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KR101886217B1 - Active Drug Delivery System with Patch in Gastrointestinal Tract - Google Patents

Active Drug Delivery System with Patch in Gastrointestinal Tract Download PDF

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Publication number
KR101886217B1
KR101886217B1 KR1020160150915A KR20160150915A KR101886217B1 KR 101886217 B1 KR101886217 B1 KR 101886217B1 KR 1020160150915 A KR1020160150915 A KR 1020160150915A KR 20160150915 A KR20160150915 A KR 20160150915A KR 101886217 B1 KR101886217 B1 KR 101886217B1
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South Korea
Prior art keywords
patch
capsule endoscope
drug delivery
delivery system
active drug
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KR1020160150915A
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Korean (ko)
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KR20180053852A (en
Inventor
박석호
박종오
이경민
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전남대학교산학협력단
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Publication of KR20180053852A publication Critical patent/KR20180053852A/en
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Publication of KR101886217B1 publication Critical patent/KR101886217B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00147—Holding or positioning arrangements
    • A61B1/00158—Holding or positioning arrangements using magnetic field
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0076—Tattooing apparatus
    • A61M37/0084—Tattooing apparatus with incorporated liquid feeding device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0043—Ultrasound therapy intra-cavitary

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Endoscopes (AREA)

Abstract

The present invention relates to a system for actively delivering a drug such as a therapeutic drug, a therapeutic cell, a diagnostic imaging drug, or a tattooing ink to a target site such as digestive organs using a patch dissolved in the body, A capsule endoscope 100 provided with a magnet 110; A patch unit 200 provided on the capsule endoscope 100 to support a drug 210 for delivery to a living body; And a magnetic field generator 300 for generating a magnetic field for driving the capsule endoscope 100.

Description

[0001] The present invention relates to a patch-type active drug delivery system,

The present invention relates to a patch type active drug delivery system, and more particularly, to a patch type active drug delivery system using a patch dissolvable in the body to treat a therapeutic drug, a therapeutic cell, a diagnostic imaging drug, To systems for actively delivering drugs.

As society becomes an aging society, effective and economical treatment for various diseases is required. In order to meet these needs, effective medical techniques have been developed using Drug Delivery System (DDS) technology to appropriately administer the necessary amount to the affected part according to the patient's individual condition. The initial drug delivery technology has been developed with a focus on therapeutic substances, but there is also a study on drug delivery systems, which is a method to efficiently deliver drugs along with therapeutic drugs. Particularly recently, a drug delivery system has been developed in which drug delivery efficiency is increased by using a targeted drug delivery system. Recently, a non-invasive in vivo imaging device has been developed for imaging a lesion using a targeted drug delivery system.

Conventional technologies related thereto have been studied on various types of drugs (lipid structures, nanoparticles, liposomes, osmotic agents and the like) and drug delivery vehicles. Such drugs and drug delivery vehicles are widely used in the fields of blood vessels Medicine, patch, etc. However, these methods are usually absorbed into the blood vessels and have a structure in which the drug is delivered. In the case of patches, however, it includes the ability to deliver drugs locally to the skin. However, these conventional drug delivery methods have limitations such as limitations of efficiency of drug delivery and side effects of drugs due to delivery of drugs through blood vessels rather than delivering drugs directly to locally diseased parts in digestive organs.

delete

Japanese Patent Application Laid-Open No. 10-2015-0096627 (publication date: 2015.08.25)

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made in view of the above problems, and it is an object of the present invention to provide a system capable of delivering a drug actively to a target site in a human body using a capsule endoscope having a drug-

To achieve these and other advantages and in accordance with the purpose of the present invention, as embodied and broadly described herein, there is provided a patch-type active drug delivery system comprising: a capsule endoscope having magnets; A patch unit provided on the capsule endoscope with a drug to be delivered to a living body; And a magnetic field generator for generating a magnetic field for driving the capsule endoscope.

