KR102055301B1 - Toothpsate composites typed effervescent and that of manufacturing method - Google Patents

Abstract

The present invention relates to a foamed tablet toothpaste composition and a manufacturing method thereof, the composition of which is 17.53% by weight of sorbitol, 10% by weight of silicon dioxide, 0.22% by weight of sodium fluoride, 0.05% by weight of pyridoxine hydrochloride, 1% by weight of sodium pyrophosphate, aspartame 1.20% by weight, ascorbic acid 0.50%, applemint flavor powder 1% by weight, campa 1.50% by weight, peppermint flavor powder 7% by weight, gum arabic 5%, sodium hydrogencarbonate 30% by weight and 10% by weight L-malic acid The formulations are mixed to form a formulation using a metal casting mold and coated with a formulation formed using 15% by weight of xylitol, and then formed by smooth grinding the surface to prevent it from being broken by drying.
Accordingly, sodium bicarbonate and malic acid (L-malic acid), which are the foaming ingredients, are added to the raw material formulation of the powder formulation, and then perforated in a casting mold to form a tablet. By coating with xylitol syrup, bubbles are produced while chewing without water, and bubbles caused by foaming can penetrate deeply between teeth, preventing aesthetic and gum diseases such as whitening, tartar prevention, and bad breath control. It provides a preventable effect.

Description

Foamed tablet toothpaste composition and its manufacturing method {Toothpsate composites typed effervescent and that of manufacturing method}

The present invention relates to an oral hygiene composition and a method for preparing the same, which is easy to deliver the refreshing feeling and oral hygiene active ingredient in the oral cavity, the natural baking soda and L-malic acid in tablets that are not toothpaste of the conventional liquid or ointment paste formulation ( The present invention relates to a foamed tablet toothpaste composition molded and compressed by adding L-malic acid) and a method of manufacturing the same.

In addition, the present invention by adding sodium bicarbonate and L-malic acid, which is a foaming ingredient, to a raw material formulation of a powder formulation, is punched in a casting mold to form a tablet and then tableted. In order to improve the product quality of tablets, it is coated with xylitol syrup or HPMC (Hydroxypropyl methylcellulose) mixture to form a bubble without chewing water, and bubbles caused by foaming penetrate deeply between teeth. It relates to aesthetics such as whitening, prevention of tartar deposition, suppression of bad breath, and foamed tablet-type toothpaste composition which can treat and prevent gum disease.

Toothpaste is a drug compound used on a toothbrush for the purpose of cleaning and polishing teeth. It consists of powder, cream, liquid, and the like. It is made to help prevent or treat disinfection, tartar disintegration, odor reduction and tooth decay or alveolar pylori. As a component, a base is mentioned first. Calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride, etc. are used for this. These are helpful for the mechanical cleaning of the teeth. If the size, hardness, and shape of the particles are not appropriate, they may damage the surface of the teeth. Therefore, the size of the particles should be about 1 to 20 µm and uniform. It is required to be sensitive, not hard, about 3 degrees of moss hard.

In addition to this base, detergents, perfumes, colorants, disinfectant disinfectants, tartar dissolving agents, neutralizing agents and the like are mixed little by little. In addition to the cream type, a binder, a stabilizer, and the like are added.

In other words, paste toothpaste is widely used as a toothpaste used for cleaning mouth and teeth, but if a certain time elapses after using the tube for a long time or leaving the lid of the tube, the front part of the tube solidifies and cannot be used easily. Often there is no. In addition, the toothpaste remaining in the tube during the use process can not be used completely, because the tube to which the toothpaste is injected disposable every time, was a waste, causing environmental pollution.

In order to solve such a problem, a toothpaste can be used relatively, and a liquid toothpaste capable of reusing a container has been proposed. However, such a liquid toothpaste is not actually used due to the problem that the liquid toothpaste composition flows easily during use and is very inconvenient and wasteful.

In addition, conventionally sold tablets toothpaste is a dry type of tablets to form a tablet at a constant pressure by tableting the powder formulation and water or gelling agent as a binder in the powder formulation is produced in a granular form after low pressure punching It takes a form to make.

In general, the manufacturing form is often made into tablets, and powder binders are not produced and sold by LG H & H, but most of them use the latter.

