KR102198434B1 - Pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, preparation method and preparation thereof - Google Patents

Abstract

The present invention relates to a composition for preventing or treating hyperlipidemia using natural plants, a method for preparing the same, and a preparation thereof, and is mainly composed of raw materials of the weights listed below. Gomchwi 40 ~ 70 minutes, Tangja 20 ~ 40 minutes, Bokryeong 10 ~ 20 minutes, Licorice 5 ~ 10 minutes. The composition for preventing or treating hyperlipidemia using a natural plant according to the present invention has no side effects, removes sputum, relieves enemies, treats tile and blood stagnation, reduces blood lipid levels, and prevents the occurrence of diseases such as arteriosclerosis, hypertension, diabetes, etc. , Reduce the risk of cardio-cerebrovascular disease.

Description

Pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, preparation method and preparation thereof TECHNICAL FIELD [0002] Pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, preparation method and preparation thereof

The present invention belongs to the field of manufacturing herbal medicines (Korean medicine, Chinese medicine: 中草葯), and more specifically, using natural plants to reduce the level of blood lipids to prevent hyperlipidemia, or to prevent hyperlipidemia, and a pharmaceutical composition for the treatment of hyperlipidemia and It relates to its manufacturing method and formulation.

In modern people, as living standards improve and lifestyle changes, the number of people who increase the level of blood lipids increases, leading to chronic diseases such as arteriosclerosis, high blood pressure, coronary artery disease and diabetes, and unexpected events such as myocardial infarction and stroke. There are also patients with acute and severe acute cardiovascular disease.

Blood lipids (blood lipids) are a generic term for total cholesterol (TC), triglycerides (TG) and lipids (phospholipids, free fatty acids) in serum, and blood lipids related to clinical trials are mainly total. It refers to cholesterol and triglycerides (triglycerides; 中性脂肪). According to the results of a 2012 (China) national survey, the average total cholesterol (TC) in adult serum was 4.5 mmol/ℓ, the incidence of hypercholesterolemia was 4.9%, and triglyceride (TG) was 1.38 mmol/ℓ on average. The incidence of hypertriglyceridemia was 13.1%, and the total incidence of hemoglobin patients reached 40.40% (Committee on Revision of Guidelines for the Prevention of Adult Hematopoietic Abnormalities in China, Chinese Circulation Magazine Oct. 31, 2016 Vol. 31, 10th term 937-950).

From 2010 to 2030, the number of cardiovascular disease-related events in Korea (China) will increase by about 9.2 million (Moran A, Gu D, Zhao D, et al. Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china.Cire Cardiovase Qutromes, 2010, 3-243-252).

Prevention and treatment of hyperlipidemia is the key to lowering the incidence of atherosclerosis.

In clinical practice, if the plasma total cholesterol concentration is 5.17 mmol/ℓ (200 mg/dℓ) or higher, it is diagnosed as hypercholesterolemia, and if the plasma triglyceride concentration is 2.3 mmol/ℓ (200 mg/dℓ) or higher, it is diagnosed as hypertriglyceridemia. do.

Today, hyperlipidemia is a treatment that improves blood lipid levels by enhancing exercise, controlling food, and improving lifestyle habits (e.g., smoking cessation, abstaining, etc.) for mild cases, and treatment with drugs for severe cases. However, as Western medicine, statins and resins are mainly used to lower serum total cholesterol and LDL (low-density lipoprotein) cholesterol levels, and betas and nicotinic acid are mainly used to lower serum triglycerides. Ryu is used. However, since all of these drugs cause impairment of liver and kidney function, long-term use is not possible, and changes in liver function are ordered to be checked while taking. If any abnormality in liver function is found, the medication must be changed or taken off. Therefore, treatment cannot achieve ideal effects because the drug cannot be taken continuously.

Thus, finding a hypolipidemic agent that can replace Western medicine, lower blood fat, and have no toxicity and side effects, is an important means to prevent hyperlipidemia and effective treatment, and to prevent hypertension, coronary arteriosclerosis and diabetes.

