KR102310234B1 - Health functional food composition for improving blood circulation, and the method for preparing the same - Google Patents

Abstract

The present invention relates to a health functional food composition for improving blood flow, and a method for manufacturing the same, and specifically, by significantly reducing triglyceride and LDL-cholesterol levels, including red ginseng extract, rice bran extract and safflower seed extract, thereby improving blood flow. It relates to a nutraceutical composition and a method for preparing the same.

Description

Health functional food composition for improving blood flow and method for preparing the same {Health functional food composition for improving blood circulation, and the method for preparing the same}

The present invention relates to a health functional food composition for improving blood flow, and a method for manufacturing the same, and specifically, by significantly reducing triglyceride and LDL-cholesterol levels, including red ginseng extract, rice bran extract and safflower seed extract, thereby improving blood flow. It relates to a nutraceutical composition and a method for preparing the same.

Recently, according to changes in the living environment such as westernization of diet, lack of exercise, and excessive stress, diseases that adversely affect blood circulation such as arteriosclerosis and cerebral infarction and diseases related to the blood or circulatory system, such as hyperlipidemia and diabetes, are increasing. Since these diseases cause a decrease in blood flow in microvessels or capillaries, the risk of adversely affecting the living body is pointed out. It has also been reported that blood flow is also related to skin itchiness, fatigue, high blood pressure, and the like.

In general, the circulation of blood, that is, blood circulates through the blood vessels around the heart, supplying oxygen to each body tissue, releasing carbon dioxide, supplying nutrients, and metabolites It is a process that regulates the functions of specific organs by transporting hormones from various endocrine glands, and performs other functions such as pathogen control, body temperature control, osmotic pressure control, and moisture control.

Blood circulation disorder refers to a condition in which blood vessels extending throughout the body lose elasticity and cholesterol, etc. are deposited on the inner wall, narrowing the lumen of blood vessels, preventing smooth blood circulation. Blood circulation disorders cause cold hands and feet, numbness of hands and feet, tight neck, stiff shoulders, memory loss, lethargy, weakened concentration, dizziness, and chronic fatigue, making it difficult to lead a normal life.

High blood pressure, arteriosclerosis, heart disease, stroke, etc., which are cardiovascular diseases caused by impaired blood circulation, are the main types of adult diseases today. Disease is the number one cause of death. This seems to be due to the tendency to increase the level of total cholesterol or triglycerides in the blood in adults as the frequency of intake of animal foods increases according to the westernized diet. It is known that an increase in the lipid component increases the viscosity of blood or interferes with the flow of blood, thereby causing cardiovascular diseases including stroke.

Looking at blood flow-related organs, plasma is composed of coagulation factors related to blood coagulation, and it exchanges various interactions with blood cells such as platelets, red blood cells, and immune cells, and maintains the equilibrium state of each cell action. have. Platelets are cells that are activated when blood vessels are damaged and are responsible for hemostasis by aggregating at the damaged site. Hemostasis can be said to be a defense mechanism to minimize blood loss from the damaged area and to maintain normal blood circulation. In normal blood vessels, homeostasis is maintained by balancing inhibitory reactions or clot decomposition reactions along with activation of the hemostatic mechanism. However, excessive hemostasis and the formation of clots obstruct blood flow and cause abnormal blood circulation, leading to lesions such as thrombus. When a thrombus is formed, blood circulation disorder is caused in the vein, which causes edema or inflammation, and causes ischemia or infarction in the artery, resulting in diseases such as myocardial infarction, stroke, and pulmonary infarction. In addition, various vascular control factors (serotonin, TXA2, PAF, etc.) are released upon activation of platelets to constrict blood vessels. When blood vessels constrict, blood flow is blocked and blood flow speed is changed, so platelet activation is amplified, and vascular endothelial damage progresses, impairing normal cardiovascular function. Such blood circulation abnormalities are known to cause the onset of vascular diseases such as arteriosclerosis, myocardial infarction, cardio ischemic disease and cerebrovascular disease (Marcus et al., 1993; Packham et al., 1994; Harker et al., 1994). ).

A number of drugs, foods, and food ingredients related to blood flow improvement have been developed and reported. However, since some functional foods have problems due to drug addiction and side effects, there is still a demand for substances that can effectively improve blood flow while being safe for the body because there are no side effects even when taken for a long time.

