KR101501065B1 - Blood flow velocity using pulse wave and ecg measurement equipment - Google Patents

Abstract

An embodiment of the present invention relates to an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram, and a technical problem to be solved is to easily measure a blood flow velocity using a pulse wave and an electrocardiogram.
To this end, one embodiment of the present invention includes at least one sensor unit for measuring an electrocardiogram and a heartbeat cycle at a predetermined region by contacting a predetermined portion of the body of the subject, A body information input unit for inputting body information of the subject; And a control unit for calculating a blood flow velocity at a predetermined site using a result value obtained by autocorrelation of a signal output from the sensor unit and body information of a subject inputted through the body information input unit, An apparatus for measuring blood flow velocity is disclosed.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a blood flow velocity measuring device using a pulse wave and an electrocardiogram,

An embodiment of the present invention relates to an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram.

In order to maintain human life, it is necessary to flow the blood released by the heartbeat along the arteries without clogging the body, and to return the blood back to the heart through the vein. This allows oxygen and nutrients to be supplied to each tissue in the body and metabolism can be used to remove the spent waste.

However, when the artery is not in good condition, the blood is not properly transferred to a specific part of the body, or a blood clot or embolization occurs in the blood, and the blood becomes turbid, the capillary blood of the specific tissue of the body is blocked to cause necrosis of the tissue, can do. For example, a thrombus in the carotid artery may cause stroke, diabetic foot or kidney damage due to diabetes or hyperlipidemia, myocardial infarction resulting from obstructing the coronary artery, or the like resulting from blocking the blood flow of the brain.

In recent years, the cause of death in Korea has been shown to be the second leading cause of death in the circulatory system diseases following cancer, and about 90% of circulatory system diseases are caused by arteriosclerosis. Arteriosclerosis is a disease in which the wall of the artery thickens and hardens and loses its elasticity. Hypertension, obesity and diabetes are the main causes. In addition, arteriosclerosis is a major cause of blood flow disorders, thrombus formation, stroke, myocardial infarction, and the like. Therefore, there is a great need for early diagnosis and prevention of cardiovascular conditions and arteriosclerosis.

In order to screen these atherosclerotic lesions, we are mainly using imaging tests together with clinical examinations. However, such a morphological test has many limitations such as an increase in medical expenses in order to examine the abnormality of blood flow which is the initial abnormality of atherosclerosis. In addition, some image examinations provide blood flow information, which is advantageous for maintaining the reliability of the human body due to the diversity of the human environment, but has problems such as early diagnosis and rising medical costs.

Therefore, it is necessary to develop a medical device product which can diagnose early in a general hospital and detect a relatively accurate heart rate and measure a blood flow velocity at a desired site to extract diseases related to body blood flow.

Patent Publication No. 10-0820159 'Method and Apparatus for Measuring Blood Pressure' Patent Publication No. 10-1019239 'Cardiovascular Analyzer'

An embodiment of the present invention provides an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram that can easily measure a blood flow velocity using a pulse wave and an electrocardiogram.

An apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention includes at least one sensor unit for measuring an electrocardiogram and a heartbeat period at a predetermined region in contact with a predetermined region of a body of a subject; A body information input unit for inputting body information of the subject; And a control unit for calculating a blood flow velocity at a predetermined site using a result value obtained by autocorrelation of a signal output from the sensor unit and body information of a subject inputted through the body information input unit.

Wherein the sensor unit comprises: an ECG sensor for measuring an electrocardiogram of a subject's body; And a PPG sensor for measuring the heartbeat period of the subject's body.

The physical information of the subject may include a distance from the heart of the subject to the fingertip, and a distance from the heart of the subject to the radial artery.

Wherein the controller comprises: a first waveform detector for detecting a QRS wave output from the ECG sensor; A second waveform detector for detecting a pulse wave output from the PPG sensor; A first calculator for deriving a first peak value by autocorrelating a waveform at different times in the waveform of the QRS wave and deriving a second peak value by autocorrelating waveforms at different times in the waveform of the pulse wave; An extracting unit for extracting a blood flow transfer time using the first peak value and the second peak value; Calculating a movement distance of the blood ejected from the heart using the body information value of the subject and dividing the calculated distance of the blood by the blood flow propagation time to calculate a blood flow velocity at a predetermined region of the subject, 2 arithmetic unit; A display unit for displaying the QRS wave and the pulse wave detected by the first and second waveform detecting units, the first and second peak values output by the first and second calculating units, and the blood flow velocity; A storage unit for storing the QRS wave and the pulse wave detected by the first and second waveform detecting units, the first and second peak values output by the first and second calculating units, and the blood flow velocity; And a controller for storing driving programs of the respective components of the control unit and controlling driving by execution of the driving program.

