaging using equipment further comprising at least one ^first coil for A method for acquiring magnetic resonance spectroscopy, the method comprising: inserting the internal structure into the external structure so that the internal structure and the external structure are coupled; placing an object inside the equipment; and sequentially acquiring carbon ( ¹³ C) and proton ( ¹ H) MRI and MRS for the object.

In addition, the internal structure inserted into the external structure is detachable, the step of separating the internal structure from the external structure; and obtaining only proton ( ¹ H) MRI and MRS of the object through the external structure.

The present invention sequentially acquires proton ( ¹ H) MRI/MRS and carbon ( ¹³ C) MRI/MRS as one coil fused through a rail, without replacing the coil and moving the animal compared to the existing single nuclide coil. It is possible to provide users with equipment and methods that can acquire proton-based excellent anatomical properties and carbon-based molecular biological properties in one image.

Specifically, the present invention enables acquisition/fusion of multi-nuclide images at the same location without replacing the coil and moving the animal, so that the possibility of positional error and diagnostic error is low compared to the existing method, so reliability can be increased. It is possible to use it efficiently in time, and it is manufactured in the form of a rail, so it is expected that it will be possible to use it by separating the internal coil when acquiring simple proton ( ¹ H) MRI/MRS as well as multi-nuclide MRI/MRS.

After all, the multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals of the present invention is a bird cage coil for the purpose of obtaining proton ( ¹ H) MRI and a bird cage for obtaining carbon ( ¹³ C) MRI through the rail. When multinuclear MRI/MRS is acquired by fusion of coils, it is possible to effectively acquire image information of two nuclides sequentially at the same location.

In addition, the fusion coil structure of the present invention has the effect of maintaining the inner diameter of the coil sufficiently for the animal to position it because it is possible to fusion into one structure through the rail structure compared to the simply overlapping structure of the bird cage coils of two nuclides. .

In addition, in order to minimize the mutual disturbance of the two coils of the present invention, there is an effect of maintaining an optimized signal-to-noise ratio (SNR) by alternately disposing the copper pillars of the two bird cage coils.

In addition, the present invention arranges a bird cage coil for obtaining proton MRI having relatively good signal size and sensitivity on the outer surface of the acrylic structure, and placing a bird cage coil for obtaining carbon MRI with a relatively small signal size on the inner surface of the inner acrylic structure. It has the effect of acquiring an optimized fusion image by considering the signal difference inherent in the two nuclides.

Therefore, the multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals of the present invention can acquire proton-carbon MRI/MRS at the same location without changing the coil or moving the animal when acquiring multi-nuclide image information. It has the advantage that it is possible to effectively acquire high-precision multi-nuclide fusion images.

In addition, the present invention is expected to contribute to the increase of the diagnostic value of multi-nuclide MRI fusion images by precisely fusion of the excellent anatomical imaging characteristics of proton MRI and molecular biological imaging information of carbon MRI through a fusion coil without positional errors.

In addition, the present invention has the effect of making it possible to effectively use both the multi-nuclide and mononuclear MRI/MRS acquisitions according to the purpose, since the two bird cage coils can be separated through the rail.

On the other hand, the effects obtainable in the present invention are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those of ordinary skill in the art to which the present invention belongs from the description below. will be able

1A and 1B show a specific example of a plan view of a polynuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals in relation to the present invention.
2A and 2B show a specific example of a side view of a multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals in accordance with the present invention.
3 shows an example of a specific arrangement of a multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals according to the present invention.

Since the present invention can apply various transformations and can have various embodiments, specific embodiments are illustrated in the drawings and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, and should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention. In describing the present invention, if it is determined that a detailed description of a related known technology may obscure the gist of the present invention, the detailed description thereof will be omitted.

Terms such as first, second, etc. may be used to describe various elements, but the elements should not be limited by the terms. The above terms are used only for the purpose of distinguishing one component from another.

Nuclear Magnetic Resonance Spectroscopy or Magnetic Resonance Spectroscopy (MRS) uses the spin of specific (1H, 13C, 23Na, 31P) atomic nuclei to interact with the main magnetic field and high frequency in a living body composed of the atoms. It is a method to investigate the state of molecules and metabolites.