1. Korea Patent No. 10-1424335 (published on July 28, 2014) 2. Korean Patent No. 10-1145426 (Announced on May 15, 2012)

The present inventors have completed the present invention by discovering that when red ginseng extract, safflower seed extract and rice bran extract are mixed in a specific ratio, the synergistic action of these substances exhibits an excellent effect on improving blood flow in the human body.

Accordingly, it is an object of the present invention to provide a health functional food composition having excellent efficacy in alleviating diabetic symptoms and lowering blood pressure while effectively improving blood flow and a method for preparing the same.

In addition, another object of the present invention is to provide a method for producing the health functional food, which does not contain other additives other than the active ingredient while increasing the absorption capacity of the active ingredient in the body.

In order to achieve the above object, the present invention provides a health functional food composition for improving blood flow comprising a mixture of red ginseng extract, safflower seed extract and rice bran extract in a weight ratio of 1: 0.5-4: 0.5-2.

Also, the present invention

(1) mixing a mixture of extracts of red ginseng, safflower seeds and rice bran in a weight ratio of 1: 0.5-4: 0.5-2, and then concentrating it under reduced pressure to prepare a concentrate mixture;

(2) drying the concentrate mixture to obtain a powder;

(3) kneading the powder using alcohol;

(4) aging the dough;

(5) forming the aged dough into granules; and

(6) drying the molded granules

It provides a method for producing a health functional food composition for improving blood flow comprising a.

The health functional food composition of the present invention has no side effects on the body even when taken for a long period of time, so it is safe for the human body and has a very good blood flow improvement effect.

In addition, since the composition of the present invention is kneaded using alcohol, it is not necessary to contain other additives such as sterilizing agents and preservatives, so side effects caused by the inclusion of additives can be avoided, and a separate treatment such as high-temperature sterilization is unnecessary. , It disintegrates quickly after ingestion, so the absorption of the active ingredient is excellent.

The present invention relates to a health functional food composition for improving blood flow comprising a mixture of red ginseng extract, safflower seed extract and rice bran extract in a weight ratio of 1: 0.5 to 4: 0.5 to 2, preferably 1: 2: 1. will be.

In addition, the composition of the present invention may further include dextrin, in which case the mixing ratio of red ginseng extract, safflower seed extract and rice germ extract and dextrin is 1: 0.5-4: 0.5-2: 0.5-4 in weight ratio, preferably may be 1:2:1:2.

Red ginseng used in the present invention uses ginseng ( Panax ginseng CA Meyer) as a raw material, and steams or other methods to steam and dry undried fresh ginseng. It is known that there is a difference between red ginseng and white ginseng in the content of saponin or the type of ginsenoside. Red ginseng should be powdered or extracted with water or alcohol to be concentrated or fermented to make it suitable for consumption, but the sum of ginsenosides Rg1 and Rb1 should be controlled to be 0.8~34mg/g. Red ginseng or its powder and extract are foods that have been safely ingested for a long time, and serious toxicity has not been reported. Red ginseng has been recognized for its functionality by the Ministry of Food and Drug Safety as it helps blood flow by enhancing immunity, improving fatigue, and inhibiting platelet aggregation.

The safflower seed used in the present invention is a safflower plant in the Asteraceae family ( Carthamus). tinctorius L.), used for oil extraction, spice, and medicine. Safflower seeds contain linoleic acid, which helps to prevent arteriosclerosis and hyperlipidemia. Linoleic acid, one of the unsaturated fatty acids, inhibits the activity of lipoproteinlipase (LPL), which is involved in fat accumulation. When lipoprotein lipase activity is increased, adipocyte absorption of triglycerides is enhanced, and linoleic acid inhibits this. In addition, it is known that it can help reduce body fat by promoting energy generation of body fat and decomposing accumulated fat.

Rice germ used in the present invention is to be separated from rice bran obtained as a by-product when milling rice. Rice buds are rich in inositol (using a water-soluble vitamin B complex), thereby supplying nutrients to brain cells, helping to get a good night's sleep, treating depression and panic disorder, reducing sudden fear, It has been reported to have an effect of preventing dementia and resolving fatty liver. It also helps the body use fat and cholesterol, and has been reported to prevent arteriosclerosis and reduce belly fat. In addition, rice germ also contains a large amount of gamma oryzanol, which is a powerful antioxidant that has anti-cancer and anti-aging effects, helps recovery after exercise and reduces pain.

