KR101617577B1 - Composition containing plant extracts for removal of heavy metals and detoxification effect - Google Patents

Abstract

The present invention relates to a composition for removing heavy metals comprising, as an active ingredient, a complex extract of Saururus chinensis, Rhynchosia nulubilis, Glycyrrhiza uralensis, Taraxacum platycarpum, and Ulmus macrocarpa having heavy metal removal and detoxication effects. The novel composition of the present invention has excellent effects of removing and detoxifying heavy metals, thereby being able to be used for preventing, improving, or treating diseases caused by heavy metals absorbed and accumulated in a human body resulting from the increase of atmospheric environmental pollution. In addition, the composition of the present invention: can be easily prepared from available plants; is harmless to a human body; and has almost no side effect even when being taken in large quantities, thereby being able to be variously applied in a functional food field.

Description

TECHNICAL FIELD The present invention relates to a composition for extracting heavy metals and detoxifying a plant extract,

The present invention relates to a composition for discharging and detoxifying heavy metals, which comprises Saururus chinensis, Black pear, Licorice, Pseudomonas sp.

Heavy metals are heavy metals with a specific gravity of 4.0 or higher among the metals present on the ground. Examples of harmful heavy metals include lead, cadmium, mercury, and arsenic. Such heavy metals are known to be highly accumulative because they do not escape from the body when they enter the body through air, water, or food. In addition, the soot, plant wastewater, and waste batteries generated by industrial development are mismanaged and discharged into the environment, polluting the environment such as soil and water quality, and the food produced in such environment is also contaminated with heavy metals, .

In the case of Korea, since the 1960s, as a result of strategically fostering steel, shipbuilding, automobiles, heavy chemical industry, etc. in the process of industrialization, there has been a problem of increasing heavy metal contamination of the atmosphere, soil and water. It is also increasing due to industrialization around the world. Especially, as the industrialization of China has progressed rapidly, the amount of domestic heavy metals is increasing due to the annual yellow dust, and recently, the concentration of toxic heavy metals in the air of Korea is increasing due to the fine dust from China, Causing great concern.

The toxicities of heavy metals are mainly caused by Minamata disease of mercury and Itaiitai disease of cadmium. However, problems such as chronic diseases such as diabetes and cardiovascular diseases caused by persistent heavy metal accumulation and increased life span It is known to be a serious problem.

Measures against heavy metals include a policy to reduce the emission of heavy metals and a method to adsorb or decompose the discharged heavy metals. However, there is a clear medical treatment method for eliminating or eliminating the toxicity of heavy metals already absorbed into the body It is absent.

Currently, there is a way to remove the heavy metals that are introduced into the body. ㅇ As a concept of alternative medicine, there is a method of injecting a chemical substance such as EDTA which can chelate heavy metals into the body, There is a problem that it is difficult to apply.

In order to normalize the activity of the detoxifying enzyme present in the liver while discharging harmful heavy metals that are absorbed and accumulated in the body and threatening the health of the human body, five kinds of plants ( Saururus chinensis , Rhynchosia nulubilis , , Glycyrrhiza uralensis , Taraxacum platycarpum, and Ulmus macrocarpa were selected. Their characteristics were as follows.

Saururus chinensis has been widely used in Chinese herbal medicine for the treatment of burns and dermatitis, and it is known to have a detoxifying action related to diuretic action and antibacterial action.

Black beans are known to be effective for detoxification, hibernation, jaundice, edema, encephalopathy, diuretic and the like according to Dongbuogaku.

Licorice is antagonistic to various polar and toxic drugs in Dong-bo-gyung, and it is known to be effective in treating drug addiction by toxic drugs, and neutralizing and detoxifying against bacterial toxins.

Poong-young refers to dandelion, and Dong-bo-gyung is said to have a good effect in releasing open reading, cutting off gnawing, breaking the lunge, loosening the reading, and eliminating the stigma. It also describes the use of Chinese medicine medicines for fever reduction, detoxification, diuretic, booster (milking), inflammation, boil healing, liver and gallbladder treatment.

Ulmus macrocarpa ( Ulmus macrocarpa ) is known to be well tolerated, taste free, poisonous, well-drained, effective for enteritis, and to treat edema.