In the magnetic resonance spectroscopy (MRS) method, in particular, hydrogen atom ( ¹ H), which is abundantly present in the human body and has high sensitivity, is widely used in the medical field.

Proton ( ¹ H) magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques are imaging of functional and metabolic pathophysiological characteristics that serve as biomarkers of various diseases as well as anatomical structures of the human body. And due to the characteristics that can be quantitatively evaluated, the importance of early diagnosis of various diseases, observation of conditions, and evaluation of drug efficacy has emerged.

In particular, the carbon ( ¹³ C) magnetic resonance/spectroscopy technique labels ¹³ C, an isotope, on a metabolite that exhibits disease-specific pathophysiological metabolic changes, and its effectiveness in diagnosing specific diseases and evaluating drug efficacy at the molecular biology level. and effectiveness were highlighted.

However, in addition to the method of obtaining ( ¹ H) MRI/MRS and ( ¹³ C) MRI/MRS through separate procedures, the method of obtaining MRI/MRS of two (proton-carbon) nuclides through a single process and device is The problem was that it didn't exist.

Therefore, in the present invention, in order to solve this problem, proton ( ¹ H) MRI/MRS and carbon ( ¹³ C) MRI/MRS are sequentially acquired as a single coil fused through a rail, compared to a conventional single-nuclide coil. The purpose is to provide a user with a device and method that can acquire proton-based excellent anatomical properties and carbon-based molecular biological properties in one image without replacement or movement of the animal.

Specifically, the present invention enables acquisition/fusion of multi-nuclide images at the same location without replacing the coil and moving the animal, so that the possibility of positional error and diagnostic error is low compared to the existing method, so reliability can be increased. In addition to multi-nuclide MRI/MRS as well as simple proton ( ¹ H) MRI/MRS, it is manufactured in a rail type that can be used efficiently and time-efficiently. has a purpose

The present invention enables the acquisition of proton ( ¹ H) MRI/MRS and acquisition of carbon ( ¹³ C) MRI/MRS sequentially with one coil fused through a rail, so that the coil replacement and It has the advantage of being able to converge proton-based excellent anatomical characteristics and carbon-based molecular biological characteristics into one image without moving the animal's position.

In addition, since multi-nuclide images can be acquired/fused at the same location without coil replacement or movement of the animal, the possibility of positional error and diagnostic error is lower than that of the fusion image obtained with the existing single-nuclide coil, so reliability can be increased. , time-efficient use is possible.

In addition, since it is manufactured in the form of a rail, it is possible to utilize not only multi-nuclide MRI/MRS but also simple proton ( ¹ H) MRI/MRS by separating the internal coil, so it is expected to be applied in various ways.

For simplification of the specification, the polynuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals proposed by the present invention is referred to as a "fusion MRI coil".

1A and 1B show a specific example of a plan view of a polynuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals in relation to the present invention.

Referring to FIG. 1A , the fusion MRI coil proposed by the present invention includes an internal structure 10 for obtaining a carbon ( ¹³ C) MRI/MRS, an external structure 20 for obtaining a proton ( ¹ H) MRI/MRS, and an internal structure. It may include a component of the screw 30 for fixing the structure 10 and the external structure 20 .

Here, the internal structure 10 may be an internal acrylic structure having an inner diameter of 50 mm and a thickness of 5 mm and a major axis length of 140 mm to which a carbon ( ¹³ C) bird cage coil for MRI/MRS acquisition will be attached.

The internal structure 10 is formed to have a smaller inner diameter and a longer axis length than the external structure 20 , and is inserted into the external structure 20 to constitute a fusion MRI coil.

In addition, in order to obtain a carbon ( ¹³ C) MRI/MRS for a small animal inside in the inserted state with the external structure 20, a bird cage coil may be attached to the inside.

In addition, the internal structure 10 may include rail coupling portions 11a and 11b for coupling to the external structure 20 in correspondence with the fine rail structure along the long axis.