In the case of powder tableting, the product is easily crushed because it is a method of tableting the powder directly, and also broken by transportation and shaking after packing, and a more serious disadvantage is that the powder dries and gets stuck in the mouth when it is chewed. There are disadvantages to feel,

In the case of granule-type perforated food, the granules are made of water or gelling agent and then manufactured by low pressure perforation, so that a slight pressure can easily change the dosage form, and there is a disadvantage of feeling a lot of foreign body with sticky feeling when chewing. have.

Therefore, the present applicant intends to propose a tablet-type toothpaste manufacturing method that compensates for the shortcomings produced through the granules and low-pressure punching.

[Related Technical Documents]

1.Jelly toothpaste and process for preparing the same (Patent Registration No. 10-1272225)

2. Method for making natural toothpaste (Patent Registration No. 10-1692232)

3. Water-free typed effervescent toothpaste composition (Patent No. 10-1056573)

The present invention has been made to solve the above problems, the object of the present invention is to form a casting mold in the shape of the formulation by adding baking foam soda sodium bicarbonate and malic acid (L-malic acid) to the raw material formulation of the powder formulation Foamed by chewing without water by coating with xylitol syrup or HPMC (Hydroxypropyl methylcellulose) mixture, etc. It is to provide a foam tablet type toothpaste composition and a method of manufacturing the aesthetics such as whitening, preventing tartar deposition, inhibiting bad breath, and the treatment and prevention of gum disease, due to the bubbles can penetrate deep between the teeth.

In addition, the present invention is to make a formulation using a metal casting mold in order to mold into a product having a tablet-like shape, and then coated with a syrup using xylitol to smoothly grind the surface by chewing tablet toothpaste once or twice to be soared. It is to provide a foamed tablet toothpaste composition and a method for producing the same that provide convenience for portability or use so that the tooth can be brushed.

However, the objects of the present invention are not limited to the above-mentioned objects, and other objects not mentioned will be clearly understood by those skilled in the art from the following description.

Foam tablet type toothpaste composition according to the characteristics of the present invention for achieving the above object is 17.53% by weight of sorbitol, 10% by weight of silicon dioxide, 0.22% by weight of sodium fluoride, 0.05% by weight of pyridoxine hydrochloride, 1% by weight of sodium pyrophosphate, aspartame 1.20% by weight, ascorbic acid 0.50%, applemint flavor powder 1% by weight, campa 1.50% by weight, peppermint flavor powder 7% by weight, gum arabic 5%, sodium hydrogencarbonate 30% by weight and 10% by weight L-malic acid After mixing the formulation to form a formulation using a metal casting mold and coating the formulation formed using 15% by weight of xylitol, it is characterized by being formed by smoothly grinding the surface to prevent breakage,

In addition, the manufacturing method of the foamed tablet toothpaste according to the embodiment of the present invention is sorbitol, silicon dioxide, sodium fluoride, pyridoxine hydrochloride, sodium pyrophosphate, aspartame, ascorbic acid, apple mint flavor powder, xylitol, camphor, peppermint flavor powder, Arabia A first step of mixing a mixture of gum, sodium bicarbonate and malic acid by mixing into a mixer; A second process of forming a tablet formulation by perforating a metal casting mold to mold the mixed toothpaste powder into a tablet-shaped form; A third process of coating and drying the formulation formed through the second process with a syrup of xylitol; And a fourth step of smoothly grinding the surface to prevent breakage when carrying the dried tablet and coated formulation formed through the three processes and removing foreign matters when chewing.

In addition, the foamed tablet toothpaste manufacturing method according to an embodiment of the present invention, the tablet toothpaste composition is 17.53% by weight of sorbitol, 10% by weight of silicon dioxide, 0.22% by weight of sodium fluoride, 0.05% by weight of pyridoxine hydrochloride, 1% by weight of sodium pyrophosphate , Aspartame 1.20 wt%, Ascorbic acid 0.50 wt%, Applemint flavor powder 1 wt%, Campa 1.50 wt%, Peppermint flavor powder 7 wt%, Arabia gum 5 wt%, Sodium bicarbonate 30 wt%, L-malic acid 10 wt% And 15% by weight of xylitol.