BACKGROUND ART [0002] The following patents are known in the prior art using materials that can be used as food for detoxifying heavy metals absorbed in the human body.

A composition for detoxifying heavy metals containing green tea catechin as an active ingredient (Korean Patent Application No. 10-2000-0039618) is known in the art for inhibiting accumulation of cadmium in the body and facilitating bone metabolism, (Broccoli sprouts, alfalfa sprouts and red clover sprouts) having a heavy metal detoxifying effect and a reproductive product composition containing the same (Korean Patent Registration No. 10-0708984) ", the effect of heavy metal detoxification on common reproductive composition A broccoli sprout, an alfalfa sprout, a red clover, and a reproductive product composition containing an effective amount of the composition and enhancing the detoxifying action against heavy metals. A functional tea beverage that decodes heavy metals and a method for manufacturing the same (Korean Patent Registration No. 10- 0839217) is a tea drink prepared by mixing extracts of green tea, white tea, black tea, and boi tea with fruit juice, Can be reduced.

In addition, "Effects of cadmium-induced liver damage on mung bean juice (Journal of the Korean Society of Food Science and Nutrition, 27, p980-986, 1998)" and "Effect of Pine Needle Extract on Cadmium-Induced Oxidative Damage in Rats The effects of superoxide dismutase, catalase and glutathione peroxidase activity on liver enzymes, increased with cadmium uptake, were investigated by the addition of mung bean juice and pine needle hydrothermal extract. . ≪ / RTI >

However, in this conventional research, since the toxic heavy metal emission and detoxification effects mainly concentrate on cadmium, researches on new extracts capable of releasing and detoxifying various harmful heavy metals are needed.

Accordingly, the present invention aims to provide a novel composition containing, as an active ingredient, a mixed extract of Saururus chinensis, Black currants, Licorice root, Pseudomonas sp., And Root seeds having harmful heavy metal release and detoxification effects.

However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

In order to accomplish the object of the present invention as described above, the present invention provides a food composition for extracting heavy metals comprising an extract of Saururus chinensis, Black beans, Licorice, Pseudomonas sp. Lt; / RTI >

In one embodiment of the present invention, the composition comprises 1 to 60 parts by weight of a Saururus chinense extract, 1 to 60 parts by weight of a black currant extract, 1 to 60 parts by weight of a licorice extract, 1 to 60 parts by weight of the peroral artificial extract, and 1 to 60 parts by weight of the rhizome extract.

In another embodiment of the present invention, the extract may be in a powder state in which each extract is concentrated and dried.

In another embodiment of the present invention, the food composition may be in the form of a drink.

In another embodiment of the present invention, the extract may be extracted using an aqueous 30 to 80% ethanol solution as an extraction solvent.

In another embodiment of the present invention, the composition may be one that discharges at least one selected heavy metal from the group consisting of arsenic, lead, cadmium, and mercury.

The composition of the present invention, which is a mixture of Saururus chinensis, Black bean, Licorice root, Pseudomonas sp., And Rootgrass extract, has an excellent effect in discharging and detoxifying heavy metals absorbed into the human body. Therefore, Improvement, and treatment. In addition, the composition of the present invention can be easily prepared as a plant that can be used as a food, harmless to the human body, and minimized in side effects even when ingested in large quantities.

FIG. 1 is a graph comparing arsenic, lead, cadmium and mercury contents in the blood of an experimental animal (A: arsenic, B: lead, C: cadmium, D : Mercury).
FIG. 2 is a graph comparing arsenic, lead, cadmium, and mercury contents in liver tissues of experimental animals (A: arsenic, B: lead, C: cadmium, D: mercury).
FIG. 3 is a graph comparing arsenic, lead, cadmium, and mercury contents in kidney tissues of an experimental animal (A: arsenic, B: lead, C: cadmium, D: mercury).
FIG. 4 is a graph showing the activity of enzyme in hepatic tissues of experimental animals in order to confirm the detoxifying effect of heavy metals according to the present invention (A: superoxide dismutase (SOD), B: catalase (CAT), C: glutathione peroxidase ), D: Glutathione S-transferase (GST)).
FIG. 5 shows the results of analysis of changes in mercury content in hair to determine the effect of the mixed extract according to the present invention on the content of human heavy metals. (A: change in mean mercury content in the hair of the experimental group (n = 15) consumed with the mixed extract of Saururus chinensis, Lycopersiconum L., Licorice root, Changes in the mean mercury content of the subjects (n = 7) who ingested the mixed extracts of Porphyra yuki and Yuguniji for 30 days)

The inventors of the present invention have invented a complex extract comprising Saururus chinensis, Black bean, Licorice root, Pseudomonas sp. Further, the present inventors have confirmed that the composition is effective for heavy metal emission effect and heavy metal detoxification, and completed the present invention.