As shown in Figure 1a, the rail coupling portions (11a, 11b) are manufactured in a T-shaped shape, the lower end of the T-shaped structure is inserted into the fine rail structure along the long axis of the external structure 20, the upper end of the rail It can be inserted in a protruding state outside the structure.

Through this, the internal structure 10 may be inserted into or separated from the external structure 20 .

In addition, the internal structure 10 may additionally include a groove into which the screw 30 is inserted.

Next, the external structure 20 may be an external acrylic structure having an inner diameter of 60 mm and a thickness of 5 mm and a major axis length of 100 mm to which a bird cage coil for acquiring proton ( ¹ H) MRI/MRS will be attached.

The external structure 20 is formed to have a larger inner diameter and a longer axis length than the internal structure 10 , and the internal structure 10 is inserted into the external structure 20 to constitute a fusion MRI coil.

In addition, in the state in which the internal structure 10 is inserted into the external structure 20, the external structure 20 is attached to the outside of the bird cage coil to acquire proton ( ¹ H) MRI/MRS for the small animal inside. can be

In addition, the external structure 20 may include a fine rail structure along the long axis in order to couple with the rail coupling portions 11a and 11b of the internal structure 10 .

That is, as shown in FIG. 1A , the rail coupling portions 11a and 11b are manufactured in a T-shape, and the lower end of the T-shaped structure is inserted into the fine rail structure along the long axis of the external structure 20, and the upper end may be inserted in a protruding state to the outside of the rail structure.

In addition, the external structure 20 may additionally include an insertion groove or an insertion hole (hole) into which the screw 30 is inserted.

In addition, the screw 30 is implemented in the form of penetrating the internal structure 10 and the external structure 20 in order to fix the internal structure 10 and the external structure 20 so that there is no movement in the coupled state.

That is, a screw structure with an inner diameter of 5 mm passing through the two acrylic structures 10 and 20 and a screw are inserted and fixed.

Referring to FIG. 1B , the screw 30 penetrates the hole of the external structure 20 and is inserted into the groove of the internal structure 10 , so that the internal structure 10 and the external structure 20 are coupled to each other in a state in which they are coupled to each other. A specific structure for fixing it so that there is no movement is shown.

2A and 2B show a specific example of a side view of a polynuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals in relation to the present invention.

2A and 2B, the two cylindrical acrylic structures 10 and 20 are formed to be accurately coupled without a gap through the rail structure to the external acrylic structure 20 and the internal acrylic structure 10 by different sizes. .

Here, the outer acrylic structure 20 has an inner diameter of 60 mm, a thickness of 5 mm, and a major axis length of 100 mm, and the inner acrylic structure 10 is produced with an inner diameter of 50 mm, a thickness of 5 mm, and a major axis length of 140 mm, and is adjacent to the inner surface of the outer acrylic structure. Each rail structure is formed on the outer surface of the inner acrylic structure.

In addition, a bird cage-type coil for the purpose of acquiring proton ( ¹ H) MRI/MRS is attached to the outer surface of the external acrylic structure 20 .

The bird cage coil is composed of 8 copper pillars and 2 end rings, and is manufactured to correspond to the long axis length to sufficiently accommodate the field of view (FOV) of MRI equipment for animals. It can be implemented so that

A bird cage-type coil for the purpose of obtaining a carbon ( ¹³ C) MRI/MRS may be attached to the inner surface of the internal acrylic structure 10.

Here, the bird cage coil is composed of eight copper pillars and two end rings, and the long axis length is designed differently to avoid mutual interference with the proton bird cage coil at the end ring, so that the signal band caused by interference is The reduction in noise ratio can be minimized.

The inner/outer acrylic structures 10 and 20 according to the present invention may be implemented with an acrylic resin having a diameter of 50/60 mm, a thickness of 5/5 mm, and a major axis length of 140/100 mm.

Here, a rail structure may be designed on adjacent surfaces of the two acrylic structures 10 and 20 .

In addition, since the rail structure is made of an acrylic material, it may not show a magnetic field even in a strong magnetic field.

