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KR101768625B1 - A method for inspecting pharmaceutical articles using infrared camera - Google Patents

A method for inspecting pharmaceutical articles using infrared camera Download PDF

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Publication number
KR101768625B1
KR101768625B1 KR1020160017237A KR20160017237A KR101768625B1 KR 101768625 B1 KR101768625 B1 KR 101768625B1 KR 1020160017237 A KR1020160017237 A KR 1020160017237A KR 20160017237 A KR20160017237 A KR 20160017237A KR 101768625 B1 KR101768625 B1 KR 101768625B1
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KR
South Korea
Prior art keywords
capsule
medicine
filling
infrared camera
state
Prior art date
Application number
KR1020160017237A
Other languages
Korean (ko)
Inventor
신용관
Original Assignee
주식회사 엔에프에이
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Publication date
Application filed by 주식회사 엔에프에이 filed Critical 주식회사 엔에프에이
Priority to KR1020160017237A priority Critical patent/KR101768625B1/en
Application granted granted Critical
Publication of KR101768625B1 publication Critical patent/KR101768625B1/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/88Investigating the presence of flaws or contamination
    • G01N21/95Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/02Details not specific for a particular testing method
    • G01N2203/06Indicating or recording means; Sensing means
    • G01N2203/0641Indicating or recording means; Sensing means using optical, X-ray, ultraviolet, infrared or similar detectors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/02Details not specific for a particular testing method
    • G01N2203/06Indicating or recording means; Sensing means
    • G01N2203/0641Indicating or recording means; Sensing means using optical, X-ray, ultraviolet, infrared or similar detectors
    • G01N2203/0647Image analysis

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The present invention relates to a method for manufacturing a capsule, which comprises collecting a medicine to be filled in a capsule in one direction of a capsule, photographing an external shape of the capsule and an ellipse of the medicine to be filled with an infrared camera after positioning the capsule at an inclined angle, And comparing the elliptical area of the photographed medicine to check the filling state.

Description

Technical Field [0001] The present invention relates to a method of inspecting a capsule filling state using an infrared camera,

The present invention relates to a capsule endoscope, comprising: collecting a medicine to be filled in a capsule in one direction of a capsule; placing the capsule at an oblique angle in a vertical direction or at an angle; And comparing the outer shape and the inner or outer shape of the photographed medicament to check the filling state, and a method for inspecting the filling state of the capsule using the infrared camera.

In general, unlike liquid medicines which can be weighed using a weight and filled in a container, tablets or capsule form drugs are first identified and sorted by the appearance of defects, and then the cumulative weight difference of tablets or capsules Each individual selected is counted and packed in a container so that no error is generated in the coefficient.

In order to determine whether there is a defective shape of a capsule or a tablet, an object to be inspected is detected by a sensor while the object is transferred using a vibrating feeder. Image coordinates are generated by a machine vision using a CCD. A method is known in which the number of pixels corresponding to the length of the object to be inspected is calculated using a method of counting the number and comparing with the reference area or using a linear sensor array to determine whether there is a defect relative to the reference .

Conventionally, in Patent Document No. 659140, a technique of a defect discrimination apparatus using vision is proposed. As shown in FIG. 1, the object 12 of the medicine supplied from the supply hopper 11 is oscillated A certain amount of water is dispersed in the hopper 13 and supplied to the rotary aligning device 14 and is passed through the gate 15 while being aligned in a row by the rotation of the rotary aligning device.

The gap between the objects is automatically adjusted by the difference between the feeding speed of the individual supplied to the gate 15 and the speed of the upper conveying conveyor 16 and the conveying object 12 on the upper conveying conveyor 16 When the detection signal is detected by the detection sensor 17, a trigger signal is generated, the camera 18 acquires an image, and the obtained image is subjected to image processing to determine whether or not the image is defective by an image processing algorithm. 19).

However, the above-described failure discrimination device has a disadvantage in that it is difficult to accurately determine the filling state when applied to a capsule, and it is difficult to grasp the filling state in an opaque capsule using a general camera.

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above-mentioned problems of the prior art, and it is an object of the present invention to simultaneously check the filling state of the medicine to be filled in the capsule, The present invention also provides a method of inspecting the filling state of a capsule using an infrared camera that allows accurate checking of the filling amount.

In order to accomplish the above object, the present invention provides a method for manufacturing a capsule, comprising: collecting a medicine to be filled inside a capsule in one direction of the capsule; placing the capsule in a vertical direction or at an oblique angle; And comparing the inner and outer shapes of the stored capsule with the inner and outer shapes of the captured medicine to check the filling state. The present invention also provides a method for inspecting the filling state of a capsule using an infrared camera.