Oriental medicine (韓方, Chinese medicine: 中藥) has done a lot of research in the area of hyperlipidemia treatment, but there are not many studies with relatively high feasibility. Most of them remain in the animal testing stage, and although some studies have entered the clinical trial stage, most of them are mainly bath medicines, and they cannot spread due to the inconvenience of long-term use. Some other prescription drugs use relatively expensive drugs, so the economic burden is relatively high when long-term use (Zhou Hongjun, Progress in Clinical Research on Treatment of Hyperlipidemia of Chinese Medicine, Modern Chinese-Chinese Combined Magazine, 2011 Jul, 20(20): 2592-2593) ).

Therefore, researching a method that is simple, easy, safe, inexpensive, and has an effect of lowering blood fat is the key to preventing and treating cardio-cerebrovascular diseases caused by hyperlipidemia.

It is an object of the present invention to provide a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants. The composition has no side effects by using natural plants that are both edible and medicinal, such as Gomchwi, Tangja, Bokryeong, and Licorice, and has no side effects. It prevents the occurrence of diseases such as diabetes and reduces the risk of cardiovascular disease.

Another object of the present invention is to provide a method of preparing a pharmaceutical composition for preventing or treating hyperlipidemia using the above-described natural plant.

Another object of the present invention is to provide an easy-to-portable and convenient hyperlipidemia preparation prepared by the method for preparing a pharmaceutical composition for preventing or treating hyperlipidemia using the above-described natural plant.

The present invention adopts the following technical configuration to achieve the above object.

The pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is prepared by the weight of the following raw materials, and the raw materials are Gomchwi 40 to 70 minutes, Tangja 20 to 40 minutes, Bokryeong 10 to 20 minutes, Licorice It consists of 5 to 10 minutes.

The pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention is prepared by the weight of the following raw materials, and the raw materials are optionally composed of 50 minutes of Gomchwi, 30 minutes of Tangja, 15 minutes of Bokryeong, and 5 minutes of licorice. do.

The gomchwi of the pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention is preferably selected for fresh gomchwi, and more preferably consists of fresh gomchwi collected in April to June each year.

In addition, the method for preparing a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is composed of washing, steaming, drying, and mixing at a predetermined mixing ratio.

The manufacturing method of the pharmaceutical composition for preventing or treating hyperlipidemia using the natural plant according to the present invention is composed of a powder by steaming a raw material (中草藥) with steam and then crushing it into about 100 to 200 eyes (目; Mash).

In addition, the method of manufacturing a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is made in the form of a formulation for convenience of carrying and taking, and the formulation includes an auxiliary material suitable for medicinal use and edible use. do.

The hyperlipidemia preparation using the natural plant according to the present invention is composed of powder, pills, granules, pieces, and capsules.

Among the specific implementation methods of the hyperlipidemia preparation using the natural plant according to the present invention, when it is prepared with powder, it can be drunk in water and the taste is bitter. In the case of pill or granule, it is relatively convenient to swallow with water. When making the pill and granule, a small amount of pork potato powder can be used as an auxiliary material.

The pork potato powder not only has relatively good adhesiveness, but also the sweet, spicy taste and flat energy of the pork potato makes the intestines and stomach comfortable, relieves the stomach and intestines, makes the enema, feces and stool well through, and relieves the liver. And kidneys, and has the effect of replenishing regular periods. Also, pork potato contains abundant mucus and a large amount of trace elements, helping to correct physiological abnormalities caused by the lack of trace elements, while improving appetite and digestion. It helps, and in ancient Chinese medicine, it is regarded as a medicinal material that supplements chi.

In another aspect, the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention may be used and applied to manufacture drugs or health supplements for preventing or treating hyperlipidemia.

In the middle of the body, phlegm becomes cloudy and blood stagnation is formed for abnormalities in the bloodstream, and in ancient medicine, the energy of the kidneys is deprived, the stomach is damaged and the energy is lost, the hand and the moist heat are not harmonious, and the cloudy moist heat circulates in the body. It is said that phlegm is formed for a long time, phlegm sputum blocks the intestines, and mud phlegm is formed in the body.

