KR101461165B1 - Hangover curing agent - Google Patents

Abstract

The present invention relates to a composition comprising a grape seed extract, a chaga mushroom extract, a thistle extract, a juli powder and a hornbug extract, wherein the grape seed extract is 42 to 48 wt%, the chaga mushroom extract is 23 to 27 wt%, the thistle extract is 12 to 17 3 to 8% by weight of the jellyfish powder, and 2 to 6% by weight of the hornberry fruit extract.

Description

Hangover curing agent < RTI ID = 0.0 >

The present invention relates to a food composition useful for hangover, and more particularly, to a composition containing grape seed extract, chaga mushroom extract, thistle extract, chestnut powder and hornbug fruit extract, showing excellent effects on hangover resolution.

Drinking is becoming a necessity for modern people who frequent drinks and entertainments and are stressed by various factors, thereby drastically increasing opportunities for drinking.

According to a survey by the Korea Institute of Health and Social Affairs, the frequency of drinking in Korea over 20 years old was about 8 days per month, 11 days for men and about 4 days for women. 4.7%, about 1 ~ 3 times a month, about 13.2%, which is very worrisome in terms of public health.

In this way, modern people eat excessive amounts of alcohol that can not be digested, and they often suffer from side effects such as thirst, general boredom, fatigue, memory loss, abdominal bloating, vomiting and diarrhea. The risk of taking is also increasing.

Hangover refers to a phenomenon of headache or heartburn after drinking a lot of alcohol, which is caused by the fact that acetaldehyde, which decomposes in the body's metabolism of alcohol, is harmful to the human body. Alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) in the liver and then decomposed into acetic acid and hydrogen by aldehyde dehydrogenase (ALDH) and excreted through the urine.

On the other hand, grape seeds account for about 3 ~ 5% of the grape weight and contain not only a large amount of fat, 9 ~ 12%, protein 8 ~ 12% and 45% of dietary fiber such as hemicellulose, ), Magnesium (Mg), and phosphorus (P). In addition, grape seeds contain a large amount of anticancer, antihypertensive, and antioxidant catechin compounds as well as plant sterols and tocopherols, and grape seed oils and extracts are widely used as functional foods, cosmetics and pharmaceuticals in various countries.

On the other hand, Inonotus obliquus is a kind of mushroom which grows birch sap as a nutrient source. Beta glucan, which acts as a superoxide dismutase, It contains several hundreds of enzymes to remove active oxygen in the body. It contains immunity-enhancing ingredients. It reduces fat and blood sugar in cholesterol, strengthens immunity, prevents adult disease, It removes the active oxygen that is formed and alkalizes it by the decrease of the acidity in the body and the cleansing of the blood flow, and strengthens the soft cells, thereby increasing the healing power of the human body.

On the other hand, thistle (Cirsium japonicum ) is a perennial herb that belongs to the family Asteraceae. Its efficacy has been well known, and it has been reported that it protects against hepatoprotective action, prevention of alcohol induced lipid oxidation, and alcoholic cirrhosis.

On the other hand, is yulpi night (Castanea crenata ), it is known that it has excellent wrinkle improving effect on the skin, protects the stomach, and detoxifies against side effects of ginseng.

On the other hand, Hovenia dulcis Thunb is a deciduous broad-leaved arboreous tree, distributed at 50-800 m above sea level in Gyeonggi-do, Gyeongsangnam-do. It is distributed in the order of hippopotamus, backbone, earth, It is also known as wood grain, cypher pear. There is a report that Hovenia natto has toxin decontamination, hematocrit, diuretic, thirst relief and detoxification in herbal medicine and phytomedicine. It is said that tea made from leaf, stem, and fruit of hinoki tree has excellent efficacy in the elimination of alcohol poisoning and protection of liver function.

On the other hand, there have been many active researches on hangover detoxification compositions for removing hangover or toxicity of alcohol due to drinking, and a variety of hangover detoxification compositions containing natural raw materials, herbal medicine materials or artificial preparations have been developed . However, conventionally developed compositions for relieving hangover have not yet exhibited satisfactory effects.