In an embodiment of the present invention, plant extracts of five species (Sambilchia, Black poison, licorice, Pseudomonas sp., And Rootgrass) were prepared (see Example 1) Tissues and kidney tissues (see Example 2), and hepatic enzyme activity was analyzed (see Example 3). In addition, the effect of mercury emission of hair through clinical experiments was confirmed (see Example 4).

As a result, it was confirmed that the combined extracts including Saururus chinensis, Black pear, Licorice, Pseudomonas aeruginosa, and Yugaepi were effective for harmful heavy metal discharge and detoxification. Accordingly, the present invention provides a food composition for extracting heavy metals, which comprises Saururus chinensis, Black pear, Licorice, Pseudomonas sp.

1 to 60 parts by weight of a Saururus chinense extract, 1 to 60 parts by weight of a black currant extract, 1 to 60 parts by weight of a licorice extract, 1 to 60 parts by weight of a peroneal extract, and 1 to 60 parts by weight of an extract, To 60 parts by weight of an extract of Leuc Formicae.

In addition, the extract may be characterized by being in a powder state in which each extract is concentrated and dried, and the food composition may be in the form of a drink.

In addition, the extract can be characterized by extracting with 30-80% ethanol aqueous solution as an extraction solvent, and the composition is capable of extracting a heavy metal selected from the group consisting of arsenic, lead, cadmium, and mercury And can be used for prevention, improvement, or treatment of diseases caused by heavy metals.

As used herein, the term "improvement" means all actions that at least reduce the degree of symptom associated with the condition being treated. At this time, the food composition may be used simultaneously or separately with the medicament for treatment before or after the onset of the disease for the prevention or improvement of the heavy metal-related disease.

As used herein, the term "food composition" refers to a food composition comprising one or more of a carrier, diluent, excipient and additives and is formulated as a tablet, pill, powder, granule, powder, And preferably, it may be a liquid formulation, but is not limited thereto.

Examples of foods that can be added to the composition of the present invention include various foods, powders, granules, tablets, capsules, syrups, drinks, gums, tea, vitamin complexes, and health functional foods. Examples of the additive that can be further included in the present invention include natural carbohydrates, flavors, nutrients, vitamins, minerals (electrolytes), flavors (synthetic flavors, natural flavors and the like), colorants, fillers, It is possible to use at least one component selected from the group consisting of an inorganic acid and a salt thereof, an organic acid, a protective colloid thickener, a PH modifier, a stabilizer, a preservative, an antioxidant, glycerin, an alcohol, a carbonating agent and a pulp. Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. As the above-mentioned flavors, natural flavors (tautatin, stevia extract (for example, rebaudioside A and glycyrrhizin) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used. The composition according to the present invention can be used in various forms such as flavorings such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and heavies, factic acid and its salts, alginic acid and its salts, , a pH adjusting agent, a stabilizer, a preservative, glycerin, an alcohol, a carbonating agent used in carbonated beverages, etc. In addition, the composition according to the present invention may contain flesh for the production of natural fruit juice and vegetable drinks . These ingredients may be used independently or in combination. Specific examples of the carrier, excipient, diluent and additives include, but are not limited to, lactose, dextrose, Cellulose, calcium carbonate, alginate, gelatin, calcium phosphate, calcium silicate, microcrystalline cellulose, polyvinylquilolidone, cellulose, polyvinylpyrrolidone, methyl cellulose, water, sugar, starch, starch, It is preferable to use at least one selected from the group consisting of syrup, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the following examples.

5 kinds of plant extract preparation method

The plant extracts used in the present invention were extracted according to generally known extraction methods and the extraction methods for the five kinds of plants obtained in the present invention are summarized as follows.