The QRS wave is composed of a Q wave indicating the contraction of the atrium, an R wave indicating the extension of the atrium, and an S wave indicating the excitation of the atrium, and the first calculating section can autocorrelate the signal values at different times of the R wave .

The blood flow velocity measuring device using the pulse wave and the electrocardiogram according to an embodiment of the present invention can easily measure the blood flow velocity using the ECG sensor and the PPG sensor.

In addition, since the embodiment of the present invention measures the blood flow velocity easily and accurately at a low cost, arteriosclerosis, cardiovascular disease and heart disease can be predicted.

1 is a view schematically showing an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention.
FIG. 2 is a block diagram showing the configuration of an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention.
3 is a view showing an electrocardiogram waveform measured by a blood flow velocity measuring apparatus using a pulse wave and an electrocardiogram according to an embodiment of the present invention.
4 is a view for explaining a method of measuring a blood flow velocity using an apparatus for measuring blood flow velocity using an ECG and a pulse wave according to an embodiment of the present invention.
5A and 5B are tables and graphs showing data values and measurement results for measuring blood flow velocity using an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention.

DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, so that those skilled in the art can easily carry out the present invention.

FIG. 1 is a view schematically showing an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention. FIG. 2 is a block diagram of a blood flow velocity measurement apparatus using a pulse wave and an electrocardiogram according to an embodiment of the present invention. FIG. 3 is a view showing an electrocardiogram waveform measured by a blood flow velocity measuring device using a pulse wave and an electrocardiogram according to an embodiment of the present invention, and FIG. 4 is a block diagram of a pulse wave and an electrocardiogram according to an embodiment of the present invention. 5A and 5B are views for explaining a method of measuring blood flow velocity using a blood flow velocity measuring apparatus using a pulse wave and an electrocardiogram according to an embodiment of the present invention. Table and graph showing measured data values and measurement results.

Referring to FIGS. 1 to 4, an apparatus for measuring blood flow velocity using a pulse wave and an electrocardiogram according to an embodiment of the present invention includes a sensor unit 10, a body information input unit 20, and a controller 30.

The sensor unit 10 contacts a predetermined part of the body of the subject and senses various bio-signals at a predetermined position. The bio-signal may include information such as an electrocardiogram and a heartbeat cycle.

The sensor unit 10 may include an electrocardiogram (ECG) sensor 110 for measuring an electrocardiogram of a subject's body and a PPG (Photoplethysmography) sensor 120 for measuring a heartbeat period of the subject's body .

The ECG sensor 110 is used for examining an electrocardiogram. The ECG sensor 110 measures and graphs the temporal fluctuation of the action potential of the myocardial cell caused by the heart beat. The ECG sensor 110 can sense the electrocardiogram by measuring the heartbeat by contacting the skin close to the heart or by contacting two sensors on both arms or hands. For example, an ECG measurement can be performed by attaching an electrode to a designated position of both arms of an ECG measurement operator, and then connecting the clamped cable to the electrode.

)를 착용시켜 심장 박동 주기, 즉 맥박을 측정할 수 있다. 또한, 요골동맥 측정 실험자의 왼손 손목의 요골동맥에 맥박을 측정하기 위하여 센서를 부착한 다음, 2차 센서를 심장쪽 조직 위에 부착할 수 있다.The PPG sensor 120 is attached to the skin such as fingertips and toes, and measures photoplethysmography in tissues. For example, the PPG measurement experimenter's left hand finger blood oxygen saturation (

) Can be worn to measure the heartbeat period, that is, the pulse. In addition, a sensor may be attached to the radial artery of the radial artery measurement operator to measure the pulse on the radial artery of the left wrist, and then the secondary sensor may be attached to the heart tissue.

In more detail, the PPG sensor 120 detects the change in blood volume in the tissue by measuring the intensity of light absorbed in the tissue after the infrared ray is incident on the tissue. The PPG sensor 120 utilizes the property that red blood cells in blood absorb infrared rays. Particularly, the PPG sensor 120 measures the amount of blood entering the capillary through the artery and the small artery, and checks whether the blood flow in the peripheral part such as the fingertip or the toe is proper. Here, since the photoelectric pulse wave fluctuates according to the heartbeat cycle, the heartbeat cycle can be determined by measuring the photoelectric pulse wave. Specifically, the blood ejected from the left ventricle of the heart to the systolic phase of the heart is transferred to each tissue of the peripheral region such as the fingertip, the toe, etc., and as the blood volume of the artery increases, the light absorbed by the tissue increases. On the other hand, in the diastole of the heart, as the blood is inhaled partially from each tissue of the peripheral region toward the heart, the light absorbed by the tissue decreases. As described above, since minute changes of the blood volume occur in the tissue in accordance with the cardiac cycle, the PPG sensor 120 can be used to measure the light absorbed by the tissue, that is, the change in the light absorbance.

