KR102123327B1 - Oil composition for spherical cleaning - Google Patents

Abstract

The present invention relates to a mixed oil composition for mouthwash. The mixed oil composition for oral cavity cleaning according to the present invention may include lavender oil.
The mixed oil composition for oral cavity cleaning according to the present invention selectively prevents or improves periodontal disease by selectively suppressing harmful bacteria that cause plaque removal and periodontal disease in the oral cavity and preventing beneficial bacteria from being killed. Also, it can be used for a long time without side effects. In addition, the mixed oil composition for oral cavity cleaning according to the present invention has an advantage of high deodorizing effect and long lasting effect.

Description

Mixed oil composition for mouthwash {OIL COMPOSITION FOR SPHERICAL CLEANING}

The present invention relates to a mixed oil composition for mouthwash. More specifically, the present invention relates to a mixed oil composition for oral cleaning to effectively clean periodontal disease-causing bacteria, including Streptococcus mutans, which cause plaque removal and periodontal disease.

The oral cavity serves as a window to supply energy to the human body, and the health condition of the body is immediately reflected. In particular, oral bacteria, which are the cause of oral diseases, invade blood vessels through blood and reach other parts of the body, and cause systemic diseases such as heart disease, stroke, diabetes, premature birth, and low birth weight (Jin LJ, et al., Hong Kong Med J.9:31-37 (2003), Pennisi E, Science, 307:1899-1901 (2005), Xu P, et al., J Bacteriol. 189:3166-3175 (2007)).

Tooth is a mineral composed of calcium phosphate, and the disease is largely decayed and periodontal disease. Dental caries accounts for most of dental diseases from children to adults, and the incidence is increasing. According to a report by the Korean Dental Association, more than 90% of children experience dental caries, and more than 80% of adults have gum disease. The main cause of tooth decay is infection by microorganisms in the oral cavity, caused by the interaction of bacteria, food, and saliva. That is, nutrients and moisture necessary for the growth of bacteria in the oral cavity are supplied by food, saliva, and dental fluid, and the environment in the oral cavity has a temperature (37°C) and pH (near neutral) suitable for microorganisms to develop.

Representative microorganisms that cause periodontal disease include Streptococcus mutans and Prevotella intermedia. The microorganisms cause microbial metabolism to generate sucrose present in food into glucose and fructose, forming insoluble glucan, a polymer of glucose, on the tooth surface. In this process, other microbes in the oral cavity adhere to the tooth surface, and a microbial membrane, that is, a dental plaque, is formed. The lactic acid accumulated in the formed plaque dissolves the enamel on the tooth surface, causing cavities. In addition, periodontal disease occurs because the disgrace is dissolved by the products of the growth of various bacteria.

Sodium bicarbonate (NaHCO3), triclosan (Triclosan, C0 ₂ H ₇ Cl ₃ O ₂ ), polyphosphate, soda fluoride (NaF), vancomycin, chlorhexidine Antibiotics such as (Chlorhexidine) and Spiramicin, or organic/inorganic fluorine have been used. However, although the above methods are effective in preventing cavities, their use is limited due to the disadvantages of vomiting, diarrhea, and antibiotic resistance. In particular, antibiotics have been generally used for bacterial infection diseases such as dental caries and periodontitis, but antibiotics not only harm all the beneficial bacteria in the human body, but when overdosed, the appearance of resistant bacteria, deterioration of the patient's immune capacity, and chronicity of the infectious disease, Causes side effects such as mycosis.

Therefore, a method has been attempted to utilize an oral cleaning composition having a natural product-based cleaning effect, and to have an effect on removing plaque in the oral cavity and cleaning harmful bacteria while being able to be used for a long period of time without side effects. However, in general, when natural substances known to have antibacterial or cleaning effects are introduced as oral cleaning compositions, they are closed.Consequent contamination occurs due to food intake and saliva, and characteristics of the oral environment where cleaning agents are washed and general cleaning compositions. Due to the characteristics of harmful bacteria in the oral cavity that are not washed or killed by, there is a problem that almost no natural product known as a cleaning or antibacterial effect can be used as it is as a composition for oral cleaning. In addition, even if it is a natural product having a high general cleaning effect, there is a problem in that it does not have the effect of selectively cleaning only harmful bacteria while preventing beneficial bacteria from being killed.

Thus, while maintaining the above-described characteristics of oral cavity and beneficial bacteria, it is possible to more selectively clean harmful bacteria, and to study and complete the mixed oil composition for oral cavity cleaning according to the present invention to provide a cleaning composition based on natural products.

KR 10-2014-0118279 A KR 10-2012-0080472 A

An object of the present invention is to provide a mixed oil composition for oral cleaning that can be used for a long period of time without side effects using natural products.

The present invention is to provide a mixed oil composition for oral cleaning to prevent or improve periodontal disease by selectively inhibiting harmful bacteria that cause plaque removal and periodontal disease in the oral cavity, and preventing beneficial bacteria from being killed.

The present invention is to provide a mixed oil composition for oral cleaning having a high effect of removing bad breath.

Another object of the present invention is to provide an oral cleanser and other quasi-drugs using the mixed oil composition for oral cleaning.

In order to achieve the above object, the mixed oil composition for oral cleaning according to an embodiment of the present invention is to include lavender oil.

The mixed oil composition for mouthwash may further include basil oil.

The mixed oil composition for mouthwash may further include peppermint oil.