Preferably, the patch portion further comprises a plurality of arrays of microneedles on one side, more preferably further comprising an adhesive layer comprising a mucoadhesive polymer on its surface.

Preferably, the capsule endoscope further includes a pair of electrode portions capable of applying current to the lesion portion in the housing constituting the external appearance.

Preferably, the capsule endoscope further includes an ultrasonic module capable of applying ultrasonic waves to the affected part.

Preferably, the capsule endoscope includes a cylindrical housing, and the patch portion is provided at one opening end of the housing.

Preferably, the capsule endoscope includes a cylindrical housing having a discharge hole formed at one side thereof, and the patch portion is arranged in a roll form in the housing so as to be dischargeable by the discharge hole.

More preferably, the capsule endoscope further includes an unloading portion for leading the patch portion in the pull-out direction.

A patch type active drug delivery system according to the present invention includes a capsule endoscope capable of translational motion or rotational motion in three dimensions by a magnetic field generated from the outside by a magnet together with a patch portion carrying a drug for delivering to a living body, It can be used as an endoscopic tattooing or biomedical imaging function for laparoscopic and robotic surgery by carrying a non-drug tattoo ink.

1 is an overall configuration diagram of a patch type active drug delivery system according to the present invention;
FIG. 2 is a configuration diagram of a capsule endoscope in a patch type active drug delivery system according to the present invention,
3 (a) and 3 (b) are views showing embodiments of a patch portion in a patch type active drug delivery system according to the present invention,
4 (a), 4 (b) and 5 (a) and 5 (b)
6 is a view showing a first embodiment of a capsule endoscope having a patch part in a patch type active drug delivery system according to the present invention,
FIG. 7 is a view showing a process of unloading a patch by a capsule endoscope according to the first embodiment of the present invention; FIG.
8 (a) and 8 (b) illustrate a second embodiment of a capsule endoscope having a patch part in a patch-type active drug delivery system according to the present invention,
9 is a view illustrating a process of unloading a patch by a capsule endoscope according to a second embodiment of the present invention.

The specific structure or functional description presented in the embodiment of the present invention is merely illustrative for the purpose of illustrating an embodiment according to the concept of the present invention, and embodiments according to the concept of the present invention can be implemented in various forms. And should not be construed as limited to the embodiments described herein, but should be understood to include all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1, the drug delivery system of the present invention includes a capsule endoscope 100 provided with a magnet 110, a patch unit 200 provided on the capsule endoscope 100 with a drug to be delivered to a living body, And a magnetic field generator 300 for generating a magnetic field for driving the capsule endoscope 100. [

The capsule endoscope 100 may have a cylindrical or spherical shape and a magnet 110 may be provided to translate or rotate the capsule endoscope 100 in a three-dimensional arbitrary direction by a magnetic field B generated by the magnetic field generating unit 300 Do.

The patch unit 200 is a plate-shaped substrate on which a drug is carried, and is transported to a target site in the human body by the capsule endoscope 100 to deliver the drug to the affected site. Specific embodiments thereof will be described with reference to the accompanying drawings do.

The magnetic field generating unit 300 may be provided by a combination of various types of coils that generate a magnetic flux by a magnetizing current to generate a magnetic field in an arbitrary direction in three dimensions, and may be, for example, a Maxwell coil, And a saddle coil, and by controlling the magnitude and direction of the magnetizing current of each coil, a magnetic field can be generated in an arbitrary direction in three-dimensional directions. The present applicant has patented various types of three-dimensional electromagnetic drive devices that generate magnetic fields in an arbitrary direction on three-dimensional directions. Such a three-dimensional electromagnetic drive device can be used for propulsion drive and / or steering drive of a capsule device For example, Patent No. 10-1001291 (Registration date: 2010.12.08), Registration No. 10-1084722 (Registration date: 2011.11.11), Registration No. 10-1084720 (Registration date: (Registration Date: 2011.11.11), Registration No. 10-1096532 (Registration Date: December 14, 2011), Registration No. 10-1256408 (Registration Date: Mar. 14, 2013), Registration No. 10-1256409 (Registration Date: 15) can be referred to. On the other hand, the magnetic field generator may be a combination of a plurality of permanent magnets capable of being driven to rotate, not an electromagnet coil.