In addition, the sensor unit 10 may integrate the ECG sensor 110 and the PPG sensor 120 together. Therefore, since the ECG sensor 110 and the PPG sensor 120 can be integrated and carried, the subject can directly measure his / her blood vessel state regardless of time or place. This allows the subject to be aware of the effect of a particular food or exercise on his or her vascular condition.

The body information input unit 20 inputs body information of the subject. For example, the body information input unit 20 inputs body information of the subject, which may include a distance from the heart of the subject to the fingertip measured beforehand, a distance from the heart to the radial artery, etc. .

The control unit 30 calculates a blood flow velocity at a predetermined site using a result value obtained by autocorrelation of a signal output from the sensor unit 10 and body information of a subject inputted through the body information input unit 20 .

In order to realize this operation, the controller 30 includes a first waveform detector 310, a second waveform detector 320, a first calculator 330, an extractor 340, a second calculator 350, A storage unit 360, a controller 380, and the like.

The first waveform detector 310 detects a QRS wave outputted from the ECG sensor 110. Referring to FIG. 3, the QRS wave may be composed of a Q wave indicating the contraction of the atrium, an R wave indicating the expansion of the atrium, and an R wave indicating the excitation of the atrium. That is, the first waveform detector 310 detects a QRS wave, which is output from the ECG sensor 110 and is related to the temporal variation of the action potential of the myocardial cell caused by the heartbeat of the subject.

The second waveform detector 320 detects a pulse wave output from the PPG sensor 120. That is, the second waveform detector 320 detects a pulsed wave, which is a photoelectronically pulse wave, output from the PPG sensor 120.

The first calculator 330 derives a first peak value by cross-correlating waveforms of different times in the QRS waveform and autocorrelates waveforms at different times in the waveform of the pulse wave, Derive the peak value. Here, the first calculator 330 may derive the first peak value and the second peak value by autocorrelating the signal values at different times of the R wave.

)는 시간 t에서의 신호값(

)만큼 시간 지연이 있을 때 즉, 시간

에서의 신호값

의 곱에 대한 평균으로 다음 수학식 1과 같이 정의된다.For example, the first calculator 330 may calculate a first peak value and a second peak value using an autocorrelation function as shown in Equation 1 below. Here, the autocorrelation function indicates a correlation between a signal value at a certain time and a signal value at another time, and an autocorrelation function

) Is the signal value at time t

), I.e., the time

The signal value at

Is defined as the following equation (1). &Quot; (1) "

[Equation 1]

에서 최대값을 가진다.On the other hand, the autocorrelation function is always a free function having a real value,

Lt; / RTI >

(2) " (2) "

&Quot; (2) "

In this way, the first calculator 330 calculates a maximum value, that is, a first peak value and a second peak value using an autocorrelation function, and then takes 1/3 of each peak value, And the heart rate can be measured.

The extraction unit 340 extracts a blood flow propagation time using the first peak value and the second peak value. That is, the extraction unit 340 extracts a blood flow transfer time, which is a time from a time point of a first peak value at which blood is discharged from the heart to a time point of a second peak value at which blood is delivered to the tissue.

The second calculating unit 350 calculates the moving distance L of the blood ejected from the heart using the body information value of the subject and divides the calculated moving distance L of the blood by the blood flow passing time, (V) at a predetermined region of the blood vessel. The moving distance L of the blood is the distance from the heart from which the blood is ejected to the position where the second peak value is measured. Here, the moving distance L of the blood can be calculated on the basis of the body information value of the subject. For example, the body information value of the subject can be calculated from the distance from the heart to the fingertip of the subject or from the heart to the radial artery And the like.