Foamed tablet toothpaste composition according to the present invention and a method for preparing the same are added to the raw material formulation of the powder formulation by adding baking foam soda sodium bicarbonate and malic acid (L-malic acid) to form a tablet in a casting mold After molding into a mold, it is coated with xylitol syrup to improve the productability of tableting tablets, and bubbles are produced by chewing without water, allowing bubbles from foaming to penetrate deeply between teeth, preventing whitening and tartar deposition. Aesthetics such as bad breath control and gum disease can be treated and prevented.

In addition, the foamed tablet toothpaste composition and the manufacturing method according to an embodiment of the present invention to form a formulation using a metal casting mold to be molded into a product having a tablet-like shape and coated with a syrup using xylitol in the following process Grinding the surface smoothly provides chewable tablet toothpaste once or twice to provide portability or ease of use for brushing by soaking.

In addition, the foamed tablet toothpaste composition and the preparation method according to an embodiment of the present invention by adding a natural baking soda and acid as the foam component to the raw material powder formulation, the foam is produced immediately chewing without water to exhibit the efficacy as a toothpaste In order to improve the productability of tableting tablets, it is a coating process using xylitol syrup, and when the toothpaste of the formulation is put into the mouth, the foaming takes place while chewing and dissolving the raw materials, and the bubbles due to foaming are deep between the teeth. It is possible to penetrate and it is effective to clean as a toothpaste.

1 is a flow chart showing a schematic process of the foamed tablet toothpaste manufacturing method according to the present invention

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings, and the following examples are provided only for better understanding of the present invention, and the contents of the present invention are limited by the embodiments. It is not.

The present invention provides a tablet of sorbitol, silicon dioxide, sodium fluoride, pyridoxine hydrochloride, sodium pyrophosphate, aspartame, ascorbic acid, apple mint flavor powder, xylitol, camphor, peppermint flavor powder, gum arabic, sodium hydrogencarbonate and malic acid. The present invention provides a tablet-type toothpaste composition and a method of manufacturing the same, which are easy to carry and can remove foreign body feeling like chewing gum, prevent whitening, tartar deposition, suppress bad breath, and treat and prevent gum disease.

Hereinafter, sorbitol, silicon dioxide, sodium fluoride, pyridoxine, sodium pyrophosphate, aspartame, ascorbic acid, apple mint flavor powder, xylitol, camphor, peppermint flavor powder, gum arabic, sodium hydrogencarbonate and malic acid used in the preparation of the present invention. Looking at the active ingredient and characteristics of, first, sorbitol (sorbitol) is a kind of hexahydric alcohol obtained by reducing hexose, such as glucose, has a sweet taste similar to sugar. Combustible and hygroscopic, white crystals, sweet and soluble in water and alcohol. It is found in juices such as apples, peaches, and rowan. Cosmetic lotions, creams, toothpastes, food additives, vitamin C (synthetic ingredients), sweeteners for diabetics, diuretics, etc. Melting point is 93 ~ 97.5 ℃. The formula is CH ₂ OH. (CHOH) ₄ CH ₂ OH. Sorbitol is a food additive and has various characteristics such as wetting control effect, protein denaturation, low calorie, low taste, hard tooth decay, insulin bean dependence, and is widely used in confectionery, food, aquatic products, toothpaste, cosmetics, and pharmaceutical industry. It is a low-moisture moisturizer with excellent heat resistance and freshness, and is widely used in foods such as toothpaste and sugar-free gum because it is not fermented by caries. In addition, it is excellent in protein denaturation and wetting control effect, it is also used as a cosmetic raw material and has excellent features to maintain the flavor of food and drink for a long time.

The silicon dioxide, called Silicon Dioxide (SiO ₂ ), is found naturally in water, plants, animals, and soils, and is primarily found in plants and cereals, with 59% of the earth's crust being silica and 95% of the known rock on earth. The above contains silicon dioxide. As a food additive, silicon dioxide is used as an antistatic agent.

The sodium fluoride is also called soda fluoride, a water-soluble sodium salt. When water containing water-soluble fluoride is used as a drink, it becomes a half-floor and bones become brittle. However, as currently tried in some countries, the addition of an appropriate amount of sodium fluoride to tap water has the effect of preventing tooth decay, strengthening hemorrhoids, enhancing acid resistance, and inhibiting the enzyme action of bacteria that ferment and produce acid. .