^In addition, a bird cage-type coil for acquiring protons ( ¹ H) with relatively high signal strength was located outside, so the effect of signal sensitivity attenuation according to distance was considered. For a structure that can minimize mutual interference with the bird cage-type coil, they can be rotated by 22.5° with respect to a concentric circle.

3 shows an example of a specific arrangement of a multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals according to the present invention.

Referring to FIG. 3 , eight coils 12a , 12b , 12c , 12d , 12e , 12f , 12g , and 12h are disposed in the internal acrylic structure 10 spaced apart by 22.5°.

In addition, eight coils 22a, 22b, 22c, 22d, 22e, 22f, 22g, 22h are disposed on the outer surface of the outer acrylic structure 20 as well, but the eight coils 12a, 12b of the inner acrylic structure 10 are disposed on the outer surface. , 12c, 12d, 12e, 12f, 12g, 12h) are spaced apart by 22.5° within a non-overlapping range to avoid mutual interference with each other.

In this way, mutual interference can be avoided, and a reduction in the signal-to-noise ratio due to the interference can be minimized.

In addition, the present invention can be implemented so that it can be effectively used for both multi-nuclide and single-nuclide MRI/MRS acquisition depending on the use since the two bird cage coils can be separated through a rail.

In addition, the present invention provides effective multi-nuclide fusion MRI/MRS acquisition by sequentially acquiring MRI/MRS without coil replacement and animal movement by fusing external/internal acrylic structures through rail structures when acquiring multi-nuclide fusion images. can be made to be possible.

When the configuration of the present invention described above is applied, by sequentially acquiring proton ( ¹ H) MRI/MRS and carbon ( ¹³ C) MRI/MRS as one coil fused through a rail, the coil compared to a conventional single-nuclide coil It is possible to provide users with equipment and methods that can acquire proton-based excellent anatomical properties and carbon-based molecular biological properties in a single image without replacement of the body and the movement of the animal.

Specifically, the present invention enables acquisition/fusion of multi-nuclide images at the same location without replacing the coil and moving the animal, so that the possibility of positional error and diagnostic error is low compared to the existing method, so reliability can be increased. It is possible to use it efficiently in time, and it is manufactured in the form of a rail, so it is expected that it will be possible to use it by separating the internal coil when acquiring simple proton ( ¹ H) MRI/MRS as well as multi-nuclide MRI/MRS.

After all, the multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals of the present invention is a bird cage coil for the purpose of obtaining proton ( ¹ H) MRI and a bird cage for obtaining carbon ( ¹³ C) MRI through the rail. When multinuclear MRI/MRS is acquired by fusion of coils, it is possible to effectively acquire image information of two nuclides sequentially at the same location.

In addition, the fusion coil structure of the present invention has the effect of maintaining the inner diameter of the coil sufficiently for the animal to position it because it is possible to fusion into one structure through the rail structure compared to the simply overlapping structure of the bird cage coils of two nuclides. .

In addition, in order to minimize the mutual disturbance of the two coils of the present invention, there is an effect of maintaining an optimized signal-to-noise ratio (SNR) by alternately disposing the copper pillars of the two bird cage coils.

In addition, the present invention arranges a bird cage coil for obtaining proton MRI having relatively good signal size and sensitivity on the outer surface of the acrylic structure, and placing a bird cage coil for obtaining carbon MRI with a relatively small signal size on the inner surface of the inner acrylic structure. It has the effect of acquiring an optimized fusion image by considering the signal difference inherent in the two nuclides.

Therefore, the multi-nuclide (hydrogen-carbon) fusion cylinder-rail type MRI coil for small animals of the present invention can acquire proton-carbon MRI/MRS at the same location without changing the coil or moving the animal when acquiring multi-nuclide image information. It has the advantage that it is possible to effectively acquire high-precision multi-nuclide fusion images.

In addition, the present invention is expected to contribute to the increase of the diagnostic value of multi-nuclide MRI fusion images by precisely fusion of the excellent anatomical imaging characteristics of proton MRI and molecular biological imaging information of carbon MRI through a fusion coil without positional errors.