The mixed oil composition for oral cleaning may include lavender oil and the basil oil may be included in an amount of 20 to 150 parts by weight based on 100 parts by weight of the lavender oil.

The mouthwash mixed oil composition may include lavender oil and the peppermint oil may be included in an amount of 20 to 150 parts by weight based on 100 parts by weight of the lavender oil.

The mixed oil composition for mouthwash may include lavender oil and 20 to 150 parts by weight of basil oil and 20 to 150 parts by weight of peppermint oil based on 100 parts by weight of lavender oil.

Oral cleanser according to another embodiment of the present invention may be to include the mixed oil composition for cleaning the mouth.

The quasi-drug according to another embodiment of the present invention may include the mixed oil composition for cleaning the mouth.

Hereinafter, the present invention will be described in more detail.

The mixed oil composition for oral cleaning according to an embodiment of the present invention is to include lavender oil.

In the present invention, "periodontal disease" is a disease in which gingival and periodontal ligaments and bone tissues supporting the teeth are inflamed, and is also commonly referred to as wind, gingivitis and periodontitis depending on the extent of the disease Is divided into Periodontitis is a relatively light and fast-recovering periodontal disease that is limited to the gums, ie, soft tissues, and gingivitis. There is a V-shaped gap between the gingiva (gum) and the teeth, and the oral pathogens attack the lower part of the gum line of this sulcus, releasing the inflammatory stimulator Lipopolysaccharide (LPS). Inflammation occurs, such as swelling of the gums and bleeding, thereby damaging the periodontal ligament and adjacent tissue. When periodontitis progresses, the periodontal ligament, and even the alveolar bone, is damaged and eventually the teeth are lost. Malnutrition such as protein and vitamins, hormonal disorders such as pregnancy or diabetes, smoking, and AIDS may make the disease worse. Also, other causes of periodontal disease include plaque and plaque. Periodontal disease of the present invention includes all regardless of the type that causes the periodontal disease, but specifically, Actinobacillus actinomycetemcomitans (Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis (Porphyromonas gingivalis), Tane One or more homogeneous selected from the group consisting of Tannerella forsythia, Treponema denticola and Fusobacterium nucleatum, and more specifically, Porphyromonas positions It can be Vallis.

In the present invention, "halt breath" is an odor originating from the oral cavity and adjacent organs, and 85 to 90% of the bad breath is derived from the oral cavity, particularly from the back of the tongue. The main components of bad breath are volatile sulfur compounds, with 90% of the total amount of volatile sulfur compounds being hydrogen sulfide made from cysteine, methyl mercaptan made from methionine, and dimethyl sulfide. These components are produced primarily by protein enzymes released by anaerobic bacteria, and the back of the tongue is the most important habitat. This part does not clean well with saliva, and has many small depressions, making it a place where bacteria can continue to live. The production of volatile sulfur compounds by anaerobic bacteria is the most important cause of bad breath, but it is also caused by oral diseases such as dental caries, periodontitis, and dry mouth. Many types of anaerobic bacteria are involved in the development of bad breath, and non-limiting examples of bad breath-causing bacteria include Porphyromonas gingivalis, which secretes many types and large amounts of enzymes.

In general, when a natural plant known for its cleaning power or antibacterial power is used as a composition for oral cleaning, it is common that the expected cleaning or antibacterial effect does not occur. In general, even in the case of extracts for natural products with known antibacterial or cleaning effects, most of them do not effectively remove plaque formed on the teeth, and Streptococcus mutans, Gingivalis, which cause periodontal disease in the oral cavity. ) Because it does not effectively kill harmful bacteria. In particular, the oral cavity is a humid environment, because food, drink, saliva, etc. are constantly moving, and contamination occurs continuously, and the cleaning agent is an environment in which washing and washing are continuously removed. This is because extracts of common natural products cannot remove harmful bacteria due to the environment in which plaque cannot be removed.

On the other hand, the excellent cleaning effect among alcohol and natural extracts can kill harmful bacteria in the oral cavity, but there is a problem of killing even beneficial bacteria in the oral cavity, thereby accelerating periodontal disease.

When the oil composition of the present invention is provided, the above-described problems can be solved. Therefore, when the natural extract provided in the present invention is made of a water (H ₂ O) extract or an alcohol extract, the effect referred to in the present invention cannot be achieved. The mixed oil composition for oral cleaning according to the present invention should be provided as an oil composition using natural products.

In particular, the alcohol extract not only kills beneficial bacteria, but also volatilizes moisture on the skin's surface in the oral cavity, thereby making oral disease worse.

The lavender oil is Lamiaceae, the lavender plant is cultivated in the Mediterranean countries, including France and the United Kingdom, lavender oil is steam distillation from the flowers and leaves of the plant (method of extracting the active ingredient of the plant with water vapor and cooling to condense) Refers to the essential oil extracted with. It is a colorless or light yellow clear liquid with a subtle woody scent and floral scent, and belongs to the middle scent (middle notes).

When the lavender oil is used, it can effectively remove harmful bacteria such as Streptococcus mutans and Gingivalis, which are the cause of periodontal disease in the oral cavity, and are effective in removing plaque. In the step, the plaque is removed together, and even harmful bacteria remaining in the plaque can be more effectively removed.

When the lavender oil is used as a mixed oil composition for cleaning the oral cavity, it can prevent and improve periodontal disease.