Pyridoxine hydrochloride is a white crystalline powder that is soluble in water but insoluble in alcohol and other organic solvents, and in yeast, grains, potatoes, cabbage, bananas, beans, meat, fish, eggs, and milk. It contains the component.

The sodium pyrophosphate is a colorless to white crystal or white crystalline powder, and the anhydride is a white powder, granular or lump pyrophosphate quality improving agent, and includes crystalline (10 hydrate) and anhydride, each of which is sodium pyrophosphate. (Crystal) and sodium pyrophosphate (anhydrous). The chemical formula is Na ₄ P ₂ O ₇ nH ₂ O. Soluble in water, insoluble in alcohol PH of aqueous solution (1 → 100) is 9.9-10.7.

Fe + +, Cu + +, Ca + + and other metal ions and strong soluble complex salts to make a strong blocking effect on metal ions. It is weatherable and changes to Na ₂ HPO ₄ when boiled in the presence of inorganic acids. Sodium pyrophosphate has a low degree of condensation, which is strong against thermal hydrolysis, and a high pH has specificity such as condensation phosphate, and is widely used in food for dispersing and peptizing action and preventing oxidation of fat.

It is used as an elasticity enhancer of fish meat products. The addition of sodium pyrophosphate, glucose and sorbic acid to fish sausage prevents the softening of products by bacteria. In dairy products, it is used as a cheese melter and emulsifier. Casein in cheese is combined with calcium, so adding condensed phosphoric acid causes calcium to fall, increasing the viscosity of casein.

In general, when used in combination with phosphate, metaphosphate, etc., the cheese becomes soft and rich in reliance. It prevents discoloration of the liver, enhances color tone and gloss, increases consistency, and improves the effective state. It is effective in preventing oxidation and increasing viscosity of soft drinks, fruits and ice creams, and soft drinks have the effect of preventing precipitation during preservation.

In addition, it is effective in the promotion of ice cream overrun and emulsion dispersion of fat, and the addition of pyrophosphate increases the casein viscosity of ice cream.

The xylitol is found in Finland as a new sweetener of natural materials that do not form the acid that causes tooth decay, and is made from gum, such as birch or oak, as a raw material, It suppresses the enamel melting by the acid produced when the sugar is broken down. This sweetener is used to promote insulin secretion and to supply energy to diabetics as a substitute for glucose for medical purposes because it does not affect the blood sugar by entering cells without intervening insulin action.

The extraction process is to first split the birch into water and heat it, the polysaccharide xylan is decomposed into xylose. The xylose can be converted to xylitol by increasing the purity through several processes and reducing it. Xylitol has a structure of five-saccharide sugar, so caries is eaten and discharged by the decayed bacteria such as mutans and sorbin bacteria. The surface of the tooth erodes, but the caries easily breaks down the hexasaccharides but not the xylitol, the pentose sugar. As a result, no acid (caused), which causes tooth decay, and eventually decayed bacteria that do not consume nutrients fall off the surface of the tooth.

In addition, xylitol has a refreshing effect that keeps the mouth cool, and is suitable for preventing tooth decay, such as promoting saliva secretion.

The aspartame is also called aspartame. Its chemical name is N-L-α-Aspartyl-L-phenylalanine Methyl Ester. It is white crystalline powder and has no odor. The sweetness level is about 200 times that of sugar, but it is 150 to 200 times according to the characteristics of food and the concentration used. The sweetness taste is the most similar to that of high sweetener, and unlike the artificial sweetener, it has no bitter taste. In the body, it breaks down, digests, and absorbs like normal protein, and enhances fruit flavors such as grapes, oranges, and lemons, and reduces the bitter taste of medicines and coffee. Calorie per 1g is 4㎉ like sugar, but since only 200% of sugar is used, it is used as a low-calorie sweetener. Aspartame is currently the most used artificial sweetener in Korea. Unlike high sweetness sweeteners such as saccharin and stevioside, they have no bitter taste and are clean. Fruit flavors such as oranges and grapes can be felt more strongly and are effective in reducing the bitter taste of coffee.