The step of collecting the medicament of the present invention in one direction of the capsule may include a configuration in which vibration acts on the capsule placed in the vertical or inclined direction, a configuration in which an acceleration force acts on the capsule placed in the vertical or oblique direction, The present invention also provides a method of inspecting a filling state of a capsule using an infrared camera having at least one structure selected from the group consisting of a structure in which a capsule placed on the capsule is applied with a centrifugal force.

In addition, comparing the inner and outer shapes of the pre-stored medicament of the present invention with the inner and outer shapes of the photographed medicament to confirm the filling state may include comparing the area of the ellipse with the direction in which the medicines are collected, And a method of inspecting the filling state of the capsule using an infrared camera that compares the state of the elliptical area of the taken medicine and the state of the filling height of the medicine to check the filling state.

In addition, the capsule of the present invention provides a method of inspecting the filling state of a capsule using an infrared camera which is supported while being supported by a support block so that the upper surface thereof is exposed.

As described above, according to the present invention, it is possible to confirm the filling state of the capsule at the same time as the filling state of the medicine to be filled in the capsule, as well as to accurately check the filling amount, check the filling state regardless of the transparency of the capsule, There is an effect that accurate measurement can be done.

1 is a perspective view showing a conventional drug testing apparatus.
2 is an operational state diagram illustrating a filling state inspection method according to the present invention.
3 and 4 are operational state diagrams illustrating a filling state inspection method according to another embodiment of the present invention, respectively.
5 to 7 are operational state diagrams illustrating a filling state inspection method according to another embodiment of the present invention, respectively.
8 is a flowchart illustrating a filling state checking method according to the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 2 is an operational state view showing a filling state inspection method according to the present invention, FIGS. 3 and 4 are operational state diagrams showing a filling state inspection method according to another embodiment of the present invention, FIG. 8 is a flowchart illustrating a filling state checking method according to another embodiment of the present invention. Referring to FIG.

In the present invention, the medicine 700 to be filled inside the capsule 500 is collected in one direction of the capsule 500 while being supported by the support block.

Then, the capsule 500 is placed at an inclined angle? With respect to the supporting block, and the infrared camera 600 photographs the outer shape of the capsule 500 and the plane shape of the medicine to be filled.

In addition, reference data composed of images according to the filling states are stored in advance in an inclined state, and the data is compared with the elliptical areas of the drugs photographed by the infrared camera 600 to confirm the filling state.

That is, data on the elliptical area of the medicine and the height L to be filled with the medicine 700 located in the inside of the capsule 500 are stored in advance for each filling state.

The step of collecting the medicine 700 in one direction of the capsule 500 includes the steps of rotating the capsule 500 in a first supporting block (not shown) rotated at a constant speed so that centrifugal force R acts on the capsule 500 placed in the oblique direction 100A) in one direction of the capsule.

In addition, the step of collecting the medicine 700 in one direction of the capsule 500 may include a step of moving the capsule 500 in a direction perpendicular to the capsule 500, The medicine is collected in one direction of the capsule through the block 100B.

The step of collecting the medicine 700 in one direction of the capsule 500 may be performed through a third support block 100C that applies the acceleration force A to the capsule 500 placed in an inclined direction at a predetermined angle Collect the medicine in one direction of the capsule.

At this time, at least one of the acceleration force, the centrifugal force, and the vibration may act simultaneously.

In addition, the capsule 500 is installed so that the upper surface thereof is exposed to the support block composed of the first, second, and third support blocks to which the centrifugal force, the vibration, the acceleration force,

5 to 7, the capsule 500 is vertically supported at one side of the first, second, and third support blocks to which the centrifugal force, the vibration, and the acceleration force are applied, and the side of the capsule 500 is supported by the infrared camera 600 ).

At this time, the upper side of the medicine to be filled in the capsule 500 does not form an ellipse and only the filled height L is photographed.

That is, when the capsule 500 supported in the vertical direction is photographed, the area of the upper surface is always constant irrespective of the filling height, and the filling state can be confirmed only by measuring the height L to be filled.

Subsequently, the capsule 500 is supported at an oblique angle, and is then filled with an external body 700a, an internal body 700b, and medicines filled inside the external body and the internal body at the time of photographing by the infrared camera 600 And a normal shape 700 that is extended to the upper side of the filling surface and divided into arc-shaped planes 700d that are differently displayed according to the filling state of the capsule taken in the same direction at an oblique angle.