Obtaining the rice germ used in the present invention can be made using a process commonly used in the art, and the "heat treatment method of rice germ" disclosed in Korean Patent No. 10-0586707 (June 8, 2006 announcement) can also be made using, specifically, the method comprising the steps of:

(1) The first step of separating rice bran from rice bran through a vibrating sieve of 30-40 mesh for rice bran obtained by milling brown rice,

(2) a second step of preparing stabilized rice bran by inhibiting the activity of lipolytic enzyme by drying the rice bran separated in the first step for 5 to 20 minutes at 110 to 130° C. and cooling it;

(3) The third step of producing stabilized rice germ by inhibiting the activity of fatty acid oxidase by drying the remaining rice germ separated in the first step for 5 to 20 minutes at 140-160° C. and then cooling it; and

(4) A fourth step of obtaining at least one selected from the stabilized rice bran by inhibiting the activity of the lipolytic enzyme in the second step and the stabilized rice bran by inhibiting the activity of the fatty acid oxidase in the third step.

The composition according to the present invention includes a combination of red ginseng extract, safflower seed extract and rice bran extract in a weight ratio of 1: 0.5 to 4: 0.5 to 2, more preferably 1: 2: 1.

In addition, the composition according to the present invention may further include dextrin, wherein the red ginseng extract, safflower seed extract, rice bud extract and dextrin are in a weight ratio of 1: 0.5-4: 0.5-2: 0.5-4, preferably 1 It may be included in a weight ratio of :2:1:2.

In addition, the composition according to the present invention may further include other components known in the art to help improve blood flow in addition to the above components. Specifically, the composition according to the present invention may further include one or more extracts selected from the group consisting of Heotgae fruit, bean sprouts, leek and buckwheat in addition to the above components. In addition, these powders may be included in an amount of 10 to 100% by weight based on the total weight of the red ginseng extract, safflower seed extract and rice germ extract in the composition.

In the composition according to the present invention, the extract of red ginseng, safflower seed and rice germ may be obtained from a mixture of red ginseng, safflower seed and rice germ, and each extract of red ginseng, safflower seed and rice germ is prepared, and then these extracts are mixed. can also be used.

In the present invention, the production of red ginseng, safflower seed and rice germ extract may be made using a process generally used in the art, and is not limited to any specific process.

For example, the red ginseng, safflower seed and rice germ extract used in the present invention can be obtained by using water, ethanol, or a mixture of water and ethanol as an extraction solvent, preferably 50 to 90% (v/ v) Alcohol or water, more preferably 80% (v/v) alcohol or hot water may be used. More preferably, a mixture of extracts obtained by using 80% (v/v) alcohol and hot water from red ginseng, safflower seeds and rice germ, respectively, may be used in the preparation of the composition according to the present invention.

The health functional food composition according to the present invention may be formulated in the form of pills, tablets, capsules, granules, syrups, beverages, and the like. The method of formulation is not particularly limited and may be performed by a process commonly used in the art.

For example, when formulated in the form of granules, the extract mixture of red ginseng, safflower seeds and rice germ can be powdered, and then formed and dried. Specifically, a method comprising the following steps It can be done:

(1) mixing a mixture of extracts of red ginseng, safflower seeds and rice germ in a specific ratio, and then concentrating it under reduced pressure to prepare a concentrate mixture;

(2) drying the concentrate mixture to obtain a powder;

(3) kneading the powder using ethanol, water or a mixture thereof, preferably 60 to 90% (v/v) alcohol, more preferably 70% (v/v) alcohol;

(4) aging at room temperature for 8 to 15 hours for sterilization of the dough and for homogenization and high pressure in the dough of alcohol;

(5) forming the aged dough into granules using a granulator; and

(6) drying the molded granules at a relative humidity of 30% and a temperature of 65 to 70° C. so that the moisture content is about 4 to 8%, preferably about 7%.

The method may further include, after step (6), (7) packaging the dried granules by dividing each dose according to the dose.

In step (1) of the above method, dextrin may be further mixed with the concentrate mixture. At this time, the red ginseng extract, safflower seed extract, rice bran extract and dextrin may be mixed in a weight ratio of 1: 0.5-4: 0.5-2: 0.5-4, preferably 1:2: 1:2 by weight.

In addition, in step (1) of the method, it is possible to prepare a concentrate mixture by further including one or more extracts selected from the group consisting of Heotgae tree fruit extract, bean sprouts extract, leek extract, and buckwheat extract.