The ascorbic acid is also called vitamin C as one of the water-soluble vitamins. Chemical formula C ₆ H ₈ O ₆ was found to be effective for scurvy, and is currently synthesized from sorbose via ketogulonic acid. In nature, it contains a lot of green tea, lemon, spinach, cabbage, etc., especially in the adrenal cortex in the animal body.

Apple mint (apple mint) is a plant that is effective in the prevention and treatment of colds, cold resistance and strong fertility, and grows well in half-shape, is a kind of herb native to Europe. It is 30 ~ 60cm in height and smells like a mixture of apples and peppermint. It is reproduced by folding or abandonment. It has a mild scent like apple and peppermint. The leaves are round and soft in egg shape, and have white hair. It smells like an apple and is used for various dishes and preservation of fragrance. It is effective for colds, cholera, gastrointestinal disorders, headaches, pain, sweating, and hysteria, and is available as tea, sweets, beverages, cosmetics, soaps, bath products, and potpourri. Drinking tea is effective in recovering from indigestion or fatigue and is used as a flavoring for meat, fish and egg dishes.

Making herbal tea with leaves is effective in recovering from indigestion or fatigue. In Europe, it is a spice that must be used in meat, and is also used in fish and egg. It is also medicinal, it is good for sterilization, dry tonic, soothing and analgesic effect.

The peppermint (Peppermint) is about 90 cm in height, the stem is straight or up from the roots, the roots spread out to the ground spreading the leaves with fine hairs are pointed to face each other, there is a leaf stem, serrated edge There are 5-8 pairs of leaf veins. The flower is purple and blooms in aquatic inflorescence in the axilla from June to July. The calyx of the bell shape is divided into 5 pieces, and the calyx of 4 parts is longer than the calyx, and the dried stems in the fresh leaves or the airy shade are also used as cooking ingredients.

Menthol, the main ingredient of peppermint essential oil, cools the skin and mucous membranes, and is effective for antibacterial and pain relief. It is used as a raw material for edible, medicinal and fragrances.

Peppermint contains a large number of menthols, which can alleviate toothache through pain relief, which can alleviate pain.It also has the effect of relieving respiratory diseases such as sore throat and tonsillitis. , Peppermint peculiar fragrance has the advantage of removing bad breath.

The gum gum (Gum arabic) is a kind of natural gum made by hardening acacia sap, and has been extracted from Acacia nilotica, but recently extracted from Acacia senegal and Vachellia (Acacia) seyal. gum, which is a polymer mixture of glycoprotein and polysaccharide, is used to obtain arabinose and ribose first extracted and separated from gum arabic, and is mainly used as a stabilizer in the food industry. Used in viscosity control, printing, cosmetics and textile industries.

The sodium bicarbonate (Sodium Bicarbonate, Sodium hydrogen carbonate) is also called as sodium hydrogen carbonate, baking soda, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, etc. It is a white crystal mass or crystal powder. The chemical formula is NaHCO ₃ . Easily soluble in water, hydrolyzed and insoluble in alcohol. Aqueous solutions of sodium hydrocarbon show weak alkali immediately after preparation, but increase in pH when left for a long time or warmed. Carbon dioxide gas is slowly generated above about 65 ° C. and decomposed when heated above 300 ° C. (2NaHCO ₃ → Na ₂ CO ₃ + H ₂ O + CO ₂ ). When used alone, the amount of gas generated is low, the expansion force is lowered, the product discolors yellow, and bitter taste is used. Therefore, it is used together with powders such as citric acid and tartaric acid.It is mainly used as an expanding agent in the manufacture of bread or biscuits. do. In particular, it is used to soften tissue cells of food by improving protein's water retention. In addition, it is widely used as an alkali agent, a buffer, etc., and is also used as a detergent substitute because it has a property of adsorbing contaminants.

The L-malic acid (L-MALIC ACID) is contained in natural fruits such as apples and grapes, and the molecular formula is HOOCCH (OH) CH ₂ COOH, chemical formula C ₄ H ₆ O _5, and is a colorless needle-shaped crystal. It is a deliquescent, colorless acicular crystal with molecular weight of 134.09, specific gravity of 1.595, melting point of 100 ℃, boiling point of 140 ℃ and well soluble in water and ethanol but insoluble in ether.