Modern medicine considers that the spleen energy is weak, the energy of the spleen is weakened, the blood circulation is poor, the water energy and moisture are not harmonious, the sputum is cured, the blood does not flow well, and the abnormality of the blood is caused by the abnormality of the blood. It is called.

The present invention cuts sputum and removes the sputum, and takes it as a principle of treatment as it treats tile and blood stagnation. The pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is characterized by lowering the blood lipid level without toxicity and side effects by selecting natural ingredients used for edible and medicinal purposes.

A detailed look at the efficacy of the natural plant, which is a raw material of the pharmaceutical composition for preventing or treating hyperlipidemia of the present invention, is as follows.

Gomchwi (馬蹄葉) has a slightly warm and spicy taste, but is not toxic. Its main effects are to remove customs, get rid of cold energy, calm cough, clear phlegm, relieve pain, and promote blood circulation. In addition, the scientific name of Gomchwi is'Ligularia fischeri ', and it is a perennial herbaceous plant distributed in the northeast of China, and is also called Mountain Resources, Ungso, and Sinyeoptakoh. In addition, Gomchwi is one of the most notable wild vegetables in the Yanbian region of Jilin Province, and is especially used by the Korean-Chinese as wraps or as a side dish. It is also one of the special vegetables indispensable in Korean food and has a unique flavor.

Bokryeong, or bokryeong, which is used as a medicinal material, is the part of the white part of the red bokryeong cut into small pieces, and is usually chopped and pressed in oriental medicine. Bokryeong has a very wide range of efficacy and is used in combination with a variety of medicinal herbs regardless of the season, and exhibits unique efficacy against all diseases of cold, warm, wind, and humid. The taste is sweet and light, and the nature is flat. Its main effect is to adjust water and moisture, strengthen the stomach, and stabilize the nerves. According to modern medical research, it is reported that Bokryeong strengthens immunity, and the polysaccharides of Bokryeong have anticancer and liver protection effects.

Tangja (枳實) tastes bitter, spicy, and sour. It is a little cold in nature, and has the effect of breaking energy, eliminating depression, and removing phlegm and blood stagnation. In addition, Tangja has an enemy in the stomach, has a swelling spleen, has a pain in the stomach, diarrhea and has a poor back, a stool disorder, a boiled sputum and inconvenient to breathe, and is mainly used for diseases such as emphysema, abscess, and organ sewage.

Licorice (甘草) has a sweet taste and good properties. It nourishes the spleen, boosts energy, removes blue fever detoxification, detoxification, stops coughing, relieves pain, and goes well with all medicines. Mainly used in cases where the stomach is weak, bored, or weak, chest pounding and weak, coughing and sputum, cramps in the abdomen and limbs, malignant boils, and toxicity. Relieve toxicity and fever.

The pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention uses all edible and medicinal materials. In particular, gomchwi is the main ingredient of the present invention and is also a edible wild vegetable. The main effect is expectorant effect. Bokryeong makes the stomach healthy and protects the liver. Since most of the people with high blood lipid levels develop fatty liver, it is very important to protect the liver because it is easy to find impaired liver function. Tangja breaks energy, eliminates depression, removes phlegm and blood stagnation, and promotes bowel movements to improve digestive efficacy. Licorice nourishes the spleen, boosts energy, detoxifies blue heat, and goes well with the efficacy of various medicines.

Therefore, the pharmaceutical composition for the prevention or treatment of hyperlipidemia using natural plants according to the present invention is detoxified by blue heat, sputum and sputum, and it passes through energy well and makes the spleen healthy, protects the liver, and finally, lesions caused by turbid phlegm and blood stagnation It can reduce the incidence of cardiovascular disease by removing and lowering blood fat, and lowering the unexpected risk due to cardiovascular disease.