The above-described manufacturing method of the present invention may be performed by a conventional method known in the art, unless otherwise specified.

The health functional food according to the present invention can set the daily dose so that the contents of ginsenosides Rb1, Rg1 and Rg3S contained in red ginseng meet the efficacy standards of the Food and Drug Administration, preferably, the daily dose of Rg1 + Rg1 + Rg3S is 10 mg. make it possible

Since the health functional food according to the present invention is kneaded and aged using alcohol, it is efficient because it does not need to contain any additives commonly used in the art for sterilization, insecticide, extension of shelf life, and convenience of formulation and manufacturing. am. In addition, since alcohol is used, the effect of shortening the drying time of the composition is obtained, and it disintegrates easily when taken, so that it is convenient to take and is quickly absorbed into the body, and the absorption of the active ingredient is excellent.

The health functional food manufactured according to the present invention can be prevented from decomposing the content of the active ingredient and the indicator component or reducing the potency, and has a high absorption rate in the body without including other additives.

Hereinafter, the contents of the present invention will be described in detail through examples. However, the following examples are intended to illustrate the present invention in more detail, and are not intended to limit the scope of the present invention.

[Example 1] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bran extract and dextrin

To each raw material of 6-year-old red ginseng, safflower seed and rice germ, a solvent was added in an amount 10 times the weight of the raw material. At this time, 80% (v/v) alcohol was added and extracted at 80 ° C. 80% (v/v) alcohol 10 times the weight was added and extracted twice at 80° C. for 10 hours (primary extraction). Then, 10 times the amount of water compared to the weight of the raw material was added, and extraction was repeated three times at 90° C. (second extraction).

The 80% (v/v) alcohol extract thus obtained was filtered, and the hot water extract of 90° C. water was cooled to 20° C., the extract was centrifuged at 7,000 rpm, and then the 80% (v/v) alcohol extract (primary extraction) and hot water extract (secondary extraction) were mixed and concentrated under reduced pressure at 65° C. to obtain a concentrate having a water content of 35%. The combined yield of red ginseng, safflower seed and rice germ extract and hot water extract was 10 to 11%.

Each of the extracts of red ginseng, safflower seed and rice germ obtained above and dextrin were mixed in the ratio shown in Table 1 below.

Mixture ratio of red ginseng extract concentrate, safflower seed extract concentrate, rice bran extract concentrate, and dextrin (based on human consumption) Red Ginseng Extract Concentrate Safflower Seed Extract Concentrate Rice Bud Extract Concentrate dextrin Daily intake weight (g) One 2 One 2 note Content of Rb1, Rg1, Rg3S per 1 g of red ginseng extract concentrate = 10 mg

The mixture mixed in the same ratio as above was dried at 70° C. to obtain a powder, and then, in order to stabilize the active ingredient and kill the mycelium during the manufacturing process, alcohol having an alcohol content of 70% (v/v) relative to water was added to the powder. It was kneaded while adding little by little to it. For homogenization and sterilization of the prepared dough, and for even distribution of 70% (v/v) alcohol ^{, apply a pressure of about 3 kg/cm 2} to the prepared dough and apply a vacuum of 70 mmHg or less for 30 minutes, then ripen at room temperature for 10 hours After this, granules were formed using a granulator so that the particle size of the granules was constant, and then dried to a moisture content of about 7%, and packaged to prepare a composition for improving blood flow.

[Example 2] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bud extract, Heotgae tree fruit extract and dextrin

A composition was prepared in the same manner as in Example 1, except that red ginseng extract: safflower seed extract: rice bud extract: hutgae tree fruit extract: dextrin was mixed in a ratio of 1: 2: 1: 2: 2 (by weight).

[Example 3] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bud extract, bean sprout extract and dextrin

A composition was prepared in the same manner as in Example 1, except that red ginseng extract: safflower seed extract: rice bud extract: bean sprout extract: dextrin was formulated in a ratio of 1: 2: 1: 2: 2: 2 (by weight).

[Example 4] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bud extract, leek extract and dextrin

A composition was prepared in the same manner as in Example 1, except that the red ginseng extract: safflower seed extract: rice bud extract: leek extract: dextrin was formulated in a ratio of 1: 2: 1: 2: 2: 2 (by weight).

[Example 5] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bran extract, buckwheat extract and dextrin

A composition was prepared in the same manner as in Example 1, except that red ginseng extract: safflower seed extract: rice bran extract: buckwheat extract: dextrin was formulated in a ratio of 1: 2: 1: 2: 2: 2 (by weight).