The control unit 400 includes a receiving unit 410 for receiving information transmitted from the capsule endoscope 100 and a control unit for controlling the motion of the capsule endoscope 100 by controlling the power applied to the magnetic field generating unit 300 420, and may further include a well-known display that outputs information transmitted from the capsule endoscope 100. [

2 is a configuration diagram of a capsule endoscope in a patch type active drug delivery system according to the present invention.

2, the capsule endoscope 100 includes a permanent magnet 110, a camera module 120, a data transfer module 130, a power supply module 140, . ≪ / RTI >

Particularly, the capsule endoscope 100 of the present invention is provided with a patch unit 200 and is used as a carrier for delivering the patch unit 200 to a target site in the human body, The present invention is also directed to a method for preparing a drug-coated tablet.

The permanent magnet 110 is magnetized in an arbitrary direction, so that the capsule endoscope 100 inserted into the human body can be driven by a magnetic field generated from the outside.

The camera module 120 captures image information, and the captured image information is transmitted to the data transmission module 130 and transmitted to the outside.

The power supply module 140 supplies operating power to the camera module 120 and the data transfer module 130, and a battery can be used.

The control module 150 can control the camera module, the data transmission module, and the power supply module according to control signals transmitted from the control unit.

The capsule endoscope 100 may be provided with a pair of electrode portions 161 and 162 for electrophoresis in the housing 101. The unloading of the patch portion 200 may be performed on the lesion portion, The skin permeability of the drug can be increased by applying power to the affected part during or after the unloading.

The capsule endoscope 100 may further include an ultrasonic module 170 capable of generating ultrasonic waves. The capsule endoscope 100 may generate ultrasound waves during or after the unloading of the patch unit 200 in the affected area, Thereby increasing the skin permeability of the drug.

The electrophoresis method and the ultrasonic therapy can be selectively used according to the drug, and the operation is performed by the control module 150.

3 (a) and 3 (b) are views showing embodiments of a patch portion in a patch type active drug delivery system according to the present invention.

3 (a), the patch part 200 is a plate-like base material carrying the drug 210, preferably a saccharide or biodegradable and biocompatible polymer which is lost by metabolism in the body Can be provided.

The drug 210 in the present invention is not limited to a therapeutic drug but may be used for treatment cells, drugs for diagnostic imaging, India Ink for colonicoscopic tattooing for laparoscopic and robotic surgery, Or ICG (Indocyanine green).

These drugs are carried in the patch unit 200, and the patch unit 200 is dissolved in the body, so that the drugs can be administered to the patient under the skin.

As another example, as shown in FIG. 3 (b), the patch portion 200 may be provided with a plurality of microneedle 220 arrays on one side. At this time, the drug 210 may be included in the micro needle 220. A substrate may be used in which the array of micro needles 220 is also lost by metabolism in the body.

The microneedle 220 has a length of about 150 to 200 μm. Thus, it is possible to provide a passage through which the drug can be injected into the subcutaneous tissue without touching the nerve, thereby achieving drug delivery through the transcutaneous administration system. In particular, transdermal drug delivery using microneedle arrays can be highly effective for delivery of high molecular weight drugs such as peptides and proteins.

3, the drug may be carried on the patch portion 200 and / or the micro needle 220, and the drug may be directly carried on the substrate or may be carried in the form of nano particles have.