In order to more clearly describe the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention, it will be described in detail as examples below first. The present invention is naturally understood by those of ordinary skill in the art, and the contents specifically described below are only for explaining the present invention, and are not limited thereto. That is, the scope of protection of the present invention cannot be limited to this.

<Example 1> Preparation of a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants

The pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention is composed of raw materials of an effective weight of 40 minutes of Gomchwi, 20 minutes of Tangja, 10 minutes of Bokryeong, and 5 minutes of licorice.

The raw material manufacturing method of the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is as follows.

1. Gomchwi(馬蹄葉)

Every year from April to June (China) in the Yanbian region of northeastern China, the leaves of Gomchwi grow to about 8 to 12cm. After picking the leaves and washing them cleanly to remove foreign substances, steam them in a cauldron for 1 to 2 minutes, and then dry them in a cool place. Grind dry Gomchwi leaves and make about 100 ~ 200 eye (Mash) powder.

2. Tangja (枳實)

Wash tangja well, cut it into 0.2 ~ 0.5cm thick, put it in a cauldron, steam for 3-4 minutes and dry. Grind the dried tangja and make about 100 ~ 200 eye (Mash) powder.

3. Bokryeong

Wash the bokryeong mass of about 0.5 ~ 0.8cm well, put it in a cauldron, steam for 2-4 minutes, dry it, and grind it to make about 100 ~ 200 mash powder.

4. Licorice (甘草)

Slice the licorice into 0.3 ~ 0.5cm thick, put it in a cauldron, steam for 3-4 minutes, dry it tightly, and grind it to make about 100 ~ 200 mash powder.

The preparation of the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is composed of pills and granules using the raw material (composition) prepared by the above-described manufacturing method.

The preparation of the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention is constituted by mixing a predetermined amount according to the above-described manufacturing method.

First, prepare 1 kg of raw materials (composition).

Second, heat 2.5ℓ of water to make it hot.

Third, prepare'pork potato paste' by dissolving 20g of pork potato powder (thinly sliced and dried in the sun) in a small amount of mineral water to prevent lumps.

Fourth, put the prepared “pork potato paste” into the prepared 2.5ℓ of hot water, stir for 0.5 to 1 minute, and turn off the heat before boiling.

Fifth, after natural cooling, 1 kg of the prepared raw material is added and stirred to soften and soften.

Sixth, finally, it is prepared in accordance with the standard as a pill (pill) or granule.

The hyperlipidemia preparation using natural plants according to the present invention prepared by the above-described method is configured to be taken three times a day, one bag at a time, based on 1 g of each bag in the case of pills or granules.

<Example 2> Preparation of a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants

The pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention is composed of raw materials of an effective weight of 50 minutes of Gomchwi, 30 minutes of Tangja, 15 minutes of Bokryeong, and 5 minutes of licorice.

The method for preparing a hyperlipidemia preparation using a natural plant according to the present invention is the same as in <Example 1>.

<Example 3> Preparation of a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants

The pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention is composed of raw materials of an effective weight of 70 minutes of Gomchwi, 40 minutes of Tangja, 20 minutes of Bokryeong, and 5 minutes of licorice.

The method for preparing a hyperlipidemia preparation using a natural plant according to the present invention is the same as in <Example 1>.

<Experimental example>

The criterion for blood lipid abnormality is hypercholesterolemia when the plasma total cholesterol concentration is 5.17 mmol/ℓ (200 mg/dℓ) or higher, and hypertriglyceridemia when the plasma triglyceride concentration is 2.3 mmol/ℓ (200 mg/dℓ) or higher. To confirm.

The present inventors selected 17 hyperlipidemia patients and designated them as an observation group, and observed changes in the indicators of blood cholesterol and blood triglycerides for 1 month and 2 months without any interference. Except for patients with relatively large changes in the indicators, Only 11 patients with relatively stable width participated in the experiment (laboratory).