It is produced through the addition of food additives used to give foods a sour taste, intermediates of the citric acid cycle, and water of fumaric acid by fumaric acid hydrolase, which is oxaloacetic acid by malic acid dehydrogenase, which is reversibly pyroic acid and CO ₂ Generated from Glyoxysomes of germinated seeds are characterized by the production of acetyl CoA and glyoxylic acid.

Figure 1 shows a flow chart illustrating a schematic process of a method for producing a foamed tablet toothpaste composition according to the present invention.

Foam tablet type toothpaste composition manufacturing method according to the invention is largely powder formulation mixing process (S100), purification process (S200), coating process (S300), drying process (S400), surface grinding process (S500) and packaging process (S600) It is configured to include).

Hereinafter, the tablet toothpaste composition of the present invention will be described in detail for each step with reference to the attached method of the present invention.

(1) Powder formulation mixing process (S100)

 Wetting agent, abrasive, thickener, preservative, sweetener, antioxidant, foaming agent, sorbitol, silicon dioxide, sodium fluoride, pyridoxine hydrochloride, sodium pyrophosphate, aspartame, ascorbic acid, applemint Powder, camphor, peppermint flavor powder, gum arabic, sodium bicarbonate and malic acid are added to a mixer and mixed.

More specifically, the foamed tablet toothpaste composition comprises 17.53 wt% of sorbitol, 10 wt% of silicon dioxide, 0.22 wt% of sodium fluoride, 0.05 wt% of pyridoxine hydrochloride, 1 wt% of sodium pyrophosphate, 1.20 wt% of aspartame, 0.50 wt% of ascorbic acid , 1% by weight of applemint flavor powder, 1.50% by weight camphor, 7% by weight peppermint flavor powder, 5% by weight gum arabic, 30% by weight sodium bicarbonate and 10% by weight L-malic acid are added to the mixer.

Wetting agents are used as sorbitol (surfactant) to increase the wettability by having a moderate humidity.

The abrasive removes dirt on the tooth surface and brightens the teeth, and uses silicon dioxide, which acts as a thickener and viscosity regulator, and the ascorbic acid, an antioxidant, blocks the oxidation reaction. The peppermint oil is used to remove bad breath and prevent toothache. The medicinal ingredient sodium fluoride provides effects such as caries prevention, pustules, whitening teeth, preventing tartar deposition, and bad breath prevention. The fluorine compound is used.

The abrasive is to remove the plaque, tartar, etc. attached to the teeth to give the original gloss to the tooth surface, the enamel quality of the tooth is 6-7, so the abrasive does not damage the quality of the tooth The hardness of 3 or less is used, and the particle diameter of an abrasive | polishing agent is a small thing of 1-20 micrometers. The content of the abrasives is limited in the above range so as not to damage the enamel of the tooth.

The sodium fluoride may be applied as a plaque remover to inhibit the bacteria in the oral cavity to remove the plaque and to exert the effect of preventing oral disease and removing bad breath.

The blowing agent is foamed when chewing tablet tablets formed through the reaction of sodium bicarbonate and malic acid, so that the raw materials dissolve better, and bubbles due to foaming can penetrate deep into the teeth, providing a cleaning effect as toothpaste. do.

(2) Refining Process (S200)

The powder formulation for preparing the mixed foam tablet toothpaste is perforated in a metal casting mold to form a tablet having a tablet shape to form a foam tablet formulation.

(3) Coating process (S300)

The formulation formed through the purification process is coated with xylitol 15% by weight syrup.

The xylitol is a natural sweetener that feels sweet and effective in preventing tooth decay. It has a five-sugar structure, and the lactic acid that eats and releases glucose, fructose, and the like, which are cavities, such as mutans or sorbin, are present in food. It is the phenomenon that the surface of teeth is corroded. Tooth decay bacteria easily decompose hexose but not xylitol. As a result, no acid, the cause of tooth decay, and cavities that do not consume nutrients fall off the tooth surface.

(4) Drying process (S400)

The formulation formed through the coating process proceeds to a drying process.

(5) Surface Grinding Process (S500)

The tableting and dried formulation formed through the drying process to smoothly grind the surface in order to prevent breakage when carrying and remove foreign matter when chewing.