Preferably, the patch portion 200 may further include an adhesive layer to which the mucoadhesive polymer may be applied to enhance adhesion to the diseased mucosa. For example, the mucoadhesive adhesive polymer may include alginate Chitosan or a derivative thereof, guar gum, xanthan gum, pectin, galactomannan, glucomannan, hyaluronic acid and glycosa Natural polymers such as glycosaminoglycans, and gelatin; Polyethylene glycol and copolymers thereof, polyacrylic acid and polymethacrylic acid derivatives, polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyvinyl pyrrolidone, A synthetic polymer such as polyvinyl amine; And semisynthetic polymers such as cellulose derivatives.

4 (a), 4 (b) and 5 (a) and 5 (b) are views showing a patch portion carrying a drug.

4 (a) and 4 (b) show that the drug is supported on the patch portion in the form of nanoparticles and that the drug is directly supported in the patch portion, and after the micro needle is inserted under the skin, the drug in the patch portion is discharged through the micro needle After the drug has migrated to the micro needle, it can be administered subcutaneously as the micro needle is dissolved.

5 (a) and 5 (b) show that the drug is supported on the microneedles in the form of nanoparticles and directly supported on the microneedles. After the microneedles are inserted under the skin, the microneedles are dissolved in the body, Input can be made.

6 is a view showing a first embodiment of a capsule endoscope having a patch part in a patch type active drug delivery system according to the present invention.

6, the capsule endoscope 100 of the present embodiment is provided with a patch portion 200 at an upper opening end of a cylindrical housing 101, and in this embodiment, the patch portion 200 includes a plurality of stacked layers .

The unloading unit 180 may be provided at a lower end of the plurality of measured patch units 200. The unloading unit 180 may be configured to unload the patch unit 200 located at the upper end thereof After that, it pushes upward the patch part located at the bottom. The unloading unit 180 may be an elastic body such as a coil spring that presses the patch unit 200 upward or may be a linear actuator for pushing up the patch unit 200 upward by an electrical signal The linear actuator may be operated by a power source of the power supply module 140 controlled by the control module.

The capsule endoscope 100 may be provided with a cover 102 capable of opening and closing the opening end thereof. The cover 102 may be opened and closed from the outside by the control module so that the capsule endoscope 100 is biodegradable It is possible to prevent the patch portion 200 from being directly exposed to the surrounding environment and being decomposed.

In another embodiment, the cover 102 may be a biodegradable material applied to the open end of the capsule endoscope 100, rather than being mechanically opened and closed at the open end of the capsule endoscope 100. Such a biodegradable cover may be decomposed The patch unit 200 is protected and removed only during the movement of the capsule endoscope to the target lesion, so that the patch unit 200 is exposed.

In addition, it should be understood that a separate cover may not be required at the opening end of the capsule endoscope 100 in consideration of the location or environment of the drug inflow and foreign part, the biodegradation speed of the patch unit, and the like.

The pair of electrode portions 161 and 162 for electrophoresis described above may be provided adjacent to the opening end of the housing 101.

7 is a view illustrating a process of unloading a patch by a capsule endoscope according to the first embodiment of the present invention.

7, the capsule endoscope 100 according to the first embodiment is moved to the target lesion portion by the magnetic field generated in the magnetic field generating portion disposed outside the body, and the capsule endoscope 100 is positioned in a state in which the patch portion 200 is directed to the target lesion portion The capsule endoscope 100 is driven forward to adhere the patch portion 200 to the target lesion portion 10 to adhere thereto. Meanwhile, electrophoresis through the electrode portion of the capsule endoscope or application of ultrasound may be performed during or after attaching the patch portion to the target lesion portion.

8 (a) and 8 (b) are views showing a second embodiment of a capsule endoscope having a patch part in a patch type active drug delivery system according to the present invention.

Referring to FIG. 8, the capsule endoscope 500 of the second embodiment may have a patch portion 200 disposed on a side surface of a cylindrical housing 501.