1. Step 1

end. Who and how

17 patients with hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) were selected. The average age of the patients was 60 years old, 10 men and 7 women. Blood cholesterol and blood triglyceride levels in the first month when the test subject enters the observation phase were measured, and samples whose random indicators were within normal levels were excluded. Even subjects suitable for the experiment measured the levels of blood cholesterol and blood triglycerides in the second and third months without any interference, and samples with random indicators within normal values were excluded.

The blood cholesterol and blood triglyceride levels in the first, second, and third months of each test subject were compared with the sample data to exclude excessively large differences, that is, those with external interference factors.

The test subjects were 11 patients with hypercholesterolemia and hypertriglyceridemia (both patients with mixed hyperlipidemia), and the average age of the patients was 57.27 years old, 6 men and 5 women.

The changes in blood lipids in the first, second, and third months observed while maintaining the usual living conditions without any interference were as shown in [Table 1].

The blood lipid data of this experiment was carried out by statistical analysis, and the data was obtained by analyzing with SPSS17.0 statistical software, and the corresponding data adopted t-test, which has statistical significance as a range of P<0.05.

Changes in hypercholesterolemia and hypertriglyceridemia in 11 natural states gender age Blood cholesterol
(mmol/ℓ) Reference value
0.01 to 5.20
mmol/ℓ Blood triglycerides
(mmol/ℓ) Reference value
0.01 to 2.30
mmol/ℓ first
month second
month third
month first
month second
month third
month female
male
male
female
female
male
female
male
male
female
male 55
58
60
80
60
38
55
61
55
55
53 5.97
5.79
6.27
7.38
5.98
5.85
5.20
5.77
5.84
5.36
5.96 5.94
5.75
6.24
7.37
5.99
5.87
5.23
5.76
5.85
5.35
5.97 5.96
5.78
6.24
7.39
5.97
5.86
5.22
5.79
5.83
5.38
5.97 4.32
3.33
5.58
3.46
5.98
9.88
2.79
2.47
2.74
3.52
3.79 4.34
3.35
5.54
3.48
5.94
9.87
2.82
2.45
2.77
3.55
3.91 4.30
3.36
5.55
3.49
5.96
9.87
2.80
2.48
2.75
3.54
3.80

I. result

1) Among blood cholesterol levels, the average value of the first month is 5.94 ± 0.56 mmol/ℓ, the average value of the second month is 5.94 ± 0.55 mmol/ℓ, and the average value of the third month is 5.94 ± 0.56 mmol/ℓ, and the three groups' The difference in data between the first and second months','first and third months', and'second and third months' was not statistically significant (t=0.669 · P>0.05, t=0.363 · P>0.05, t =1.048P>0.05).

2) Among the levels of triglycerides in the blood, the average value in the first month is 4.35 ± 2.15 mmol/ℓ, the average value in the second month is 4.37 ± 2.13 mmol/ℓ, and the average value in the third month is 4.35 ± 2.14 mmol/ℓ. The difference between Joe's data was not statistically significant (t=1.424 · P>0.05, t=0.585 · P>0.05, t=1.208 · P>0.05).

All. conclusion

The subjects of this experiment did not show a distinct change in the blood lipid index in the general living environment.

2. Step 2

end. Who and how

Through the selection method, 11 patients with hypercholesterolemia and hypertriglyceridemia (all patients with mixed hyperlipidemia) were confirmed as subjects. The average age of the patients is 57.27 years old, with 6 men and 5 women.

In a general living environment, the hyperlipidemia agent according to the present invention according to the present invention is taken 1 packet once a day, 3 times a day, and blood lipids (blood cholesterol and blood triglycerides) before taking, 1 month, 2 months ) Was measured (see [Table 2]).

The levels of blood cholesterol and triglycerides in the blood in'before and after 1 month of administration' and'before and after 2 months of administration' of the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention were compared.

For statistical analysis, data were obtained by adopting SPSS17.0 statistical software, adopting t-test, and having statistical significance as a range of P<0.05.