The display unit 360 displays the QRS wave and the pulse wave detected by the first and second waveform detectors 310 and 320 and the first and second peak values outputted by the first and second calculating units 330 and 350 , And blood flow velocity. Thus, the blood vessel state of the subject can be easily diagnosed through the blood flow rate output through the display unit 360, and the degree of arteriosclerosis can be known. In addition, the display unit 360 can display various information besides the above-described data by using an LCD (Liquid Crystal Display) or the like. For example, as shown in FIGS. 5A and 5B, the display unit 360 displays data values and measurement results for measuring blood flow velocity using a blood flow velocity measuring device using the present pulse wave and an electrocardiogram as a table or a graph . The blue color in FIG. 5B is the result of electrocardiogram measurement through the ECG sensor, and the red color represents the measurement result of the heartbeat cycle through the PPG sensor.

The storage unit 370 stores the QRS wave and the pulse wave detected by the first and second waveform detectors 310 and 320 and the first and second peak values outputted by the first and second calculating units 330 and 350, Value, and blood flow rate.

The controller 380 stores the driving programs of the respective components of the control unit 30 and controls the driving by executing the driving programs. That is, the controller 380 receives signals from the electrodes and sensors attached to the body of the subject by the execution of the driving program, and calculates and displays the blood flow velocity of the subject using the signal values measured for a predetermined time .

Although not shown, the control unit 30 may include a communication unit for transmitting the measured various information to the outside, thereby enabling the medical institution to diagnose the blood vessel condition of the patient and to grasp the degree of arteriosclerosis.

On the other hand, although not shown, the components of the control unit 30 may be mounted on one or more printed circuit boards, and such printed circuit boards may be provided and protected within an integral control box .

In this case, the control box may be formed of a composite resin composition against an impact from the outside of the box.

The composite resin composition is a mixed resin of a polypropylene resin and an intermolecular material in which an engineering plastic is kneaded. The composite resin composition is excellent in thermal deformation temperature, impact resistance and mechanical strength, and can be effectively used for parts inside a vehicle.

Such a composite resin composition may include a polypropylene resin, an engineering plastic, a rubber-based resin, and an inorganic filler.

The polypropylene resin may be contained in an amount of 30 to 60 parts by weight based on 100 parts by weight of the composite resin composition. If the content of the polypropylene resin is less than 30 parts by weight, the price competitiveness may be low. If the content of the polypropylene resin exceeds 60 parts by weight, heat resistance may be deteriorated.

The engineering plastic may be included in an amount of 25 to 60 parts by weight based on 100 parts by weight of the composite resin composition. If the content of the engineering plastic is less than 25 parts by weight, the strength may be reduced. If the engineering plastic is more than 60 parts by weight, the price competitiveness may be lowered. The engineering plastic may be at least one of polycarbonate and polyphenylene oxide resin, preferably polyphenylene oxide resin.

The rubber-based resin is added to improve the impact resistance of the composite resin composition, and may be included in an amount of 1 to 20 parts by weight based on 100 parts by weight of the composite resin composition. If the content of the rubber-based resin is less than 1 part by weight, it may be susceptible to impact, while if it exceeds 20 parts by weight, the heat resistance may decrease. The rubber-based resin may be at least one of styrene-ethylene-butylene-styrene (SEBS), ethylene-propylene rubber (EPR), ethylene-butylene rubber (EBR) and ethylene-octene rubber (EOR).

The inorganic filler is added to improve the elastic modulus of the composite resin composition, and may be included in an amount of 1 to 20 parts by weight based on 100 parts by weight of the composite resin composition. If the content of the inorganic filler is less than 1 part by weight, the rigidity may be deteriorated. If the content is more than 20 parts by weight, it may become too stiff. The inorganic filler may be at least one of talc, barium sulfate, calcium carbonate, clay and mica, and is preferably talc having a particle size of 0.5 to 10 mu m.

In the present invention, a control box formed by molding the composite resin composition may be provided. Such a control box is manufactured through an extrusion process and an injection process, which are known in the art, so that the respective components constituting the control unit 30 mounted therein can be protected from external impacts.

According to the apparatus for measuring the blood flow velocity using the pulse wave and the electrocardiogram according to an embodiment of the present invention, the blood flow velocity can be easily measured using the ECG sensor 110 and the PPG sensor 120, By measuring blood flow velocity at a simple and accurate cost, it is possible to easily predict atherosclerosis, cardiovascular disease and heart disease.

The present invention can also be embodied as computer-readable codes on a computer-readable recording medium. A computer-readable recording medium includes all kinds of recording apparatuses in which data that can be read by a computer system is stored. Examples of the computer-readable recording medium include ROM, RAM, CD-ROM, magnetic tape, hard disk, floppy disk, flash memory, optical data storage, And the like. The computer readable recording medium may also be distributed over a networked computer system and stored and executed as computer readable code in a distributed manner.