Further, the capsule 500 may be supported only in the vertical direction, and may measure only the filling height L at the time of photographing by the infrared camera 600.

The capsule 500 has a filling height L of a medicine filling surface supported in an inclined state on the supporting block during shooting by the infrared camera 600 after the camera 500 is inclined and only an arcuate plane 700d connected thereto, To be compared with each other.

The operation of the present invention constructed as described above will be described.

2 to 8, the capsule 500 is supported through any one of the first, second, and third support blocks 100A, 100B, and 100C, Centrifugal force, accelerating force, and the like are actuated to collect the medicine inside the capsule 500 in one direction of the capsule.

At this time, the vibration, centrifugal force, and acceleration force acting on the first, second, and third support blocks are set to be the same as those at the time of measurement of data that is stored in advance.

The installation position of the infrared camera 600 and the tilted position with respect to the first, second, and third support blocks are set in advance.

Subsequently, the capsule 500 to be supplied in a state in which the medicine is collected by any one of the first, second, and third support blocks is photographed by the infrared camera 600.

At this time, the infrared camera 600 simultaneously photographs the outer shape of the capsule as well as the plane shape formed by the filling state of the medicine packed inside the capsule.

That is, the capsules are captured by an infrared camera, a line drawn by the outer body and the inner body, a filling surface formed by collecting in one direction of the capsules, and an arched surface connected to the filling surface.

Further, when the capsules are supported in the vertical direction, the filling height (L) or the area is measured from the side.

The filling state of the medicine can be checked by comparing only the chemical filling height of the capsule taken by the infrared camera with the reference data corresponding to the stored archetype plane.

500 ... capsules
600 ... Infrared camera
700 ... drugs

Claims (6)

A medicine is filled in the capsule by centrifugal force acting on the capsule during rotation of the first support block while being adsorbed and supported in a state in which the upper surface of the capsule is exposed around the first support block on the disk rotating at a constant speed, Collecting in a direction,
Photographing the outside and inside shapes of the capsule which is inclined at the upper portion of the capsule in the vertical direction when the capsule rotated along the first support block is inclined at a predetermined angle with an infrared camera,
Comparing the outside and inside shapes of the previously stored capsules with the outside and inside shapes of the photographed medicines to check the filling state,
A shape of the capsule taken by the infrared camera is defined as a filling surface expressing the shape of the filling height of the medicine to be filled inside the outer body and the inner body and an arc shape representing the shape of the upper surface of the medicine to be filled while being connected thereto A Method of Examination of the Filling Status of Capsules Using a Flat Infrared Camera.
delete 2. The method according to claim 1, wherein comparing the outside and inside shapes of the previously stored capsule with the outside and inside shapes of the photographed medicine to confirm the filling state includes: And comparing the data of the area of the ellipse and the filling height of the medicine with the state of the medicine stored in advance to check the filling state of the capsule. delete delete delete
KR1020160017237A 2016-02-15 2016-02-15 A method for inspecting pharmaceutical articles using infrared camera KR101768625B1 (en)

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Application Number Priority Date Filing Date Title
KR1020160017237A KR101768625B1 (en) 2016-02-15 2016-02-15 A method for inspecting pharmaceutical articles using infrared camera

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KR1020160017237A KR101768625B1 (en) 2016-02-15 2016-02-15 A method for inspecting pharmaceutical articles using infrared camera

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102150970B1 (en) * 2019-07-12 2020-09-02 (주)엔에프에이 Device for inspecting drugs with backlihgt source
CN112957339A (en) * 2021-02-09 2021-06-15 桂林华信制药有限公司 Preparation process of valsartan capsule
KR102455028B1 (en) 2022-03-10 2022-10-17 주식회사 제이에스티 Apparatus for inspecting vial drugs
KR102544143B1 (en) * 2022-09-14 2023-06-16 주식회사 제이에스티 Oral drug testing device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001221747A (en) * 2000-02-03 2001-08-17 Suntory Ltd Imaging method of liquid filling container and device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001221747A (en) * 2000-02-03 2001-08-17 Suntory Ltd Imaging method of liquid filling container and device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102150970B1 (en) * 2019-07-12 2020-09-02 (주)엔에프에이 Device for inspecting drugs with backlihgt source
CN112957339A (en) * 2021-02-09 2021-06-15 桂林华信制药有限公司 Preparation process of valsartan capsule
KR102455028B1 (en) 2022-03-10 2022-10-17 주식회사 제이에스티 Apparatus for inspecting vial drugs
KR102544143B1 (en) * 2022-09-14 2023-06-16 주식회사 제이에스티 Oral drug testing device

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