The ginger oil (Ginger Oil) refers to the essential oil extracted from the root of ginger. It is a pale yellow liquid with a characteristic spicy, strong scent of ginger, and belongs to the top note.

On the other hand, when the lavender oil and ginger oil are used in combination, it can have a periodontal disease prevention and improvement effect.

On the other hand, as described above, the lavender oil refers to being provided as an oil or essential oil. When lavender is extracted with water, the prevention and improvement effect of periodontal disease is significantly lower because harmful bacteria in the oral cavity such as Streptococcus mutans and Gingivalis cannot be effectively removed. There is a losing problem. In addition, when alcohol extracts are used, even beneficial bacteria are killed, which causes the periodontal disease in the oral cavity to worsen. Therefore, the lavender is limited to lavender oil, and when water or alcohols are extracted with a solvent, the effect of the present invention cannot be achieved.

In addition, as described above, the ginger oil is also provided as oil or essential oil. In the case of extracting ginger with water, the prevention and improvement effect of periodontal disease is significantly low because harmful bacteria in the oral cavity such as Streptococcus mutans and Gingivalis cannot be effectively removed. There is a losing problem. In addition, when alcohol extracts are used, even beneficial bacteria are killed, which causes the periodontal disease in the oral cavity to worsen. Therefore, the ginger is limited to ginger oil, and when water or alcohols are extracted with a solvent, the effect of the present invention cannot be achieved.

The mixed oil composition for mouthwash may further include basil oil.

The basil oil refers to an essential oil extracted by steam distillation extraction method (a method of extracting an aromatic active ingredient of a plant with water vapor and cooling and condensing it with cooling water) from the flowers and leaves of basil.

When the basil oil is mixed, the effect of selectively killing harmful bacteria may be excellent without killing the beneficial bacteria present in the oral cavity. In addition, the effect of removing harmful bacteria and plaques in the oral cavity may be increased due to a synergistic effect due to interaction with the lavender oil.

Meanwhile, the basil oil is limited to oil or oils.

Like the above-mentioned lavender oil, when using water or alcohol as a solvent in the case of the basil, the effect of removing the flask and harmful bacteria is greatly lowered, so it cannot be used as a composition for cleaning in the oral cavity, or even beneficial bacteria are removed and moisture is lost in the oral cavity It can cause problems that cause periodontal disease to accelerate. Therefore, when using an extract prepared by using basil or water or a solvent as a solvent, it cannot produce the effect of preventing and improving periodontal disease referred to in the present invention, and thus cannot be used as a composition for oral cleaning proposed in the present invention.

The mixed oil composition for mouthwash may further include peppermint oil.

The peppermint oil is Mentha piperita or Mentha Refers to essential oils collected by steam distillation from arvensis leaves, flowers, and stems. It is a colorless or pale yellow liquid, characterized by a distinct scent and a strong spicy taste.

The effect of removing the plaque and harmful bacteria in which the peppermint oil is mixed can be greatly increased. That is, it can be mixed with the lavender oil to significantly increase the removal of harmful bacteria and plaques in the oral cavity due to the synergistic effect of interaction, so that a better effect can be exhibited in a relatively small amount in the prevention and improvement of dental diseases.

Meanwhile, the peppermint oil is limited to oil or oils.

Like the above-mentioned lavender oil or basil oil, in the case of the peppermint, when water or alcohol is used as a solvent, the effect of removing the flask and harmful bacteria is greatly lowered, so it cannot be used as a composition for cleaning in the oral cavity, or even remove beneficial bacteria Problems that cause my periodontal disease to accelerate by causing my water loss can occur.

Therefore, when using an extract prepared by using peppermint as a solvent for water or alcohol, it is impossible to prevent and improve the periodontal disease in the present invention. Therefore, it cannot be used as a composition for cleaning mouths presented in the present invention when used with water or alcohol extracts.

The mixed oil composition for oral cleaning may include lavender oil and the basil oil may be included in an amount of 20 to 150 parts by weight based on 100 parts by weight of the lavender oil.

In the case of the above range, the effect of removing plaque and removing harmful bacteria in the oral cavity is increased by synergistic effect due to interaction.

The mouthwash mixed oil composition may include lavender oil and the peppermint oil may be included in an amount of 20 to 150 parts by weight based on 100 parts by weight of the lavender oil.

In the case of the above range, the effect of removing plaque and removing harmful bacteria in the oral cavity is increased by synergistic effect due to interaction.

The mixed oil composition for mouthwash may include lavender oil and 20 to 150 parts by weight of basil oil and 20 to 150 parts by weight of peppermint oil based on 100 parts by weight of lavender oil.

In the case of the above range, it is possible to prevent the killing of beneficial bacteria while increasing the antibacterial effect due to the synergistic effect of the interaction of each oil, thereby enhancing the killing effect of harmful bacteria. In addition, the effect of removing the plaque can be greatly increased. Therefore, in the case of the above range, it has an advantage that it can be used for a long period of time without a problem of side effects with a certain amount of content compared to a single oil composition.

Furthermore, it is possible to more effectively kill the bacteria that cause bad breath, so that the bad breath can be reduced and its persistence can be maintained for a long time.

Preferably, the mixed oil composition for oral cleaning may further include carrot seed oil.

When the carrot seed oil is further included, it has an advantage that an antibacterial power and a plaque removal effect by interaction are increased. In addition, it can increase the effect of reducing bad breath and preventing and improving periodontal disease.