The syrup is pulverized and then the organic solvent is added in an amount of 2 to 200 times, preferably 10 to 30 times, based on the weight of the organic solvent. The resulting mixture is extracted at 10 to 70 DEG C for 1 to 10 days, preferably 2 to 5 days, Followed by drying. The extraction solvent may be ethanol, methanol, dichloromethane or the like, preferably 30 to 80% aqueous ethanol solution.

After the black bean is pulverized, the organic solvent is added in an amount of 2 to 200 times, preferably 10 to 30 times, based on the volume, and the mixture is extracted at 10 to 70 ° C for 1 to 10 days, preferably for 2 to 5 days, Followed by drying. The extraction solvent may be ethanol, methanol, dichloromethane or the like, preferably 30 to 80% aqueous ethanol solution.

After the licorice is pulverized, the organic solvent is added in an amount of 2 to 200 times, preferably 10 to 30 times, based on the volume thereof, and the mixture is extracted at 10 to 70 DEG C for 1 to 10 days, preferably for 2 to 5 days, Followed by drying. The extraction solvent may be ethanol, methanol, dichloromethane or the like, preferably 30 to 80% aqueous ethanol solution.

The organic solvent is pulverized to a volume of 2 to 200 times, preferably 10 to 30 times the volume of the organic solvent, extracted at 10 to 70 DEG C for 1 to 10 days, preferably 2 to 5 days, filtered, Followed by drying. The extraction solvent may be ethanol, methanol, dichloromethane or the like, preferably 30 to 80% aqueous ethanol solution.

After the crumbs are crushed, an organic solvent of 2 to 200 times, preferably 10 to 30 times, is added to the volume thereof, and the mixture is extracted at 10 to 70 ° C for 1 to 10 days, preferably for 2 to 5 days, filtered, Followed by drying. The extraction solvent may be ethanol, methanol, dichloromethane or the like, preferably 30 to 80% aqueous ethanol solution.

Specifically, in a preferred embodiment of the present invention, an extractor equipped with a reflux apparatus is used to agitate Saururus chinensis, black beans, licorice root, porcupinosarcoma, and rhizome or its dried product at 20 ° C in 30% ethanol aqueous solution at 50 ° C for 48 hours The extract was filtered, and the filtrate was concentrated under reduced pressure to obtain an ethanol extract. When necessary, an excipient such as maltodextrin was added to the extract, and the extract powder was obtained by lyophilization or spray drying.

Determination of heavy metal emission effect through animal experiment

Three weeks old male Sprague Dawley rats were purchased for 1 week preliminary breeding and adapted to the breeding environment.

In the experimental group, 10 mice were placed in each group with heavy metals and normal controls not subjected to the sample treatment, heavy metal control, and heavy metal administration and the sample administration of the compound extract as a sample. Arsenic, lead, cadmium, and mercury were used as the heavy metals in the experimental animals, and 30ml of lead and cadmium, and 15ml of arsenic and mercury were orally administered at 2ml per bird. All treatments except normal control were administered daily for 4 weeks. Ordinary doses of the same amount of distilled water were administered orally. The extracts of Saururus chinensis, Black chestnut, Licorice, Porcupineus and Yukuni were fed via feed and were fed at a level of 200 mg / kg / day. The drinking water was supplied freely without restriction. The conditions of the breeding room were maintained at 25 ° C, 50% relative humidity and 12 hours of sunshine. The body weight of the experimental animals was measured once a week for a certain period of time, and the body weight was measured. After 4 weeks of heavy metal and sample administration, the animals were fasted for 12 hours and sacrificed by anesthetizing the animals with ethyl ether.

After collecting the blood, blood samples and blood samples were collected and separated. After the blood collection, the liver and kidney were rapidly extracted and weighed. For liver enzymatic analysis, PBS was perfused, and the tissue was divided into 1 g portions and stored at -70 ° C. For the ICP analysis, each tissue was stored at -70 ° C and analyzed.