Specifically, a plurality of patch portions 200 are arranged inside the capsule endoscope 500 so as to have a roll shape as a whole, and an unloading portion 580 (see FIG. 5) for pushing the patch portion 200 in a radial direction ). The unloading portion 580 may be an elastic body such as a spring-like spring for pushing the patch portion in the radial direction, or an actuator that is driven by an electrical signal may be used.

On the other hand, a cutout hole 501a is formed in the side surface of the housing 501, and the patch unit 200 can be discharged through the discharge hole 501a.

Electrode portions 561 and 562 for electrophoresis may be provided along the periphery of the housing 501 in this embodiment.

9 is a view illustrating a process of unloading a patch by a capsule endoscope according to a second embodiment of the present invention.

9, the capsule endoscope 500 according to the second embodiment moves to the target lesion part by the magnetic field generated in the magnetic field generating part disposed outside the body, and the side surface of the capsule endoscope 500 closely contacts the target lesion part 10 The capsule endoscope 500 rotates, so that the patch unit 200 can be attached to the target lesion portion 10. As described in the previous embodiment, electrophoresis through the electrode portion of the capsule endoscope or application of ultrasound may be performed during or after attaching the patch portion to the target lesion portion.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions. It will be apparent to those of ordinary skill in the art.

100, 500: capsule endoscope 101, 501: housing
110, 510: permanent magnet 120: camera module
130: Data transfer module 140, 540: Power supply module
150: Control modules 161, 162, 561, 562:
170: ultrasonic module 200: patch part
210: drug 220: micro needle
300: magnetic field generator 400: control unit

Claims (8)

A capsule endoscope having a magnet;
1. A capsule endoscope comprising: a patch part having an adhesive layer containing a mucoadhesive polymer on its surface and carrying a medicament for delivery to a living body;
And a magnetic field generator for generating a magnetic field for driving the capsule endoscope . The patch active drug delivery system of claim 1, wherein the patch section further comprises a plurality of micro needle arrays on one side. delete The patch active drug delivery system according to claim 1, wherein the capsule endoscope further comprises a pair of electrode parts capable of applying current to the affected part in a housing constituting an external appearance. The patch active drug delivery system according to claim 1, wherein the capsule endoscope further comprises an ultrasonic module capable of applying ultrasound to the affected part. The patch active drug delivery system according to claim 1, wherein the capsule endoscope includes a cylindrical housing, and the patch unit is provided at an opening end of the housing. The patch type active drug delivery system according to claim 1, wherein the capsule endoscope comprises a cylindrical housing having a discharge hole formed at one side thereof, and the patch portion is disposed in a roll form in the housing to be discharged to the discharge hole. system. 8. The patch active drug delivery system according to claim 6 or 7, wherein the capsule endoscope further comprises an unloading portion for leading the patch portion in the pull-out direction.
KR1020160150915A 2016-11-14 2016-11-14 Active Drug Delivery System with Patch in Gastrointestinal Tract KR101886217B1 (en)

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AU2019269636A1 (en) 2018-05-17 2020-11-19 Massachusetts Institute Of Technology Systems for electrical stimulation
CN112512396A (en) * 2018-05-31 2021-03-16 海王星医疗公司 Apparatus and method for enhanced visualization of small intestine
KR102187439B1 (en) * 2019-01-30 2020-12-07 주식회사 라파스 Minimally invasive skin biopsy method using microneedle patch
CN113993560B (en) 2019-02-01 2024-05-07 麻省理工学院 System and method for liquid injection
KR102239107B1 (en) * 2019-02-19 2021-04-13 전남대학교산학협력단 Module type Capsule Endoscope capable of Disassembling and Assembling in the Digestive tract
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
US12121677B2 (en) 2021-01-29 2024-10-22 Neptune Medical Inc. Devices and methods to prevent inadvertent motion of dynamically rigidizing apparatuses
CN114558241B (en) * 2021-12-31 2024-01-12 北京化工大学 Drug delivery type endoscope device based on polymer soluble microneedle
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