The kerosene seed should be included as an oil, and when used as a water extract or an alcohol extract like the other natural products described above, the effect of the present invention cannot be achieved.

In addition, more preferably, the mixed oil composition for cleaning the mouth contains lavender oil and 20 to 150 parts by weight of basil oil with respect to 100 parts by weight of the lavender oil; Peppermint oil may be 20 to 150 parts by weight and 10 to 50 parts by weight of carrot seed oil.

In the case of the above range, the synergistic effect of the antibacterial and cleaning effect may be increased by interaction. In particular, when the carrot seed oil exceeds 50 parts by weight, not only the palatability is greatly reduced due to its peculiar fragrance, but there is also a problem that the synergistic effect does not appear due to the relatively high content of the carrot seed oil. In addition, when the carrot seed oil is contained in less than 10 parts by weight, there is a problem that the synergistic effect of using the carrot seed oil does not appear.

Preferably, the mixed oil composition for cleaning the mouth contains lavender oil and 20 to 150 parts by weight of basil oil with respect to 100 parts by weight of the lavender oil; Peppermint oil 20 to 150 parts by weight; Carrot seed oil may be 10 to 50 parts by weight of jasmine oil 1 to 5 parts by weight and tarragon oil 1 to 5 parts by weight.

In the case of the above range, the synergistic effect by interaction of each oil greatly increases the plaque removal and harmful bacteria suppression activity and does not kill beneficial bacteria. In particular, in the case of the above range, the flavor according to the combination of each oil is the best, and thus it can be provided as a mixed oil composition for oral cleaning with high palatability.

The jasmine oil and the tarragon oil are limited to oil, like other oils, and when using the extract of jasmine or tarragon itself or water or alcohol as a solvent, the purpose of the present invention Can not achieve.

The periodontal disease prevention and improvement oil composition may include ginger oil and 20 to 150 parts by weight of the basil oil relative to 100 parts by weight of the ginger oil.

In the case of the above range, the effect of removing plaque and removing harmful bacteria in the oral cavity is increased by synergistic effect due to interaction.

The periodontal disease prevention and improvement oil composition may include ginger oil and 20 to 150 parts by weight of the peppermint oil with respect to 100 parts by weight of the ginger oil.

In the case of the above range, the effect of removing plaque and removing harmful bacteria in the oral cavity is increased by synergistic effect due to interaction.

The periodontal disease prevention and improvement oil composition may include ginger oil and 20 to 150 parts by weight of basil oil and 20 to 150 parts by weight of peppermint oil based on 100 parts by weight of the ginger oil.

In the case of the above range, it is possible to prevent the killing of beneficial bacteria while increasing the antibacterial effect due to the synergistic effect of the interaction of each oil, thereby enhancing the killing effect of harmful bacteria. In addition, the effect of removing the plaque can be greatly increased. Therefore, in the case of the above range, it has an advantage that it can be used for a long period of time without a problem of side effects with a certain amount of content compared to a single oil composition.

Furthermore, it is possible to more effectively kill the bacteria that cause bad breath, so that the bad breath can be reduced and its persistence can be maintained for a long time.

Preferably, the oil composition for preventing and improving periodontal disease may further include carrot seed oil.

When the carrot seed oil is further included, it has an advantage that an antibacterial power and a plaque removal effect by interaction are increased. In addition, it can increase the effect of reducing bad breath and preventing and improving periodontal disease.

The kerosene seed should be included as an oil, and when used as a water extract or an alcohol extract like the other natural products described above, the effect of the present invention cannot be achieved.

Also more preferably, the oil composition for preventing and improving periodontal disease includes ginger oil and 20 to 150 parts by weight of basil oil with respect to 100 parts by weight of the ginger oil; Peppermint oil may be 20 to 150 parts by weight and 10 to 50 parts by weight of carrot seed oil.

In the case of the above range, the synergistic effect of the antibacterial and cleaning effect may be increased by interaction. In particular, when the carrot seed oil exceeds 50 parts by weight, not only the palatability is greatly reduced due to its peculiar fragrance, but there is also a problem that the synergistic effect does not appear due to the relatively high content of the carrot seed oil. In addition, when the carrot seed oil is contained in less than 10 parts by weight, there is a problem that the synergistic effect of using the carrot seed oil does not appear.

Preferably, the oil composition for preventing and improving periodontal disease includes ginger oil and 20 to 150 parts by weight of basil oil with respect to 100 parts by weight of the ginger oil; Peppermint oil 20 to 150 parts by weight; Carrot seed oil may be 10 to 50 parts by weight of jasmine oil 1 to 5 parts by weight and tarragon oil 1 to 5 parts by weight.

In the case of the above range, the synergistic effect by interaction of each oil greatly increases the plaque removal and harmful bacteria suppression activity and does not kill beneficial bacteria. In particular, in the case of the above range, the flavor according to the combination of each oil is the best, and thus it can be provided as an oil composition for preventing and improving periodontal disease with high palatability.

Oral cleanser according to another embodiment of the present invention may be to include the mixed oil composition for cleaning the mouth.

The oral cleansing agent is defined as including a composition capable of gargling the oral cavity and other agents for exhibiting cleaning and antibacterial activity in the oral cavity. On the other hand, the mouthwash for achieving the purpose of the present invention should be an oil-based composition, it is preferable not to mix a surfactant or an allolator. The specific formulation is defined to include both a composition and a mixing range that can be selected and mixed by those skilled in the art.