As shown in FIG. 1, significant heavy metal reduction was measured in the heavy metals contained in the blood due to the consumption of the extracts of lead, cadmium, and mercury, except for arsenic, by the mixed extract of Saururus chinensis, black poison, licorice root, Especially, lead and cadmium showed higher emission effect. As a result of analysis of heavy metal content in liver tissues, lead and cadmium contents decreased with ingestion of saururus chinensis, black poison, licorice root, pork broth, and yugaepi mixed extract as shown in Fig. 2, and arsenic and mercury tended to decrease slightly. FIG. 3 shows the results of analysis of heavy metal content in the kidney tissues. As a result of intake of Sambilchia, Black poison, Licorice, Poonggolyong, and Yugaekmi mixed extract, arsenic, cadmium, and lead were decreased.

Analysis of Liver Enzyme Activity by Animal Experiment

Enzyme solution was prepared by the following method to analyze the effect of heavy metals on the liver of experimental animals.

A 0.25 M sucrose solution (1 mM EDTA added) was added 9 times (w / v) per gram of liver tissue and then ground with a glass homogenizer. The supernatant was centrifuged at 700 x g for 20 min at 4 ° C, and the supernatant was centrifuged at 4 ° C and 10,000 x g to separate the supernatant and pellet. The supernatant was used as a sample to measure superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione S-transferase (GST). The pellet was dispersed with 1 ml of 0.25 M sucrose solution, Respectively.

SOD-like activity was measured by the Marklund-marklund method. 2.6 ml of tris-HCl buffer (50 mM tris + 10 mM EDTA, pH 8.5) was added to 0.2 ml of the sample, followed by addition of 0.1 ml of 7.2 mM pyrogallol, reaction at 25 ° C for 10 minutes, and then the reaction was stopped by adding 0.1 ml of 1 M HCl. The amount of pyrogallol oxidized in the liquid was measured at 420 nm.

The activity of GPx was measured by using the assay kit (abcam, UK) using the principle that the absorbance of NADPH decreased at 340 nm when oxidized glutathione (GSSG) was reduced by glutathione reductase and NADPH. 1 nmole of NADPH was decreased.

CAT activity was measured by modifying the Cohen method. The reaction was stopped by adding 5 ml of 6 mM H ₂ O ₂ solution to 5 ml of 6 mM H ₂ O ₂ solution and then reacting for 3 minutes. After the reaction was stopped by adding 1 ml of 6 N H ₂ SO _{4, 7} ml of 1 mM KMnO ₄ solution was added and the reduced KMnO ₄ The absorbance was measured at 480 nm.

GST activity was measured according to Mannervic's method. Reaction mixture 100 μl of the sample was added to 900 μl of 0.5 mM 1-Chloro-2,4-dinitrobenzene (CDNB) + 0.5 mM reduced glutathione (GSH) in 1 × PBS and the resulting GSH-CDNB was incubated for 5 minutes at 340 nm After measurement, the molecular extinction coefficient of CDNB was used to denote the number of μmoles of CDNB contained per mg protein per minute.

As shown in FIG. 4, SOD, CAT, GPx, and GST activities decreased as the liver heavy metal content was increased. As a result, when the mixed extracts of Saururus chinensis, The activity of the enzyme was significantly increased. Therefore, it was found that the plant extract improves the activity of enzymes degraded by administration of heavy metals, and is involved in the detoxification of heavy metals.

Determination of mercury emission from hair through clinical experiment

To investigate the effect of Saururus chinensis, Lycopersicon esculentum, Lycopersiconum, Pseudomonas aeruginosa, and Yugiofumi mixture extracts on the body heavy metal content, the intake of 400 mg / day was determined by tableting, and then 30 normal university students .

These subjects were divided into two groups and were fed with the extracts of Saururus chinensis, Black chestnut, Licorice root, Poonggolyun, and Yukun pei mixed extract (n = 15) for 30 days at the same time as the hair harvesting. The hair was collected on the last day and the mercury content The changes of mercury levels before and after ingestion of mixed extracts of Saururus chinensis, Black poison, Licorice, Pseudomonas aeruginosa, and. In the control group (n = 15), the mercury content in the hair was analyzed by taking the test start date and the placebo for 30 days.

As a result, there was no significant change in mercury content in the hair of the control group. However, in the case of the experimental group consumed with the extract of Saururus chinensis, Black poison, Licorice root, Pseudomonas aeruginosa, and Yuguni pei, the result of 30 days of intake showed a slight decrease in the average value of 15 persons as shown in FIG. 5A, In the case of the subjects (n = 7) who had a mercury concentration of 1 ppm or more in the hair before the administration of the extract, the amount of mercury in the hair was measured by taking a mixture containing Saururus chinensis, Black poison, Licorice root, Of the total population.