(6) Packaging Process (S600)

Foamed tablet toothpaste in the form of the ground tablets is packaged according to use.

Sorbitol, silicon dioxide, sodium fluoride, pyridoxine hydrochloride, sodium pyrophosphate, xylitol, aspartame, ascorbic acid, apple mint flavor powder, camphor, peppermint flavor powder, gum arabic, sodium hydrogencarbonate, The antimicrobial activity of the living body and the effect acceptability of the expanded tablet toothpaste produced under the same conditions of tableting, coating, drying and surface grinding were adjusted and compared with the examples.

Hereinafter, specific examples will be described.

(Example 1)

As shown in Table 1, 17.53% by weight of sorbitol, 10% by weight of silicon dioxide, 0.22% by weight of sodium fluoride, 0.05% by weight of pyridoxine hydrochloride, 1% by weight of sodium pyrophosphate, 1.20% by weight of aspartame, 0.50% by weight of ascorbic acid, apple 1 wt% mint flavor powder, 1.50 wt% camphor, 7 wt% peppermint powder, 5 wt% gum arabic, 30 wt% sodium bicarbonate and 10 wt% L-malic acid were mixed and a metal casting mold was used. After preparing the formulation and coating with 15% by weight of xylitol, the surface was smoothly ground to dry and prevent breakage to prepare a tablet foamed tablet toothpaste composition.

(Example 2)

As shown in Table 1, 18.53% by weight of sorbitol, 11% by weight of silicon dioxide, 0.22% by weight of sodium fluoride, 0.05% by weight of pyridoxine hydrochloride, 1% by weight of sodium pyrophosphate, 1.20% by weight of aspartame, 0.50% by weight of ascorbic acid, apple 1 wt% mint flavor powder, 1.50 wt% camphor, 7 wt% peppermint powder, 5 wt% gum arabic, 30 wt% sodium bicarbonate and 10 wt% L-malic acid were mixed and a metal casting mold was used. After preparing the formulation and coating with 13% by weight of xylitol, the surface was smoothly ground to dry and prevent breakage to prepare a tablet foamed tablet toothpaste composition.

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 Composition comparison table Example 1 Example 2 Sorbitol 17.53 18.53 Silicon dioxide 10.00 11.00 Sodium fluoride 0.22 0.22 Yeonsam pyridoxine 0.05 0.05 Sodium pyrophosphate 1.00 1.00 Xylitol 15.00 13.00 Aspartame 1.20 1.20 Ascorbic acid 0.50 0.50 Apple Mint Flavor Powder 1.00 1.00 Kampa 1.50 1.50 Peppermint Flavored Powder 7.00 7.00 Aramia Sword 5.00 5.00 Sodium bicarbonate 30.00 30.00 Malic acid 10.00 10.00

Experimental Example 1

Experimental Example 1 below is to test the in vitro antibacterial activity against oral harmful bacteria of each tablet type and uncoated tablet type of Table 1, 4 g of the sample prepared in Example was put into a 300 ml Erlenmeyer flask, sterilization treatment Then, 1 ml of diluted culture medium and 99 ml of phosphate buffer (pH 7.0) were added, followed by shaking culture (120 rpm) for 24 hours at 37 ° C. In addition, the test strain was taken out of the frozen state, inoculated in a Nutrient broth, and then incubated for 48 hours in an incubator at 37 ° C. After incubation for 12-20 hours in the incubator again after 1% (v / v) inoculation, the reduction rate of each strain was measured as compared to the initial bacterial count.

Test strains are microorganisms that cause tooth decay in the oral cavity. ; ATCC 25586).

After incubation for another 12-20 hours, the initial bacterial count was compared with the number of strains (cells / ml) and reduction rate (%) after 2 days.

The results described above are shown in Table 2 below when the antimicrobial activity (sterilization power) is summarized in Table 2 below as a percentage of the bactericidal rate obtained as a percentage by the concentration of the remaining bacteria to the initial inoculation concentration.