The quasi-drug according to another embodiment of the present invention may include the mixed oil composition for cleaning the mouth.

The quasi-drug composition of the present invention may include a quasi-drug for oral cavity. The components included in the quasi-drug composition of the present invention may include ingredients commonly used in oral quasi-drug compositions in addition to the active ingredient as an active ingredient, for example, abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, pharmaceutical ingredients, flavors Agents, pigments, solvents, brighteners, solubilizers or pH adjusting agents.

The quasi-drug composition for oral use of the present invention may be prepared in any formulation conventionally prepared in the art, for example, toothpaste, mouthwash, mouthwash, gum, candy, mouth spray, oral ointment, oral varnish , Oral brush and gum massage cream, but is not limited thereto.

As an example, when the quasi-drug composition for oral cavity of the present invention is a formulation of toothpaste, it may include a wetting agent, abrasive agent, a binder, a foaming agent, a flavoring agent, a sweetening agent, a colorant, a preservative, a drug substance, a solvent, a pH adjusting agent, and the like.

The wetting agent is to prevent the powder from becoming a paste in the components of the toothpaste and to prevent the toothpaste from solidifying in the air, 1 to 60 weight of the total weight of the composition by mixing glycerin, sorbit, propylene glycol, polyethylene glycol, etc. alone or in combination of two or more. %, specifically 10 to 50% by weight may be used.

The foaming agent disperses the toothpaste in the oral cavity to increase the cleaning effect, and acts as a surfactant to clean the oral contamination. Surfactants such as sodium lauryl sulfate, sodium lauryl sarcosinate, sodium alkyl sulfosuccinate, sucrose fatty acid ester alone Or by mixing two or more, 0.5 to 10% by weight of the total weight of the composition, specifically 0.5 to 5% by weight may be used.

The binder is to prevent separation between the powder and the liquid component in the toothpaste, by mixing cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylcellulose, sodium alginate, carrageenan, xanthan gum or the like, or by mixing two or more thereof 0.1 to 5% by weight of the total weight of the composition, specifically 0.3 to 2% by weight can be used.

The abrasive removes deposits on the tooth surface without scratching the surface of the tooth and allows the original luster of the tooth to be calcium carbonate (CaCO ₃ ), dicalcium phosphate (CaHPO ₄ , CaHPO ₄ 2H ₂ O), silicic anhydride (SiO ₂ 2H ₂ O), aluminum hydroxide (Al(OH) ₃ ), pyrophosphate, magnesium carbonate, etc. alone or in combination of two or more, 1 to 60% by weight of the total weight of the composition, specifically 10 to 50% by weight Can be used.

The flavoring agent is intended to enhance the feeling of use by giving a feeling of refreshment and odor to toothpaste, and 1 to 60% by weight, specifically 0.01 to 5% by weight of the total weight of the composition by mixing natural or synthetic fragrances alone or in combination of two or more. Can be used.

The sweetener is intended to remove unpleasant taste or freshness from the raw material of toothpaste, and saccharic acid, aspartame, xylitol, licorice acid, etc., alone or in combination of two or more, 1 to 60% by weight of the total weight of the composition, specifically 0.01 to 5% by weight can be used.

The present invention is to provide a mixed oil composition for oral cleaning that can be used for a long time without side effects using natural products.

The mixed oil composition for oral cavity cleaning according to the present invention selectively prevents or improves periodontal disease by selectively suppressing harmful bacteria that cause plaque removal and periodontal disease in the oral cavity and preventing beneficial bacteria from being killed.

The mixed oil composition for oral cavity cleaning according to the present invention has an advantage of having high anti-odor and long-lasting effect.

The present invention provides oral cleansing agents and other quasi-drugs that can prevent or improve periodontal disease by utilizing the mixed oil composition for oral cleaning.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art to which the present invention pertains can easily practice. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein.

[Production Example 1: Preparation of oil composition, etc.]

1. Preparation of lavender oil and a mixed oil composition comprising the same

Lavender oil (A0), basil oil (A2), peppermint oil (A3), carrot seed oil (A4), jasmine oil (A5), and tarragon oil (A6) are mixed and mixed as shown in Table 1 below. An oil composition was prepared.

A0 A2 A3 A4 A5 A6 M1 100 10 - - - - M2 100 20 - - - - M3 100 75 - - - - M4 100 150 - - - - M5 100 170 - - - - M6 100 - 10 - - - M7 100 - 20 - - - M8 100 - 75 - - - M9 100 - 150 - - - M10 100 - 170 - - - M11 100 75 75 5 - - M12 100 75 75 10 - - M13 100 75 75 30 - - M14 100 75 75 50 - - M15 100 75 75 60 - - M16 100 75 75 30 0.5 0.5 M17 100 75 75 30 One One M18 100 75 75 30 3 3 M19 100 75 75 30 5 5 M20 100 75 75 30 6 6

(Unit: parts by weight)

2. Hot water extract Produce

(1) Preparation of lavender hot water extract

After crushing the dried lavender leaves, an extract was prepared using hot water, and filtered and concentrated to prepare a lavender hot water extract (B0).

(2) Preparation of other hot water extracts

Basil hot water extract (B2), peppermint hot water extract (B3), and carrot seed hot water extract (B4) were prepared using the same method as the lavender hot water extract.

3. Preparation of alcohol extract

(1) Preparation of lavender alcohol extract

After crushing the dried lavender leaves, an extract was prepared using ethanol as a solvent. Lavender alcohol extract (C0) was prepared by mixing it with purified water so that it could be used as a composition for oral cleaning.