[Example 6] Preparation of a composition comprising a combination of red ginseng extract, safflower seed extract, rice bud extract, Heotgae tree fruit extract, bean sprout extract, leek extract, buckwheat extract and dextrin

A composition was prepared in the same manner as in Example 1, except that the red ginseng extract: safflower seed extract: rice bud extract: Heotgae tree fruit extract: bean sprouts extract: leek extract: buckwheat extract: dextrin was 1: 2: 1: 0.5: 0.5: 0.5 : 0.5 : 2 (based on weight) was blended.

[Comparative Example 1] Preparation of red ginseng extract

A red ginseng extract was prepared in the same manner as in Example 1.

[Comparative Example 2] Preparation of safflower seed extract

A safflower seed extract was prepared in the same manner as in Example 1.

[Comparative Example 3] Preparation of rice germ extract

A rice germ extract was prepared in the same manner as in Example 1.

[Test Example 1] Test to confirm the decrease of the active ingredient

In the granules prepared in Example 1, the content of the sum of ginsenosides Rb1, Rg1, and Rg3S, which are active ingredients contained in red ginseng, was analyzed by the Ministry of Food and Drug Safety certified analysis method in order to check whether the active ingredient was decreased during the manufacturing process. was carried out, and the results are shown in Table 2 below.

Sum of Rb1 + Rg1 + Rg3S (mg) Content contained in raw materials 10 Example 1 Content contained in the composition 9.7

From Table 2, it can be seen that the composition prepared according to the present invention does not cause a problem of reduction of the active ingredient during the manufacturing process.

[Test Example 2] Bacterial death confirmation test

In order to confirm that the bacteria are killed by the kneading process in which alcohol is added in the present invention, the raw materials used in the mixing process before kneading were contaminated with E. coli. After compounding, it was confirmed whether or not E. coli was killed in the sample obtained by bereavement of the alcohol dough of Example 1, and the results are shown in Table 3 below.

Detecting E. coli in samples before kneading after contamination of raw materials Detecting E. coli in samples that were killed after contamination with raw materials and kneaded with alcohol Example 1 positivity voice Comparative Example 1 positivity voice Comparative Example 2 positivity voice Comparative Example 3 positivity voice

From Table 3, it can be seen that all of E. coli is killed by the kneading process using the alcohol of the present invention even if a separate disinfectant is not used.

[Test Example 3] Cholesterol level evaluation

After breeding 6-week-old rats (male white paper) for 1 week, the dietary composition of Table 4 was administered to the general diet group from 7 weeks of age to 6 weeks (Group 1), and the high-fat diet group (High Fat Diet, HFD 45%) The dietary composition of the composition of Table 4 was administered (Group 2), and the other high-fat diet group (HFD 45%) was administered with the composition of any one of Examples 1 or Comparative Examples 1 to 3 together with the dietary composition of Table 4 It was administered in an amount of 26 mg/kg (Groups 3 to 6), and the blood circulation improvement efficacy of each group was evaluated. Specifically, the blood circulation improvement efficacy was evaluated through an in vivo experiment measuring blood total cholesterol (TC), triglyceride (TG), HDL-cholesterol and LDL-cholesterol levels.

Dietary composition table administered to the general diet group for 6 weeks Furtherance gm% kcal% protein 20 20 carbohydrate 66 68 Fat 5 12

Dietary composition table containing 45% of HFD administered to the high-fat diet group for 6 weeks Furtherance gm% kcal% protein 24 20 carbohydrate 41 35 Fat 24 45

Administration material and daily dose (daily dose is based on rat body weight) test group classification diet dosing substance Daily Dose (mg/kg) Group 1 general food general diet - Red ginseng, safflower seed, rice bran mixed product 0 Group 2 It's a high fat diet HFD 45% - Red ginseng, safflower seed, rice bran mixed product 0 Group 3 It's a high fat diet HFD 45% Example 1 Red ginseng, safflower seed, rice bran mixed product 26 Group 4 It's a high fat diet HFD 45% Example 2 Mixed product of red ginseng, safflower seed, rice bran, and Heotgae tree fruit 26 Group 5 It's a high fat diet HFD 45% Example 3 Mixed product of red ginseng, safflower seed, rice bran, and bean sprouts 26 Group 6 It's a high fat diet HFD 45% Example 4 Red ginseng, safflower seed, rice bran, and leek mixed product 26 Group 7 It's a high fat diet HFD 45% Example 5 Red ginseng, safflower seed, rice bran, and buckwheat mixed product 26 Group 8 It's a high fat diet HFD 45% Example 6 Mixed products of red ginseng, safflower seed, rice bran, hemp tree fruit, bean sprouts, leek and buckwheat 26 Group 9 It's a high fat diet HFD 45% Comparative Example 1 Red Ginseng Powder Granules 26 Group 10 It's a high fat diet HFD 45% Comparative Example 2 Safflower Seed Powder Granules 26 Group 11 It's a high fat diet HFD 45% Comparative Example 3 Rice Bud Powder Granules 26