Korean Patent No. 10-0773889 (composition for hangover poultice containing the liquid herb extract as an active ingredient and method for producing the same) comprises 12 to 28.5% by weight of the mushroom extract, 18.5 to 22% by weight of the mushroom extract, 19 to 20% Wherein the extract is selected from the group consisting of citrate extract, citric acid extract, citric acid extract, citric acid extract, citrate extract, citrate extract, And a liquid extract made of 2 to 3% by weight of a liquid watershed as an active ingredient. However, there has been no description of the composition for sputum roots including grape seed extract, chaga mushroom extract, thistle extract, chestnut powder and Hovenia dulcis extract. Korean Patent Laid-Open No. 10-2011-0056014 (a hangover rescue composition containing a hanbok tree young branch extract) is prepared by finely crushing a young branch of a hinoki tree to a size of 1 to 2 cm and adding 10 times the volume of water, The filtrate was filtered through a filter to concentrate the filtrate to a concentration of 18 to 22 Brix. The filtrate was extracted with 59.9% by weight of the extract of Hovenia dulcis Thunb., 5.0% by weight of Hovenia dulcis extract, 3.0% by weight of honey, 3.0% by weight of liquid fructose, 0.07% by weight of sodium citrate, 0.05% by weight of grapefruit seed extract, 1.0% by weight of powdery moss extract, 3.0% by weight of liquid oligosaccharide, 1.5% by weight of pine needle extract, 1.0% by weight of cinnamon extract, 0.065% by weight, and 25.215% by weight of purified water. However, there has been no description of the composition for sputum roots including grape seed extract, chaga mushroom extract, thistle extract, chestnut powder and Hovenia dulcis extract.

It is an object of the present invention to provide a food composition for hangover breaks which is made of a natural material and has a stable human body.

It is another object of the present invention to provide a food composition useful as a hangover remedy which improves the resistance of the body and suppresses side effects after drinking very effectively.

It is also an object of the present invention to provide a food composition for hangover which is effective for restoring damaged liver function and for alleviating or treating alcohol dependence and alcohol dependence.

In order to attain the above object, the food composition for hangover of the present invention is characterized by including grape seed extract, chaga mushroom extract, thistle extract, jellyfish powder and hornoya fruit extract.

Hereinafter, the grape seed extract, chaga mushroom extract, thistle extract, horsetail powder, Hovenia dulcis extract and food composition containing the horsetail used as an active ingredient thereof will be described in detail.

In the present invention, a variety of extraction methods commonly used in the technical field of the present invention can be used as a method for obtaining grape seed extract, chaga mushroom extract, thistle extract or Hovenia dulici extract. For example, , A solvent in which methanol, ethanol, propanol, butanol, glycerol, propylene glycol, 1,3-butylene glycol and the like are used alone or as a mixture of two or more thereof may be used as an extraction solvent. Preferably, a 40 to 80% aqueous solution of ethanol can be used.

In addition, the extract of the present invention includes not only the extract obtained by the above-mentioned extraction solvent, but also an extract obtained through a conventional purification process. For example, by separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatographies (made for separation by size, charge, hydrophobicity or affinity), and the like, Fractions are also included in the extract of the present invention.

The extract of the present invention also includes extracts obtained through subcritical and supercritical extraction methods widely used as methods for extracting useful components from natural products. These extraction methods have advantages in that they are faster in extraction speed than general extraction methods and harmless to the environment because they use substances (for example, supercritical carbon dioxide) which are harmless to the environment as extraction solvents.

In the present invention, the grape seed, the carrot mushroom, the thistle or the Houttuynia chinensis which is the material of the extraction can be dried or used as it is. The drying method may be dry drying or hot air drying. In addition, grape seed, chaga mushroom, thistle or Hovenia dulcis can be used by pulverizing them. If the materials are pulverized, they can be easily extracted.

In addition, the grape seed extract, chaga mushroom extract, thistle extract or Hovenia dulcis extract of the present invention can be used in a liquid state, but it is preferable to prepare the grape seed extract in powder form by an additional process such as vacuum distillation, freeze drying or spray drying Do.