Analysis of the therapeutic effect of hypercholesterolemia and hypertriglyceridemia in 11 patients gender age Blood cholesterol
(mmol/ℓ) Reference value
0.01 to 5.20
mmol/ℓ Blood triglycerides
(mmol/ℓ) Reference value
0.01 to 2.30
mmol/ℓ Taking
I'm Taking
1 month Taking
2 months Taking
I'm Taking
1 month Taking
2 months female
male
male
female
female
male
female
male
male
female
male 55
58
60
80
60
38
55
61
55
55
53 5.96
5.78
6.24
7.39
5.97
5.86
5.22
5.79
5.83
5.38
5.97 5.5
5.33
5.74
6.96
5.00
5.68
4.67
5.50
5.20
5.83
4.65 5.10
4.94
5.07
4.61
4.38
5.02
4.20
4.95
4.87
4.62
2.08 4.30
3.36
5.55
3.49
5.96
9.87
2.80
2.48
2.75
3.54
3.80 3.67
1.97
3.91
2.38
4.57
7.27
2.18
2.40
2.10
3.0
2.97 2.20
1.48
0.81
1.48
2.93
4.65
1.40
1.85
1.39
2.53
2.38

I. result

1) The mean value of blood cholesterol before dose is 5.94 ± 0.56 mmol/ℓ, and the mean value of blood cholesterol samples 1 month after dose is 5.37 ± 0.65 mmol/ℓ, the difference is statistically significant (t=6.011, P<0.05 ).

2) The mean value of blood cholesterol before dose is 5.94 ± 0.56 mmol/ℓ, and the mean value of blood cholesterol samples 2 months after dose is 4.53 ± 0.86 mmol/ℓ, the difference is statistically significant (t=4.649, P<0.05 ).

3) The average value of blood triglyceride before administration is 4.35 ± 2.14 mmol/ℓ, and the average value of blood triglyceride samples 1 month after administration is 3.31 ± 1.56 mmol/ℓ, and the difference is statistically significant (t=5.019, P <0.05).

4) The average value of blood triglyceride before administration is 4.35 ± 2.14 mmol/ℓ, and the average value of blood triglyceride samples 2 months after administration is 2.28 ± 0.97 mmol/ℓ, and the difference is statistically significant (t=5.451, P <0.05).

3. Analysis

Most of the onset age of hyperlipidemia was 55 years or older, and the onset age was gradually decreasing, and the youngest patient in this group was 38 years old. It is very important to control blood lipids before onset. Simply controlling with food may work for some patients, but it cannot last long and affects the quality of life. It can be seen that the data in the first stage of this experimental group do not have statistical significance.

By taking the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention, it is possible to control fat metabolism and lower blood fat, and accordingly, the data in the second stage of this experimental group can be said to have statistical significance. I can.

Other embodiments of the present invention were also subjected to the same interference experiment, and accordingly, data related to other effects also have statistical significance. From these experiments, it can be seen that the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention has the effect of lowering the levels of blood cholesterol and blood triglycerides among patients with hypercholesterolemia and hypertriglyceridemia. there was.

4. Case tracking of hyperlipidemia typical

<Case 1>

Momo Park, male, 53 years old, detection of blood cholesterol 5.97 mmol/ℓ, blood triglyceride 3.80 mmol/ℓ, judgment as moderate fatty liver, hyperlipidemia. No history of high blood pressure, coronary artery disease, diabetes, etc. There are usual symptoms of constipation. I tried to control food before, but I couldn't see the effect (it is very difficult to change my lifestyle, and I change my meat diet to vegetarianism, so I often get hungry).

After taking the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention, digestive function was remarkably improved, and regular bowel movements were performed, and after 2 months of taking, blood cholesterol was 2.08 mmol/ℓ, blood triglycerides Showed a distinct effect falling to 2.38 mmol/ℓ.

<Case 2>

Momo Wang, male, 38 years old, detection of blood cholesterol 5.86 mmol/ℓ, blood triglyceride 9.87 mmol/ℓ. Overweight, no other medical history, judged as hyperlipidemia.