The measurement results of total cholesterol (TC), triglyceride (TG), HDL-cholesterol and LDL-cholesterol levels in blood according to oral administration are shown in Table 7 below (unit: mg/dl).

division Group 1 Group 2
Group 3
Group 4 Group 5 Group 6 Group 7 Group 8 Group 9 Group 10 Group 116 TC 55.0 91.5 68.6 63.9 65.4 66.3 64.8 62.2 90.7 89.6 92.2 TG 119.8 350.3 172.3 165.2 165.3 168.2 165.9 160.4 348.8 345.0 351.1 HDL 20.7 21.4 39.8 45.0 43.4 42.6 44.1 46.8 23.2 23.6 22.7 LDL 30.6 39.14 19.2 18.2 18.5 18.6 18.1 17.1 40.1 33.2 38.6

Referring to Table 7, groups 9 to 11, which are groups administered alone with red ginseng, safflower seed or rice germ, showed little improvement on all cholesterol, triglyceride, HDL and LDL levels, whereas red ginseng extract, safflower seed extract, rice germ extract and In the case of Group 3 administered with Example 1, which is a combination formulation of dextrin, it can be confirmed that excellent improvement effects are exhibited in all items, and the synergistic effect according to the combination of the three substances is shown with a significant difference in the degree of improvement. it can be seen that there is

In addition, in the case of Groups 4 to 8 administered with Examples 2 to 6, which additionally contained other ingredients in addition to the complex formulation of red ginseng, safflower seeds and rice bran, the total cholesterol, triglyceride, HDL and LDL levels were improved. It can be seen that the effect is shown.

[Test Example 4] Evaluation of the effect of improving blood circulation in the human body

For the human application efficacy test, a total of 40 males and females with blood circulation disorders over 40 years of age were randomly divided into 4 groups of 10 people, and then, among the products of Example 1 and Comparative Examples 1 to 3, Either one was ingested twice a day for 6 weeks in a daily dosage amount, respectively, and the effect due to blood circulation improvement was evaluated, and the results are shown in Table 8 below.

division have a clear effect in effect so so no effect Total (persons) Side effects (persons) Example 1 8 One One 0 10 0 Comparative Example 1 0 One One 8 10 0 Comparative Example 2 0 One 0 9 10 0 Comparative Example 3 0 0 2 8 10 0

Referring to Table 8, it can be seen that, when the red ginseng extract, the safflower seed extract, or the rice bran extract was administered alone, little effect was observed, whereas when Example 1 was administered, most participants showed a clear blood improvement effect.

[Test Example 5] Evaluation of blood circulation improvement effect according to active ingredient content

According to the composition of the active ingredient content of the daily dose as shown in Table 9 below, a composition product for improving blood flow was prepared by the method described in Example 1, and a total of 120 men and women with blood circulation disorders over 40 years of age were randomly assigned to 10 people each. After dividing into 12 groups, the subjects were ingested twice a day for 6 weeks in a daily dosage amount, and the effect of improving blood circulation was evaluated, and the results are shown in Table 10 below.

product no Red Ginseng Extract Safflower Seed Extract Rice Bud Extract dextrin One One 0.1 One 2 2 One 0.5 One 2 3 One 4 One 2 4 One 6 One 2 5 One 2 0.1 2 6 One 2 0.5 2 7 One 2 2 2 8 One 2 4 2 9 One 2 One 0.1 10 One 2 One 0.5 11 One 2 One 4 12 One 2 One 6

product no have a clear effect in effect so so no effect Total (persons) Side effects (persons) One 4 One 3 2 10 0 2 7 2 0 One 10 0 3 8 One One 0 10 0 4 5 One 2 2 10 0 5 4 2 3 One 10 0 6 8 One One 0 10 0 7 8 2 0 0 10 0 8 4 3 One 2 10 0 9 3 3 2 2 10 0 10 7 One 2 0 10 0 11 8 0 2 0 10 0 12 5 2 2 One 10 0

From Table 10, it can be seen that the composition for improving blood flow according to the present invention exhibits excellent blood flow improvement effect within the content combination range of the components, but when the content combination range of the components is out of the appropriate range, the efficacy is lowered.