Antimicrobial Results Test strain Experimental Example 1 Experimental Example 2 Strap Tucker Carcass Mutans Experimental group 460 ± 80/88 480 ± 90/93 Control 9280 ± 100 (95% increase) 9480 ± 100 (97% increase) Peugeot bacterium nucleus Experimental group 830 ± 70/80 850 ± 90/80 Control 8539 ± 110 (93% increase) 8779 ± 110 (93% increase)

As can be seen from Experimental Example 1, as shown in Table 2, in the control group without xylitol, the number of strains increased with time. However, in case of the experimental group, the number of strains is greatly reduced over time, and it can be seen that the antibacterial effect of the foamed tablet toothpaste composition of the present invention is excellent. From the above results, the present invention is expected to effectively remove various harmful caries in the oral cavity to prevent periodontal disease.

Experimental Example 2

Experimental Example 2 below is to use the composition of Examples 1 to 2 prepared in accordance with the composition ratio shown in Table 1 above for each adult 10 men and women, bad breath removal, plaque removal, feeling 5 points Sensory tests were performed according to the scale method and the average values are shown in Table 3 below.

Sensory test result Inspection items Example 1 Example 2 Bad breath 4.7 4.5 Gingivitis suppression 4.5 4.5 Plaque removal 4.6 4.4 Feeling 4.4 4.3

Very good 5, Good 4, Usually 3, Bad 2, Very bad 1

As can be seen from the above Experimental Example 2, as shown in Table 3, as the content of xylitol increases plaque removal and bad breath removal, but the feeling is gradually improved, in particular, xylitol-containing gingivitis inhibitory effect It was confirmed that the degree of preference corresponding to.

Therefore, the tablet-type toothpaste composition in the present invention is 17.53 wt% sorbitol, 10 wt% silicon dioxide, 0.22 wt% sodium fluoride, 0.05 wt% pyridoxine hydrochloride, 15 wt% xylitol, 1 wt% sodium pyrophosphate, 1.20 wt%, Foamed tablet form consisting of 0.50% ascorbic acid, 1% applemint flavor powder, 1.50% camphor, 7% peppermint powder, 7% gum arabic, 30% sodium bicarbonate and 10% L-malic acid It can be seen that the composition can satisfy all of bad breath removal, gingivitis removal, plaque removal and feeling of use.

In the above, the specific embodiments of the present invention have been described in detail, but the terms specifically used herein are only used for the purpose of describing the present invention, and the scope of the present invention as defined in the appended claims is limited. It was not used to. Therefore, those of ordinary skill in the art can make various modifications and various other equivalent embodiments therefrom.

Claims (3)

Sorbitol 17.53 wt%, Silicon dioxide 10 wt%, Sodium fluoride 0.22 wt%, Pyridoxine hydrochloride 0.05 wt%, Sodium pyrophosphate 1 wt%, Aspartame 1.20 wt%, Ascorbic acid 0.50 wt%, Applemint flavor powder 1 wt%, Campa 1.50% by weight, peppermint flavored powder 7% by weight, gum arabic 5%, sodium bicarbonate 30% by weight and L-malic acid 10% by weight of the formulation was prepared using a metal casting mold 15% by weight of xylitol Foam coated tablet toothpaste composition, characterized in that it is formed by smoothly grinding the surface in order to coat the formulation formed using, and then dried to prevent breakage.
Sorbitol 17.53 wt%, silicon dioxide 10 wt%, sodium fluoride 0.22 wt%, pyridoxine hydrochloride 0.05 wt%, sodium pyrophosphate 1 wt%, aspartame 1.20 wt%, ascorbic acid 0.50 wt%, applemint flavor powder 1 wt%, camphor A first step of adding 1.50% by weight, peppermint flavored powder 7% by weight, gum arabic 5%, sodium bicarbonate 30% by weight and L-malic acid 10% by weight into a mixer;
A second step of forming a tablet formulation by perforating a metal casting mold to mold the mixed toothpaste powder into a tablet-shaped form;
A third step of coating and drying the 85% by weight tablet-formulated formulation formed through the second process with 15% by weight of xylitol syrup; And
Foamed tablet-type toothpaste, characterized in that it comprises a; a fourth step of smoothly grinding the surface in order to prevent breakage when carrying the tablet and the formulation formed by coating the coating formed through the three process and remove foreign substances when chewing; Manufacturing method. delete

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