On the other hand, the outer surface of the body information input unit 20 is coated with a fragrance material having a function of treating a respiratory disease or the like, thereby improving the user's fatigue and health.

The functional oil may be mixed with 95 to 97% by weight of a perfume, 3 to 5% by weight of a functional oil, 50% by weight of a spruce leaf oil, And 50 wt% of kernel oil (kernel oil).

It is preferable that the functional oil is mixed in an amount of 3 to 5% by weight based on the perfume. If the mixing ratio of the functional oil is less than 3 wt%, the effect is insignificant. If the mixing ratio of the functional oil exceeds 5 wt%, the function is not greatly improved, but the manufacturing cost is greatly increased.

Spruce leaf oil in the functional oil is an oil obtained from the spruce leaf and has good effect on treating blood pressure increase due to pain, depression, psychological stress.

Peach kernel oil is effective in treating respiratory-related diseases such as sedation, bronchitis and pain relief.

Since the functional oil is coated on the outer surface of the body information input unit 20, fatigue recovery and health of the user can be improved.

As described above, the present invention is not limited to the above-described embodiment, but may be applied to a blood flow measuring apparatus using an electrocardiogram and a pulse wave according to the present invention. It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.

10: sensor unit 20: body information input unit
30: control unit 110: ECG sensor
120: PPG sensor 310: first waveform detector
320: second waveform detection unit 330: first calculation unit
340: extracting unit 350: second calculating unit
360: display section 370: storage section
380: Controller

Claims (5)

At least one sensor part (10) for measuring an electrocardiogram and a heartbeat period at a predetermined part in contact with a predetermined part of the body of the subject; A body information input unit 20 for inputting body information of the subject; And a control unit for calculating a blood flow velocity at a predetermined site using a result value obtained by autocorrelation of a signal output from the sensor unit 10 and body information of a subject inputted through the body information input unit 20 30,
The sensor unit 10 includes an ECG sensor 110 for measuring an electrocardiogram of a subject's body; And a PPG sensor (120) for measuring a heartbeat period of the subject's body,
The controller 30 includes a first waveform detector 310 for detecting a QRS wave output from the ECG sensor 110; A second waveform detector 320 for detecting a pulse wave output from the PPG sensor 120; A first operation unit 330 for deriving a first peak value by autocorrelating waveforms of different times in the waveform of the QRS wave and deriving a second peak value by autocorrelating waveforms at different times in the waveform of the pulse wave ); An extracting unit 340 for extracting a blood flow transfer time using the first peak value and the second peak value; Calculating a movement distance of the blood ejected from the heart using the body information value of the subject and dividing the calculated distance of the blood by the blood flow propagation time to calculate a blood flow velocity at a predetermined region of the subject, 2 operation unit 350; A QRS wave and a pulse wave detected by the first and second waveform detectors 310 and 320 and first and second peak values and a blood flow velocity output by the first and second calculators 330 and 350 A display unit 360 for displaying an image; The QRS and pulse wave detected by the first and second waveform detectors 310 and 320 and the first and second peak values and the blood flow velocity output by the first and second calculating units 330 and 350 are stored A storage unit 370 for storing the data; And a controller (380) that stores driving programs of the respective components of the control unit (30) and controls driving by execution of the driving program,
The first waveform detecting unit 310, the second waveform detecting unit 320, the first calculating unit 330, the extracting unit 340, the second calculating unit 350, the display unit 360, the storing unit 370, 380 are implemented on a printed circuit board, the printed circuit board is provided inside and protected by an integral control box,
The control box is formed of a composite resin composition comprising a polypropylene resin, an engineering plastic, a rubber-based resin, and an inorganic filler,
Wherein the polypropylene resin is 30 to 60 parts by weight, the engineering plastic is 25 to 60 parts by weight, the rubber-based resin is 1 to 20 parts by weight, the inorganic filler is 1 to 20 parts by weight based on 100 parts by weight of the composite resin composition And the blood flow velocity measuring device using the pulse wave and the electrocardiogram. delete The method according to claim 1,
Wherein the body information of the subject includes a distance from the heart of the subject to the fingertip, and a distance from the heart of the subject to the radius of the radial artery. delete The method according to claim 1,
The QRS wave consists of a Q wave indicating the contraction of the atrium, an R wave indicating the expansion of the atrium, and an S wave indicating the excitation of the atrium,
Wherein the first calculator (330) autocorrelates the signal values at different times of the R waves, and the blood flow velocity measuring device using the pulse wave and the electrocardiogram.

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