In addition, the pulp powder of the present invention can be prepared by drying the pulp by natural drying or hot-air drying, and then pulverizing the pulp.

Meanwhile, the present invention can be used to produce a food composition for hangover marinades, which exhibits an excellent effect in eliminating hangover, by using the grape seed extract, chaga mushroom extract, thistle extract, urnae powder and Hovenia dulcis extract prepared as described above. Preferably, the food composition of the present invention for hangover is composed of 42 to 48% by weight of grape seed extract, 23 to 27% by weight of chaga mushroom extract, 12 to 17% by weight of thistle extract, 3 to 8% by weight of zulberry powder, By weight to 6% by weight. When the above range is satisfied, the alcohol decomposing ability is very excellent, and an excellent effect can be exhibited on hangover resolution.

In addition, the food composition of the present invention for hangover can be manufactured as a powder, a granule, a tablet, a capsule, a candy, a gum or a food in the form of a drink, and other natural or synthetic substances and additives May be further included.

The present invention can produce a food composition for hungry poultry which is made of a natural material and has secured human stability.

In addition, the present invention can prepare a food composition for hangover break which can enhance the resistance of the body and can suppress the side effects after drinking very effectively.

In addition, the present invention can produce a food composition useful in hangover, which effectively restores damaged liver function and is effective in improving or treating alcohol dependence and alcohol dependence.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following embodiments, and includes modifications of equivalent technical ideas.

Production Example 1: Preparation of Food Composition for Hangover

Grape seed, chaga mushroom, thistle or Hovenia dulcis were dried and finely ground to a predetermined size. A 70% aqueous ethanol solution was added to each of the pulverized raw materials, and the mixture was extracted by heating at 100 to 150 ° C for 3 to 6 hours with stirring. Then, the extracts were filtered using a filter cloth and then lyophilized to prepare an extract powder of raw materials. In addition, the hull was dried and finely pulverized to prepare a hull.

The resulting grape seed extract powder (42 to 48 wt.%), Chrysanthemum extract powder (23 to 27 wt.%), Thistle extract powder (12 to 17 wt.%), Hulli powder (3 to 8 wt.%) And mixed to give a hangover food composition.

Comparative Example  1 to 5: preparation of composition for sputum horn

In this Comparative Example, the components in the composition components of the food composition for hangover in hunch of Preparation Example 1 were excluded one by one to prepare Comparative Examples 1 to 5 (see Table 1).

Production Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Grape seed extract ○ - ○ ○ ○ ○ Mushroom extract ○ ○ - ○ ○ ○ Thistle extract ○ ○ ○ - ○ ○ Juli powder ○ ○ ○ ○ - ○ Houttuynia fruit extract ○ ○ ○ ○ ○ -

Comparative Example  6 to 10: Preparation of composition for sputum rouge

In this Comparative Example, Comparative Examples 6 to 10 were prepared by varying the composition ratio of the food composition for hangover breakage of Production Example 1 (see Table 2).

Production Example 1 Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Grape seed extract 42 to 48 wt% 23 to 27 wt% 12 to 17 wt% 3 to 8 wt% 2 to 6 wt% 42 to 48 wt% Mushroom extract 23 to 27 wt% 42 to 48 wt% 3 to 8 wt% 2 to 6 wt% 12 to 17 wt% 2 to 6 wt% Thistle extract 12 to 17 wt% 3 to 8 wt% 42 to 48 wt% 23 to 27 wt% 3 to 8 wt% 23 to 27 wt% Julie
powder 3 to 8 wt% 2 to 6 wt% 23 to 27 wt% 42 to 48 wt% 23 to 27 wt% 12 to 17 wt% Houttuynia fruit extract 2 to 6 wt% 12 to 17 wt% 2 to 6 wt% 12 to 17 wt% 42 to 48 wt% 3 to 8 wt%

Experimental Example  One: ADH Wow ALDH Activity measurement of in vitro )

In this Experimental Example, the activities of ADH and ALDH were measured for the composition for hangover hunting prepared in Preparation Example 1 and Comparative Examples 1 to 10.