(2) Preparation of other alcohol extracts

Basil alcohol extract (C2), peppermint alcohol extract (C3), and carrot seed alcohol extract (C4) were prepared using the same method as the method for preparing the lavender alcohol extract.

[Production Example 2: Preparation of oil composition, etc.]

1. Preparation of mixed oil composition

Commercially available ginger oil (A1), basil oil (A2), peppermint oil (A3), carrot seed oil (A4), jasmine oil (A5), and tarragon oil (A6) are mixed as shown in Table 2 below. An oil composition was prepared.

A1 A2 A3 A4 A5 A6 H1 100 10 - - - - H2 100 20 - - - - H3 100 75 - - - - H4 100 150 - - - - H5 100 170 - - - - H6 100 - 10 - - - H7 100 - 20 - - - H8 100 - 75 - - - H9 100 - 150 - - - H10 100 - 170 - - - H11 100 75 75 5 - - H12 100 75 75 10 - - H13 100 75 75 30 - - H14 100 75 75 50 - - H15 100 75 75 60 - - H16 100 75 75 30 0.5 0.5 H17 100 75 75 30 One One H18 100 75 75 30 3 3 H19 100 75 75 30 5 5 H20 100 75 75 30 6 6

(Unit: parts by weight)

2. Ginger Hydrothermal Preparation of extract and ginger alcohol extract

After crushing the dried ginger, an extract was prepared using hot water, and filtered and concentrated to prepare a ginger hot water extract (B1). In addition, after crushing the dried ginger leaves, an extract was prepared using ethanol as a solvent. Ginger alcohol extract (C1) was prepared by mixing it with purified water to be used as a composition for oral cleaning.

[Experimental Example 1: Oral cleansing, periodontal disease prevention and improvement effect test]

1. Antibacterial experiment

(1) Experiment of antibacterial activity against Streptococcus mutans

Streptococcus mutans bacteria, known as typical harmful bacteria of periodontal disease, were inoculated in a solid medium and cultured for 3 to 4 days. The control group was treated only with purified water, and after treatment with the preparation examples A0, M1 to M20, B0 to B6, and C0 to C6, the cells were cultured after 24 hours.

Before and after the treatment of the purified water and the preparation example, the absorbance was measured at 650 nm to examine the growth inhibitory capacity (%).

For objective comparison, the result of using purified water (control) was set to 100, and the value of each example was divided by the value of the growth inhibitory ability of the control to allow comparative evaluation. The results (antibacterial activity test for Mutans bacteria: Mu) are shown in Table 2 below. The values shown in [Table 3] indicate that the lower the number, the better the antibacterial power against Streptococcus mutans.

(2) Antibacterial activity test against Gingivalis

In order to evaluate the antibacterial activity against Gingivalis, a well-known cause of periodontal disease and bad breath, Gingivalis was inoculated in a solid medium and cultured for 3 to 4 days. The control group was treated only with purified water, and after treatment with the preparation examples A0, M1 to M20, B0 to B6, and C0 to C6, the cells were cultured after 24 hours.

Before and after the treatment of the purified water and the preparation example, the absorbance was measured at 650 nm to investigate the growth inhibitory ability.

For objective comparison, the result of using purified water (control) was set to 100, and the value of each example was divided by the value of the growth inhibitory ability of the control to allow comparative evaluation. The results (antibacterial activity test for G. valerian bacteria: Gv) are shown in [Table 2] below. The values shown in [Table 3] indicate that the lower the number, the better the antibacterial power against Gingivalis.

(3) Lactobacillus reuteri (Lactobacillus reuteri) bacteria retention test

Lactobacillus reuteri bacteria, known as one of the representative beneficial bacteria that have a beneficial effect on preventing tooth decay and other periodontal disease by inhibiting the mutans bacteria, are cultured in a medium The medium was inoculated and cultured for 3 to 4 days. The control group was treated only with purified water, and after treatment with the preparation examples A0, M1 to M20, B0 to B6, and C0 to C6, the cells were cultured after 24 hours.

Before and after the treatment of the purified water and the preparation example, the absorbance was measured at 650 nm to investigate the growth inhibitory ability.

For objective comparison, the result of using purified water (control) was set to 100, and the value of each example was divided by the value of the growth inhibitory ability of the control to allow comparative evaluation. The results (Lactobacillus luteeri bacterium retention test: Rt) are shown in Table 2 below. The value shown in [Table 3] shows that the higher the number, the more conservative the Lactobacillus reuteri bacteria are. It is excellent.

Mu Gv Rt Control 100 100 100 A0 8.75 7.65 16.41 M1 10.81 8.45 21.4 M2 5.33 4.21 19.5 M3 4.15 3.75 18.65 M4 4.67 4.13 20.48 M5 8.54 8.46 21.52 M6 11.91 9.53 19.33 M7 4.36 3.86 19.75 M8 3.25 3.57 21.6 M9 3.23 4.03 22.38 M10 8.94 7.46 23.4 M11 3.15 3.68 23.24 M12 2.31 3.24 45.68 M13 2.21 2.84 47.15 M14 2.14 2.41 41.2 M15 4.57 3.97 27.4 M16 4.07 4.97 45.17 M17 2.14 2.31 58.47 M18 1.89 2.11 57.14 M19 2.14 2.14 54.12 M20 4.11 4.45 43.54 B0 87 79 89 B2 97 88 79 B3 73 76.14 86 B4 118.45 117.17 107.6 C0 0.15 0.41 0.14 C2 0.14 0.78 0.03 C3 0.78 0.48 0.14 C4 0.17 0.48 0.78

(Unit: index)

Referring to [Table 3] above, in the case of the hot water extract, it may be reduced to a small incubation level to produce a low level of cleaning effect, but it can be seen that it is reduced to a small extent without discrimination between harmful bacteria and beneficial bacteria. It can be seen that the number of bacteria has increased.