[Formulation Example 1] Pills

After mixing 90 mg of the composition of Example 1, 5 mg of glutinous rice starch and 5 mg of purified water, 100 mg of pills were prepared according to a conventional method.

[Formulation Example 2] Tablet

After mixing 3 g of the composition of Example 1, 0.1 g of corn starch, 0.11 g of lactose, and 2 mg of magnesium stearate, tableting was performed according to a conventional tablet manufacturing method to prepare tablets.

[Formulation Example 3] Capsules

After mixing 2.5 g of the composition of Example 1, 0.1 g of corn starch, 0.1 g of lactose, and 2 mg of magnesium stearate, it was filled into a gelatin capsule according to a conventional capsule preparation method to prepare a capsule.

[Formulation Example 4] Granules

After mixing 4 g of the composition of Example 1, 50 mg of soybean extract, 200 mg of glucose, and 600 mg of corn starch, 100 mg of 30% ethanol was added and dried at 65° C. to form granules, and then filled in a bag.

[Formulation Example 5] Drink

1 g of the composition of Example 1, 0.1 g of citric acid, 100 g of fructooligosaccharide, and 900 g of purified water were mixed and stirred, heated, filtered, sterilized, and refrigerated according to a conventional beverage preparation method to prepare a drink.

[Formulation Example 6] Pills

After mixing 90 mg of the composition of Example 6, 5 mg of glutinous rice starch, and 5 mg of purified water, 100 mg of pills were prepared according to a conventional method.

[Formulation Example 2] Tablet

3 g of the composition of Example 6, 0.1 g of corn starch, 0.11 g of lactose, and 2 mg of magnesium stearate were mixed, and then tableted according to a conventional tablet manufacturing method to prepare tablets.

[Formulation Example 3] Capsules

After mixing 2.5 g of the composition of Example 6, 0.1 g of corn starch, 0.1 g of lactose, and 2 mg of magnesium stearate, it was filled into a gelatin capsule according to a conventional capsule preparation method to prepare a capsule.

[Formulation Example 4] Granules

After mixing 4 g of the composition of Example 6, 50 mg of soybean extract, 200 mg of glucose, and 600 mg of corn starch, 100 mg of 30% ethanol was added and dried at 65° C. to form granules, which were then filled in a bag.

[Formulation Example 5] Drink

1 g of the composition of Example 6, 0.1 g of citric acid, 100 g of fructooligosaccharide, and 900 g of purified water were mixed and stirred, heated, filtered, sterilized, and refrigerated according to a conventional beverage preparation method to prepare a drink.

Claims (7)

Red ginseng extract, safflower seed extract and rice bran extract 1: 0.5-4: a mixture of 0.5-2 weight ratio; And as an additional extract, a health functional food composition for improving blood flow comprising an extract of Heotgae tree fruit. The health functional food composition for improving blood flow according to claim 1, wherein the red ginseng extract, safflower seed extract and rice germ extract are mixed in a weight ratio of 1:2:1. The blood flow improvement according to claim 1, wherein the composition further contains dextrin, and the red ginseng extract, safflower seed extract, rice bran extract and dextrin are mixed in a weight ratio of 1: 0.5-4: 0.5-2: 0.5-4. For health functional food composition. The health functional food composition for improving blood flow according to claim 3, wherein the red ginseng extract, safflower seed extract, rice bran extract and dextrin are mixed in a weight ratio of 1:2:1:2. The health functional food composition for improving blood flow according to claim 1, wherein the composition is a health supplement composition. [Claim 2] The health functional food composition for improving blood flow according to claim 1, wherein the additional extract is composed of a Heotgae tree fruit extract, bean sprouts extract, leek extract and buckwheat extract. The health functional food composition for improving blood flow according to claim 1, wherein the additional extract is included in an amount of 10 to 100% by weight based on the total weight of the red ginseng extract, safflower seed extract and rice germ extract.