In addition, the present invention has the effect of making it possible to effectively use both the multi-nuclide and mononuclear MRI/MRS acquisitions according to the purpose, since the two bird cage coils can be separated through the rail.

The detailed description of the preferred embodiments of the present invention disclosed as described above is provided to enable any person skilled in the art to make and practice the present invention. Although the above has been described with reference to preferred embodiments of the present invention, it will be understood by those skilled in the art that various modifications and changes can be made to the present invention without departing from the scope of the present invention. For example, those skilled in the art can use each configuration described in the above-described embodiments in a way in combination with each other. Accordingly, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

The present invention may be embodied in other specific forms without departing from the spirit and essential characteristics of the present invention. Accordingly, the above detailed description should not be construed as restrictive in all respects but as exemplary. The scope of the present invention should be determined by a reasonable interpretation of the appended claims, and all modifications within the equivalent scope of the present invention are included in the scope of the present invention. The present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. In addition, claims that are not explicitly cited in the claims may be combined to form an embodiment or may be included as a new claim by amendment after filing.

Claims (12)

In the equipment for acquiring magnetic resonance imaging (Magnetic Resonance Imaging, MRI) and magnetic resonance spectroscopy (MRS),
an internal structure for acquiring carbon ( ¹³ C) MRI and MRS of an object disposed inside the equipment; and
It is possible to insert the internal structure, and an external structure for obtaining the proton ( ¹ H) MRI and MRS of the object;
The inner structure further comprises at least one first coil for acquiring the carbon ( ¹³ C) MRI and MRS,
The outer side of the external structure further comprises at least one second coil for acquiring the proton ( ¹ H) MRI and MRS,
In a state in which the internal structure is inserted into the external structure and the internal structure and the external structure are combined, carbon ( ¹³ C) and proton ( ¹ H) MRI and MRS for the object can be sequentially obtained,

The internal structure inserted into the external structure is detachable,
In the state in which the internal structure is separated, the external structure can acquire only proton ( ¹ H) MRI and MRS for the object,

A fine rail is provided on the inside of the external structure along the long axis,
The outer side of the internal structure further includes a rail coupling part having a protrusion structure that can be inserted into the rail,
By inserting the rail coupling part into the rail, the internal structure and the external structure are coupled,

The internal structure includes a groove formed in a specific area,
The external structure includes a hole formed corresponding to the position of the groove,
In a state in which the internal structure and the external structure are coupled, the screw is inserted and coupled to the groove through the hole to support the coupling;

The inner structure and the outer structure are cylindrical,
The outer structure has a larger inner diameter and a major axis length than the inner structure,
The first coil and the second coil are plural,
The apparatus for acquiring magnetic resonance images and magnetic resonance spectroscopy, characterized in that the first coil and the second coil are vertically arranged so as not to overlap each other.
delete delete The method of claim 1,
The rail coupling portion is provided in a "T" shape,
The "ㅣ" part of the "T"-shaped rail coupling part is inserted into the rail,
Equipment for acquiring magnetic resonance imaging and magnetic resonance spectroscopy, characterized in that the "-" part of the "T"-shaped rail coupling part is exposed to the outside of the rail so that the internal structure and the external structure are coupled.
delete delete The method of claim 1,
The internal structure is an acrylic structure having an inner diameter of 50 mm, a thickness of 5 mm and a major axis length of 140 mm,
The external structure is an apparatus for acquiring magnetic resonance images and magnetic resonance spectroscopy, characterized in that the acrylic structure has an inner diameter of 60 mm, a thickness of 5 mm, and a major axis length of 100 mm.
delete The method of claim 1,
8 each of the first coil and the second coil,
The first coil is disposed on the inside of the internal structure so as to be spaced apart at an angle of 45 °,
The second coil is an apparatus for acquiring magnetic resonance imaging and magnetic resonance spectroscopy, characterized in that it is disposed on the outside of the external structure to be spaced apart at an angle of 45° so as not to vertically overlap with the first coil.
10. The method of claim 9,
The first coil and the second coil are spaced apart at an angle of 22.5° from each other and vertically overlapping each other. delete delete

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