On the other hand, in the case of the alcohol extract, it can be seen that the number of bacteria rapidly decreases as an effect on the alcohol itself rather than a difference in effect depending on the type of the natural product. In particular, in the case of an oral cleaner using alcohol, it is accompanied by a loss of moisture in the epidermis in the oral cavity, so considering the fact that harmful bacteria grow faster after bacterial cleaning and accelerates the formation of plago, which makes it a good environment for oral disease. It can be seen that the problem caused by is much larger, and the improvement effect according to the type of natural product does not appear.

When using lavender oil (A0), it can be seen that harmful bacteria are reduced. In particular, referring to M2 to M4, M6 to M9, it can be seen that when the lavender oil is used in combination with basil oil (A2) or peppermint oil (A3) while maintaining a constant content, a synergistic effect due to interaction appears.

On the other hand, referring to M12 to M14 in a certain range, it can be seen that when the carrot seed oil (A4) is mixed with other oils while maintaining a constant mixing ratio, it has an effect of preventing the beneficial bacteria from being killed. That is, it can be seen that the effect of antimicrobial bacteria is increased by mixing in a certain range, and that the beneficial bacteria can be killed.

When jasmine oil (A5) and tarragon oil (A6) are mixed in a certain range, it can be seen that the antibacterial power of harmful bacteria can be doubled due to the synergistic effect by interaction, and the effect of preventing beneficial bacteria from disappearing is highest. . Therefore, in the case of the above range, it is possible to prepare a mixed oil composition for oral cleaning, which can effectively remove harmful bacteria with a smaller content, while preventing the beneficial bacteria from being killed in the oral cavity.

2. Plaque removal effect experiment

To 20 testers, purified water (Control) and preparation examples A0, M1 to M20, B0 to B6, and C0 to C6 were provided as mouthwashes, and the effect of removing plaques before and after gargling was tested.

The degree to which the plaque was removed was evaluated, and the results are shown in [Table 4] below. The degree of removal of the plaque was evaluated by ductation through plaque coloring, and the result was evaluated by an index of 1 to 10 based on purified water 5. The higher the number, the better.

Plaque Control 5 A0 4 M1 4 M2 4 M3 4 M4 4 M5 4 M6 4 M7 7 M8 7 M9 6 M10 4 M11 7 M12 7 M13 7 M14 7 M15 7 M16 6 M17 8 M18 9 M19 9 M20 6 B0 5 B2 5 B3 5 B4 5 C0 8 C2 8 C3 8 C4 8

(Unit: index)

Referring to [Table 4], it can be seen that in the case of a hot water extract, the same effect as that of normal purified water is obtained. It can be seen that this is an effect due to the use of water as a solvent rather than a characteristic according to the difference in the material of each natural product. In addition, it can be seen that even when peppermint is used, when used as a hot water extract, there is no significant synergistic effect in removing plaque.

On the other hand, in the case of alcohol extract, it can be seen that the effect of removing the plaque is higher than that of purified water, but this is an effect of alcohol, and it can be seen that there is no difference according to the use of each natural product. In addition, when using alcohol as described above, considering that the generation of plaque is accelerated due to the death of beneficial bacteria and loss of water in the epidermis in the oral cavity, the problem of the mouthwash containing conventional ethanol is not solved according to the use of the natural product. Was confirmed.

Lavender oil (A0) can be seen that the effect of removing the plaque is slightly lower than that of purified water. In addition, even when the basil oil (A2) is mixed, it is not known that the plaque removal effect is noticeably increased. However, it can be seen that when the peppermint oil (A3) is mixed in a certain range, the effect of removing the plaque is increased as a synergistic effect.

In particular, referring to M17 to M19, it can be seen that when the jasmine oil (A5) and the tarragon oil (A6) are included in a certain range, the plaque removal effect is significantly increased. Even in the case of the test subject, in the case of M18 and M19, it was evaluated that the refreshing feeling after gargling was superior to other experimental examples.

[Experimental Example 2: Oral cleansing, periodontal disease prevention and improvement effect test]

1. Antibacterial experiment

In the same manner as Experimental Example 1 above, the antibacterial activity against Streptococcus mutans bacteria, the antibacterial activity against Gingivalis bacteria, and the preservation against Lactobacillus reuteri bacteria were carried out, and the results were as follows. It is shown in [Table 5].