Alcohol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH) in the liver and then decomposed into acetic acid and hydrogen by aldehyde dehydrogenase (ALDH) and excreted through the urine. Decay of acetaldehyde must be done quickly to effectively relieve hangover.

The activity of ADH and ALDH was measured by modifying 'Blandino's method (Bostian et al., 1978)', and the absorbance was used as an index of the NADH production rate at 340 nm.

Promoting ADH activity Promoting ALDH activity Production Example 1 11.3% 42.5% Comparative Example 1 5.2% 15.3% Comparative Example 2 5.1% 14.8% Comparative Example 3 5.4% 15.0% Comparative Example 4 4.8% 15.1% Comparative Example 5 5.0% 14.5% Comparative Example 6 5.2% 14.7% Comparative Example 7 4.6% 14.2% Comparative Example 8 4.7% 15.0% Comparative Example 9 4.5% 14.9% Comparative Example 10 5.3% 15.6%

From the results of the measurement (see Table 3), it was confirmed that the food composition for hangover resolution of Production Example 1 was superior in the activity of promoting the activity of ADH and ALDH as compared with Comparative Examples 1 to 10, .

Experimental Example 2: Blood alcohol concentration over time after administration of food composition for hangover

In this experiment, blood alcohol concentration was measured over time after administration of the composition for hangover treatment prepared in Preparation Example 1 and Comparative Examples 1 to 10 to 60 rats.

Five of 60 mice were administered with 0.6 ml of distilled water as a control group and 0.3 ml of alcohol (alcoholic water, 40% v / v) 30 minutes after the administration of distilled water.

On the other hand, the remaining 5 out of 60 animals were divided into 5 groups according to Preparation Example 1, and the remaining 50 animals were administered with 0.6 ml of each of Comparative Examples 1 to 10, 0.3 ml of alcohol (alcoholic water, 40% v / v) Respectively. Thereafter, blood was collected from the heart in each treatment group at 0, 0.5, 1.0, 2.0, and 3.0 hours, and the alcohol concentration was measured.

Elapsed time (hours)
0 0.5 1.0 2.0 3.0 Control group 0.0325 0.0030 0.0351 ± 0.0040 0.0301 0.0030 0.0297 ± 0.0032 0.0252 0.0025 Production Example 1 0.0249 0.0019 0.0221 ± 0.0014 0.0185 0.0010 0.0156 + 0.0004 0.0137. + -. 0.0003 Comparative Example 1 0.0285 0.0028 0.0274 0.0025 0.0260 ± 0.0022 0.0245 ± 0.0018 0.0205 0.0016 Comparative Example 2 0.0285 0.0030 0.0276 0.0025 0.0263 ± 0.0022 0.0242 0.0018 0.0198 ± 0.0015 Comparative Example 3 0.0280 0.0028 0.0269 ± 0.0023 0.0254 0.0020 0.0236 ± 0.0017 0.0196 0.0015 Comparative Example 4 0.0277 ± 0.0029 0.0265 ± 0.0022 0.0250 ± 0.0020 0.0230 ± 0.0017 0.0187 ± 0.0014 Comparative Example 5 0.0278 ± 0.0028 0.0266 ± 0.0022 0.0252 0.0021 0.0233 ± 0.0017 0.0201 0.0016 Comparative Example 6 0.0269 ± 0.0025 0.0257 0.0019 0.0247 0.0019 0.0227 ± 0.0016 0.0195 ± 0.0013 Comparative Example 7 0.0274 0.0027 0.0267 0.0025 0.0254 0.0020 0.0230 ± 0.0016 0.0201 0.0013 Comparative Example 8 0.0280 0.0028 0.0270 ± 0.0028 0.0258 0.0022 0.0233 ± 0.0017 0.0199 ± 0.0014 Comparative Example 9 0.0291 + 0.0030 0.0273 ± 0.0028 0.0260 0.0024 0.0235 ± 0.0018 0.0201 0.0013 Comparative Example 10 0.0268 ± 0.0023 0.0255 + 0.0021 0.0247 0.0019 0.0228 ± 0.0016 0.0193 0.0012

As a result of the measurement (see Table 4), it was confirmed that the blood alcohol was significantly reduced upon administration of the food composition for hangover as prepared in Preparation Example 1. From this, it was confirmed that the composition of the present invention had a good hangover resolution effect.