[Production Example 1] Powder

Saururus chinensis, Black bean, Licorice, Rootgrass, and Rootgrass extract 2g

Lactose 1g

The above components are mixed and packed in airtight bags to prepare powders.

[Production Example 2] refine

300 mg of Saururus chinensis, Black bean, Licorice root, Rootgrass, and Rootgrass extract

Lactose 100mg

Methylcellulose 95 mg

Magnesium stearate 5 mg

After mixing the above components, tablets are prepared by tableting according to a conventional tablet preparation method.

[Manufacturing Example 3]

Saururus chinensis, Black bean, Licorice root, Porcupine root, and Root seed extract 200mg

Lactose 50mg

Corn starch 50 mg

After mixing the above components, they are filled in gelatin capsules according to a conventional capsule preparation method to prepare capsules.

[Production Example 4]

40% by weight of germinated brown rice, 30% by weight of barley, 20% by weight of yulmu and 10% by weight of alpha-fine powder were mixed and granulated to a grain size of 60 mesh by a pulverizer.

40% by weight of black beans, 30% by weight of black sesame and 30% by weight of perilla seed are dispersed, and then 60-mesh seed grain powder is prepared by a pulverizer.

The dried Saururus chinensis, Black bean, Licorice, Pseudomonas sp., And Root seed extracts of the present invention are dried using a spray drier.

5% by weight of dried powder of 75% by weight of the cereal grains, 20% by weight of seed grains, and 300 mg of Saururus chinensis, Black currant, Licorice root, Pseudomonas sp., And Rootgrass extract is blended and granulated.

[Production Example 5]

Candy was prepared by adding 0.5% by weight of dry powder of 60% by weight of sugar, 39% by weight of starch syrup, 0.5% by weight of flavor and 300 mg of Saururus chinensis, Black currant, Licorice root, Pseudomonas sp.

[Manufacturing Example 6]

A mixture of 3% by weight of powdered milk, 7% by weight of sprayed milk, and 1% by weight of water, 16.9% by weight of the present invention and 5% by weight of dry powder of 300 mg of Saururus chinensis, Black bean, Licorice root, Pseudomonas sp., And Rootbeer extract are added to prepare biscuits by a conventional method.

[Manufacturing Example 7]

5 weight% of honey, 3 weight% of fructose, 0.0001 weight% of sodium riboflavin hydrochloride, 0.0001 weight% of pyridoxine hydrochloride and 86.9998 weight% of water and 5 weight% of Saururus chinensis, black liquorice, licorice root, To produce health beverages.

[Manufacturing Example 8] Health functional food

15 wt% of octacosanol powder, 15 wt% of lactose hydrolyzate powder, 15 wt% of isolated soybean protein powder, 15 wt% of chito oligosaccharide 10 wt% of yeast extract powder, 10 wt% of vitamin mineral mixture, 4.6 wt% of magnesium stearate, 0.2% by weight of glycerin fatty acid ester, 0.2% by weight of glycerol fatty acid ester, and 20% by weight of Saururus chinensis, Black bean, Licorice root, Pseudomonas sp., And Root seed extract of the present invention are blended to prepare a refined health functional food.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (6)

A composition for the removal of heavy metals comprising an extract of Saururus chinensis, Black beans, Licorice, Porcupineol, and Rootbeam as an active ingredient, characterized in that the composition has a discharging and detoxifying effect of heavy metals selected from the group consisting of lead and mercury .
The method according to claim 1,
1 to 60 parts by weight of a Saururus chinense extract, 1 to 60 parts by weight of a black currant extract, 1 to 60 parts by weight of a licorice extract, 1 to 60 parts by weight of a percolated extract, 1 to 60 parts by weight of an extract of rhizome.
The method according to claim 1,
Wherein the extract is in a powder state in which each extract is concentrated and dried.
The method according to claim 1,
Wherein the food composition is in the form of a beverage.
The method according to claim 1,
Wherein the extract is extracted with an aqueous 30 to 80% ethanol solution as an extraction solvent.
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