Mu Gv Rt Control 100 100 100 A1 6.47 5.74 9.41 H1 9.79 7.41 13.47 H2 4.89 5.11 14.31 H3 3.96 4.04 14.34 H4 4.13 3.94 16.12 H5 7.97 8.14 18.95 H6 9.81 9.14 21.14 H7 3.84 3.47 18.41 H8 3.78 3.57 19.47 H9 4.79 3.87 20.47 H10 9.61 8.71 24.71 H11 3.45 3.64 24.41 H12 2.14 3.34 44.17 H13 2.07 2.64 43.35 H14 1.81 2.08 41.25 H15 3.71 3.74 24.46 H16 4.78 5.47 46.47 H17 2.11 2.14 60.14 H18 1.74 1.89 51.41 H19 1.97 2.33 53.87 H20 4.74 4.45 39.74 B1 74 71 76 C1 0.14 0.62 0.24

(Unit: index)

Referring to the [Table 3] and [Table 5], in the case of the hot water extract, it may be reduced to a small incubation level to produce a low cleaning effect, but it can be seen that it decreases to a small extent without discriminating between harmful bacteria and beneficial bacteria. In the case of B4, it can be seen that the number of bacteria increased.

On the other hand, in the case of the alcohol extract, it can be seen that the number of bacteria rapidly decreases as an effect on the alcohol itself rather than a difference in effect depending on the type of the natural product. In particular, in the case of an oral cleaner using alcohol, it is accompanied by a loss of moisture in the epidermis in the oral cavity, so considering the fact that harmful bacteria grow faster after bacterial cleaning and accelerates the formation of plago, which makes it a good environment for oral disease. It can be seen that the problem caused by is much larger, and the improvement effect according to the type of natural product does not appear.

Referring to [Table 5], it can be seen that harmful bacteria are reduced when ginger oil (A1) is used. In particular, referring to H2 to H4, H6 to H9, it can be seen that when used in combination with basil oil (A2) or peppermint oil (A3) while maintaining a certain content, a synergistic effect due to interaction appears.

On the other hand, referring to H12 to H14 in a certain range, it can be seen that when the carrot seed oil (A4) is mixed with other oils while maintaining a constant mixing ratio, it can be seen that it has an effect of preventing beneficial bacteria from being killed. That is, it can be seen that the effect of antimicrobial bacteria is increased by mixing in a certain range, and that the beneficial bacteria can be killed.

When jasmine oil (A5) and tarragon oil (A6) are mixed in a certain range, it can be seen that the antibacterial power of harmful bacteria can be doubled due to the synergistic effect by interaction, and the effect of preventing beneficial bacteria from disappearing is highest. . Therefore, in the case of the above range, it is possible to prepare an oil composition for preventing and improving periodontal disease, which can effectively remove harmful bacteria with a smaller content and prevent the beneficial bacteria from being killed in the oral cavity.

2. Plaque removal effect experiment

Purified water (Control) and preparation examples of A1, H1 to H20, B1 to B6, and C1 to C6 were provided to 20 testers as mouthwashes, and plaque removal effects before and after gargling were tested.

The degree to which the plaque was removed was evaluated, and the results are shown in [Table 6] below. The degree of removal of the plaque was evaluated by ductation through plaque coloring, and the result was evaluated by an index of 1 to 10 based on purified water 5. The higher the number, the better.

Plaque Control 5 A1 5 H1 5 H2 5 H3 5 H4 4 H5 4 H6 4 H7 7 H8 7 H9 6 H10 4 H11 7 H12 7 H13 7 H14 7 H15 7 H16 6 H17 8 H18 9 H19 9 H20 6 B1 5 C1 8

(Unit: index)

Referring to [Table 4] and [Table 6], it can be seen that in the case of the hot water extract, it has the same effect as the normal purified water. It can be seen that this is an effect due to the use of water as a solvent rather than a characteristic according to the difference in the material of each natural product. In addition, it can be seen that even when peppermint is used, when used as a hot water extract, there is no significant synergistic effect in removing plaque.

On the other hand, in the case of alcohol extract, it can be seen that the effect of removing the plaque is higher than that of purified water, but this is an effect of alcohol, and it can be seen that there is no difference according to the use of each natural product. In addition, when using alcohol as described above, considering that the generation of plaque is accelerated by the death of beneficial bacteria and the loss of moisture in the epidermis in the oral cavity, the problem of the mouthwash containing conventional ethanol is not solved according to the use of the natural product. Was confirmed.

Referring to [Table 6], the ginger oil (A1) is not particularly effective in removing plaques because the plaque removal effect shows the effect of purified water compared to purified water. In addition, even when the basil oil (A2) is mixed, it is not known that the plaque removal effect is noticeably increased. However, it can be seen that when the peppermint oil (A3) is mixed in a certain range, the effect of removing the plaque is increased as a synergistic effect.

In particular, referring to H17 to H19, it can be seen that when the jasmine oil (A5) and the tarragon oil (A6) are included in a certain range, the plaque removal effect is significantly increased. Even in the case of the test subject, H18 and H19 were evaluated to have a superior refreshing feeling after gargling compared to other experimental examples.

The preferred embodiments of the present invention have been described in detail above, but the scope of the present invention is not limited to this, and various modifications and improvements of those skilled in the art using the basic concepts of the present invention defined in the following claims are also provided. It belongs to the scope of rights.

Claims (8)

Contains an oil composition using natural products,
The oil composition includes ginger oil,
It further includes basil oil, peppermint oil, carrot seed oil, jasmine oil and tarragon oil,
With respect to 100 parts by weight of the ginger oil,
20 to 150 parts by weight of basil oil, 20 to 150 parts by weight of peppermint oil, 10 to 50 parts by weight of carrot seed oil, 1 to 5 parts by weight of jasmine oil, and 1 to 5 parts by weight of tarragon oil,
Excellent in removing plaque in the oral cavity and selectively suppressing harmful bacteria that cause periodontal disease
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