Example  One: Manufacturing example  1 hangover Resolvability  Research

In this Example, 60 adult healthy men (25 to 50 years old, 5 to 25 years of drinking experience) were divided into two groups according to the number of subjects And clinical trials were conducted.

Drinking was prohibited for 24 hours before and after the experiment, and on the day of the experiment, the experiment was performed with fasting.

Five of the 60 patients were treated with 75 ml of distilled water and 30 minutes after the administration of distilled water, the animals were adjusted to have an alcohol concentration of 0.5 g / kg body weight (alcoholic strength, 40% v / v) .

In the meantime, 5 out of 60 patients were divided into Preparation Example 1, and the remaining 50 patients were divided into 5 patients, and each of Comparative Examples 1 to 10 was treated with 75 ml each, followed by allowing to stand still for 30 minutes. After that, it was adjusted to be 0.5 g / 1 kg of alcohol (alcoholic strength, 40% v / v), and the whole amount was drunk within 10 minutes.

Headache, nausea, vomiting, and palpitation, which are representative symptoms of hangover, were evaluated and the results are shown in Table 5 below. At this time, the headache, vomiting, and degree of visual complexion were both "5: no, 4: none, 3: normal, 2: slightly, 1: very severe".

headache throw up Goal complexion Control group 2.1 2.5 2.6 2.2 Production Example 1 4.3 4.6 4.2 4.6 Comparative Example 1 3.3 3.5 3.6 3.4 Comparative Example 2 3.0 3.5 3.4 3.3 Comparative Example 3 3.4 3.6 3.8 3.4 Comparative Example 4 3.5 3.3 3.7 3.7 Comparative Example 5 3.2 3.2 3.5 3.3 Comparative Example 6 3.1 3.4 3.3 3.6 Comparative Example 7 3.3 3.1 3.4 3.0 Comparative Example 8 3.4 3.0 3.2 3.6 Comparative Example 9 3.3 3.6 3.4 3.6 Comparative Example 10 3.8 3.7 3.7 3.8

The results of the test (see Table 5) showed that the food composition for hangover hunting prepared in Preparation Example 1 showed excellent results in the evaluation items of headache, vomiting, dryness and color. On the other hand, it was confirmed that when any one of the food compositions for hangover is excluded or the composition ratio is changed, the hangover resolution effect is lowered.

Manufacturing example  2: Manufacture of hangover food

In this Production Example, a hangover food was prepared as follows.

(1) beverage manufacturing

0.25 g of citric acid, 35 g of fructose, 60 g of lemon juice, and 20 mg of the food composition for hangover breakage in Production Example 1 were mixed, and a small-sized beverage was prepared by hanging in accordance with a usual beverage preparation method.

(2) Chewing gum manufacturing

26.1% by weight of a chewing gum, 70.9% by weight of sugar, 1% by weight of a flavor and 2% by weight of water were mixed and 20 mg of a food composition for hangover was added to prepare a typical chewing gum. .

(3) Candy manufacturing

After mixing with 63% by weight of sugar, 36.9% by weight of starch syrup, and 0.1% by weight of fragrance, 20 mg of the food composition for hangover preparation of Production Example 1 was added and hanged according to a conventional candy manufacturing method to prepare small candies.

Claims (4)

Grape seed extract, chaga mushroom extract, thistle extract, juli powder, and Hovenia dulcis extract.
The method according to claim 1,
The composition may comprise,
Characterized in that it comprises 42 to 48% by weight of grape seed extract, 23 to 27% by weight of chaga mushroom extract, 12 to 17% by weight of thistle extract, 3 to 8% by weight of horsetail powder and 2 to 6% by weight of horsetail fruit extract (Canceled).
A hangover drinking drink containing the food composition of claim 1 or 2.
A chewable chewing gum comprising the food composition for hangover of claim 1 or 2.