After taking the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention for two months, blood cholesterol was 5.02 mmol/ℓ and blood triglycerides fell to 4.65 mmol/ℓ, so the effect was clear.

<Case 3>

Mother-in-law, female, 55 years old, blood cholesterol 5.96 mmol/ℓ, blood triglyceride 4.30 mmol/ℓ detection. Often suffers from insomnia and lacks energy. Determined as hyperlipidemia.

After taking the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention for two months, the abdomen feels comfortable, and the condition has improved a lot, blood cholesterol is 5.10 mmol/ℓ, blood triglyceride is 2.20 mmol/ℓ And the effect was clear.

<Case 4>

Aunt, male, 60 years old, detects 6.24 mmol/ℓ of cholesterol in blood and 5.55 mmol/ℓ of triglycerides in blood. Early diabetes with 7.2 mmol/ℓ of blood sugar. No other diseases. Judging as hyperlipidemia with diabetes. Diabetes should suppress high sugar intake and supplement high protein foods, but vegetarian alone cannot. Therefore, it is very difficult to lower blood fat.

After taking the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants according to the present invention for two months, blood cholesterol fell to 5.07 mmol/L and blood triglycerides fell to 0.81 mmol/L, showing a very satisfactory effect on blood sugar control. .

<Case 5>

Aunt, female, 80 years old, has a history of high blood pressure for many years. Blood cholesterol 7.39 mmol/ℓ, blood triglyceride 3.49 mmol/ℓ detection. Determined as hyperlipidemia accompanied by high blood pressure.

After taking the pharmaceutical composition for preventing or treating hyperlipidemia using a natural plant according to the present invention for two months, blood cholesterol and triglycerides in the blood drop to 4.61 mmol/L and 1.48 mmol/L, indicating that it is effective in treating hypertension. .

To be clear, the above embodiments of the present invention are examples for explaining the present invention, and are not limited to practicing the present invention, and those skilled in the art to which the present invention pertains may be implemented in other forms based on the above-described contents. I can. Therefore, not all of them can be described here. Therefore, similar implementations derived from the technical solutions of the present invention belong to the protection scope of the present invention.

Claims (9)

It relates to a pharmaceutical composition for the prevention or treatment of hyperlipidemia using natural plants that lower the levels of blood cholesterol and blood triglycerides in patients with hypercholesterolemia and hypertriglyceridemia,
The active ingredient of the composition is composed of raw materials by weight of Gomchwi 40 to 70 minutes, Tangja 20 to 40 minutes, Bokryeong 10 to 20 minutes, and licorice 5 to 10 minutes,
The composition is a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, characterized in that it can be applied to drugs for preventing and treating the hyperlipidemia.
delete delete delete In the method for producing a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants that lower the levels of blood cholesterol and blood triglycerides in patients with hypercholesterolemia and hypertriglyceridemia,
The method for preparing a pharmaceutical composition for preventing or treating hyperlipidemia using the natural plant is to wash and steam and dry Gomchwi, Tangja, Bokryeong and Licorice to make a powder of 100 to 200 mesh, then gomchwi 40 to 70 minutes, Tangja. Method for producing a pharmaceutical composition for preventing or treating hyperlipidemia using natural plants, characterized in that mixing with a weight raw material of 20 to 40 minutes, bokryeong 10 to 20 minutes, licorice 5 to 10 minutes.
In the preparation for the prevention or treatment of hyperlipidemia using natural plants that lower the level of blood cholesterol and blood triglycerides in patients with hypercholesterolemia and hypertriglyceridemia,
In the pharmaceutical composition for preventing or treating hyperlipidemia using natural plants of claim 1, porcine potato powder is included as an auxiliary material,
The formulation is composed of powder, eggs, granules, pieces or capsules, and can be applied to the manufacture of drugs for preventing and treating hyperlipidemia. Formulations for preventing or treating hyperlipidemia using natural plants. delete delete delete